Exposure of female rats to an environmentally relevant mixture of brominated flame retardants targets the ovary, affecting folliculogenesis and steroidogenesis

Biology of Reproduction

Volumn 94, Issue 1, 2016, Pages

  Lefèvre, Pavine L C ^a   Berger, Robert G ^a   Ernest, Sheila R ^a   Gaertner, Dean W ^b   Rawn, Dorothea F K ^b   Wade, Michael G ^c   Robaire, Bernard ^a   Hales, Barbara F ^a  

^a MCGILL UNIVERSITY   (Canada)

^b FOOD RESEARCH DIVISION   (Canada)

^c HEALTH CANADA   (Canada)

Author keywords

Androgens; Brominated flame retardants; Catalase; Endocrine disrupters; Folliculogenesis; Hbcdd; Insulin like factor 3; Ovary; Oxidative stress; Pbde; Steroidogenesis; Toxicology

Indexed keywords

17 HYDROXYPREGNENOLONE; BROMINATED HYDROCARBON; CATALASE; CYP17A1 PROTEIN, RAT; DUST; FLAME RETARDANT; INSULIN; LEYDIG INSULIN-LIKE PROTEIN; POLLUTANT; PROTEIN; STEROID; STEROID 17ALPHA MONOOXYGENASE; TESTOSTERONE;

ANALYSIS; ANIMAL; BIOSYNTHESIS; DOSE RESPONSE; DRUG EFFECTS; DUST; ENZYMOLOGY; FEMALE; GENETICS; METABOLISM; OVARY; OVARY FOLLICLE; POLLUTANT; PREGNANCY; RAT; SPRAGUE DAWLEY RAT; TOXICITY;

17-ALPHA-HYDROXYPREGNENOLONE; ANIMALS; CATALASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DUST; ENVIRONMENTAL POLLUTANTS; FEMALE; FLAME RETARDANTS; HYDROCARBONS, BROMINATED; INSULIN; OVARIAN FOLLICLE; OVARY; PREGNANCY; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; STEROID 17-ALPHA-HYDROXYLASE; STEROIDS; TESTOSTERONE;

EID: 84957892270     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.115.134452     Document Type: Article

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