Mitogenic effect of oxidized low-density lipoprotein on vascular smooth muscle cells mediated by activation of Ras/Raf/MEK/MAPK pathway

British Journal of Pharmacology

Volumn 132, Issue 7, 2001, Pages 1531-1541

  Yang, C M ^a   Chien, C S ^a   Hsiao, L D ^a   Pan, S L ^a   Wang, C C ^a   Chiu, C T ^a   Lin, C C ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

Cell proliferation; MEK; Mitogen activated protein kinase; Protein kinase C; Tyrosine kinase; Vascular smooth muscle cell

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CALCIUM; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; G PROTEIN COUPLED RECEPTOR; GENISTEIN; HERBIMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE; OXIDIZED LOW DENSITY LIPOPROTEIN; PROTEIN KINASE C; RAF PROTEIN; RAS PROTEIN; STAUROSPORINE; THAPSIGARGIN;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVATION; GENE OVEREXPRESSION; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE;

EID: 0035067083     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703976     Document Type: Article

References (42)

1. A ras-dependent pathway regulates RNA polymerase II phosphorylation in cardiac myocytes: Implications for cardiac hypertrophy
2. Proliferative and cytotoxic effects of mildly oxidized low density lipoproteins on vascular smooth muscle cells
3. Oxidized low-density lipoprotein is chemotactic for arterial smooth muscle cells in culture
4. Signal transduction via the MAP kinases: Proceed at your own RSK
5. Oxidized low density lipoproteins induce mRNA expression and release of endothelin from human and porcine endothelium
6. Two distinct Raf domains mediate interaction with Ras
7. Construction and applications of a highly transmissible murine retrovirus shuttle vector
8. 44 mitogen activated protein kinase and c-fos expression in aortic smooth muscle cells
9. Dominant-negative Ras(15A) protein, but not Ras(N17), binds irreversibly to CDC25 GDP-GTP exchange protein
10. Oxidized low-density lipoprotein stimulates protein kinase C (PKC) and induces expression of PKC-isotypes via prostaglandin-h-synthase in P388D1
11. Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits
12. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
13. A synthetic inhibitor of the mitogen-activated protein kinase cascade
14. Oxidatively modified LDL contains phospholipids with platelet-activating factor-like activity and stimulates the growth of smooth muscle cells
15. G beta gamma interactions with PH domains and Ras-MAPK signaling pathways
16. PDGF β-receptors stimulates tyrosine phosphorylation of GAP and association of GAP with a signalling complex
17. Cell cycle targets of Ras/Raf signalling
18. Protein kinase Cα activates RAF-1 by direct phosphorylation
19. A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf
20. Mechanism of the antihypertensive effect of K depletion in the SHR
21. Role of Janus kinase/signal transducer and activator of transcription and mitogen-activated protein kinase cascades in angiotensin II- and platelet-derived growth factor-induced vascular smooth muscle cell proliferation
22. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
23. Angiotensin II stimulation of protein tyrosine phosphorylation and protein kinase activation in rat aortic smooth muscle cells
24. Endothelial and smooth muscle cells alter LDL in vitro by free radical oxidation
25. Oxidized low density lipoprotein-mediated activation of phospholipase D in smooth muscle cells: A possible role in cell proliferation and atherogenesis
26. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
27. Isolation and partial characterization of polypeptide belonging to apolipoprotein B from low density lipoproteins in human plasma
28. G protein-coupled receptors and signaling pathways regulating growth response
29. Transmembrane receptors and intracellular pathways that control cell proliferation
30. Oxidized low density lipoproteins stimulate phosphoinositide turnover in cultured vascular smooth muscle cells
31. Thromboxane A2 and vascular smooth muscle cell proliferation
32. The growth-promoting effect of low-density lipoprotein may be mediated by a pertussis toxin-sensitive mitogen-activated protein kinase pathway
33. Function of Ras as a molecular switch in signal transduction
34. ras
35. Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic
36. The sequence of cell and matrix changes in atherosclerotic lesions of coronary arteries in the first forty years of life
37. Beyond cholesterol: Modifications of low-density lipoprotein that increase its atherogenicity
38. Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids
39. Native and oxidized LDL enhancess production of PDGF-AA and the surface expression of PDGF receptors in cultured human smooth muscle cells
40. Ras-stimulated extracellular signal-related kinase I and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27
41. Role of oxidized low density lipoprotein in atherogenesis
42. Tumor necrosis factor-α- and interleukin-1β-stimulated cell proliferation through activation of mitogen-activated protein kinase in canine tracheal smooth muscle cells