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Volumn 185, Issue 1, 2009, Pages 51-62

Endocrine effects of hexabromocyclododecane (HBCD) in a one-generation reproduction study in Wistar rats

Author keywords

Brominated flame retardants; Development; Endocrine disruption; Hexabromocyclododecane (HBCD); Rats; Reproduction

Indexed keywords

ALKALINE PHOSPHATASE; HEXABROMOCYCLODODECANE; IMMUNOGLOBULIN G;

EID: 58349112311     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2008.12.003     Document Type: Article
Times cited : (120)

References (62)
  • 1
    • 0035044432 scopus 로고    scopus 로고
    • Feasibility and potential gains of enhancing the subacute rat study protocol (OECD test guideline no 407) by additional parameters selected to determine endocrine modulation. A pre-validation study to determine endocrine-mediated effects of the antiandrogenic drug flutamide
    • Andrews P., Freyberger A., Hartmann E., Eiben R., Loof I., Schmidt U., Temerowski M., and Becka M. Feasibility and potential gains of enhancing the subacute rat study protocol (OECD test guideline no 407) by additional parameters selected to determine endocrine modulation. A pre-validation study to determine endocrine-mediated effects of the antiandrogenic drug flutamide. Arch. Toxicol. 75 (2001) 65-73
    • (2001) Arch. Toxicol. , vol.75 , pp. 65-73
    • Andrews, P.1    Freyberger, A.2    Hartmann, E.3    Eiben, R.4    Loof, I.5    Schmidt, U.6    Temerowski, M.7    Becka, M.8
  • 2
    • 25644452125 scopus 로고    scopus 로고
    • A robust characterization of retinoic acid response elements based on a comparison of sites in three species
    • Balmer J.E., and Blomhoff R. A robust characterization of retinoic acid response elements based on a comparison of sites in three species. J. Steroid Biochem. Mol. Biol. 96 (2005) 347-354
    • (2005) J. Steroid Biochem. Mol. Biol. , vol.96 , pp. 347-354
    • Balmer, J.E.1    Blomhoff, R.2
  • 3
    • 0030612393 scopus 로고    scopus 로고
    • The rat TSHbeta gene contains distinct response elements for regulation by retinoids and thyroid hormone
    • Breen J.J., Hickok N.J., and Gurr J.A. The rat TSHbeta gene contains distinct response elements for regulation by retinoids and thyroid hormone. Mol. Cell Endocrinol. 131 (1997) 137-146
    • (1997) Mol. Cell Endocrinol. , vol.131 , pp. 137-146
    • Breen, J.J.1    Hickok, N.J.2    Gurr, J.A.3
  • 4
    • 0036398351 scopus 로고    scopus 로고
    • Sensory organ development in the inner ear: molecular and cellular mechanisms
    • Bryant J., Goodyear R.J., and Richardson G.P. Sensory organ development in the inner ear: molecular and cellular mechanisms. Br. Med. Bull. 63 (2002) 39-57
    • (2002) Br. Med. Bull. , vol.63 , pp. 39-57
    • Bryant, J.1    Goodyear, R.J.2    Richardson, G.P.3
  • 5
    • 58349095301 scopus 로고    scopus 로고
    • Cantón, R.F., 2008. In vitro anti-androgenicity of a selection of brominated flame retardants (BFRs) and derivatives. In: Brominated flame retardants and their metabolites. Novel insights into endocrine disruptive properties (Thesis). Utrecht University, pp. 81-96.
    • Cantón, R.F., 2008. In vitro anti-androgenicity of a selection of brominated flame retardants (BFRs) and derivatives. In: Brominated flame retardants and their metabolites. Novel insights into endocrine disruptive properties (Thesis). Utrecht University, pp. 81-96.
  • 6
    • 33749324495 scopus 로고    scopus 로고
    • In vitro effects of brominated flame retardants and metabolites on CYP17 catalytic activity: a novel mechanism of action?
    • Cantón R.F., Sanderson J.T., Nijmeijer S., Bergman A., Letcher R.J., and Van den Berg M. In vitro effects of brominated flame retardants and metabolites on CYP17 catalytic activity: a novel mechanism of action?. Toxicol. Appl. Pharmacol. 216 (2006) 274-281
    • (2006) Toxicol. Appl. Pharmacol. , vol.216 , pp. 274-281
    • Cantón, R.F.1    Sanderson, J.T.2    Nijmeijer, S.3    Bergman, A.4    Letcher, R.J.5    Van den Berg, M.6
  • 7
    • 58349097033 scopus 로고    scopus 로고
    • In vitro effects of commercial hexabromocyclododecane (HBCD) and its individual stereo-isomers on aromatase activity
    • Cantón R.F., and Van den Berg M. In vitro effects of commercial hexabromocyclododecane (HBCD) and its individual stereo-isomers on aromatase activity. Toxicologist 96 (2007) 386
    • (2007) Toxicologist , vol.96 , pp. 386
    • Cantón, R.F.1    Van den Berg, M.2
  • 9
    • 0020613933 scopus 로고
    • Effect of early nutrition on serum cholesterol levels in adult rats challenged with high fat diet
    • Coates P.M., Brown S.A., Sonawane B.R., and Koldovsky O. Effect of early nutrition on serum cholesterol levels in adult rats challenged with high fat diet. J. Nutr. 113 (1983) 1046-1050
    • (1983) J. Nutr. , vol.113 , pp. 1046-1050
    • Coates, P.M.1    Brown, S.A.2    Sonawane, B.R.3    Koldovsky, O.4
  • 11
    • 40349116028 scopus 로고    scopus 로고
    • Brominated flame retardants as possible endocrine disrupters
    • Darnerud P.O. Brominated flame retardants as possible endocrine disrupters. Int. J. Androl. 31 (2008) 152-160
    • (2008) Int. J. Androl. , vol.31 , pp. 152-160
    • Darnerud, P.O.1
  • 13
    • 0042427646 scopus 로고    scopus 로고
    • Effect of the period of treatment with a single dose of propylthiouracil on the antibody response in rats
    • Duarte C.G., Azzolini A.E., and Assis-Pandochi A.I. Effect of the period of treatment with a single dose of propylthiouracil on the antibody response in rats. Int. Immunopharmacol. 3 (2003) 1419-1427
    • (2003) Int. Immunopharmacol. , vol.3 , pp. 1419-1427
    • Duarte, C.G.1    Azzolini, A.E.2    Assis-Pandochi, A.I.3
  • 14
    • 43849086681 scopus 로고    scopus 로고
    • Two-generation reproductive toxicity study of the flame retardant hexabromocyclododecane in rats
    • Ema M., Fujii S., Hirata-Koizumi M., and Matsumoto M. Two-generation reproductive toxicity study of the flame retardant hexabromocyclododecane in rats. Reprod. Toxicol. 25 (2008) 335-351
    • (2008) Reprod. Toxicol. , vol.25 , pp. 335-351
    • Ema, M.1    Fujii, S.2    Hirata-Koizumi, M.3    Matsumoto, M.4
  • 15
    • 33645220896 scopus 로고    scopus 로고
    • Impaired behaviour, learning and memory, in adult mice neonatally exposed to hexabromocyclododecane (HBCDD)
    • Eriksson P., Fischer C., Wallin M., Jakobsson E., and Frederisson A. Impaired behaviour, learning and memory, in adult mice neonatally exposed to hexabromocyclododecane (HBCDD). Environ. Toxicol. Pharmacol. 21 (2006) 317-322
    • (2006) Environ. Toxicol. Pharmacol. , vol.21 , pp. 317-322
    • Eriksson, P.1    Fischer, C.2    Wallin, M.3    Jakobsson, E.4    Frederisson, A.5
  • 16
    • 58349115555 scopus 로고    scopus 로고
    • European Commission, 2008. Risk assessment of hexabromocyclododecane, CAS No: 25637-99-4, Final draft, May 2008 (http://ecb.jrc.ec.europa.eu/esis/).
    • European Commission, 2008. Risk assessment of hexabromocyclododecane, CAS No: 25637-99-4, Final draft, May 2008 (http://ecb.jrc.ec.europa.eu/esis/).
  • 18
    • 29244462305 scopus 로고    scopus 로고
    • Subacute effects of the brominated flame retardants hexabromocyclododecane and tetrabromobisphenol A on hepatic cytochrome P450 levels in rats
    • Germer S., Piersma A.H., Van der Ven L.T.M., Kamyschnikow A., Schmitz H.J., and Schrenk D. Subacute effects of the brominated flame retardants hexabromocyclododecane and tetrabromobisphenol A on hepatic cytochrome P450 levels in rats. Toxicology 218 (2006) 229-236
    • (2006) Toxicology , vol.218 , pp. 229-236
    • Germer, S.1    Piersma, A.H.2    Van der Ven, L.T.M.3    Kamyschnikow, A.4    Schmitz, H.J.5    Schrenk, D.6
  • 20
    • 38449116576 scopus 로고    scopus 로고
    • Developmental origins of health and disease: new insights
    • Hanson M.A., and Gluckman P.D. Developmental origins of health and disease: new insights. Basic Clin. Pharmacol. Toxicol. 102 (2008) 90-93
    • (2008) Basic Clin. Pharmacol. Toxicol. , vol.102 , pp. 90-93
    • Hanson, M.A.1    Gluckman, P.D.2
  • 21
    • 0033796676 scopus 로고    scopus 로고
    • Effect of long-term high-fat feeding on energy balance and liver oxidative activity in rats
    • Iossa S., Lionetti L., Mollica M.P., Crescenzo R., Barletta A., and Liverini G. Effect of long-term high-fat feeding on energy balance and liver oxidative activity in rats. Br. J. Nutr. 84 (2000) 377-385
    • (2000) Br. J. Nutr. , vol.84 , pp. 377-385
    • Iossa, S.1    Lionetti, L.2    Mollica, M.P.3    Crescenzo, R.4    Barletta, A.5    Liverini, G.6
  • 23
    • 40949144529 scopus 로고    scopus 로고
    • Time trend of hexabromocyclododecane in the breast milk of Japanese women
    • Kakimoto K., Akutsu K., Konishi Y., and Tanaka Y. Time trend of hexabromocyclododecane in the breast milk of Japanese women. Chemosphere 71 (2008) 1110-1114
    • (2008) Chemosphere , vol.71 , pp. 1110-1114
    • Kakimoto, K.1    Akutsu, K.2    Konishi, Y.3    Tanaka, Y.4
  • 24
    • 38449093343 scopus 로고    scopus 로고
    • Effect of high fat diet on the volume of liver and quantitative feature of Kupffer cells in the female rat: a stereological and ultrastructural study
    • Kiki I., Altunkaynak B.Z., Altunkaynak M.E., Vuraler O., Unal D., and Kaplan S. Effect of high fat diet on the volume of liver and quantitative feature of Kupffer cells in the female rat: a stereological and ultrastructural study. Obes. Surg. 17 (2007) 1381-1388
    • (2007) Obes. Surg. , vol.17 , pp. 1381-1388
    • Kiki, I.1    Altunkaynak, B.Z.2    Altunkaynak, M.E.3    Vuraler, O.4    Unal, D.5    Kaplan, S.6
  • 25
    • 0025270730 scopus 로고
    • Effect of dietary fat on the induction of hepatic microsomal cytochrome P450 isozymes by phenobarbital
    • Kim H.J., Choi E.S., and Wade A.E. Effect of dietary fat on the induction of hepatic microsomal cytochrome P450 isozymes by phenobarbital. Biochem. Pharmacol. 39 (1990) 1423-1430
    • (1990) Biochem. Pharmacol. , vol.39 , pp. 1423-1430
    • Kim, H.J.1    Choi, E.S.2    Wade, A.E.3
  • 26
    • 0036097035 scopus 로고    scopus 로고
    • Evaluation of the 20-day pubertal female assay in Sprague-Dawley rats treated with DES, tamoxifen, testosterone, and flutamide
    • Kim H.S., Shin J.H., Moon H.J., Kim T.S., Kang I.H., Seok J.H., Kim I.Y., Park K.L., and Han S.Y. Evaluation of the 20-day pubertal female assay in Sprague-Dawley rats treated with DES, tamoxifen, testosterone, and flutamide. Toxicol. Sci. 67 (2002) 52-62
    • (2002) Toxicol. Sci. , vol.67 , pp. 52-62
    • Kim, H.S.1    Shin, J.H.2    Moon, H.J.3    Kim, T.S.4    Kang, I.H.5    Seok, J.H.6    Kim, I.Y.7    Park, K.L.8    Han, S.Y.9
  • 27
    • 34548606099 scopus 로고    scopus 로고
    • Gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin alters retinoid homeostasis in maternal and perinatal tissues of the Holtzman rat
    • Kransler K.M., Tonucci D.A., McGarrigle B.P., Napoli J.L., and Olson J.R. Gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin alters retinoid homeostasis in maternal and perinatal tissues of the Holtzman rat. Toxicol. Appl. Pharmacol. 224 (2007) 29-38
    • (2007) Toxicol. Appl. Pharmacol. , vol.224 , pp. 29-38
    • Kransler, K.M.1    Tonucci, D.A.2    McGarrigle, B.P.3    Napoli, J.L.4    Olson, J.R.5
  • 28
    • 2542484641 scopus 로고    scopus 로고
    • Evaluation for reliability and feasibility of the draft protocol for the enhanced rat 28-day subacute study (OECD Guideline 407) using androgen antagonist flutamide
    • Kunimatsu T., Yamada T., Miyata K., Yabushita S., Seki T., Okuno Y., and Matsuo M. Evaluation for reliability and feasibility of the draft protocol for the enhanced rat 28-day subacute study (OECD Guideline 407) using androgen antagonist flutamide. Toxicology 200 (2004) 77-89
    • (2004) Toxicology , vol.200 , pp. 77-89
    • Kunimatsu, T.1    Yamada, T.2    Miyata, K.3    Yabushita, S.4    Seki, T.5    Okuno, Y.6    Matsuo, M.7
  • 29
    • 0242287838 scopus 로고    scopus 로고
    • Are brominated flame retardants endocrine disruptors?
    • Legler J., and Brouwer A. Are brominated flame retardants endocrine disruptors?. Environ. Int. 29 (2003) 879-885
    • (2003) Environ. Int. , vol.29 , pp. 879-885
    • Legler, J.1    Brouwer, A.2
  • 31
    • 58349103245 scopus 로고    scopus 로고
    • Lilienthal, H., Van der Ven, L.T.M., Piersma, A.H., Vos, J.G. Neurobehavioral effects of the brominated flame retardant hexabromocyclododecane (HBCD) in rats after pre- and postnatal exposure, in press, doi:10.1016/j.toxlet.2008.12.002.
    • Lilienthal, H., Van der Ven, L.T.M., Piersma, A.H., Vos, J.G. Neurobehavioral effects of the brominated flame retardant hexabromocyclododecane (HBCD) in rats after pre- and postnatal exposure, in press, doi:10.1016/j.toxlet.2008.12.002.
  • 32
    • 58349120540 scopus 로고    scopus 로고
    • Influence of prenatal exposure to selected organohalogans on infant sexual and neurological development
    • Meijer L., Brouwer A., de Jong F.H.J., Bergman A., and Sauer P.J.J. Influence of prenatal exposure to selected organohalogans on infant sexual and neurological development. Organohalog. Comp. 70 (2008) 658-661
    • (2008) Organohalog. Comp. , vol.70 , pp. 658-661
    • Meijer, L.1    Brouwer, A.2    de Jong, F.H.J.3    Bergman, A.4    Sauer, P.J.J.5
  • 33
    • 52049112581 scopus 로고    scopus 로고
    • Serum concentrations of neutral and phenolic organohalogens in pregnant women and some of their infants in The Netherlands
    • Meijer L., Weiss J., Van Velzen M., Brouwer A., Bergman A., and Sauer P.J. Serum concentrations of neutral and phenolic organohalogens in pregnant women and some of their infants in The Netherlands. Environ. Sci. Technol. 42 (2008) 3428-3433
    • (2008) Environ. Sci. Technol. , vol.42 , pp. 3428-3433
    • Meijer, L.1    Weiss, J.2    Van Velzen, M.3    Brouwer, A.4    Bergman, A.5    Sauer, P.J.6
  • 34
    • 0018560354 scopus 로고
    • Anti-androgen TSAA-291. I. Anti-androgenic effects of a new steroid TSAA-291 (16 beta-ethyl-17 beta-hydroxy-4-oestren-3-one) and its derivatives
    • Nakayama R., Masuoka M., Masaki T., and Shimamoto K. Anti-androgen TSAA-291. I. Anti-androgenic effects of a new steroid TSAA-291 (16 beta-ethyl-17 beta-hydroxy-4-oestren-3-one) and its derivatives. Acta Endocrinol. Suppl. (Copenh) 229 (1979) 2-23
    • (1979) Acta Endocrinol. Suppl. (Copenh) , vol.229 , pp. 2-23
    • Nakayama, R.1    Masuoka, M.2    Masaki, T.3    Shimamoto, K.4
  • 35
    • 0036277925 scopus 로고    scopus 로고
    • The retinoid signaling system-a target in dioxin toxicity
    • Nilsson C.B., and Håkansson H. The retinoid signaling system-a target in dioxin toxicity. Crit. Rev. Toxicol. 32 (2002) 211-232
    • (2002) Crit. Rev. Toxicol. , vol.32 , pp. 211-232
    • Nilsson, C.B.1    Håkansson, H.2
  • 37
    • 48549093762 scopus 로고    scopus 로고
    • Disruption of retinoid transport, metabolism and signaling by environmental pollutants
    • Novak J., Benisek M., and Hilscherova K. Disruption of retinoid transport, metabolism and signaling by environmental pollutants. Environ. Int. 34 (2008) 898-913
    • (2008) Environ. Int. , vol.34 , pp. 898-913
    • Novak, J.1    Benisek, M.2    Hilscherova, K.3
  • 38
    • 38749132313 scopus 로고    scopus 로고
    • Expression of hepatic UDP-glucuronosyltransferase 1A1 and 1A6 correlated with increased expression of the nuclear constitutive androstane receptor and peroxisome proliferator-activated receptor alpha in male rats fed a high-fat and high-sucrose diet
    • Osabe M., Sugatani J., Fukuyama T., Ikushiro S., Ikari A., and Miwa M. Expression of hepatic UDP-glucuronosyltransferase 1A1 and 1A6 correlated with increased expression of the nuclear constitutive androstane receptor and peroxisome proliferator-activated receptor alpha in male rats fed a high-fat and high-sucrose diet. Drug Metab. Dispos. 36 (2008) 294-302
    • (2008) Drug Metab. Dispos. , vol.36 , pp. 294-302
    • Osabe, M.1    Sugatani, J.2    Fukuyama, T.3    Ikushiro, S.4    Ikari, A.5    Miwa, M.6
  • 39
    • 0032093690 scopus 로고    scopus 로고
    • Cytokines, estrogen, and postmenopausal osteoporosis-the second decade
    • Pacifici R. Cytokines, estrogen, and postmenopausal osteoporosis-the second decade. Endocrinology 139 (1998) 2659-2661
    • (1998) Endocrinology , vol.139 , pp. 2659-2661
    • Pacifici, R.1
  • 40
    • 37449024524 scopus 로고    scopus 로고
    • Spatial and temporal changes of chlorinated pesticides, PCBs, dioxins (PCDDs/PCDFs) and brominated flame retardants in human breast milk from Northern Russia
    • Polder A., Gabrielsen G.W., Odland J.O., Savinova T.N., Tkachev A., Loken K.B., and Skaare J.U. Spatial and temporal changes of chlorinated pesticides, PCBs, dioxins (PCDDs/PCDFs) and brominated flame retardants in human breast milk from Northern Russia. Sci. Total Environ. 391 (2008) 41-54
    • (2008) Sci. Total Environ. , vol.391 , pp. 41-54
    • Polder, A.1    Gabrielsen, G.W.2    Odland, J.O.3    Savinova, T.N.4    Tkachev, A.5    Loken, K.B.6    Skaare, J.U.7
  • 41
    • 33745303735 scopus 로고    scopus 로고
    • Retinoid signaling in inner ear development
    • Romand R., Dolle P., and Hashino E. Retinoid signaling in inner ear development. J. Neurobiol. 66 (2006) 687-704
    • (2006) J. Neurobiol. , vol.66 , pp. 687-704
    • Romand, R.1    Dolle, P.2    Hashino, E.3
  • 42
    • 33947163299 scopus 로고    scopus 로고
    • Vitamin A supplementation and retinoic acid treatment in the regulation of antibody responses in vivo
    • Ross A.C. Vitamin A supplementation and retinoic acid treatment in the regulation of antibody responses in vivo. Vitam. Horm. 75 (2007) 197-222
    • (2007) Vitam. Horm. , vol.75 , pp. 197-222
    • Ross, A.C.1
  • 43
    • 34447538175 scopus 로고    scopus 로고
    • Effects of dietary retinoids and carotenoids on immune development
    • Ruhl R. Effects of dietary retinoids and carotenoids on immune development. Proc. Nutr. Soc. 66 (2007) 458-469
    • (2007) Proc. Nutr. Soc. , vol.66 , pp. 458-469
    • Ruhl, R.1
  • 45
    • 0031034376 scopus 로고    scopus 로고
    • Consumption of a high fat diet impairs reproductive performance in Sprague-Dawley rats
    • Shaw M.A., Rasmussen K.M., and Myers T.R. Consumption of a high fat diet impairs reproductive performance in Sprague-Dawley rats. J. Nutr. 127 (1997) 64-69
    • (1997) J. Nutr. , vol.127 , pp. 64-69
    • Shaw, M.A.1    Rasmussen, K.M.2    Myers, T.R.3
  • 46
    • 0036206395 scopus 로고    scopus 로고
    • Dose-response modeling of continuous endpoints
    • Slob W. Dose-response modeling of continuous endpoints. Toxicol. Sci. 66 (2002) 298-312
    • (2002) Toxicol. Sci. , vol.66 , pp. 298-312
    • Slob, W.1
  • 47
    • 38449110528 scopus 로고    scopus 로고
    • What is a practical threshold?
    • Slob W. What is a practical threshold?. Toxicol. Pathol. 35 (2007) 848-849
    • (2007) Toxicol. Pathol. , vol.35 , pp. 848-849
    • Slob, W.1
  • 49
    • 9444243357 scopus 로고    scopus 로고
    • Characterization of the resistance to the anorectic and endocrine effects of leptin in obesity-prone and obesity-resistant rats fed a high-fat diet
    • Tulipano G., Vergoni A.V., Soldi D., Muller E.E., and Cocchi D. Characterization of the resistance to the anorectic and endocrine effects of leptin in obesity-prone and obesity-resistant rats fed a high-fat diet. J. Endocrinol. 183 (2004) 289-298
    • (2004) J. Endocrinol. , vol.183 , pp. 289-298
    • Tulipano, G.1    Vergoni, A.V.2    Soldi, D.3    Muller, E.E.4    Cocchi, D.5
  • 50
    • 0032532254 scopus 로고    scopus 로고
    • Retinoids and their receptors in skeletal development
    • Underhill T.M., and Weston A.D. Retinoids and their receptors in skeletal development. Microsc. Res. Technol. 43 (1998) 137-155
    • (1998) Microsc. Res. Technol. , vol.43 , pp. 137-155
    • Underhill, T.M.1    Weston, A.D.2
  • 53
    • 0026002211 scopus 로고
    • An enzyme-linked immunosorbent assay of anti-sheep red blood cell antibodies of the classes M, G, and A in the rat
    • Van Loveren H., Verlaan A.P., and Vos J.G. An enzyme-linked immunosorbent assay of anti-sheep red blood cell antibodies of the classes M, G, and A in the rat. Int. J. Immunopharmacol. 13 (1991) 689-695
    • (1991) Int. J. Immunopharmacol. , vol.13 , pp. 689-695
    • Van Loveren, H.1    Verlaan, A.P.2    Vos, J.G.3
  • 54
    • 0037394594 scopus 로고    scopus 로고
    • Immunotoxicological consequences of perinatal chemical exposures: a plea for inclusion of immune parameters in reproduction studies
    • Van Loveren H., Vos J., Putman E., and Piersma A. Immunotoxicological consequences of perinatal chemical exposures: a plea for inclusion of immune parameters in reproduction studies. Toxicology 185 (2003) 185-191
    • (2003) Toxicology , vol.185 , pp. 185-191
    • Van Loveren, H.1    Vos, J.2    Putman, E.3    Piersma, A.4
  • 56
    • 0025032163 scopus 로고
    • Immunotoxicity of bis(tri-n-butyltin)oxide in the rat: effects on thymus-dependent immunity and on nonspecific resistance following long-term exposure in young versus aged rats
    • Vos J.G., De Klerk A., Krajnc E.I., Van Loveren H., and Rozing J. Immunotoxicity of bis(tri-n-butyltin)oxide in the rat: effects on thymus-dependent immunity and on nonspecific resistance following long-term exposure in young versus aged rats. Toxicol. Appl. Pharmacol. 105 (1990) 144-155
    • (1990) Toxicol. Appl. Pharmacol. , vol.105 , pp. 144-155
    • Vos, J.G.1    De Klerk, A.2    Krajnc, E.I.3    Van Loveren, H.4    Rozing, J.5
  • 57
    • 32644472539 scopus 로고    scopus 로고
    • PBDE and HBCDD levels in blood from Dutch mothers and infants-analysis project within the Dutch Groningen Infant Cohort. The third international workshop on brominated flame retardants
    • Weiss J., Meijer L., Sauer P., Linderholm L., Athanassiadis I., and Bergman A. PBDE and HBCDD levels in blood from Dutch mothers and infants-analysis project within the Dutch Groningen Infant Cohort. The third international workshop on brominated flame retardants. BFR 2004 (2004) 71-74
    • (2004) BFR , vol.2004 , pp. 71-74
    • Weiss, J.1    Meijer, L.2    Sauer, P.3    Linderholm, L.4    Athanassiadis, I.5    Bergman, A.6
  • 58
    • 0035717798 scopus 로고    scopus 로고
    • Uterotrophic and Hershberger assays for n-butylbenzene in rats
    • Yamasaki K., Sawaki M., Noda S., and Takatsuki M. Uterotrophic and Hershberger assays for n-butylbenzene in rats. Arch. Toxicol. 75 (2002) 703-706
    • (2002) Arch. Toxicol. , vol.75 , pp. 703-706
    • Yamasaki, K.1    Sawaki, M.2    Noda, S.3    Takatsuki, M.4
  • 59
    • 0026652491 scopus 로고
    • Modulation of the levels of cytochromes P450 in rat liver and lung by dietary lipid
    • Yoo J.S., Smith T.J., Ning S.M., Lee M.J., Thomas P.E., and Yang C.S. Modulation of the levels of cytochromes P450 in rat liver and lung by dietary lipid. Biochem. Pharmacol. 43 (1992) 2535-2542
    • (1992) Biochem. Pharmacol. , vol.43 , pp. 2535-2542
    • Yoo, J.S.1    Smith, T.J.2    Ning, S.M.3    Lee, M.J.4    Thomas, P.E.5    Yang, C.S.6
  • 61
    • 16844363318 scopus 로고    scopus 로고
    • Levels of hexabromocyclododecane in harbor porpoises and common dolphins from western European seas, with evidence for stereoisomer-specific biotransformation by cytochrome p450
    • Zegers B.N., Mets A., Van Bommel R., Minkenberg C., Hamers T., Kamstra J.H., Pierce G.J., and Boon J.P. Levels of hexabromocyclododecane in harbor porpoises and common dolphins from western European seas, with evidence for stereoisomer-specific biotransformation by cytochrome p450. Environ. Sci. Technol. 39 (2005) 2095-2100
    • (2005) Environ. Sci. Technol. , vol.39 , pp. 2095-2100
    • Zegers, B.N.1    Mets, A.2    Van Bommel, R.3    Minkenberg, C.4    Hamers, T.5    Kamstra, J.H.6    Pierce, G.J.7    Boon, J.P.8
  • 62
    • 0034470351 scopus 로고    scopus 로고
    • Thyroid hormone action in fetal brain development and potential for disruption by environmental chemicals
    • Zoeller R.T., and Crofton K.M. Thyroid hormone action in fetal brain development and potential for disruption by environmental chemicals. Neurotoxicology 21 (2000) 935-945
    • (2000) Neurotoxicology , vol.21 , pp. 935-945
    • Zoeller, R.T.1    Crofton, K.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.