Icariin inhibits oxidized low-density lipoprotein-induced proliferation of vascular smooth muscle cells by suppressing activation of extracellular signal-regulated kinase 1/2 and expression of proliferating cell nuclear antigen

Molecular Medicine Reports

Volumn 13, Issue 3, 2016, Pages 2899-2903

  Hu, Yanwu ^a,b   Liu, Kai ^a   Yan, Mengtong ^a   Zhang, Yang ^a   Wang, Yadi ^a   Ren, Liqun ^a  

^a JILIN UNIVERSITY   (China)

^b TONGHUA NORMAL UNIVERSITY   (China)

Author keywords

Extracellular signal regulated kinase 1 2; Icariin; Oxidized low density lipoprotein; Proliferating cell nuclear antigen; Vascular smooth muscle cell proliferation

Indexed keywords

CYCLINE; ICARIIN; MITOGEN ACTIVATED PROTEIN KINASE 1; OXIDIZED LOW DENSITY LIPOPROTEIN; FLAVONOID; LOW DENSITY LIPOPROTEIN; MAPK1 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE 3;

ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; INTERPHASE; MTT ASSAY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE CELL; WESTERN BLOTTING; ATHEROSCLEROSIS; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; GENETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PRECLINICAL STUDY; PROTEIN PROCESSING; SMOOTH MUSCLE CELL; VASCULAR SMOOTH MUSCLE;

ATHEROSCLEROSIS; CELL PROLIFERATION; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; FLAVONOIDS; HUMANS; LIPOPROTEINS, LDL; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PHOSPHORYLATION; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 84958721664     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2016.4813     Document Type: Article

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