The brominated flame retardant BDE-47 causes oxidative stress and apoptotic cell death in vitro and in vivo in mice

NeuroToxicology

Volumn 48, Issue , 2015, Pages 68-76

  Costa, Lucio G ^a,b   Pellacani, Claudia ^b   Dao, Khoi ^a   Kavanagh, Terrance J ^a   Roque, Pamela J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF PARMA   (Italy)

Author keywords

Apoptosis; BDE 47; Glutathione; Oxidative stress; Thyroid hormone

Indexed keywords

2,2',4,4' TETRABROMODIPHENYL ETHER; 8 ISOPROSTANE; CASPASE 3; FLAME RETARDANT; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; LIOTHYRONINE; MALONALDEHYDE; REACTIVE OXYGEN METABOLITE; THYROXINE; UNCLASSIFIED DRUG; 2,2',4,4'-TETRABROMODIPHENYL ETHER; BIOLOGICAL MARKER; DIPHENYL ETHER DERIVATIVE; GCLM PROTEIN, MOUSE; THYROID HORMONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; BLOOD LEVEL; BRAIN LEVEL; BRAIN NERVE CELL; CELL VIABILITY; CEREBELLAR GRANULE NEURON; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EMBRYO; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVATION; FREE LIOTHYRONINE INDEX; FREE THYROXINE INDEX; IN VITRO STUDY; IN VIVO STUDY; LIOTHYRONINE BLOOD LEVEL; LIPID PEROXIDATION; LIVER LEVEL; MALE; MOLECULAR DYNAMICS; MOUSE; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; SIGNAL TRANSDUCTION; THYROXINE BLOOD LEVEL; TOXICITY TESTING; ANIMAL; BLOOD; CELL CULTURE; CEREBELLUM; COCULTURE; DEFICIENCY; DOSE RESPONSE; DRUG EFFECTS; GENETICS; IC50; KNOCKOUT MOUSE; METABOLISM; NERVE CELL; NEUROTOXICITY SYNDROMES; PATHOLOGY; RISK ASSESSMENT;

MUS;

ANIMALS; APOPTOSIS; BIOMARKERS; CELLS, CULTURED; CEREBELLUM; COCULTURE TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAME RETARDANTS; GLUTAMATE-CYSTEINE LIGASE; HALOGENATED DIPHENYL ETHERS; INHIBITORY CONCENTRATION 50; MALE; MICE, KNOCKOUT; NEURONS; NEUROTOXICITY SYNDROMES; OXIDATIVE STRESS; RISK ASSESSMENT; THYROID HORMONES;

EID: 84925585488     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2015.03.008     Document Type: Article

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