Photosensitive TRPs

Handbook of Experimental Pharmacology

Volumn 223, Issue , 2014, Pages 795-826

  Hardie, Roger C ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Drosophila; Phospholipase C; Photoreceptors; Phototransduction

Indexed keywords

CALCIUM ION; CALMODULIN; DIACYLGLYCEROL; INACTIVATION NO AFTERPOTENTIAL D PROTEIN; MELANOPSIN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOLIPASE C BETA4; POLYUNSATURATED FATTY ACID; PROTON; RHODOPSIN; SCAFFOLD PROTEIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; TRANSIENT RECEPTOR POTENTIAL CHANNEL 7; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; TRANSIENT RECEPTOR POTENTIAL LIKE CHANNEL; UNCLASSIFIED DRUG; CALCIUM CHANNEL; FK 506 BINDING PROTEIN; INACTIVATION NO AFTERPOTENTIAL F PROTEIN; MOESIN; PROTEIN; TRP LIKE CHANNEL;

ARTICLE; AVOIDANCE BEHAVIOR; CALCIUM TRANSPORT; CHANNEL GATING; DROSOPHILA; GENE; GENE STRUCTURE; GENETIC DISORDER; HUMAN; INAF GENE; KINETICS; LARVA; MALPIGHIAN TUBULE; MELANOCYTE; MUTANT; NEGATIVE FEEDBACK; NONHUMAN; PHENOTYPE; PHOTORECEPTOR; PHOTOSENSITIVITY; PHOTOTRANSDUCTION; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; RETINA DEGENERATION; RETINA GANGLION CELL; SMELLING; SYNAPSE; SYNAPTIC TRANSMISSION; CELL MEMBRANE TRANSPORT; COMPLEX FORMATION; GENE EXPRESSION; INAD GENE; PHARMACOLOGICAL BLOCKING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TRP GENE; TRPL GENE;

ANIMALS; CALCIUM; DROSOPHILA; DROSOPHILA PROTEINS; HUMANS; PHOTORECEPTOR CELLS; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 84958536250     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/978-3-319-05161-1_4     Document Type: Article

References (179)

1. 3 receptor is essential for growth and differentiation but not for vision in Drosophila. Neuron 18:881-887
2. Albert AP, Large WA (2003) Synergism between inositol phosphates and diacylglycerol on native TRPC6-like channels in rabbit portal vein myocytes. J Physiol 552:789-795
3. Albert AP, Large WA (2006) Signal transduction pathways and gating mechanisms of native TRP-like cation channels in vascular myocytes. J Physiol 570:45-51
4. Alloway PG, Dolph PJ (1999) A role for the light-dependent phosphorylation of visual arrestin. Proc Natl Acad Sci USA 96:6072-6077
5. Arendt D (2003) Evolution of eyes and photoreceptor cell types. Int J Dev Biol 47:563-571
6. Astorga G, Hartel S, Sanhueza M, Bacigalupo J (2012) TRP, TRPL and cacophony channels mediate Ca(2+) influx and exocytosis in photoreceptors axons in Drosophila. PLoS One 7: e44182
7. Bahner M, Frechter S, Da Silva N, Minke B, Paulsen R, Huber A (2002) Light-regulated subcellular translocation of Drosophila TRPL channels induces long-term adaptation and modifies the light-induced current. Neuron 34:83-93
8. Barash S, Suss E, Stavenga DG, Rubinstein CT, Selinger Z, Minke B (1988) Light reduces the excitation efficiency in the nss mutant of the sheep blowfly Lucilia. J Gen Physiol 92:307-330
9. Barritt G, Rychkov G (2005) TRPs as mechanosensitive channels. Nat Cell Biol 7:105-107
10. Beech DJ (2012) Integration of transient receptor potential canonical channels with lipids. Acta physiologica (Oxford, England) 204:227-237
11. Bellono NW, Oancea E (2013) UV light phototransduction depolarizes human melanocytes. Channels (Austin, Tex 7)
12. Bellono NW, Kammel LG, Zimmerman AL, Oancea E (2013) UV light phototransduction activates transient receptor potential A1 ion channels in human melanocytes. Proc Natl Acad Sci USA 110:2383-2388
13. Berson DM (2003) Strange vision: ganglion cells as circadian photoreceptors. Trends Neurosci 26:314-320
14. Bloomquist BT, Shortridge RD, Schneuwly S, Pedrew M, Montell C, Steller H, Rubin G, Pak WL (1988) Isolation of putative phospholipase C gene of Drosophila, norpA and its role in phototransduction. Cell 54:723-733
15. Byk T, BarYaacov M, Doza YN, Minke B, Selinger Z (1993) Regulatory arrestin cycle secures the fidelity and maintenance of the fly photoreceptor cell. Proc Natl Acad Sci USA 90:1907-1911
16. Cerny AC, Oberacker T, Pfannstiel J, Weigold S, Will C, Huber A (2013) Mutation of light-dependent phosphorylation sites of the drosophila transient receptor potential-like (TRPL) ion channel affects its subcellular localization and stability. J Biol Chem 288:15600-15613
17. Cheng Y, Nash HA (2007) Drosophila TRP channels require a protein with a distinctive motif encoded by the inaF locus. Proc Natl Acad Sci USA 104:17730-17734
18. Chevesich J, Kreuz AJ, Montell C (1997) Requirement for the PDZ domain protein, INAD, for localization of the TRP store-operated channel to a signalling complex. Neuron 18:95-105
19. Chorna-Ornan I, Tzarfaty V, Ankri-Eliahoo G, Joel-Almagor T, Meyer NE, Huber A, Payre F, Minke B (2005) Light-regulated interaction of Dmoesin with TRP and TRPL channels is required for maintenance of photoreceptors. J Cell Biol 171:143-152
20. Christensen AP, Corey DP (2007) TRP channels in mechanosensation: direct or indirect activation? Nat Rev Neurosci 8:510-521
21. Chu B, Liu CH, Sengupta S, Gupta A, Raghu P, Hardie RC (2013a) Common mechanisms regulating dark noise and quantum bump amplification in Drosophila photoreceptors. J Neurophysiol 109:2044-2055
22. Chu B, Postma M, Hardie RC (2013b) Fractional Ca(2+) currents through TRP and TRPL channels in Drosophila photoreceptors. Biophys J 104:1905-1916
23. Chyb S, Raghu P, Hardie RC (1999) Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL. Nature 397:255-259
24. Cockcroft S (2009) Phosphatidic acid regulation of phosphatidylinositol 4-phosphate 5-kinases. Biochim Biophys Acta 1791:905-912
25. Cook B, Minke B (1999) TRP and calcium stores in Drosophila phototransduction. Cell Calcium 25:161-171
26. Cook B, BarYaacov M, BenAmi HC, Goldstein RE, Paroush Z, Selinger Z, Minke B (2000) Phospholipase C and termination of G-protein-mediated signalling in vivo. Nat Cell Biol 1465-7392(2):296-301
27. Cosens DJ, Manning A (1969) Abnormal electroretinogram from a Drosophila mutant. Nature 224:285-287
28. Delgado R, Bacigalupo J (2009) Unitary recordings of TRP and TRPL channels from isolated Drosophila retinal photoreceptor rhabdomeres: activation by light and lipids. J Neurophysiol 101:2372-2379
29. Do MT, Yau KW (2010) Intrinsically photosensitive retinal ganglion cells. Physiol Rev 90:1547-1581
30. Dolph PJ, Ranganathan R, Colley NJ, Hardy RW, Socolich M, Zuker CS (1993) Arrestin function in inactivation of G protein-coupled receptor rhodopsin in vivo. Science 260:1910-1916
31. Du J, Xie J, Yue L (2009) Modulation of TRPM2 by acidic pH and the underlying mechanisms for pH sensitivity. J Gen Physiol 134:471-488
32. Estacion M, Sinkins WG, Schilling WP (2001) Regulation of Drosophila transient receptor potential-like (TRPL) channels by phospholipase C-dependent mechanisms. J Physiol 530:1-19
33. Fehon RG, McClatchey AI, Bretscher A (2010) Organizing the cell cortex: the role of ERM proteins. Nat Rev Mol Cell Biol 11:276-287
34. Ferreira PA, Pak WL (1994) Bovine phospholipase C highly homologous to the NorpA protein of Drosophila is expressed specifically in cones. J Biol Chem 269:3129-3131
35. Fu Y, Liao HW, Do MT, Yau KW (2005) Non-image-forming ocular photoreception in vertebrates. Curr Opin Neurobiol 15:415-422
36. Garcia-Murillas I, Pettitt T, Macdonald E, Okkenhaug H, Georgiev P, Trivedi D, Hassan B, Wakelam M, Raghu P (2006) lazaro encodes a lipid phosphate phosphohydrolase that regulates phosphatidylinositol turnover during Drosophila phototransduction. Neuron 49:533-546
37. 2+ entry. Proc Natl Acad Sci USA 93:14146-14151
38. Goel M, Garcia R, Estacion M, Schilling WP (2001) Regulation of Drosophila TRPL channels by immunophilin FKBP59. J Biol Chem 276:38762-38773
39. Graham DM, Wong KY, Shapiro P, Frederick C, Pattabiraman K, Berson DM (2008) Melanopsin ganglion cells use a membrane-associated rhabdomeric phototransduction cascade. J Neurophysiol 99:2522-2532
40. Gu Y, Oberwinkler J, Postma M, Hardie RC (2005) Mechanisms of light adaptation in Drosophila photoreceptors. Curr Biol 15:1228-1234
41. Hambrecht J, Zimmer S, Flockerzi V, Cavalie A (2000) Single-channel currents through transient-receptor-potential-like (TRPL) channels. Pflugers Archiv Eur J Physiol 440:418-426
42. Hankins MW, Peirson SN, Foster RG (2008) Melanopsin: an exciting photopigment. Trends Neurosci 31:27-36
43. Hardie RC (1991) Whole-cell recordings of the light-induced current in Drosophila photoreceptors: evidence for feedback by calcium permeating the light sensitive channels. Proc R Soc Lond B 245:203-210
44. 2+ facilitates and inactivates but does not directly excite light-sensitive channels in Drosophila photoreceptors. J Neurosci 15:889-902
45. 2+ concentration in Drosophila photoreceptors. J Neurosci 16:2924-2933
46. Hardie RC (2003) Regulation of TRP channels via lipid second messengers. Annu Rev Physiol 65:735-759
47. Hardie RC (2005) Inhibition of phospholipase C activity in Drosophila photoreceptors by 1, 2-bis (2-aminophenoxy)ethane N, N, N', N'-tetraacetic acid (BAPTA) and di-bromo BAPTA. Cell Calcium 38:547-556
48. Hardie RC (2007) TRP channels and lipids: from Drosophila to mammalian physiology. J Physiol 578:9-25
49. Hardie RC (2011) A brief history of trp: commentary and personal perspective. Pflugers Arch 461:493-498
50. Hardie RC (2012) Phototransduction mechanisms in Drosophila microvillar photoreceptors. WIREs Membr Transp Signal 1:2162-2187. doi:10.1002/wmts.20
51. Hardie RC, Franze K (2012) Photomechanical responses in Drosophila photoreceptors. Science 338:260-263
52. 2+ channel in Drosophila photoreceptors. Neuron 8:643-651
53. Hardie RC, Minke B (1994) Spontaneous activation of light-sensitive channels in Drosophila photoreceptors. J Gen Physiol 103:389-407
54. Hardie RC, Mojet MH (1995) Magnesium-dependent block of the light-activated and trp-dependent conductance in Drosophila photoreceptors. J Neurophysiol 74:2590-2599
55. Hardie RC, Postma M (2008) Phototransduction in microvillar photoreceptors of Drosophila and other invertebrates. In: Albright TD, Masland, R (eds) The senses-A comprehensive reference (eds. Basbaum K, Shepherd, Westheimer), vision vol 1. Academic Press, Oxford, pp 77-130
56. 3 is not sufficient. Cell Calcium 24:153-163
57. 2+ limits the development of the light response in Drosophila photoreceptors. Proc Biol Sci 252:223-229
58. 301 mutant and TRPL cation channels expressed in a stably transfected Drosophila cell line. Cell Calcium 21:431-440
59. 2 levels in Drosophila photoreceptors. Neuron 30:149-159
60. Hardie RC, Martin F, Cochrane GW, Juusola M, Georgiev P, Raghu P (2002) Molecular basis of amplification in Drosophila phototransduction. Roles for G protein, phospholipase C, and diacylglycerol kinase. Neuron 36:689-701
61. Hardie RC, Gu Y, Martin F, Sweeney ST, Raghu P (2004) In vivo light-induced and basal phospholipase C activity in Drosophila photoreceptors measured with genetically targeted phosphatidylinositol 4, 5-bisphosphate- sensitive ion channels (Kir2.1). J Biol Chem 279:47773-47782
62. Harteneck C, Obukhov AG, Zobel A, Kalkbrenner F, Schultz G (1995) The Drosophila cation channel Trpl expressed in insect Sf9 cells is stimulated by agonists of G-protein-coupled receptors. FEBS Lett 358:297-300
63. 2+. J Physiol London 524:179-194
64. Hicks JL, Liu X, Williams DS (1996) Role of the NinaC proteins in photoreceptor cell structure: ultrastructure of ninaC deletion mutants and binding to actin filaments. Cell Motil Cytoskele-ton 35:367-379
65. Hofmann T, Obukhov AG, Schaefer M, Harteneck C, Gudermann T, Schultz G (1999) Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 397:259-263
66. Hong YS, Park S, Geng C, Baek K, Bowman JD, Yoon J, Pak WL (2002) Single amino acid change in the fifth transmembrane segment of the TRP Ca2+ channel causes massive degeneration of photoreceptors. J Biol Chem 277:33884-33889
67. 2+ influx pathway in Sf9 insect cells following expression of the transient receptor potential-like (trpl) protein of Drosophila. Biochem Biophys Res Commun 201:1050-1056
68. Huang J, Liu CH, Hughes SA, Postma M, Schwiening CJ, Hardie RC (2010) Activation of TRP channels by protons and phosphoinositide depletion in Drosophila photoreceptors. Curr Biol 20:189-197
69. Huber A (2001) Scaffolding proteins organize multimolecular protein complexes for sensory signal transduction. Eur J Neurosci 14:769-776
70. 2+ channel essential for phosphoinositide-mediated photoreception, forms a signaling complex with NorpA, InaC and InaD. EMBO J 15:7036-7045
71. Huber A, Sander P, Paulsen R (1996b) Phosphorylation of the InaD gene product, a photoreceptor membrane protein required for recovery of visual excitation. J Biol Chem 271:11710-11717
72. 2+ channel assembled in a signaling complex by the PDZ domain protein INAD is phosphorylated through the interaction with protein kinase C (ePKC). FEBS Lett 425:317-322
73. Jenkins GH, Fisette PL, Anderson RA (1994) Type I phosphatidylinositol 4-phosphate 5-kinase isoforms are specifically stimulated by phosphatidic acid. J Biol Chem 269:11547-11554
74. Jors S, Kazanski V, Foik A, Krautwurst D, Harteneck C (2006) Receptor-induced activation of Drosophila TRP{gamma} by polyunsaturated fatty acids. J Biol Chem 281:29693-29702
75. Ju M, Shi J, Saleh SN, Albert AP, Large WA (2010) Ins(1, 4, 5)P3 interacts with PIP2 to regulate activation of TRPC6/C7 channels by diacylglycerol in native vascular myocytes. J Physiol 588:1419-1433
76. Karagiosis SA, Ready DF (2004) Moesin contributes an essential structural role in Drosophila photoreceptor morphogenesis. Development 131:725-732
77. Katz B, Minke B (2009) Drosophila photoreceptors and signaling mechanisms. Front Cell Neurosci 3:2
78. Katz B, Minke B (2012) Phospholipase C-mediated suppression of dark noise enables single-photon detection in Drosophila photoreceptors. J Neurosci 32:2722-2733
79. Katz B, Oberacker T, Richter D, Tzadok H, Peters M, Minke B, Huber A (2013) The Drosophila TRP and TRPL are assembled as homomultimeric channels in vivo. J Cell Sci 126(14):3121-3133
80. Kiselev A, Socolich M, Vinos J, Hardy RW, Zuker CS, Ranganathan R (2000) A molecular pathway for light-dependent photoreceptor apoptosis in Drosophila. Neuron 28:139-152
81. 2+ and Calmodulin, and by guanosine 5'[gamma-thio]triphosphate. Biochem J 316:793-803
82. Lan L, Brereton H, Barritt GJ (1998) The role of calmodulin-binding sites in the regulation of the Drosophila TRPL cation channel expressed in Xenopus laevis oocytes by Ca2+, inositol 1, 4, 5-trisphosphate and GTP-binding proteins. Biochem J 330:1149-1158
83. Lee SJ, Montell C (2001) Regulation of the rhodopsin protein phosphatase, RDGC, through interaction with calmodulin. Neuron 32:1097-1106
84. Lee J, Song M, Hong S (2013) Negative regulation of the novel norpA(P24) suppressor, diehard4, in the endo-lysosomal trafficking underlies photoreceptor cell degeneration. PLoS Genet 9: e1003559
85. Lemonnier L, Trebak M, Putney JW Jr (2008) Complex regulation of the TRPC3, 6 and 7 channel subfamily by diacylglycerol and phosphatidylinositol-4, 5-bisphosphate. Cell Calcium 43:506-514
86. Leung HT, Geng C, Pak WL (2000) Phenotypes of trpl mutants and interactions between the transient receptor potential (TRP) and TRP-like channels in Drosophila. J Neurosci 20:6797-6803
87. Leung HT, Tseng-Crank J, Kim E, Mahapatra C, Shino S, Zhou Y, An L, Doerge RW, Pak WL (2008) DAG lipase activity is necessary for TRP channel regulation in Drosophila photoreceptors. Neuron 58:884-896
88. Lev S, Katz B, Minke B (2012) The activity of the TRP-like channel depends on its expression system. Channels (Austin Tex) 6:86-93
89. Li HS, Montell C (2000) TRP and the PDZ protein, INAD, form the core complex required for retention of the signalplex in Drosophila photoreceptor cells. J Cell Biol 150:1411-1422
90. 2+ channel function. Proc Natl Acad Sci USA 96:13474-13479
91. Liedtke W (2007) TRPV channels' role in osmotransduction and mechanotransduction. Handb Exp Pharmacol 179:473-487
92. Lin SY, Corey DP (2005) TRP channels in mechanosensation. Curr Opin Neurobiol 15:350-357
93. Lin JY, Fisher DE (2007) Melanocyte biology and skin pigmentation. Nature 445:843-850
94. Liu M, Parker LL, Wadzinski BE, Shieh BH (2000) Reversible phosphorylation of the signal transduction complex in Drosophila photoreceptors. J Biol Chem 275:12194-12199
95. 2+ selectivity filter in the Drosophila transient receptor potential channel. J Neurosci 27:604-615
96. 2+-dependent metarhodopsin inactivation mediated by Calmodulin and NINAC myosin III. Neuron 59:778-789
97. Liu J, Ward A, Gao J, Dong Y, Nishio N, Inada H, Kang L, Yu Y, Ma D, Xu T, Mori I, Xie Z, Xu XZ (2010) C. Elegans phototransduction requires a G protein-dependent cGMP pathway and a taste receptor homolog. Nat Neurosci 13:715-722
98. Liu W, Wen W, Wei Z, Yu J, Ye F, Liu CH, Hardie RC, Zhang M (2011) The INAD scaffold is a dynamic, redox-regulated modulator of signaling in the Drosophila eye. Cell 145:1088-1101
99. Lucas P, Ukhanov K, Leinders-Zufall T, Zufall F (2003) A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction. Neuron 40:551-561
100. Macpherson MR, Pollock VP, Kean L, Southall TD, Giannakou ME, Broderick KE, Dow JA, Hardie RC, Davies SA (2005) Transient receptor potential-like (TRPL) channels are essential for calcium signalling and fluid transport in a Drosophila epithelium. Genetics 169:1541-1552
101. Maroto R, Raso A, Wood TG, Kurosky A, Martinac B, Hamill OP (2005) TRPC1 forms the stretch-activated cation channel in vertebrate cells. Nat Cell Biol 7:179-185
102. Masai I, Suzuki E, Yoon CS, Kohyama A, Hotta Y (1997) Immunolocalization of Drosophila eye-specific diacylgylcerol kinase, rdgA, which is essential for the maintenance of the photo-receptor. J Neurobiol 32:695-706
103. Matsumoto H, Kurien BT, Takagi Y, Kahn ES, Kinumi T, Komori N, Yamada T, Hayashi F, Isono K, Pak WL et al (1994) Phosrestin I undergoes the earliest light-induced phosphorylation by a calcium/calmodulin-dependent protein kinase in Drosophila photoreceptors. Neuron 12:997-1010
104. Mecklenburg KL, Takemori N, Komori N, Chu B, Hardie RC, Matsumoto H, O'Tousa JE (2010) Retinophilin is a light-regulated phosphoprotein required to suppress photoreceptor dark noise in Drosophila. J Neurosci 30:1238-1249
105. Mederos y Schnitzler M, Storch U, Meibers S, Nurwakagari P, Breit A, Essin K, Gollasch M, Gudermann T (2008) Gq-coupled receptors as mechanosensors mediating myogenic vasocon-striction. EMBO J 27:3092-3103
106. Minke B (1977) Drosophila mutant with a transducer defect. Biophys Struct Mech 3:59-64
107. Minke B (1982) Light-induced reduction in excitation efficiency in the trp mutant of Drosophila. J Gen Physiol 79:361-385
108. Minke B (2010) The history of the Drosophila TRP channel: the birth of a new channel superfam-ily. J Neurogenet 24:216-233
109. Minke B, Selinger Z (1991) Inositol lipid pathway in fly photoreceptors: excitation, calcium mobilization and retinal degeneration. Prog Retinal Res 11:99-124
110. Minke B, Wu C, Pak WL (1975) Induction of photoreceptor voltage noise in the dark in Drosophila mutant. Nature 258:84-87
111. Mishra P, Socolich M, Wall MA, Graves J, Wang Z, Ranganathan R (2007) Dynamic Scaffolding in a G Protein-Coupled Signaling System. Cell 131:80-92
112. Montell C (1999) Visual transduction in Drosophila. Annu Rev Cell Dev Biol 15:231-268
113. Montell C (2011) The history of TRP channels, a commentary and reflection. Pflugers Arch 461:499-506
114. Montell C, Rubin GM (1989) Molecular characterization of Drosophila trp locus, a putative integral membrane protein required for phototransduction. Neuron 2:1313-1323
115. Niemeyer BA, Suzuki E, Scott K, Jalink K, Zuker CS (1996) The Drosophila light-activated conductance is composed of the two channels TRP and TRPL. Cell 85:651-659
116. Oberwinkler J, Stavenga DG (2000) Calcium transients in the rhabdomeres of dark-and light-adapted fly photoreceptor cells. J Neurosci 20:1701-1709
117. Obukhov AG, Schultz G, Luckhoff A (1998) Regulation of heterologously expressed transient receptor potential-like channels by calcium ions. Neuroscience 85:487-495
118. Okada T, Inoue R, Yamazaki K, Maeda A, Kurosaki T, Yamakuni T, Tanaka I, Shimizu S, Ikenaka K, Imoto K, Mori Y (1999) Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7-Ca2 +-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor. J Biol Chem 274:27359-27370
119. Otsuguro K, Tang J, Tang Y, Xiao R, Freichel M, Tsvilovskyy V, Ito S, Flockerzi V, Zhu MX, Zholos AV (2008) Isoform-specific inhibition of TRPC4 channel by phosphatidylinositol 4, 5-bisphosphate. J Biol Chem 283:10026-10036
120. Pak WL (1995) Drosophila in vision research: The Friedenwald lecture. Invest Ophthalmol Vis Sci 36:2340-2357
121. Panda S, Nayak SK, Campo B, Walker JR, Hogenesch JB, Jegla T (2005) Illumination of the melanopsin signaling pathway. Science 307:600-604
122. 2+ underlies the voltage dependence of Drosophila TRPL channel. J Gen Physiol 129:17-28
123. Parnas M, Katz B, Lev S, Tzarfaty V, Dadon D, Gordon-Shaag A, Metzner H, Yaka R, Minke B (2009a) Membrane lipid modulations remove divalent open channel block from TRP-Like and NMDA channels. J Neurosci 29:2371-2383
124. Parnas M, Peters M, Dadon D, Lev S, Vertkin I, Slutsky I, Minke B (2009b) Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels. Cell Calcium 45:300-309
125. Patel A, Sharif-Naeini R, Folgering JR, Bichet D, Duprat F, Honore E (2010) Canonical TRP channels and mechanotransduction: from physiology to disease states. Pflugers Arch 460:571-581
126. Paulsen R, Bahner M, Huber A (2000) The PDZ assembled "transducisome" of microvillar photoreceptors: the TRP/TRPL problem. Pflugers Arch 439:R181-R183
127. Peng L, Popescu DC, Wang N, Shieh BH (2008) Anchoring TRP to the INAD macromolecular complex requires the last 14 residues in its carboxyl terminus. J Neurochem 104:1526-1535
128. Phillips AM, Bull A, Kelly LE (1992) Identification of a Drosophila gene encoding a calmodulin-binding protein with homology to the trp phototransduction gene. Neuron 8:631-642
129. Popescu DC, Ham A-JL, Shieh B-H (2006) Scaffolding protein INAD regulates deactivation of vision by promoting phosphorylation of transient receptor potential by rye protein kinase C in Drosophila. J Neurosci 26:8570-8577
130. 2+ reach millimolar concentrations after single photon absorption in Drosophila photoreceptor microvilli? Biophys J 77:1811-1823
131. Poteser M, Schleifer H, Lichtenegger M, Schernthaner M, Stockner T, Kappe CO, Glasnov TN, Romanin C, Groschner K (2011) PKC-dependent coupling of calcium permeation through transient receptor potential canonical 3 (TRPC3) to calcineurin signaling in HL-1 myocytes. Proc Natl Acad Sci USA 108:10556-10561
132. Provencio I, Rodriguez IR, Jiang G, Hayes WP, Moreira EF, Rollag MD (2000) A novel human opsin in the inner retina. J Neurosci 20:600-605
133. Quick K, Zhao J, Eijkelkamp N, Linley JE, Rugiero F, Cox JJ, Raouf R, Gringhuis M, Sexton JE, Abramowitz J, Taylor R, Forge A, Ashmore J, Kirkwood N, Kros CJ, Richardson GP, Freichel M, Flockerzi V, Birnbaumer L, Wood JN (2012) TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells. Open Biol 2:120068
134. Raghu P (2006) Regulation of Drosophila TRPC channels by protein and lipid interactions. Semin Cell Dev Biol 17:646-653
135. Raghu P, Hardie RC (2009) Regulation of Drosophila TRPC channels by lipid messengers. Cell Calcium 45:566-573
136. 3 receptor gene. Mol Cell Neurosci 15:429-445
137. Raghu P, Usher K, Jonas S, Chyb S, Polyanovsky A, Hardie RC (2000b) Constitutive activity of the light-sensitive channels TRP and TRPL in the Drosophila diacylglycerol kinase mutant, rdgA. Neuron 26:169-179
138. Ranganathan R, Bacskai BJ, Tsien RY, Zuker CS (1994) Cytosolic calcium transients: spatial localization and role in Drosophila photoreceptor cell function. Neuron 13:837-848
139. Reuss H, Mojet MH, Chyb S, Hardie RC (1997) In vivo analysis of the Drosophila light-sensitive channels, TRP and TRPL. Neuron 19:1249-1259
140. Rosenbaum EE, Brehm KS, Vasiljevic E, Liu CH, Hardie RC, Colley NJ (2011) XPORT-dependent transport of TRP and rhodopsin. Neuron 72:602-615
141. Running Deer JL, Hurley JB, Yarfitz SL (1995) G protein control of Drosophila photoreceptor phospholipase C. J Biol Chem 270:12623-12628
142. Ryu S, Liu B, Yao J, Fu Q, Qin F (2007) Uncoupling proton activation of vanilloid receptor TRPV1. J Neurosci 27:12797-12807
143. Satoh AK, O'Tousa JE, Ozaki K, Ready DF (2005) Rab11 mediates post-Golgi trafficking of rhodopsin to the photosensitive apical membrane of Drosophila photoreceptors. Development 132:1487-1497
144. Scott K, Zuker CS (1998) Assembly of the Drosophila phototransduction cascade into a signalling complex shapes elementary responses. Nature 395:805-808
145. q a protein function in vivo: genetic dissection of its role in photoreceptor cell physiology. Neuron 15:919-927
146. Scott K, Sun YM, Beckingham K, Zuker CS (1997) Calmodulin regulation of Drosophila light-activated channels and receptor function mediates termination of the light response in vivo. Cell 91:375-383
147. Semtner M, Schaefer M, Pinkenburg O, Plant TD (2007) Potentiation of TRPC5 by Protons. J Biol Chem 282:33868-33878
148. Sengupta S, Barber TR, Xia H, Ready DF, Hardie RC (2013) Depletion of PtdIns(4, 5)P2 underlies retinal degeneration in Drosophila trp mutants. J Cell Sci 126:1247-1259
149. Sharif-Naeini R, Dedman A, Folgering JH, Duprat F, Patel A, Nilius B, Honore E (2008) TRP channels and mechanosensory transduction: insights into the arterial myogenic response. Pflugers Arch 456:529-540
150. Shieh BH, Niemeyer B (1995) A novel protein encoded by the InaD gene regulates recovery of visual transduction in Drosophila. Neuron 14:201-210
151. 2+ channel by INAD in Drosophila photoreceptors. Neuron 16:991-998
152. Spassova MA, Hewavitharana T, Xu W, Soboloff J, Gill DL (2006) A common mechanism underlies stretch activation and receptor activation of TRPC6 channels. Proc Natl Acad Sci USA 103:16586-16591
153. Steele FR, Washburn T, Rieger R, O'Tousa JE (1992) Drosophila retinal degeneration C (rdgC) encodes a novel serine/threonine protein phosphatase. Cell 69:669-676
154. Stortkuhl KF, Hovemann BT, Carlson JR (1999) Olfactory adaptation depends on the trp Ca2+ channel in Drosophila. J Neurosci 19:4839-4846
155. Su Z, Zhou X, Haynes WJ, Loukin SH, Anishkin A, Saimi Y, Kung C (2007) Yeast gain-of-function mutations reveal structure-function relationships conserved among different subfamilies of transient receptor potential channels. Proc Natl Acad Sci USA 104:19607-19612
156. Suchyna TM, Johnson JH, Hamer K, Leykam JF, Gage DA, Clemo HF, Baumgarten CM, Sachs F (2000) Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels. J Gen Physiol 115:583-598
157. Trebak M, Lemonnier L, Dehaven WI, Wedel BJ, Bird GS, Putney JW Jr (2009) Complex functions of phosphatidylinositol 4, 5-bisphosphate in regulation of TRPC5 cation channels. Pflugers Arch 457:757-769
158. Trost C, Marquart A, Zimmer S, Philipp S, Cavalie A, Flockerzi V (1999) Ca2 +-dependent interaction of the trpl cation channel and calmodulin. FEBS Lett 451:257-263
159. Tsunoda S, Sierralta J, Sun YM, Bodner R, Suzuki E, Becker A, Socolich M, Zuker CS (1997) A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade. Nature 388:243-249
160. Tsunoda S, Sun Y, Suzuki E, Zuker C (2001) Independent anchoring and assembly mechanisms of INAD signaling complexes in Drosophila photoreceptors. J Neurosci 21:150-158
161. Vaca L, Sinkins WG, Hu Y, Kunze DL, Schilling WP (1994) Activation of recombinant trp by thapsigargin in Sf9 insect cells. Am J Physiol Cell Physiol 267:C1501-C1505
162. Vinos J, Jalink K, Hardy RW, Britt SG, Zuker CS (1997) A G protein-coupled receptor phospha-tase required for rhodopsin function. Science 277:687-690
163. Voolstra O, Beck K, Oberegelsbacher C, Pfannstiel J, Huber A (2010) Light-dependent phosphor-ylation of the Drosophila transient receptor potential (TRP) ion channel. J Biol Chem 285:14275-14284
164. Wang T, Jiao Y, Montell C (2005a) Dissecting independent channel and scaffolding roles of the Drosophila transient receptor potential channel. J Cell Biol 171:685-694
165. 2+ exchanger CalX. Neuron 45:367-378
166. Wang YY, Chang RB, Liman ER (2010) TRPA1 Is a Component of the Nociceptive Response to CO2. J Neurosci 30:12958-12963
167. Warr CG, Kelly LE (1996) Identification and characterization of two distinct calmodulin-binding sites in the Trpl ion-channel protein of Drosophila melanogaster. Biochem J 314:497-503
168. Warren EJ, Allen CN, Brown RL, Robinson DW (2006) The light-activated signaling pathway in SCN-projecting rat retinal ganglion cells. Eur J Neurosci 23:2477-2487
169. Wes PD, Chevesich J, Jeromin A, Rosenberg C, Stetten G, Montell C (1995) TRPC1, a human homolog of a Drosophila store-operated channel. Proc Natl Acad Sci USA 92:9652-9656
170. Wes PD, Xu XZ, Li HS, Chien F, Doberstein SK, Montell C (1999) Termination of phototransduction requires binding of the NINAC myosin III and the PDZ protein INAD. Nat Neurosci 2:447-453
171. Wicks NL, Chan JW, Najera JA, Ciriello JM, Oancea E (2011) UVA phototransduction drives early melanin synthesis in human melanocytes. Curr Biol 21:1906-1911
172. Xiang Y, Yuan Q, Vogt N, Looger LL, Jan LY, Jan YN (2010) Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall. Nature 468:921-926
173. Xu XZS, Li HS, Guggino WB, Montell C (1997) Coassembly of TRP and TRPL produces a distinct store-operated conductance. Cell 89:1155-1164
174. Xu XZS, Choudhury A, Li XL, Montell C (1998) Coordination of an array of signaling proteins through homo-and heteromeric interactions between PDZ domains and target proteins. J Cell Biol 142:545-555
175. Xu XZS, Chien F, Butler A, Salkoff L, Montell C (2000) TRP gamma, a Drosophila TRP-related subunit, forms a regulated cation channel with TRPL. Neuron 26:647-657
176. Yau KW, Hardie RC (2009) Phototransduction motifs and variations. Cell 139:246-264
177. Yin J, Kuebler WM (2010) Mechanotransduction by TRP channels: general concepts and specific role in the vasculature. Cell Biochem Biophys 56:1-18
178. Yoon J, Ben-Ami HC, Hong YS, Park S, Strong LL, Bowman J, Geng C, Baek K, Minke B, Pak WL (2000) Novel mechanism of massive photoreceptor degeneration caused by mutations in the trp gene of Drosophila. J Neurosci 20:649-659
179. Zhu X, Chu PB, Peyton M, Birnbaumer L (1995) Molecular cloning of a widely expressed human homologue for the Drosophila trp gene. FEBS Lett 373:193-198