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Volumn 67, Issue 10, 2015, Pages 2691-2701

Reduction in Disease Progression by Inhibition of Transforming Growth Factor a–CCL2 Signaling in Experimental Posttraumatic Osteoarthritis

Author keywords

[No Author keywords available]

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; BENZOXAZINE DERIVATIVE; CCL2 PROTEIN, RAT; MONOCYTE CHEMOTACTIC PROTEIN 1; QUINAZOLINE DERIVATIVE; RS 504393; SPIRO COMPOUND; TRANSFORMING GROWTH FACTOR ALPHA; TYRPHOSTIN;

EID: 84958074257     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/ART.39255     Document Type: Article
Times cited : (62)

References (47)
  • 2
    • 0034800418 scopus 로고    scopus 로고
    • Understanding NSAIDs: From aspirin to COX-2
    • Green GA. Understanding NSAIDs: from aspirin to COX-2. Clin Cornerstone 2001;3:50–60.
    • (2001) Clin Cornerstone , vol.3 , pp. 50-60
    • Green, G.A.1
  • 3
    • 33751058800 scopus 로고    scopus 로고
    • Posttraumatic osteoarthritis: A first estimate of incidence, preva-lence, and burden of disease
    • Brown TD, Johnston RC, Saltzma CL, Marsh JL, Buckwalter JA. Posttraumatic osteoarthritis: a first estimate of incidence, preva-lence, and burden of disease. J Orthop Trauma 2006;20:739–44.
    • (2006) J Orthop Trauma , vol.20 , pp. 739-744
    • Brown, T.D.1    Johnston, R.C.2    Saltzma, C.L.3    Marsh, J.L.4    Buckwalter, J.A.5
  • 5
    • 84872080405 scopus 로고    scopus 로고
    • A 2-year randomised, double-blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor, cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee
    • Hellio le Graverand MP, Clemmer RS, Redifer P, Brunell RM, Hayes CW, Brandt KD, et al. A 2-year randomised, double-blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor, cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee. Ann Rheum Dis 2013;72:187–95.
    • (2013) Ann Rheum Dis , vol.72 , pp. 187-195
    • Hellio Le Graverand, M.P.1    Clemmer, R.S.2    Redifer, P.3    Brunell, R.M.4    Hayes, C.W.5    Brandt, K.D.6
  • 6
    • 84872091677 scopus 로고    scopus 로고
    • Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: Results of a double-blind, rando-mised placebo-controlled trial
    • Reginster JY, Badurski J, Bellamy N, Bensen W, Chapurlat R, Chevalier X, et al. Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, rando-mised placebo-controlled trial. Ann Rheum Dis 2013;72:179–86.
    • (2013) Ann Rheum Dis , vol.72 , pp. 179-186
    • Reginster, J.Y.1    Badurski, J.2    Bellamy, N.3    Bensen, W.4    Chapurlat, R.5    Chevalier, X.6
  • 7
    • 0142135684 scopus 로고    scopus 로고
    • Tumor necrosis factor a activation of the apoptotic cascade in murine articular chondrocytes is associated with the induction of metalloproteinases and specific pro-resorptive factors
    • Cho TJ, Lehmann W, Edgar C, Sadeghi C, Hou A, Einhorn TA, et al. Tumor necrosis factor a activation of the apoptotic cascade in murine articular chondrocytes is associated with the induction of metalloproteinases and specific pro-resorptive factors. Arthritis Rheum 2003;48:2845–54.
    • (2003) Arthritis Rheum , vol.48 , pp. 2845-2854
    • Cho, T.J.1    Lehmann, W.2    Edgar, C.3    Sadeghi, C.4    Hou, A.5    Einhorn, T.A.6
  • 8
    • 4344688108 scopus 로고    scopus 로고
    • Post-traumatic osteoarthritis: The role of accelerated chondrocyte senescence
    • Martin JA, Brown T, Heiner A, Buckwalter JA. Post-traumatic osteoarthritis: the role of accelerated chondrocyte senescence. Biorheology 2004;41:479–91.
    • (2004) Biorheology , vol.41 , pp. 479-491
    • Martin, J.A.1    Brown, T.2    Heiner, A.3    Buckwalter, J.A.4
  • 9
    • 36049030602 scopus 로고    scopus 로고
    • Transforming growth factor a suppression of articular chondro-cyte phenotype and Sox9 expression in a rat model of osteoar-thritis
    • Appleton CT, Usmani SE, Bernier SM, Aigner T, Beier F. Transforming growth factor a suppression of articular chondro-cyte phenotype and Sox9 expression in a rat model of osteoar-thritis. Arthritis Rheum 2007;56:3693–705.
    • (2007) Arthritis Rheum , vol.56 , pp. 3693-3705
    • Appleton, C.T.1    Usmani, S.E.2    Bernier, S.M.3    Aigner, T.4    Beier, F.5
  • 11
    • 0030891983 scopus 로고    scopus 로고
    • Enhanced cleavage of type II collagen by colla-genases in osteoarthritic articular cartilage
    • Billinghurst RC, Dahlberg L, Ionescu M, Reiner A, Bourne R, Rorabeck C, et al. Enhanced cleavage of type II collagen by colla-genases in osteoarthritic articular cartilage. J Clin Invest 1997;99: 1534–45.
    • (1997) J Clin Invest , vol.99 , pp. 1534-1545
    • Billinghurst, R.C.1    Dahlberg, L.2    Ionescu, M.3    Reiner, A.4    Bourne, R.5    Rorabeck, C.6
  • 12
    • 0027590955 scopus 로고
    • Immunolocalization of selected cytokines and proteases in canine articular cartilage after transarticular loading
    • Pickvance EA, Oegema TR, Thompson RC. Immunolocalization of selected cytokines and proteases in canine articular cartilage after transarticular loading. J Orthop Res 1993;11:313–23.
    • (1993) J Orthop Res , vol.11 , pp. 313-323
    • Pickvance, E.A.1    Oegema, T.R.2    Thompson, R.C.3
  • 13
    • 33847373688 scopus 로고    scopus 로고
    • Forced mobilization accelerates pathogene-sis: Characterization of a preclinical surgical model of osteoar-thritis
    • Appleton CT, McErlain DD, Pitelka V, Schwartz N, Bernier SM, Henry JL, et al. Forced mobilization accelerates pathogene-sis: characterization of a preclinical surgical model of osteoar-thritis. Arthritis Res Ther 2007;9:R13.
    • (2007) Arthritis Res Ther , vol.9 , pp. 13
    • Appleton, C.T.1    McErlain, D.D.2    Pitelka, V.3    Schwartz, N.4    Bernier, S.M.5    Henry, J.L.6
  • 14
    • 34447509660 scopus 로고    scopus 로고
    • Global analyses of gene expression in early experimental osteoarthritis
    • Appleton CT, Pitelka V, Henry J, Beier F. Global analyses of gene expression in early experimental osteoarthritis. Arthritis Rheum 2007;56:1854–68.
    • (2007) Arthritis Rheum , vol.56 , pp. 1854-1868
    • Appleton, C.T.1    Pitelka, V.2    Henry, J.3    Beier, F.4
  • 15
    • 22144471571 scopus 로고    scopus 로고
    • TGF-a and ErbB2 production in synovial joint tissue: Increased expression in arthritic joints
    • Hallbeck AL, Walz TM, Briheim K, Wasteson A. TGF-a and ErbB2 production in synovial joint tissue: increased expression in arthritic joints. Scand J Rheumatol 2005;34:204–11.
    • (2005) Scand J Rheumatol , vol.34 , pp. 204-211
    • Hallbeck, A.L.1    Walz, T.M.2    Briheim, K.3    Wasteson, A.4
  • 16
    • 73349091526 scopus 로고    scopus 로고
    • Rho/ROCK and MEK/ERK activation by transforming growth factor-a induces articular cartilage degradation
    • Appleton CT, Usmani SE, Mort JS, Beier F. Rho/ROCK and MEK/ERK activation by transforming growth factor-a induces articular cartilage degradation. Lab Invest 2010;90:20–30.
    • (2010) Lab Invest , vol.90 , pp. 20-30
    • Appleton, C.T.1    Usmani, S.E.2    Mort, J.S.3    Beier, F.4
  • 17
    • 84863823891 scopus 로고    scopus 로고
    • Transforming growth factor-a induces endothelin receptor A expression in osteoarthritis
    • Usmani SE, Appleton CT, Beier F. Transforming growth factor-a induces endothelin receptor A expression in osteoarthritis. J Orthop Res 2012;30:1391–7.
    • (2012) J Orthop Res , vol.30 , pp. 1391-1397
    • Usmani, S.E.1    Appleton, C.T.2    Beier, F.3
  • 18
    • 23844443142 scopus 로고    scopus 로고
    • Targeted disruption of Mig-6 in the mouse genome leads to early onset degenerative joint disease
    • Zhang YW, Su Y, Lanning N, Swiatek PJ, Bronson RT, Sigler R, et al. Targeted disruption of Mig-6 in the mouse genome leads to early onset degenerative joint disease. Proc Natl Acad Sci U S A 2005;102:11740–5.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 11740-11745
    • Zhang, Y.W.1    Su, Y.2    Lanning, N.3    Swiatek, P.J.4    Bronson, R.T.5    Sigler, R.6
  • 19
    • 34848827653 scopus 로고    scopus 로고
    • EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors by osteoblasts: Implications for osteolytic bone metastases
    • Zhu J, Jia X, Xiao G, Kang Y, Partridge NC, Qin L. EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors by osteoblasts: implications for osteolytic bone metastases. J Biol Chem 2007;282:26656–64.
    • (2007) J Biol Chem , vol.282 , pp. 26656-26664
    • Zhu, J.1    Jia, X.2    Xiao, G.3    Kang, Y.4    Partridge, N.C.5    Qin, L.6
  • 21
    • 84887920943 scopus 로고    scopus 로고
    • Monocyte chemotactic protein-1 inhibits chondrogenesis of syno-vial mesenchymal progenitor cells: An in vitro study
    • Harris Q, Seto J, O’Brien K, Lee PS, Kondo C, Heard BJ, et al. Monocyte chemotactic protein-1 inhibits chondrogenesis of syno-vial mesenchymal progenitor cells: an in vitro study. Stem Cells 2013;31:2253–65.
    • (2013) Stem Cells , vol.31 , pp. 2253-2265
    • Harris, Q.1    Seto, J.2    O’Brien, K.3    Lee, P.S.4    Kondo, C.5    Heard, B.J.6
  • 22
    • 3142673366 scopus 로고    scopus 로고
    • Using the gene ontology for microarray data mining: A comparison of methods and application to age effects in human prefrontal cortex
    • Pavlidis P, Qin J, Arango V, Mann JJ, Sibille E. Using the gene ontology for microarray data mining: a comparison of methods and application to age effects in human prefrontal cortex. Neu-rochem Res 2004;29:1213–22.
    • (2004) Neu-Rochem Res , vol.29 , pp. 1213-1222
    • Pavlidis, P.1    Qin, J.2    Arango, V.3    Mann, J.J.4    Sibille, E.5
  • 23
    • 0030931594 scopus 로고    scopus 로고
    • Aggrecan degradation in human intervertebral disc and articular cartilage
    • Sztrolovics R, Alini M, Roughley PJ, Mort JS. Aggrecan degradation in human intervertebral disc and articular cartilage. Biochem J 1997;326:235–41.
    • (1997) Biochem J , vol.326 , pp. 235-241
    • Sztrolovics, R.1    Alini, M.2    Roughley, P.J.3    Mort, J.S.4
  • 24
    • 17144453055 scopus 로고    scopus 로고
    • TNFa suppresses link protein and type II collagen expression in chondrocytes: Role of MEK1/2 and NF-kB signaling pathways
    • Seguin CA, Bernier SM. TNFa suppresses link protein and type II collagen expression in chondrocytes: role of MEK1/2 and NF-kB signaling pathways. J Cell Physiol 2003;197:356–69.
    • (2003) J Cell Physiol , vol.197 , pp. 356-369
    • Seguin, C.A.1    Bernier, S.M.2
  • 26
    • 77649179852 scopus 로고    scopus 로고
    • G-protein-coupled receptor independent, immunomodulatory properties of chemokine CXCL9
    • Gong JH, Nicholls EF, Elliott MR, Brown KL, Hokamp K, Roche FM, et al. G-protein-coupled receptor independent, immunomodulatory properties of chemokine CXCL9. Cell Immunol 2010;261:105–13.
    • (2010) Cell Immunol , vol.261 , pp. 105-113
    • Gong, J.H.1    Nicholls, E.F.2    Elliott, M.R.3    Brown, K.L.4    Hokamp, K.5    Roche, F.M.6
  • 27
    • 33646044696 scopus 로고    scopus 로고
    • Preclinical analysis of the analinoquinazoline AG1478, a specific small molecule inhibitor of EGF receptor tyrosine kinase
    • Ellis AG, Doherty MM, Walker F, Weinstock J, Nerrie M, Vitali A, et al. Preclinical analysis of the analinoquinazoline AG1478, a specific small molecule inhibitor of EGF receptor tyrosine kinase. Biochem Pharmacol 2006;71:1422–34.
    • (2006) Biochem Pharmacol , vol.71 , pp. 1422-1434
    • Ellis, A.G.1    Doherty, M.M.2    Walker, F.3    Weinstock, J.4    Nerrie, M.5    Vitali, A.6
  • 28
    • 0028968949 scopus 로고
    • Tyrosine kinase inhibition: An approach to drug development
    • Levitzki A, Gazit A. Tyrosine kinase inhibition: an approach to drug development. Science 1995;267:1782–8.
    • (1995) Science , vol.267 , pp. 1782-1788
    • Levitzki, A.1    Gazit, A.2
  • 29
    • 0028171075 scopus 로고
    • Epidermal-growth-factor-dependent activation of the src-family kinases
    • Osherov N, Levitzki A. Epidermal-growth-factor-dependent activation of the src-family kinases. Eur J Biochem 1994;225:1047–52.
    • (1994) Eur J Biochem , vol.225 , pp. 1047-1052
    • Osherov, N.1    Levitzki, A.2
  • 30
    • 0034682767 scopus 로고    scopus 로고
    • Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: Binding to a common chemokine receptor motif within the helical bundle
    • Mirzadegan T, Diehl F, Ebi B, Bhakta S, Polsky I, McCarley D, et al. Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle. J Biol Chem 2000;275:25562–71.
    • (2000) J Biol Chem , vol.275 , pp. 25562-25571
    • Mirzadegan, T.1    Diehl, F.2    Ebi, B.3    Bhakta, S.4    Polsky, I.5    McCarley, D.6
  • 31
    • 67349245487 scopus 로고    scopus 로고
    • Osteoarthritis in patients with anterior cruciate ligament rupture: A review of risk factors
    • Louboutin H, Debarge R, Richou J, Selmi TA, Donell ST, Neyret P, et al. Osteoarthritis in patients with anterior cruciate ligament rupture: a review of risk factors. Knee 2009;16:239–14.
    • (2009) Knee , vol.16 , pp. 239-314
    • Louboutin, H.1    Debarge, R.2    Richou, J.3    Selmi, T.A.4    Donell, S.T.5    Neyret, P.6
  • 32
    • 0025910696 scopus 로고
    • Mechanical overload of a single compartment induces early degenerative changes in the rabbit knee: A preliminary study
    • Goodman SB, Lee J, Smith RL, Csongradi JC, Fornasier VL. Mechanical overload of a single compartment induces early degenerative changes in the rabbit knee: a preliminary study. J Invest Surg 1991;4:161–70.
    • (1991) J Invest Surg , vol.4 , pp. 161-170
    • Goodman, S.B.1    Lee, J.2    Smith, R.L.3    Csongradi, J.C.4    Fornasier, V.L.5
  • 33
    • 0028201015 scopus 로고
    • Changes in cartilage metabolism in arthritis are reflected by altered serum and syno-vial fluid levels of the cartilage proteoglycan aggrecan: Implications for pathogenesis
    • Poole AR, Ionescu M, Swan A, Dieppe PA. Changes in cartilage metabolism in arthritis are reflected by altered serum and syno-vial fluid levels of the cartilage proteoglycan aggrecan: implications for pathogenesis. J Clin Invest 1994;94:25–33.
    • (1994) J Clin Invest , vol.94 , pp. 25-33
    • Poole, A.R.1    Ionescu, M.2    Swan, A.3    Dieppe, P.A.4
  • 34
    • 0029997374 scopus 로고    scopus 로고
    • Tumor necrosis factor-a (TNF-a) in canine osteoarthritis: Immuno-localization of TNF-a, stromelysinandTNFreceptorsincanine osteoarthritic cartilage
    • Kammermann JR, Kincaid SA, Rumph PF, Baird DK, Visco DM. Tumor necrosis factor-a (TNF-a) in canine osteoarthritis: immuno-localization of TNF-a, stromelysinandTNFreceptorsincanine osteoarthritic cartilage. Osteoarthritis Cartilage 1996;4:23–34.
    • (1996) Osteoarthritis Cartilage , vol.4 , pp. 23-34
    • Kammermann, J.R.1    Kincaid, S.A.2    Rumph, P.F.3    Baird, D.K.4    Visco, D.M.5
  • 35
    • 0035076487 scopus 로고    scopus 로고
    • Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: Associations with degenerative changes
    • Tetlow LC, Adlam DJ, Woolley DE. Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: associations with degenerative changes. Arthritis Rheum 2001;44:555–94.
    • (2001) Arthritis Rheum , vol.44 , pp. 555-594
    • Tetlow, L.C.1    Adlam, D.J.2    Woolley, D.E.3
  • 36
    • 84863226474 scopus 로고    scopus 로고
    • Joint immobilization prevents murine osteoar-thritis and reveals the highly mechanosensitive nature of prote-ase expression in vivo
    • Burleigh A, Chanalaris A, Gardiner MD, Driscoll C, Boruc O, Saklatvala J, et al. Joint immobilization prevents murine osteoar-thritis and reveals the highly mechanosensitive nature of prote-ase expression in vivo. Arthritis Rheum 2012;64:2278–88.
    • (2012) Arthritis Rheum , vol.64 , pp. 2278-2288
    • Burleigh, A.1    Chanalaris, A.2    Gardiner, M.D.3    Driscoll, C.4    Boruc, O.5    Saklatvala, J.6
  • 37
    • 85137333048 scopus 로고    scopus 로고
    • Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model
    • Zhang X, Xhu J, Liu F, Li Y, Chandra A, Levin LS, et al. Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model. Bone Res 2013;2:14715.
    • (2013) Bone Res , vol.2
    • Zhang, X.1    Xhu, J.2    Liu, F.3    Li, Y.4    Chandra, A.5    Levin, L.S.6
  • 38
    • 84878007459 scopus 로고    scopus 로고
    • Tran-sient anabolic effects accompany epidermal growth factor receptor signal activation in articular cartilage in vivo
    • Shepard JB, Jeong JW, Maihle NJ, O’Brien S, Dealy CN. Tran-sient anabolic effects accompany epidermal growth factor receptor signal activation in articular cartilage in vivo. Arthritis Res Ther 2013;15:R60.
    • (2013) Arthritis Res Ther , vol.15 , pp. 60
    • Shepard, J.B.1    Jeong, J.W.2    Maihle, N.J.3    O’Brien, S.4    Dealy, C.N.5
  • 39
    • 84894358274 scopus 로고    scopus 로고
    • Cartilage-specific deletion of Mig-6 results in osteoarthritis-like disorder with excessive articular chondrocyte proliferation
    • Staal B, Williams BO, Beier F, Vande Woude GF, Zhang YW. Cartilage-specific deletion of Mig-6 results in osteoarthritis-like disorder with excessive articular chondrocyte proliferation. Proc Natl Acad Sci U S A 2013;111:9590–5.
    • (2013) Proc Natl Acad Sci U S A , vol.111 , pp. 9590-9595
    • Staal, B.1    Williams, B.O.2    Beier, F.3    Vande Woude, G.F.4    Zhang, Y.W.5
  • 40
    • 84908377358 scopus 로고    scopus 로고
    • Dis-turbed cartilage and joint homeostasis resulting from a loss of mitogen-inducible gene 6 in a mouse model of joint dysfunction
    • Pest MA, Russell BA, Zhang YW, Jeong JW, Beier F. Dis-turbed cartilage and joint homeostasis resulting from a loss of mitogen-inducible gene 6 in a mouse model of joint dysfunction. Arthritis Rheumatol 2014;66:2816–27.
    • (2014) Arthritis Rheumatol , vol.66 , pp. 2816-2827
    • Pest, M.A.1    Russell, B.A.2    Zhang, Y.W.3    Jeong, J.W.4    Beier, F.5
  • 42
    • 69949118870 scopus 로고    scopus 로고
    • Syndecan-4 regulates ADAMTS-2 activation and cartilage breakdown in osteoarthritis
    • Echtermeyer F, Bertrand J, Dreier R, Meinecke I, Neugebauer K, Fuerst M, et al. Syndecan-4 regulates ADAMTS-2 activation and cartilage breakdown in osteoarthritis. Nat Med 2009;15: 1072–6.
    • (2009) Nat Med , vol.15 , pp. 1072-1076
    • Echtermeyer, F.1    Bertrand, J.2    Dreier, R.3    Meinecke, I.4    Neugebauer, K.5    Fuerst, M.6
  • 43
    • 71549136203 scopus 로고    scopus 로고
    • Modulating hedgehog signaling can attenuate the severity of osteoarthritis
    • Lin AC, Seeto BL, Bartoszko JM, Khoury MA, Whetstone H, Ho L, et al. Modulating hedgehog signaling can attenuate the severity of osteoarthritis. Nat Med 2009;15:1421–5.
    • (2009) Nat Med , vol.15 , pp. 1421-1425
    • Lin, A.C.1    Seeto, B.L.2    Bartoszko, J.M.3    Khoury, M.A.4    Whetstone, H.5    Ho, L.6
  • 44
    • 77953208836 scopus 로고    scopus 로고
    • Tran-scriptional regulation of endochondral ossification by HIF-2a during skeletal growth and osteoarthritis development
    • Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, Ohba S, et al. Tran-scriptional regulation of endochondral ossification by HIF-2a during skeletal growth and osteoarthritis development. Nat Med 2010;16: 648–86.
    • (2010) Nat Med , vol.16 , pp. 648-686
    • Saito, T.1    Fukai, A.2    Mabuchi, A.3    Ikeda, T.4    Yano, F.5    Ohba, S.6
  • 47
    • 77953183739 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-2a is a catabolic regulator of osteoarthritic cartilage destruction
    • Yang S, Kim J, Ryu JH, Oh H, Chun CH, Kim BJ, et al. Hypoxia-inducible factor-2a is a catabolic regulator of osteoarthritic cartilage destruction. Nat Med 2010;16:687–93.
    • (2010) Nat Med , vol.16 , pp. 687-693
    • Yang, S.1    Kim, J.2    Ryu, J.H.3    Oh, H.4    Chun, C.H.5    Kim, B.J.6


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