Strong inhibition of the polyol pathway diverts glucose flux to protein glycation leading to rapid establishment of secondary complications in diabetes mellitus

Journal of Diabetes and its Complications

Volumn 30, Issue 3, 2016, Pages 398-405

  Jagdale, Ashwini D ^a   Bavkar, Laxman N ^a   More, Tanaji A ^a   Joglekar, Madhav M ^a   Arvindekar, Akalpita U ^a  

^a SHIVAJI UNIVERSITY   (India)

Author keywords

Aldose reductase; Citronellol; Combinatorial therapy; Epalrestat; Limonene; Protein glycation

Indexed keywords

ALDEHYDE REDUCTASE; CARBONYL DERIVATIVE; CITRONELLOL; EPALRESTAT; FRUCTOSE; LIMONENE; POLYOL; XYLOSE; ENZYME INHIBITOR; GLUCOSE; POLYMER; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ASSAY; ENZYME INHIBITION; FLUORESCENCE; GLUCOSE TRANSPORT; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN GLYCOSYLATION; RAT; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; URINALYSIS; ANIMAL; ANTAGONISTS AND INHIBITORS; CARBOHYDRATE METABOLISM; CHEMICALLY INDUCED; COMPLICATION; DIABETIC COMPLICATION; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; GLYCOSYLATION; METABOLISM;

ALDEHYDE REDUCTASE; ANIMALS; CARBOHYDRATE METABOLISM; DIABETES COMPLICATIONS; DIABETES MELLITUS, EXPERIMENTAL; ENZYME INHIBITORS; GLUCOSE; GLYCOSYLATION; METABOLIC NETWORKS AND PATHWAYS; POLYMERS; RATS; STREPTOZOCIN;

EID: 84958213871     PISSN: 10568727     EISSN: 1873460X     Source Type: Journal    
DOI: 10.1016/j.jdiacomp.2016.01.001     Document Type: Article

References (61)

1. S. Adisakwattana, W. Sompong, and A. Meeprom Cinnamic acid and its derivatives inhibit fructose-mediated protein glycation International Journal of Molecular Sciences 13 2012 1778 1789
2. N. Ahmed Advanced glycation end products- Role in pathology of diabetic complications Diabetes Research and Clinical Practice 67 2005 3 21
3. C. Akhileshwari, G. Raghu, P. Muthenna, H. Niklaus, H.N. Mueller, and P. Suryanaryana G.B. Reddy Bioflavonoid ellagic acid inhibits aldose reductase: Implications for prevention of diabetic complications Journal of Functional Foods 6 2014 374 383
4. N.A. Ansari, and R. Ali Physicochemical analysis of poly-l-lysine: An insight into the changes induced in lysine residues of proteins on modification with glucose IUBMB Life 63 2011 26 29
5. D. Badawy, H.M. EI-Bassossy, A. Fahmy, and A. Azhar Aldose reductase inhibitors zopolrestat and ferulic acid alleviate hypertension associated with diabetes: effect on vascular reactivity Canadian Journal of Physiology and Pharmacology 91 2013 101 107
6. J.R. Baker, D.V. Zyzak, and S.R. Thorpe Chemistry of the fructosamine assay: d-glucosone is the product of oxidation of amadori compounds Clinical Chemistry 40 1994 1950 1955
7. E. Boel, J. Selmer, H.J. Flodgaard, and T. Jensen Diabetic late complications: Will aldose reductase inhibitors or inhibitors of advanced glycosylation end product formation hold promise? Journal of Diabetes and its Complications 9 1995 104 129
8. W.K. Bolton, D.C. Cattran, M.E. Williams, S.G. Adler, G.B. Appel, and K. Cartwright J.P. Wuerth Randomized trial of an inhibitor of formation of advanced glycation end products in diabetic nephropathy American Journal of Nephrology 24 2004 32 40
9. M. Brownlee Biochemistry and molecular cell biology of diabetic complications Nature 414 2001 813 820
10. S. Chetan, S.M. Dharmesh, and N.G. Malleshi Inhibition of aldose reductase from cataracted eye lenses by finger millet (Eleusine coracana) polyphenols Bioorganic and Medicinal Chemistry 16 2008 10085 10090
11. C.B. Cui, S.K. Jeong, Y.S. Lee, S.O. Lee, I.J. Kang, and S.S. Lim Inhibitory activity of caffeoylquinic acids from the aerial parts of Artemisia princes on rat lens aldose reductase and on the formation of advanced glycation end products Journal of the Korean Society for Applied Biological Chemistry 56 2009 655 662
12. A. Del-Corso, F. Balestri, E.D. Bugno, R. Moschini, M. Cappiello, and S. Sartini U. Mura A new approach to control the enigmatic activity of aldose reductase PloS One 8 2013 1 8
13. B.T. Doumas, W.A. Watson, and H.G. Biggs Albumin standards and the measurement of serum albumin with bromcresol green Clinica Chimica Acta 31 1971 87 96
14. M. Dunlop Aldose reductase and the role of the polyol pathway in diabetic nephropathy Kidney International 58 2000 S-3 S-12
15. G.L. Ellman Tissue sulfhydryl groups Archives of Biochemistry and Biophysics 82 1959 70 77
16. R.L. Engerman, and T.S. Kern Aldose reductase inhibition fails to prevent retinopathy in diabetic and galactosemic dogs Diabetes 42 1993 820 825
17. J.L. Figarola, S. Scott, S. Loera, C. Tessler, P. Chu, and L. Weiss S. Rahbar LR-90 a new advanced glycation end product inhibitor prevents progression of diabetic nephropathy in streptozotocin-diabetic rats Diabetologia 46 2003 1140 1152
18. R.N. Frank Perspectives in diabetes the aldose reductase controversy Diabetes 43 1994 169 172
19. Y. Hamada, J. Nakamura, K. Naruse, T. Komori, K. Kato, and Y. Kasuya N. Hotta Epalrestat, an aldose reductase inhibitor, reduces the levels of nepsilon-(carboxymethyl) lysine protein adducts and their precursors in erythrocytes from diabetic patients Diabetes Care 23 2000 1539 1544
20. S. Hayman, and J.H. Kinoshita Isolation and properties of lens aldose reductase Journal of Biological Chemistry 240 1965 877 882
21. N. Hotta, Y. Akanuma, R. Kawamori, K. Matsuoka, Y. Oka, and M. Shichiri Y. Shigeta Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy Diabetes Care 29 2006 1538 1544
22. A.D. Jagdale, S.P. Kamble, M.L. Nalawade, and A.U. Arvindekar Citronellol: A potential antioxidant and aldose reductase inhibitor from Cymbopogon citratus International Journal of Pharmacy and Pharmaceutical Sciences 7 2015 203 209
23. A.G. Jagtap, and P.B. Patil Antihyperglycemic activity and inhibition of advanced glycation end product formation by Cuminum cyminum in streptozotocin induced diabetic rats Food and Chemical Toxicology 48 2010 2030 2036
24. D.S. Jang, G.Y. Lee, Y.S. Kim, Y.M. Lee, C.S. Kim, J.L. Yoo, and J.S. Kim Anthraquinones from the seeds of Cassia tora with inhibitory activity on protein glycation and aldose reductase Biological and Pharmaceutical Bulletin 30 2007 2207 2210
25. D.S. Jang, Y.M. Lee, H. Jeong, and J.S. Kim Constituents of the flowers of Platycodon grandiflorum with inhibitory activity on advanced glycation end products and rat lens aldose reductase In Vitro Archives of Pharmacal Research 33 2010 875 880
26. H.O. Jauregui, N.T. Hayner, J.L. Driscoll, R. Williams-Holland, M.H. Lipsky, and P.M. Galletti Trypan blue dye uptake and lactate dehydrogenase in adult rat hepatocytes - freshly isolated cells, cell suspension and primary monolayer cultures In Vitro 17 1981 1100 1110
27. M.M. Joglekar, S.N. Panaskar, A.D. Chougale, M.J. Kulkarni, and A.U. Arvindekar A novel mechanism for antiglycative action of limonene through stabilization of protein conformation Molecular Biosystems 9 2013 2463 2472
28. B.K. Kilhovd, I. Giardino, P.A. Torjesen, K.I. Birkeland, T.J. Berg, and P.J. Thornalley K.F. Hanssen Increased serum levels of the specific AGE-compound methylglyoxal-derived hydroimidazolone in patients with type 2 diabetes Metabolism 52 2003 163 167
29. M.S. Kumar, P.Y. Reddy, and P.A. Kumar Effect of dicarbonyls induced browning on alpha-crystalline chaperone-like activity: Physiological significance and caveats of in vitro aggregation assays Biochemical Journal 379 2004 273 282
30. S. Kushwaha, A. Vikram, P.P. Trivedi, and G.B. Jena Alkaline, Endo III and FPG modified comet assay as biomarkers for the detection of oxidative DNA damage in rats with experimentally induced diabetes Mutation Research 726 2011 242 250
31. E.H. Lee, D.G. Song, J.Y. Lee, C.H. Pan, B.H. Um, and S.H. Jung Inhibitory effect of the compounds isolated from Rhus verniciflua on aldose reductase and advanced glycation endproducts Biological & Pharmaceutical Bulletin 31 2008 1626 1630
32. H.S. Lee Cuminaldehyde: Aldose reductase and α-glucosidase Inhibitor derived from Cuminum cyminum L. Seeds Journal of Agricultural and Food Chemistry 53 2005 2446 2450
33. J. Lee, D.S. Jang, N.H. Kim, Y.M. Lee, J. Kim, and J.S. Kim Galloyl glucoses from the seeds of Cornus officinalis with inhibitory activity against protein glycation, aldose reductase, and cataractogenesis ex Vivo Biological & Pharmaceutical Bulletin 34 2011 443 446
34. V. Lewerenz, S. Hanelt, C. Nastevska, C. El-Bahay, E. Röhrdanz, and R. Kahl Antioxidants protect primary rat hepatocyte cultures against acetaminophen-induced DNA strand breaks but not against acetaminophen-induced cytotoxicity Toxicology 191 2003 179 187
35. X. Li, T. Zheng, S. Sang, and L. Lv Quercetin inhibits advanced glycation end product formation by trapping methylglyoxal and glyoxal Journal of Agricultural and Food Chemistry 62 2014 12152 12158
36. O.H. Lowry, N.J. Rosenbrough, A.L. Farr, and R.J. Randall Protein measurement with the Folin phenol reagent Journal of Biological Chemistry 193 1951 265 275
37. H.P. Misra, and I. Fridovich The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase Journal of Biological Chemistry 247 1972 3170 3175
38. T. Morikawa, A. Kishi, and Y. Pongpiriyadacha Structures of new friedelane-type triterpenes and eudesmane-type sesquiterpene and aldose reductase inhibitors from Salacia chinensis Journal of Natural Products 66 2003 1191 1196
39. ε - (carboxymethyl) lysine Biochemical Journal 442 2012 221 230
40. A. Nakamura, and S. Goto Analysis of protein carbonyls with 2, 4-dinitrophenyl hydrazine and its antibodies by immunoblot in two-dimensional gel electrophoresis Journal of Biochemistry 119 1996 768 774
41. J.R. Nyengaard, Y. Ido, C. Kilo, and J.R. Williamson Interactions between hyperglycemia and hypoxia implications for diabetic retinopathy Diabetes 53 2004 2931 2938
42. A. Oda, C. Bannai, T. Yamaoka, T. Katori, T. Matsushima, and K. Yamashita Inactivation of Cu, Zn-superoxide dismutase by in vitro glycosylation and in erythrocytes of diabetic patients Hormone and Metabolic Research 26 1994 1 4
43. M. Odjakava, E. Popova, M. AI Sharif, and R. Mironova Plant derived agents with anti-glycation activity 10 2012 INTECH: University of Rijeka Croatia 223 256
44. U.D. Palanisamy, L.T. Ling, T. Manaharan, and D.R. Appleton Rapid isolation of geraniin from Nephelium lappaceum rind waste and its anti-hyperglycemic activity Food Chemistry 12 2011 21 27
45. S.N. Panaskar, M.M. Joglekar, S.S. Taklikar, V.S. Haldavnekar, and A.U. Arvindekar Aegle marmelos Correa leaf extract prevents secondary complications in streptozotocin-induced diabetic rats and demonstration of limonene as a potent antiglycating agent Journal of Pharmacy and Pharmacology 65 2013 884 894
46. S.B. Patil, V.A. Ghadyale, S.S. Taklikar, C.R. Kulkarni, and A.U. Arvindekar Insulin secretagogue, alpha-glucosidase and antioxidant activity of some selected spices in streptozotocin-induced diabetic rats Plant Foods for Human Nutrition 66 2011 85 89
47. X. Peng, Z. Zheng, K.W. Cheng, F. Shah, G.X. Ren, F. Chen, and M. Wang Inhibitory effect of mung bean extract and its constituents vitexin and isovitexin on the formation of advanced glycation endproducts Food Chemistry 106 2008 475 481
48. M.A. Pfeifer, M.P. Schumer, and D.A. Gelber Aldose reductase inhibitors: The end of an era or the need for different trial designs? Diabetes 46 1997 S82 S89
49. K.V. Ramana Aldose reductase: New insights for an old enzyme Biomolecular Concepts 2 2011 103 114
50. H.L. Rittner, V. Hafner, P.K. Klimiuk, L.I. Szweda, J.J. Goronzy, and C.M. Weyand Aldose reductase functions as a detoxification system for lipid peroxidation products in vasculitis Journal of Clinical Investigation 103 1999 1007 1013
51. W. Sampong, A. Meeprom, H. Cheng, and A. Adisakwattana A comparative study of ferulic acid on different monosaccharide-mediated protein glycation and oxidative damage in bovine serum albumin Molecules 18 2013 13886 13903
52. D.R. Sell, and V.M. Monnier Isolation, purification and partial characterization of novel fluorophores from aging human insoluble collagen-rich tissue Connective Tissue Research 19 1989 77 92
53. A.A.F. Sima, V. Nathanial, A. Prashar, V. Bril, and D.A. Greene Endoneurial microvessels in human diabetic neuropathy, endothelial cell dysjunction and lack of treatment effect by aldose reductase inhibitor Diabetes 40 1991 1090 1099
54. R. Singh, A. Barden, T. Mori, and L. Beilin Advanced glycation end products: A review Diabetologia 44 2001 129 146
55. S. Srivastava, S.J. Watowich, and J.M. Petrash Structural and kinetic determinants of aldehyde reduction by aldose reductase Biochemistry 38 1999 42 54
56. W. Sun, P.J. Oates, J.B. Coutcher, C. Gerhardinger, and M. Lorenzi A selective aldose reductase inhibitor of a new structural class prevents or reverses early retinal abnormalities in experimental diabetic retinopathy Diabetes 55 2006 2757 2762
57. P. Suryanarayana, P.A. Kumar, and M. Saraswat Inhibition of aldose reductase by tannoid principles of Emblica officinalis: Implications for the prevention of sugar cataract Molecular Vision 10 2004 148 154
58. P.J. Thornalley, A. Langborg, and H.S. Minhas Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose Biochemical Journal 344 1999 109 116
59. E. Toth, A. Racz, J. Toth, P.M. Kaminski, M.S. Wolin, Z. Bagi, and A. Koller Contribution of polyol pathway to arteriolar dysfunction in hyperglycemia, Role of oxidative stress, reduced NO, and enhanced PGH2/TXA2 mediation American Journal of Physiology. Heart and Circulatory Physiology 293 2007 H3096 H3104
60. L. Wirasathien, T. Pengsuparp, R. Suttisri, H. Ueda, M. Moriyasu, and K. Kawanishi Inhibitors of aldose reductase and advanced glycation end-products formation from the leaves of Stelechocarpus cauliflorus R.E. Fr Phytomedicine 14 2007 546 550
61. S. Zhang, F.Y. Chai, H. Yan, Y. Guo, and J.J. Harding Effects of N-acetylcysteine and glutathione ethyl ester drops on streptozotocin-induced diabetic cataract in rats Molecular Vision 14 2008 862 870