Multiple biomarkers of the cytotoxicity induced by BDE-47 in human embryonic kidney cells

Chemosphere

Volumn 126, Issue , 2015, Pages 32-39

  Wu, Huifeng ^a   Cao, Lulu ^a,b   Li, Fei ^a   Lian, Peiwen ^c   Zhao, Jianmin ^a  

^a YANTAI INSTITUTE OF COASTAL ZONE RESEARCH   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c YANTAI YUHUANGDING HOSPITAL   (China)

Author keywords

BDE 47; Cell apoptosis; Cytotoxicity; HEK293 cells; Metabolomics; ROS

Indexed keywords

CELL DEATH; CELL PROLIFERATION; ETHERS; FLAME RETARDANTS; GENE EXPRESSION; METABOLISM; ORGANIC POLLUTANTS;

BDE-47; BROMINATED FLAME RETARDANTS; CELL APOPTOSIS; HEK293 CELLS; HUMAN EMBRYONIC KIDNEY CELLS; METABOLOMICS; MULTIPLE BIOMARKERS; POLYBROMINATED DIPHENYL ETHER (PBDES);

CYTOTOXICITY;

2,2',4,4' TETRA BROMODIPHENYL ETHER; ALANINE; ALCOHOL; ASPARTIC ACID; CREATINE; GLUTATHIONE; LACTIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE; POLYBROMINATED DIPHENYL ETHER; PROTEIN BAD; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GLUCOSE; 2,2',4,4'-TETRABROMODIPHENYL ETHER; BIOLOGICAL MARKER; DIPHENYL ETHER DERIVATIVE; FLAME RETARDANT;

AMINO ACID; APOPTOSIS; BIOASSAY; BIOMARKER; EMBRYO; METABOLISM; PBDE; POLLUTION EXPOSURE; PUBLIC HEALTH; TOXICITY;

APOPTOSIS; ARTICLE; BIOASSAY; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; EMBRYO; ENERGY METABOLISM; GENE EXPRESSION; HEK293 CELL LINE; HUMAN; HUMAN CELL; KIDNEY CELL; OXIDATIVE STRESS; DNA DAMAGE; DRUG EFFECTS; EPITHELIUM CELL; METABOLISM;

ALANINE; APOPTOSIS; ASPARTIC ACID; BIOLOGICAL ASSAY; BIOMARKERS; CELL PROLIFERATION; CREATINE; DNA DAMAGE; ENERGY METABOLISM; EPITHELIAL CELLS; ETHANOL; FLAME RETARDANTS; GLUTATHIONE; HALOGENATED DIPHENYL ETHERS; HEK293 CELLS; HUMANS; LACTIC ACID; OXIDATIVE STRESS;

EID: 84924247773     PISSN: 00456535     EISSN: 18791298     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2015.01.055     Document Type: Article

References (59)

1. Alaee M., Arias P., Sjodin A., Bergman A. An overview of commercially used brominated flame retardants, their applications, their use patterns in different countries/regions and possible modes of release. Environ. Int. 2003, 29:683-689.
2. An J., Yin L., Shang Y., Zhong Y., Zhang X., Wu M., Yu Z., Sheng G., Fu J., Huang Y. The combined effects of BDE47 and BaP on oxidatively generated DNA damage in L02 cells and the possible molecular mechanism. Mutat. Res-Gen. Tox. En. 2011, 721:192-198.
3. Bradman A., Castorina R., Sjodin A., Fenster L., Jones R.S., Harley K.G., Chevrier J., Holland N.T., Eskenazi B. Factors associated with serum polybrominated diphenyl ether (PBDE) levels among school-age children in the CHAMACOS cohort. Environ. Sci. Technol. 2012, 46:7373-7381.
4. Chen D., Hale R.C. A global review of polybrominated diphenyl ether flame retardant contamination in birds. Environ. Int. 2010, 36:800-811.
5. Chen D., Mai B., Song J., Sun Q., Luo Y., Luo X., Zeng E., Hale R.C. Polybrominated diphenyl ethers in birds of prey from Northern China. Environ. Sci. Technol. 2007, 41:1828-1833.
6. Chen X., Huang C., Wang X., Chen J., Bai C., Chen Y., Chen X., Dong Q., Yang D. BDE-47 disrupts axonal growth and motor behavior in developing zebrafish. Aquat. Toxicol. 2012, 120:35-44.
7. Crump D., Jagla M.M., Chiu S., Kennedy S.W. Detection of PBDE effects on mRNA expression in chicken (Gallus domesticus) neuronal cells using real-time RT-PCR and a new differential display method. Toxicol. in Vitro 2008, 22:1337-1343.
8. de Wit C.A. An overview of brominated flame retardants in the environment. Chemosphere 2002, 46:583-624.
9. de Wit C.A., Herzke D., Vorkamp K. Brominated flame retardants in the Arctic environment-trends and new candidates. Sci. Total Environ. 2010, 408:2885-2918.
10. Dondero F., Dagnino A., Jonsson H., Capri F., Gastaldi L., Viarengo A. Assessing the occurrence of a stress syndrome in mussels (Mytilus edulis) using a combined biomarker/gene expression approach. Aquat. Toxicol. 2006, 78:S13-S24.
11. 2-induced damage and iron homeostasis in human cells. Free Radical Bio. Med. 2007, 43:1165-1175.
12. Emond C., Raymer J.H., Studabaker W.B., Garner C.E., Birnbaum L.S. A physiologically based pharmacokinetic model for developmental exposure to BDE-47 in rats. Toxicol. Appl. Pharm. 2010, 242:290-298.
13. Erratico C.A., Moffatt S.C., Bandiera S.M. Comparative oxidative metabolism of BDE-47 and BDE-99 by rat hepatic microsomes. Toxicol. Sci. 2011, 123:37-47.
14. Fan W.M.T. Metabolite profiling by one- and two-dimensional NMR analysis of complex mixtures. Prog. Nucl. Mag. Res. Sp. 1996, 28:161-219.
15. Feng J., Li J., Wu H., Chen Z. Metabolic responses of HeLa cells to silica nanoparticles by NMR-based metabolomic analyses. Metabolomics 2013, 9:874-886.
16. 1H NMR spectroscopy. BBA-Gen. Subjects 2003, 1619:151-158.
17. Hakk H., Huwe J.K., Murphy K., Rutherford D. Metabolism of 2,2',4,4'-Tetrabromodiphenyl Ether (BDE-47) in Chickens. J. Agr. Food Chem. 2010, 58:8757-8762.
18. Hale R.C., La Guardia M.J., Harvey E., Gaylor M.O., Mainor T.M. Brominated flame retardant concentrations and trends in abiotic media. Chemosphere 2006, 64:181-186.
19. He W., He P., Wang A., Xia T., Xu B., Chen X. Effects of PBDE-47 on cytotoxicity and genotoxicity in human neuroblastoma cells in vitro. Mutat. Res-Gen. Tox. En. 2008, 649:62-70.
20. Hites R.A. Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. Environ. Sci. Technol. 2004, 38:945-956.
21. Huwe J.K., Hakk H., Birnbaum L.S. Tissue distribution of polybrominated diphenyl ethers in male rats and implications for biomonitoring. Environ. Sci. Technol. 2008, 42:7018-7024.
22. L. Embo J. 1997, 16:1686-1694.
23. Jakobsson K., Fang J., Athanasiadou M., Rignell-Hydbom A., Bergman A. Polybrominated diphenyl ethers in maternal serum, umbilical cord serum, colostrum and mature breast milk. Insights from a pilot study and the literature. Environ. Int. 2012, 47:121-130.
24. Ji C., Wu H., Wei L., Zhao J., Lu H., Yu J. Proteomic and metabolomic analysis of earthworm Eisenia fetida exposed to different concentrations of 2,2',4,4'-tetrabromodiphenyl ether. J. Proteomics 2013, 91:405-416.
25. Jin J., Liu W., Wang Y., Tang X. Levels and distribution of polybrominated diphenyl ethers in plant, shellfish and sediment samples from Laizhou Bay in China. Chemosphere 2008, 71:1043-1050.
26. Kawashiro Y., Fukata H., Sato K., Aburatani H., Takigami H., Mori C. Polybrominated diphenyl ethers cause oxidative stress in human umbilical vein endothelial cells. Hum. Exp. Toxicol. 2009, 28:703-713.
27. Kerr J.F.R., Wyllie A.H., Currie A.R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Brit. J. Cancer 1972, 26:239-257.
28. Kodavanti P.R.S., Coburn C.G., Moser V.C., MacPhail R.C., Fenton S.E., Stoker T.E., Rayner J.L., Kannan K., Birnbaum L.S. Developmental exposure to a commercial PBDE mixture, DE-71: neurobehavioral, hormonal, and reproductive effects. Toxicol. Sci. 2010, 116:297-312.
29. Lema S.C., Dickey J.T., Schultz I.R., Swanson P. Dietary exposure to 2,2',4,4'-tetrabromodiphenyl ether (PBDE-47) alters thyroid status and thyroid hormone-regulated gene transcription in the pituitary and brain. Environ. Health Perspect. 2008, 116:1694-1699.
30. Liang S., Zhao Q., Qin Z., Zhao X., Yang Z., Xu X. Levels and distribution of polybrominated diphenyl ethers in various tissues of foraging hens from an electronic waste recycling area in South China. Environ. Toxicol. Chem. 2008, 27:1279-1283.
31. Liu X., Zhang L., You L., Cong M., Zhao J., Wu H., Li C., Liu D., Yu J. Toxicological responses to acute mercury exposure for three species of Manila clam Ruditapes philippinarum by NMR-based metabolomics. Environ. Toxicol. Phar. 2011, 31:323-332.
32. T method. Methods 2001, 25:402-408.
33. Mingeotleclercq M.P., Brasseur R., Schanck A. Molecular-parameters involved in aminoglycoside nephrotoxicity. J. Toxicol. Env. Health 1995, 44:263-300.
34. Oliveira P.F., Alves M.G., Rato L., Silva J., Sa R., Barros A., Sousa M., Carvalho R.A., Cavaco J.E., Socorro S. Influence of 5α-dihydrotestosterone and 17β-estradiol on human Sertoli cells metabolism. Int. J. Androl. 2011, 34:E612-E620.
35. Pan X., Tang J., Li J., Guo Z., Zhang G. Levels and distributions of PBDEs and PCBs in sediments of the Bohai Sea, North China. J. Environ. Monitor. 2010, 12:1234-1241.
36. Parsons H.M., Ludwig C., Gunther U.L., Viant M.R. Improved classification accuracy in 1-and 2-dimensional NMR metabolomics data using the variance stabilising generalised logarithm transformation. Bmc Bioinform. 2007, 8:234.
37. Pellacani C., Buschini A., Galati S., Mussi F., Franzoni S., Costa L.G. Evaluation of DNA damage induced by 2 polybrominated diphenyl ether flame retardants (BDE-47 and BDE-209) in SK-N-MC cells. Int. J. Toxicol. 2012, 31:372-379.
38. Petros A.M., Olejniczak E.T., Fesik S.W. Structural biology of the Bcl-2 family of proteins. BBA-Mol. Cell Res. 2004, 1644:83-94.
39. Rademacher T., Parekh R., Dwek R. Glycobiology. Annu. Rev. Biochem. 1988, 57:785-838.
40. Rato L., Alves M.G., Socorro S., Carvalho R.A., Cavaco J.E., Oliveira P.F. Metabolic modulation induced by oestradiol and DHT in immature rat Sertoli cells cultured in vitro. Biosci. Rep. 2012, 32:61-69.
41. Schecter A., Johnson-Welch S., Tung K.C., Harris T.R., Papke O., Rosen R. Polybrominated diphenyl ether (PBDE) levels in livers of US human fetuses and newborns. J. Toxicol. Env. Heal. A 2007, 70:1-6.
42. Shao J., White C.C., Dabrowski M.J., Kavanagh T.J., Eckert M.L., Gallagher E.P. The role of mitochondrial and oxidative injury in BDE 47 toxicity to human fetal liver hematopoietic stem cells. Toxicol. Sci. 2008, 101:81-90.
43. Song R.F., Duarte T.L., Almeida G.M., Farmer P.B., Cooke M.S., Zhang W., Sheng G., Fu J., Jones G.D.D. Cytotoxicity and gene expression profiling of two hydroxylated polybrominated diphenyl ethers in human H295R adrenocortical carcinoma cells. Toxicol. Lett. 2009, 185:23-31.
44. Tagliaferri S., Caglieri A., Goldoni M., Pinelli S., Alinnovi R., Poli D., Pellacani C., Giordano G., Mutti A., Costa L.G. Low concentrations of the brominated flame retardants BDE-47 and BDE-99 induce synergistic oxidative stress-mediated neurotoxicity in human neuroblastoma cells. Toxicol. in Vitro 2010, 24:116-122.
45. U.S. EPA, 2010. An Exposure Assessment of Polybrominated Diphenyl Ethers (PBDE) (Final). U.S. Environmental Protection Agency, Washington, DC, pp. 378.
46. Wan Y., Hu J., Zhang K., An L. Trophodynamics of polybrominated diphenyl ethers in the marine food web of Bohai Bay, North China. Environ. Sci. Technol. 2008, 42:1078-1083.
47. 2 cells and the potential molecular mechanism. Toxicol. Lett. 2012, 209:193-201.
48. Williams T.D., Turan N., Diab A.M., Wu H., Mackenzie C., Bartie K.L., Hrydziuszko O., Lyons B.P., Stentiford G.D., Herbert J.M., Abraham J.K., Katsiadaki I., Leaver M.J., Taggart J.B., George S.G., Viant M.R., Chipman K.J., Falciani F. Towards a system level understanding of non-model organisms sampled from the environment: a network biology approach. PloS Comput. Biol. 2011, 7:e1002126.
49. Wu H., Li X., Feng J., Li W., Li Z., Liao P., Wu Y., Pei F. Comparison of biochemical effects induced by Changle between male and female rats using NMR and ICP-MS techniques. J. Rare Earth. 2006, 24:108-114.
50. Wu H., Southam A.D., Hines A., Viant M.R. High-throughput tissue extraction protocol for NMR- and MS-based metabolomics. Anal. Biochem. 2008, 372:204-212.
51. Wu H., Liu X., Zhang X., Ji C., Zhao J., Yu J. Proteomic and metabolomic responses of clam Ruditapes philippinarum to arsenic exposure under different salinities. Aquat. Toxicol. 2013, 136:91-100.
52. Xu L. Methods of Chemometrics 2004, Science Press, Beijing, pp 221-227.
53. Yan C., Huang D., Zhang Y. The involvement of ROS overproduction and mitochondrial dysfunction in PBDE-47-induced apoptosis on Jurkat cells. Exp. Toxicol. Pathol. 2011, 63:413-417.
54. L and Bcl-2, displaces Bax and promotes cell-death. Cell 1995, 80:285-291.
55. Yogui G.T., Sericano J.L. Polybrominated diphenyl ether flame retardants in the US marine environment: a review. Environ. Int. 2009, 35:655-666.
56. 1H NMR) based metabolomics. Environ. Toxicol. Phar. 2011, 32:218-225.
57. Zhang L., Liu X., You L., Zhou D., Wu H., Li L., Zhao J., Feng J., Yu J. Metabolic responses in gills of Manila clam Ruditapes philippinarum exposed to copper using NMR-based metabolomics. Mar. Environ. Res. 2011, 72:33-39.
58. Zhong Y., Wang L., Yin L., An J., Hou M., Zheng K., Zhang X., Wu M., Yu Z., Sheng G., Fu J. Cytotoxic effects and oxidative stress response of six PBDE metabolites on human L02 cells. J. Environ. Sci. Heal. A 2011, 46:1320-1327.
59. Zorov D.B., Juhaszova M., Sollott S.J. Mitochondrial ROS-induced ROS release: an update and review. BBA-Bioenergetics 2006, 1757:509-517.