Human whole-body biodistribution and dosimetry of a new PET tracer, [11C]ketoprofen methyl ester, for imagings of neuroinflammation

Nuclear Medicine and Biology

Volumn 41, Issue 7, 2014, Pages 594-599

  Ohnishi, Akihito ^a   Senda, Michio ^a   Yamane, Tomohiko ^a   Sasaki, Masahiro ^a   Mikami, Tomoko ^a   Nishio, Tomoyuki ^a   Ikari, Yasuhiko ^a   Nishida, Hiroyuki ^a   Shukuri, Miho ^b   Takashima, Tadayuki ^b   Mawatari, Aya ^b   Doi, Hisashi ^b   Watanabe, Yasuyoshi ^b   Onoe, Hirotaka ^b  

^a INSTITUTE OF BIOMEDICAL RESEARCH AND INNOVATION   (Japan)

^b RIKEN   (Japan)

Author keywords

Biodistribution; Dosimetry; Neuroinflammation; NSAIDs

Indexed keywords

ACETIC ACID DERIVATIVE; ARYLACETATE PRECURSOR; CARBON 11; DRUG METABOLITE; KETOPROFEN METHYL ESTER C 11; MACROGOL 400; TRACER; UNCLASSIFIED DRUG; KETOPROFEN; KETOPROFEN METHYL ESTER;

ABSENCE OF SIDE EFFECTS; ADULT; ARTICLE; BLADDER; BLOOD SAMPLING; BRAIN CORTEX; CAMERA; CONTROLLED STUDY; DOSIMETRY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG PENETRATION; DRUG PURITY; DRUG SAFETY; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; ISOTOPE LABELING; MALE; METHYLATION; NERVOUS SYSTEM INFLAMMATION; NORMAL HUMAN; PET SCANNER; PLASMA CLEARANCE; POSITRON EMISSION TOMOGRAPHY; RADIATION DOSE DISTRIBUTION; RADIOACTIVITY; RADIOCHEMISTRY; WHOLE BODY SCINTISCANNING; ANALOGS AND DERIVATIVES; ANIMAL; BRAIN; CLINICAL TRIAL; DIAGNOSTIC USE; INFLAMMATION; METABOLISM; PROCEDURES; RADIOMETRY; RAT; SAFETY; SCINTISCANNING; TISSUE DISTRIBUTION; TRANSPORT AT THE CELLULAR LEVEL;

ADULT; ANIMALS; BIOLOGICAL TRANSPORT; BRAIN; HUMANS; INFLAMMATION; KETOPROFEN; MALE; POSITRON-EMISSION TOMOGRAPHY; RADIOACTIVE TRACERS; RADIOMETRY; RATS; SAFETY; TISSUE DISTRIBUTION;

EID: 84904462220     PISSN: 09698051     EISSN: 18729614     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2014.04.008     Document Type: Article

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