Intestinal organoids as tissue surrogates for toxicological and pharmacological studies

Biochemical Pharmacology

Volumn 85, Issue 12, 2013, Pages 1721-1726

  Kuratnik, Anton ^a   Giardina, Charles ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Embryonic stem cells; High throughput screening; Induced pluripotent cells; Intestinal organoids; Intestinal stem cells

Indexed keywords

CANCER PREVENTION; COLON CANCER; COLORECTAL CANCER; CYTOPLASM; EMBRYONIC STEM CELL; ENTERITIS; ENTEROPATHY; GASTROINTESTINAL DISEASE; HIGH THROUGHPUT SCREENING; HUMAN; IN VIVO STUDY; INTESTINAL CRYPTS; INTESTINAL ORGANOID; INTESTINAL STEM CELL; INTESTINE EPITHELIUM; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVIEW; STEM CELL; TOXICOLOGY;

EID: 84878835012     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.04.016     Document Type: Note

References (60)

1. M.J. Evans, and M.H. Kaufman Establishment in culture of pluripotential cells from mouse embryos Nature 292 1981 154 156 (Pubitemid 11050741)
2. J.A. Thomson, J. Itskovitz-Eldor, S.S. Shapiro, M.A. Waknitz, J.J. Swiergiel, and V.S. Marshall Embryonic stem cell lines derived from human blastocysts Science 282 1998 1145 1147 (Pubitemid 28516247)
3. C. Mason, and P. Dunnill Assessing the value of autologous and allogeneic cells for regenerative medicine Regen Med 4 2009 835 853
4. T. Zhao, Z.N. Zhang, Z. Rong, and Y. Xu Immunogenicity of induced pluripotent stem cells Nature 474 2011 212 215
5. S.D. Schwartz, J.P. Hubschman, G. Heilwell, V. Franco-Cardenas, C.K. Pan, and R.M. Ostrick Embryonic stem cell trials for macular degeneration: a preliminary report Lancet 379 2012 713 720
6. S. Miyamoto, and D.W. Rosenberg Role of Notch signaling in colon homeostasis and carcinogenesis Cancer Sci 102 2011 1938 1942
7. B.D. Simons, and H. Clevers Stem cell self-renewal in intestinal crypt Exp Cell Res 317 2011 2719 2724
8. A. Humphries, and N.A. Wright Colonic crypt organization and tumorigenesis Nat Rev Cancer 8 2008 415 424 (Pubitemid 351744961)
9. T. Sato, J.H. van Es, H.J. Snippert, D.E. Stange, R.G. Vries, and M. van den Born Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts Nature 469 2011 415 418
10. N. Barker, and H. Clevers Lineage tracing in the intestinal epithelium Curr Protoc Stem Cell Biol 2010 [chapter 5: unit 5A 4]
11. N. Barker, and H. Clevers Tracking down the stem cells of the intestine: strategies to identify adult stem cells Gastroenterology 133 2007 1755 1760 (Pubitemid 350180827)
12. S. Roth, P. Franken, A. Sacchetti, A. Kremer, K. Anderson, and O. Sansom Paneth cells in intestinal homeostasis and tissue injury PLoS ONE 7 2012 e38965
13. M.T. Abreu Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function Nat Rev Immunol 10 2010 131 144
14. M. Candela, M. Guidotti, A. Fabbri, P. Brigidi, C. Franceschi, and C. Fiorentini Human intestinal microbiota: cross-talk with the host and its potential role in colorectal cancer Crit Rev Microbiol 37 2011 1 14
15. E.V. Loftus Jr. Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences Gastroenterology 126 2004 1504 1517 (Pubitemid 38649869)
16. A. Jemal, F. Bray, M.M. Center, J. Ferlay, E. Ward, and D. Forman Global cancer statistics CA Cancer J Clin 61 2011 69 90
17. U.I.G. Consortium, J.C. Barrett, J.C. Lee, C.W. Lees, N.J. Prescott, and C.A. Anderson Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region Nat Genet 41 2009 1330 1334
18. A.I. Thompson, and C.W. Lees Genetics of ulcerative colitis Inflamm Bowel Dis 17 2011 831 848
19. S. van Sommeren, M.C. Visschedijk, E.A. Festen, D.J. de Jong, C.Y. Ponsioen, and C. Wijmenga HNF4alpha and CDH1 are associated with ulcerative colitis in a Dutch cohort Inflamm Bowel Dis 17 2011 1714 1718
20. A. Swidsinski, V. Loening-Baucke, and A. Herber Mucosal flora in Crohn's disease and ulcerative colitis - an overview J Physiol Pharmacol 60 Suppl 6 2009 61 71
21. T. Yamada, M. Yoshikawa, M. Takaki, S. Torihashi, Y. Kato, and Y. Nakajima In vitro functional gut-like organ formation from mouse embryonic stem cells Stem Cells 20 2002 41 49 (Pubitemid 34118909)
22. T. Ueda, T. Yamada, D. Hokuto, F. Koyama, S. Kasuda, and H. Kanehiro Generation of functional gut-like organ from mouse induced pluripotent stem cells Biochem Biophys Res Commun 391 2010 38 42
23. S. Torihashi, M. Kuwahara, T. Ogaeri, P. Zhu, M. Kurahashi, and T. Fujimoto Gut-like structures from mouse embryonic stem cells as an in vitro model for gut organogenesis preserving developmental potential after transplantation Stem Cells 24 2006 2618 2626 (Pubitemid 46053000)
24. S. Torihashi Formation of gut-like structures in vitro from mouse embryonic stem cells Methods Mol Biol 330 2006 279 285
25. R. Matsuura, H. Kogo, T. Ogaeri, T. Miwa, M. Kuwahara, and Y. Kanai Crucial transcription factors in endoderm and embryonic gut development are expressed in gut-like structures from mouse ES cells Stem Cells 24 2006 624 630 (Pubitemid 44464766)
26. M. Kuwahara, T. Ogaeri, R. Matsuura, H. Kogo, T. Fujimoto, and S. Torihashi In vitro organogenesis of gut-like structures from mouse embryonic stem cells Neurogastroenterol Motil 16 Suppl. 1 2004 14 18 (Pubitemid 38580934)
27. L. Cao, J.D. Gibson, S. Miyamoto, V. Sail, R. Verma, and D.W. Rosenberg Intestinal lineage commitment of embryonic stem cells Differentiation 81 2011 1 10
28. A.B. McLean, K.A. D'Amour, K.L. Jones, M. Krishnamoorthy, M.J. Kulik, and D.M. Reynolds Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed Stem Cells 25 2007 29 38 (Pubitemid 46052972)
29. K.A. D'Amour, A.D. Agulnick, S. Eliazer, O.G. Kelly, E. Kroon, and E.E. Baetge Efficient differentiation of human embryonic stem cells to definitive endoderm Nat Biotechnol 23 2005 1534 1541 (Pubitemid 41752931)
30. A. Kubo, K. Shinozaki, J.M. Shannon, V. Kouskoff, M. Kennedy, and S. Woo Development of definitive endoderm from embryonic stem cells in culture Development 131 2004 1651 1662 (Pubitemid 38559291)
31. A.F. Schier Nodal signaling in vertebrate development Annu Rev Cell Dev Biol 19 2003 589 621 (Pubitemid 37487362)
32. H. Tiedemann, M. Asashima, H. Grunz, and W. Knochel Pluripotent cells (stem cells) and their determination and differentiation in early vertebrate embryogenesis Dev Growth Differ 43 2001 469 502 (Pubitemid 32953769)
33. P.W. Pan, A. Rodriguez, and S. Parkkila A systematic quantification of carbonic anhydrase transcripts in the mouse digestive system BMC Mol Biol 8 2007 22
34. H. Poirier, I. Niot, P. Degrace, M.C. Monnot, A. Bernard, and P. Besnard Fatty acid regulation of fatty acid-binding protein expression in the small intestine Am J Physiol 273 1997 G289 G295
35. F. Beck, F. Tata, and K. Chawengsaksophak Homeobox genes and gut development Bioessays 22 2000 431 441 (Pubitemid 30308269)
36. J.R. Spence, C.N. Mayhew, S.A. Rankin, M.F. Kuhar, J.E. Vallance, and K. Tolle Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro Nature 470 2011 105 109
37. K.W. McCracken, J.C. Howell, J.M. Wells, and J.R. Spence Generating human intestinal tissue from pluripotent stem cells in vitro Nat Protoc 6 2011 1920 1928
38. T. Sato, R.G. Vries, H.J. Snippert, M. van de Wetering, N. Barker, and D.E. Stange Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche Nature 459 2009 262 265
39. P. Jung, T. Sato, A. Merlos-Suarez, F.M. Barriga, M. Iglesias, and D. Rossell Isolation and in vitro expansion of human colonic stem cells Nat Med 17 2011 1225 1227
40. T. Sato Novel intestinal stem cell culture system Inflamm Regen 32 2012 43 47
41. S. Yui, T. Nakamura, T. Sato, Y. Nemoto, T. Mizutani, and X. Zheng Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5(+) stem cell Nat Med 18 2012 618 623
42. R. Kawashima, Y.I. Kawamura, T. Oshio, A. Son, M. Yamazaki, and T. Hagiwara Interleukin-13 damages intestinal mucosa via TWEAK and Fn14 in mice-a pathway associated with ulcerative colitis Gastroenterology 141 2011 2119 2129
43. M. Ramasundara, S.T. Leach, D.A. Lemberg, and A.S. Day Defensins and inflammation: the role of defensins in inflammatory bowel disease J Gastroenterol Hepatol 24 2009 202 208
44. J.P. Williams, S.L. Brown, G.E. Georges, M. Hauer-Jensen, R.P. Hill, and A.K. Huser Animal models for medical countermeasures to radiation exposure Radiat Res 173 2010 557 578
45. G. Hua, T.H. Thin, R. Feldman, A. Haimovitz-Friedman, H. Clevers, and Z. Fuks Crypt base columnar stem cells in small intestines of mice are radioresistant Gastroenterology 143 2012 1266 1276
46. S.S. Zeki, T.A. Graham, and N.A. Wright Stem cells and their implications for colorectal cancer Nat Rev Gastroenterol Hepatol 8 2011 90 100
47. B.M. Boman, J.Z. Fields, K.L. Cavanaugh, A. Guetter, and O.A. Runquist How dysregulated colonic crypt dynamics cause stem cell overpopulation and initiate colon cancer Cancer Res 68 2008 3304 3313
48. V. Fedirko, R.M. Bostick, W.D. Flanders, Q. Long, E. Sidelnikov, and A. Shaukat Effects of vitamin d and calcium on proliferation and differentiation in normal colon mucosa: a randomized clinical trial Cancer Epidemiol Biomarkers Prev 18 2009 2933 2941
49. S.S. Dronamraju, J.M. Coxhead, S.B. Kelly, J. Burn, and J.C. Mathers Cell kinetics and gene expression changes in colorectal cancer patients given resistant starch: a randomised controlled trial Gut 58 2009 413 420
50. G. Caderni, D. Palli, L. Lancioni, A. Russo, C. Luceri, and C. Saieva Dietary determinants of colorectal proliferation in the normal mucosa of subjects with previous colon adenomas Cancer Epidemiol Biomarkers Prev 8 1999 219 225 (Pubitemid 29114199)
51. F.A. Sinicrope, G. Roddey, M. Lemoine, S. Ruan, L.C. Stephens, and M.L. Frazier Loss of p21WAF1/Cip1 protein expression accompanies progression of sporadic colorectal neoplasms but not hereditary nonpolyposis colorectal cancers Clin Cancer Res 4 1998 1251 1261 (Pubitemid 28213337)
52. R.M. Bostick, L. Fosdick, G.A. Grandits, T.J. Lillemoe, J.R. Wood, and P. Grambsch Colorectal epithelial cell proliferative kinetics and risk factors for colon cancer in sporadic adenoma patients Cancer Epidemiol Biomarkers Prev 6 1997 1011 1019 (Pubitemid 28007410)
53. A. Kazanjian, T. Noah, D. Brown, J. Burkart, and N.F. Shroyer Atonal homolog 1 is required for growth and differentiation effects of notch/gamma-secretase inhibitors on normal and cancerous intestinal epithelial cells Gastroenterology 139 918-28 2010 928.e1 928.e6
54. J.H. van Es, M.E. van Gijn, O. Riccio, M. van den Born, M. Vooijs, and H. Begthel Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells Nature 435 2005 959 963 (Pubitemid 40896322)
55. C. Klotz, T. Aebischer, and F. Seeber Stem cell-derived cell cultures and organoids for protozoan parasite propagation and studying host-parasite interaction Int J Med Microbiol 302 2012 203 209
56. S.R. Finkbeiner, X.L. Zeng, B. Utama, R.L. Atmar, N.F. Shroyer, and M.K. Estes Stem cell-derived human intestinal organoids as an infection model for rotaviruses MBio 3 2012 e00159 e212
57. Z. Liu, N. Li, and J. Neu Tight junctions, leaky intestines, and pediatric diseases Acta Paediatr 94 2005 386 393
58. C.A. Rubio, and R. Befrits Increased lysozyme expression in gastric biopsies with intestinal metaplasia and pseudopyloric metaplasia Int J Clin Exp Med 2 2009 248 253
59. M. Capuano, L. Iaffaldano, N. Tinto, D. Montanaro, V. Capobianco, and V. Izzo MicroRNA-449a overexpression, reduced NOTCH1 signals and scarce goblet cells characterize the small intestine of celiac patients PLoS ONE 6 2011 e29094
60. T. Sato, D.E. Stange, M. Ferrante, R.G. Vries, J.H. Van Es, and S. Van den Brink Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium Gastroenterology 141 2011 1762 1772