Perinatal exposure to BDE-99 causes decreased protein levels of cyclin D1 via GSK3β activation and increased ROS production in rat pup livers

Toxicological Sciences

Volumn 137, Issue 2, 2014, Pages 491-498

  Blanco, Jordi ^a,b   Mulero, Miquel ^b   Domingo, Jose L ^a   Sanchez, Domènec J ^a,b  

^a Laboratory of Toxicology and Environmental Health   (Spain)

^b UNIVERSITAT ROVIRA I VIRGILI   (Spain)

Author keywords

Akt; BDE 99; Cyclin D1; CYP enzyme system; GSK3 ; Reactive oxygen species; Thyroid hormone receptors

Indexed keywords

2,2 ',4,4 ',5 PENTABROMODIPHENYL ETHER; CONSTITUTIVE ANDROSTANE RECEPTOR; CYCLIN D1; CYTOCHROME P450; CYTOCHROME P450 2B1; DIPHENYL ETHER DERIVATIVE; GLYCOGEN SYNTHASE KINASE 3BETA; MESSENGER RNA; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; THYROID HORMONE; THYROID HORMONE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION; GESTATIONAL AGE; LACTATION; LIVER TOXICITY; MALE; NONHUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PRENATAL EXPOSURE; RAT;

AKT; BDE-99; CYCLIN D1.; CYP ENZYME SYSTEM; GSK3Β; REACTIVE OXYGEN SPECIES; THYROID HORMONE RECEPTORS;

ANIMALS; ANTIOXIDANTS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CYCLIN D1; FEMALE; FLAME RETARDANTS; GLYCOGEN SYNTHASE KINASE 3; HALOGENATED DIPHENYL ETHERS; LIVER; MALE; MATERNAL EXPOSURE; ORGAN SIZE; OXIDATIVE STRESS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 84893366568     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kft257     Document Type: Article

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