The pro-fibrotic properties of transforming growth factor on human fibroblasts are counteracted by caffeic acid by inhibiting myofibroblast formation and collagen synthesis

Cell and Tissue Research

Volumn 363, Issue 3, 2016, Pages 775-789

  Mia, Masum M ^a   Bank, Ruud A ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Caffeic acid; Collagen; Fibrosis; Lysyl hydroxylase; Myofibroblasts

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CAFFEIC ACID PHENETHYL ESTER; COLLAGEN TYPE 1; FIBRONECTIN; MESSENGER RNA; SMAD2 PROTEIN; SMAD3 PROTEIN; TENASCIN; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR SNAIL1; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; ACTA2 PROTEIN, HUMAN; ACTIN; ACTIN BINDING PROTEIN; CAFFEIC ACID DERIVATIVE; MUSCLE PROTEIN; PHENETHYL ALCOHOL; PLOD2 PROTEIN, HUMAN; PROCOLLAGEN LYSINE 2 OXOGLUTARATE 5 DIOXYGENASE; SMAD PROTEIN; TRANSCRIPTION FACTOR; TRANSGELIN;

ACTA2 GENE; ADULT; ANTIFIBROTIC ACTIVITY; ARTICLE; CELLULAR DISTRIBUTION; CELLULAR, SUBCELLULAR AND MOLECULAR BIOLOGICAL PHENOMENA AND FUNCTIONS; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; GENE; GENE EXPRESSION REGULATION; GLI1 GENE; GLI2 GENE; HUMAN; HUMAN CELL; LUNG FIBROBLAST; MOLECULAR DYNAMICS; MYOFIBROBLAST FORMATION; PLOD2 GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SKIN FIBROBLAST; TAGLN GENE; UPREGULATION; ANALOGS AND DERIVATIVES; BIOSYNTHESIS; CELL NUCLEUS; DRUG EFFECTS; FIBROBLAST; FIBROSIS; GENETICS; METABOLISM; MYOFIBROBLAST; PATHOLOGY; PROTEIN TRANSPORT; YOUNG ADULT;

ACTINS; ADULT; CAFFEIC ACIDS; CELL NUCLEUS; COLLAGEN TYPE I; FIBROBLASTS; FIBRONECTINS; FIBROSIS; GENE EXPRESSION REGULATION; HUMANS; MICROFILAMENT PROTEINS; MUSCLE PROTEINS; MYOFIBROBLASTS; PHENYLETHYL ALCOHOL; PROCOLLAGEN-LYSINE, 2-OXOGLUTARATE 5-DIOXYGENASE; PROTEIN TRANSPORT; RNA, MESSENGER; SMAD PROTEINS; TENASCIN; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA1; YOUNG ADULT;

EID: 84958741300     PISSN: 0302766X     EISSN: 14320878     Source Type: Journal    
DOI: 10.1007/s00441-015-2285-6     Document Type: Article

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