Isoform-specific inhibition of TRPC4 channel by phosphatidylinositol 4,5-bisphosphate

Journal of Biological Chemistry

Volumn 283, Issue 15, 2008, Pages 10026-10036

  Otsuguro, Ken Ichi ^a,d   Tang, Jisen ^b   Tang, Yufang ^b   Xiao, Rui ^b   Freichel, Marc ^c   Tsvilovskyy, Volodymyr ^c   Ito, Shigeo ^d   Flockerzi, Veit ^c   Zhu, Michael X ^b   Zholos, Alexander V ^a,e  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b OHIO STATE UNIVERSITY   (United States)

^c SAARLAND UNIVERSITY   (Germany)

^d HOKKAIDO UNIVERSITY   (Japan)

^e Medical Biology Centre   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; AMINO ACIDS; ANIMAL CELL CULTURE; CALCIUM; HYDROGEN; LAWS AND LEGISLATION; ORGANIC ACIDS; PHOSPHOLIPIDS; PHOSPHORIC ACID; POSITIVE IONS; PRESSURE EFFECTS;

ACTIN CYTOSKELETON; BINDING MOTIFS; BISPHOSPHATE; C TERMINUSES; CATION CHANNELS; CHANNEL ACTIVATIONS; CHANNEL OPENINGS; CHANNEL REGULATIONS; COUPLED RECEPTORS; CYTOCHALASIN D; CYTOSKELETON; CYTOSOLIC; IN VITRO; ISOFORM; MEMBRANE POTENTIALS; MYOCYTES; PERTUSSIS TOXINS; PHOSPHATIDYLINOSITOL; PHOSPHOINOSITIDES; PHOSPHOLIPASE C; REGULATORY FACTORS; SMOOTH MUSCLES; TRANSIENT RECEPTOR POTENTIALS; UNDERLYING MECHANISMS;

ENDOTHELIAL CELLS;

ACTIN; ARGININE; CALCIUM; CYTOCHALASIN D; EZRIN; F ACTIN; GUANINE NUCLEOTIDE BINDING PROTEIN; LEUCINE; PDZ PROTEIN; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; SODIUM PROTON EXCHANGE PROTEIN; THREONINE; TRANSIENT RECEPTOR POTENTIAL CHANNEL 4; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPROTEIN; NUCLEIC ACID SYNTHESIS INHIBITOR; PHOSPHOLIPASE C; POLYPHOSPHOINOSITIDE; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRPC4 ION CHANNEL;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CYTOSKELETON; EMBRYO; HUMAN; HUMAN CELL; ILEUM; IN VITRO STUDY; INHIBITION KINETICS; PDZ DOMAIN; PRIORITY JOURNAL; PROTEIN BINDING; ANIMAL; CELL LINE; CELL MEMBRANE POTENTIAL; DRUG ANTAGONISM; DRUG EFFECT; ENDOTHELIUM CELL; GENETICS; METABOLISM; MOUSE; MUSCLE CELL; PHYSIOLOGY; PROTEIN MOTIF; PROTEIN TERTIARY STRUCTURE; SMOOTH MUSCLE;

ACTINS; AMINO ACID MOTIFS; ANIMALS; CALCIUM; CELL LINE; CYTOCHALASIN D; CYTOSKELETON; ENDOTHELIAL CELLS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HUMANS; ILEUM; MEMBRANE POTENTIALS; MICE; MUSCLE CELLS; MUSCLE, SMOOTH; NUCLEIC ACID SYNTHESIS INHIBITORS; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHATIDYLINOSITOL PHOSPHATES; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; TRPC CATION CHANNELS; TYPE C PHOSPHOLIPASES;

EID: 44349107703     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M707306200     Document Type: Article

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