Overexpression of SIRT3 disrupts mitochondrial proteostasis and cell cycle progression

Protein and Cell

Volumn 7, Issue 4, 2016, Pages 295-299

  Wang, Xiaofei ^a   Tang, Haiping ^a   Chen, Yuling ^a   Chi, Binghuan ^b   Wang, Shiyu ^c   Lv, Yang ^c   Wu, Di ^c   Ge, Renshan ^b   Deng, Haiteng ^a  

^a TSINGHUA UNIVERSITY   (China)

^b WENZHOU MEDICAL UNIVERSITY   (China)

^c CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; CHOLECYSTOKININ OCTAPEPTIDE; CYTOCHROME C OXIDASE; HYDROGEN PEROXIDE; LONG CHAIN 3 HYDROXYACYL COENZYME A DEHYDROGENASE; REACTIVE OXYGEN METABOLITE; SIRTUIN 3; CHAPERONIN 60; SIRT3 PROTEIN, HUMAN;

ARTICLE; CARCINOGENESIS; CELL CYCLE PROGRESSION; CELL VIABILITY; CONTROLLED STUDY; DENATURING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; DOWN REGULATION; GENE ONTOLOGY; GENE OVEREXPRESSION; HEK293 CELL LINE; HUMAN; HUMAN CELL; MITOCHONDRION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN HOMEOSTASIS; PROTEOMICS; UPREGULATION; WESTERN BLOTTING; CELL CYCLE CHECKPOINT; GENETICS; METABOLISM; REAL TIME POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

BLOTTING, WESTERN; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CHAPERONIN 60; HEK293 CELLS; HUMANS; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; SIRTUIN 3;

EID: 84958780203     PISSN: 1674800X     EISSN: 16748018     Source Type: Journal    
DOI: 10.1007/s13238-016-0251-z     Document Type: Article

References (14)

1. Alhazzazi TY, Kamarajan P, Verdin E, Kapila YL (2011) SIRT3 and cancer: tumor promoter or suppressor? Biochim Biophys Acta 1816:80–88
2. Ashraf N, Zino S, Macintyre A, Kingsmore D, Payne AP, George WD, Shiels PG (2006) Altered sirtuin expression is associated with node-positive breast cancer. Br J Cancer 95:1056–1061
3. Carracedo A, Cantley LC, Pandolfi PP (2013) Cancer metabolism: fatty acid oxidation in the limelight. Nat Rev Cancer 13:227–232
4. Cohen HT, McGovern FJ (2005) Renal-cell carcinoma. N Engl J Med 353:2477–2490
5. Debeb BG, Zhang X, Krishnamurthy S, Gao H, Cohen E, Li L, Rodriguez AA, Landis MD, Lucci A, Ueno NT et al (2010) Characterizing cancer cells with cancer stem cell-like features in 293T human embryonic kidney cells. Mol Cancer 9:180
6. Finley LW, Haigis MC (2012) Metabolic regulation by SIRT3: implications for tumorigenesis. Trends Mol Med 18:516–523
7. Kim HS, Patel K, Muldoon-Jacobs K, Bisht KS, Aykin-Burns N, Pennington JD, van der Meer R, Nguyen P, Savage J, Owens KM et al (2010) SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell 17:41–52
8. McDonnell E, Peterson BS, Bomze HM, Hirschey MD (2015) SIRT3 regulates progression and development of diseases of aging. Trends Endocrinol Metab 26:486–492
9. Papa L, Germain D (2014) SirT3 regulates the mitochondrial unfolded protein response. Mol Cell Biol 34:699–710
10. Qiu X, Brown K, Hirschey MD, Verdin E, Chen D (2010) Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab 12:662–667
11. Sherr CJ, Roberts JM (1999) CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 13:1501–1512
12. Verdin E, Hirschey MD, Finley LW, Haigis MC (2010) Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling. Trends Biochem Sci 35:669–675
13. Yang Y, Chen KY, Tong Q (2011) Murine Sirt3 protein isoforms have variable half-lives. Gene 488:46–51
14. Yu W, Dittenhafer-Reed KE, Denu JM (2012) SIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status. J Biol Chem 287:14078–14086