A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling

Immunity

Volumn 44, Issue 2, 2016, Pages 368-379

  Ní Cheallaigh, Clíona ^a,b   Sheedy, Frederick J ^a   Harris, James ^c   Muñoz Wolf, Natalia ^b   Lee, Jinhee ^d   West, Kim ^d   McDermott, Eva Palsson ^b   Smyth, Alicia ^e   Gleeson, Laura E ^a   Coleman, Michelle ^a   Martinez, Nuria ^d   Hearnden, Claire H A ^b   Tynan, Graham A ^b   Carroll, Elizabeth C ^b   Jones, Sarah A ^c   Corr, Sinéad C ^b   Bernard, Nicholas J ^b   Hughes, Mark M ^b   Corcoran, Sarah E ^b   O'Sullivan, Mary ^a   Fallon, Ciara M ^a   Kornfeld, Hardy ^d   Golenbock, Douglas ^d   Gordon, Stephen V ^e   O'Neill, Luke A J ^b   Lavelle, Ed C ^b   Keane, Joseph ^a   more..

^a ST JAMES S HOSPITAL   (Ireland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

^c MONASH UNIVERSITY   (Australia)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^e UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Autophagy; Interferon gamma; Mal; Phagolysosome maturation; TIRAP; Tuberculosis

Indexed keywords

ADAPTOR PROTEIN; BECLIN 1; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GAMMA INTERFERON RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 12P40; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 27; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; MYD88 ADAPTOR LIKE PROTEIN; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN; STAT1 PROTEIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; GAMMA INTERFERON; INTERFERON RECEPTOR; INTERLEUKIN 1 RECEPTOR; MEMBRANE PROTEIN; PROTEIN BINDING; SMALL INTERFERING RNA; TIRAP PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOIMMUNITY; AUTOPHAGOSOME; AUTOPHAGY; BACTERIAL LOAD; BACTERIAL VIRULENCE; BACTERICIDAL ACTIVITY; BINDING AFFINITY; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA POLYMORPHISM; EMBRYO; GENE MUTATION; GENETIC VARIABILITY; HOMOZYGOTE; IN VITRO STUDY; IN VIVO STUDY; LUNG TUBERCULOSIS; MACROPHAGE FUNCTION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHAGOLYSOSOME; PHAGOSOME; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; GENETIC ASSOCIATION STUDY; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HEK293 CELL LINE; HUMAN; IMMUNOLOGY; INNATE IMMUNITY; KNOCKOUT MOUSE; MACROPHAGE; METABOLISM; MICROBIOLOGY; PHYSIOLOGY;

ANIMALS; AUTOPHAGY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HEK293 CELLS; HUMANS; IMMUNITY, INNATE; INTERFERON-GAMMA; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; MYCOBACTERIUM TUBERCULOSIS; POLYMORPHISM, GENETIC; PROTEIN BINDING; RECEPTORS, INTERFERON; RECEPTORS, INTERLEUKIN-1; RNA, SMALL INTERFERING; TUBERCULOSIS, PULMONARY;

EID: 84958621412     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2016.01.019     Document Type: Article

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