Potentially Inappropriate Anticholinergic Medication Use in Community-Dwelling Older Adults: A National Cross-Sectional Study

Drugs and Aging

Volumn 32, Issue 5, 2015, Pages 379-389

  Kachru, Nandita ^a   Carnahan, Ryan M ^b   Johnson, Michael L ^a   Aparasu, Rajender R ^a  

^a UNIVERSITY OF HOUSTON   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; CHOLINERGIC RECEPTOR BLOCKING AGENT; CYCLOBENZAPRINE; DICYCLOVERINE; HYDROXYZINE; PROMETHAZINE;

AGE; AGED; ANXIETY DISORDER; ARTICLE; CROSS-SECTIONAL STUDY; EDUCATION; FEMALE; HUMAN; MALE; MEDICATION ERROR; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SEX DIFFERENCE; VERY ELDERLY; BEHAVIOR; DRUG EFFECTS; EDUCATIONAL STATUS; EPIDEMIOLOGY; GEOGRAPHY; HEALTH SERVICE; HEALTH STATUS; INAPPROPRIATE PRESCRIBING; PREVALENCE; SOCIOECONOMICS; STATISTICAL MODEL; STATISTICS AND NUMERICAL DATA; UNITED STATES;

AGED; AGED, 80 AND OVER; BEHAVIOR; CHOLINERGIC ANTAGONISTS; CROSS-SECTIONAL STUDIES; EDUCATIONAL STATUS; FEMALE; GEOGRAPHY; HEALTH SERVICES NEEDS AND DEMAND; HEALTH STATUS; HUMANS; INAPPROPRIATE PRESCRIBING; MALE; MODELS, STATISTICAL; PREVALENCE; RETROSPECTIVE STUDIES; SEX FACTORS; SOCIOECONOMIC FACTORS; UNITED STATES;

EID: 84930042490     PISSN: 1170229X     EISSN: 11791969     Source Type: Journal    
DOI: 10.1007/s40266-015-0257-x     Document Type: Article

References (45)

1. Beers MH, Ouslander JG, Rollingher I, et al. Explicit criteria for determining inappropriate medication use in nursing home residents. Arch Intern Med. 1991;151:1825–32.
2. Stuck AE, Beers MH, Steiner A, et al. Inappropriate medication use in community-residing older persons. Arch Intern Med. 1994;154:2195–200.
3. Liu GG, Christensen DB. The continuing challenge of inappropriate prescribing in the elderly:an update of the evidence. JAMA. 2002;42:847–57.
4. Beers MH, Ouslander JG, Fingold SF, et al. Inappropriate medication prescribing in skilled-nursing facilities. Ann Intern Med. 1992;117:684–9.
5. Gurwitz JH, Soumerai SB, Avorn J. Improving medication prescribing and utilization in the nursing home. J Am Geriatr Soc. 1990;38:542–52.
6. Willcox SM, Himmelstein DU, Woolhandler S. Inappropriate drug prescribing for the community-dwelling elderly. JAMA. 1994;272(4):292–6.
7. United States General Accounting Office. Prescription drugs and the elderly. Many still receive potentially harmful drugs despite recent improvements: report to the Honorable Ron Wyden, House of Representatives. Washington, DC: US General Accounting Office, 1995.
8. Aparasu RR, Fliginger SE. Inappropriate medication prescribing for the elderly by office-based physicians. Ann Pharmacother. 1997;31:823–9.
9. Fu AZ, Jiang JZ, Reeves JH, et al. Potentially inappropriate medication use and healthcare expenditures in the US community-dwelling elderly. Med Care. 2007;45:472–6.
10. Beers MH. Explicit criteria for determining potentially inappropriate medication use by the elderly: an update. Arch Intern Med. 1997;157:1531–6.
11. Fick DM, Cooper JW, Wade WE, et al. Updating the Beers Criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts. Arch Intern Med. 2003;163:2716–24.
12. American Geriatrics Society 2012 Beers Criteria Update Expert Panel. American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2012;60(4):616–31.
13. Boustani M, Campbell N, Fox C, et al. Impact of anticholinergics on the aging brain: a review and practical application. Aging Health. 2008;4(3):311.
14. Carnahan RM, Lund BC, Perry PJ, et al. The concurrent use of anticholinergics and cholinesterase inhibitors: rare event or common practice? J Am Geriatr Soc. 2004;52(12):2082–7.
15. Mintzer J, Burns A. Anticholinergic side-effects of drugs in elderly adults. J R Soc Med. 2000;93(9):457–62.
16. Fox C, Smith T, Maidment I, et al. Effects of medications with anti-cholinergic properties on cognitive function, delirium, physical function and mortality: a systematic review. Age Aging. 2014;43(5):604–15.
17. Hilmer SN, Mager DE, Simonsick EM, et al. Drug burden index score and functional decline in older adults. Am J Med. 2009;122(12):1142–9.
18. Shelton PS, Fritsch MA, Scott MA. Assessing medication appropriateness in the elderly: areview of available measures. Drugs Aging. 2000;16(6):437–50.
19. Tune L, Carr S, Hoag E, et al. Anticholinergic effects of drugs commonly prescribed for the elderly: potential means for assessing risk of delirium. Am J Psychiatry. 1992;149(10):1393–4.
20. Lau DT, Kasper JD, Potter DE, et al. Potentially inappropriate medication prescriptions among elderly nursing home residents: their scope and associated resident and facility characteristics. Health Serv Res. 2004;39(5):1257–76.
21. Caterino JM, Emond JA, Camargo CA. Inappropriate medication administration to the acutely ill elderly: a nationwide emergency department study, 1992–2000. JAm Geriatr Soc. 2004;52:1847–55.
22. Bergman A, Olsson J, Carlsten A, et al. Evaluation of the quality of drug therapy among elderly patients in nursing homes. Scand J Prim Health Care. 2007;25(1):9–14.
23. Perri M 3rd, Menon AM, Deshpande AD, et al. Adverse outcomes associated with inappropriate drug use in nursing homes. Ann Pharmacother. 2005;39(3):405–11.
24. Wawruch M, Macugova A, Kostkova L, et al. The use of medications with anticholinergic properties and risk factors for their use in hospitalized elderly patients. Pharmacoepidemiol Drug Saf. 2012;21:170–6.
25. Kumpula EK, Bell JS, Soini H, et al. Anticholinergic drug use and mortality among residents of long-term care facilities: a prospective cohort study. J Clin Pharmacol. 2011;51(2):256–63.
26. Jessen F, Kaduszkiewicz H, Daerr M, et al. Anticholinergic drug use and risk for dementia: target for dementia prevention. Eur Arch Psychiatry Clin Neurosci. 2010;260(Suppl 2):S111–5.
27. Fox C, Richardson K, Maidment ID, et al. Anticholinergic medication use and cognitive impairment in the older population: the Medical Research Council Cognitive Function and Ageing Study. J Am Geriatr Soc. 2011;59:1477–83.
28. Kolanowski A, Fick DM, Campbell J, et al. A preliminary study of anticholinergic burden and relationship to a quality of life indicator, engagement in activities, in nursing home residents with dementia. J Am Med Dir Assoc. 2009;10(4):252–7.
29. Bhattacharya R, Chatterjee S, Carnahan RM, et al. Prevalence and predictors of anticholinergic agents in elderly outpatients with dementia. Am J Geriatr Pharmacother. 2011;9(6):434–41.
30. Sura SD, Carnahan RM, Chen H, et al. Prevalence and determinants of anticholinergic medication use in elderly dementia patients. Drugs Aging. 2013;30(10):837–44.
31. Chatterjee S, Mehta S, Sherer JT, et al. Prevalence and predictors of anticholinergic medication use in elderly nursing home residents with dementia: analysis of data from the 2004 National Nursing Home Survey. Drugs Aging. 2010;27(12):987–97.
32. Medical Expenditure Panel Survey. Agency for Healthcare Research and Quality (AHRQ) (online). http://meps.ahrq.gov/mepsweb/data_stats/download_data/pufs/h137/h137doc.pdf. Accessed 9 July 2013.
33. Cohen JW, Cohen SB, Banthin JS. The Medical Expenditure Panel Survey: a national information resource to support healthcare cost research and inform policy and practice. Med Care. 2009;47(7 Suppl 1):S44–50.
34. Andersen R, Newman JF. Societal and individual determinants of medical care utilization in the United States. Milbank Mem Fund Q Health Soc. 1973;51(1):95–124.
35. Andersen RM. Revisiting the behavioralmodel and access to medical care: does it matter? J Health Soc Behav. 1995;36(1):1–10.
36. Piecoro LT, Browning SR, Prince TS, et al. A database analysis of potentially inappropriate drug use in an elderly Medicaid population. Pharmacotherapy. 2000;20(2):221–8.
37. Curtis LH, Ostbye T, Sendersky V, et al. Inappropriate prescribing for elderly Americans in a large outpatient population. Arch Intern Med. 2004;164:1621–5.
38. Spence MM, Shin PJ, Lee EA, et al. Risk of injury associated with skeletal muscle relaxant use in older adults. Ann Pharmacother. 2013;47:993–8.
39. Hong IS, Bishop JR. Anticholinergic use in children and adolescents after initiation of antipsychotic therapy. Ann Pharmacother. 2010; 44(7–8): 1171–80.
40. Wastesson JW, Ringbäck Weitoft G, Johnell K. Educational disparities in antipsychotic drug use among older adults with and without dementia in Sweden. Acta Psychiatr Scand. Epub 2014. doi:10.1111/acps.12378.
41. Zhang Y, Baicker K, Newhouse JP. Geographic variation in the quality of prescribing. N Engl J Med. 2010;363(21):1985–8.
42. Qato DM, Trivedi AN. Receipt of high risk medications among elderly enrollees in Medicare Advantage plans. J Gen Intern Med. 2013;28(4):546–53.
43. National Institute of Mental Health. Anxiety disorders [NIH publication no. 09 3879]. Bethesda: National Institutes of Health, US Department Of Health And Human Services, 2009. http://www.nimh.nih.gov/health/publications/anxiety-disorders/nimhanxiety_34436.pdf. Accessed 15 Mar 2015.
44. Llorca PM, Spadone C, Sol O, et al. Efficacy and safety of hydroxyzine in the treatment of generalized anxiety disorder: a 3-month double-blind study. J Clin Psychiatry. 2002;63:1020–7.
45. Miyata S, Hirano S, Ohsawa M, et al. Chlorpheniramine exerts anxiolytic-like effects and activates prefrontal 5-HT systems in mice. Psychopharmacology. 2011;213(2–3):441–52.