Bactericidal antibiotics promote reactive oxygen species formation and inflammation in human sinonasal epithelial cells

International Forum of Allergy and Rhinology

Volumn 6, Issue 2, 2016, Pages 191-200

  Kohanski, Michael A ^a   Tharakan, Anuj ^a   Lane, Andrew P ^a   Ramanathan, Murugappan ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antibiotics; Inflammasome; Innate immunity; Rhinosinusitis; ROS; TNF

Indexed keywords

AMOXICILLIN; CLARITHROMYCIN; INTERLEUKIN 1BETA; LACTATE DEHYDROGENASE; LEVOFLOXACIN; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; ANTIINFECTIVE AGENT; AUTACOID; NFE2L2 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR;

ACUTE SINUSITIS; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CHRONIC SINUSITIS; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOSCOPIC SINUS SURGERY; ENZYME RELEASE; ENZYME SYNTHESIS; EPITHELIUM CELL; FLUORESCENCE; HUMAN; HUMAN CELL; HUMAN TISSUE; LIMIT OF QUANTITATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SINONASAL EPITHELIUM CELL; CELL DEATH; DRUG EFFECTS; GENETICS; IMMUNOLOGY; INFLAMMATION; METABOLISM; OXIDATIVE STRESS; PARANASAL SINUS; PATHOLOGY; PHYSIOLOGY;

ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; CELL DEATH; CELLS, CULTURED; EPITHELIAL CELLS; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PARANASAL SINUSES; REACTIVE OXYGEN SPECIES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84957890815     PISSN: 20426976     EISSN: 20426984     Source Type: Journal    
DOI: 10.1002/alr.21646     Document Type: Article

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