Antimicrobials and chronic rhinosinusitis with or without polyposis in adults: An evidenced-based review with recommendations

International Forum of Allergy and Rhinology

Volumn 3, Issue 1, 2013, Pages 31-47

  Soler, Zachary M ^a   Oyer, Samuel L ^a   Kern, Robert C ^b   Senior, Brent A ^c   Kountakis, Stilianos E ^d   Marple, Bradley F ^e   Smith, Timothy L ^f  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d MEDICAL COLLEGE OF GEORGIA   (United States)

^e UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^f OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Antibiotics; Antifungals; Chronic rhinosinusitis; Evidence based medicine; Macrolides

Indexed keywords

ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; DOXYCYCLINE; METHYLPREDNISOLONE; OFLOXACIN; PLACEBO;

ARTICLE; CHRONIC RHINOSINUSITIS; DRUG COST; EVIDENCE BASED MEDICINE; FOLLOW UP; GASTROINTESTINAL SYMPTOM; HUMAN; NOSE POLYP; PEAK NASAL INSPIRATORY FLOW; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SIDE EFFECT; SMELLING DISORDER; SYSTEMATIC REVIEW; TREATMENT DURATION; TREATMENT OUTCOME;

ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; CHRONIC DISEASE; EVIDENCE-BASED MEDICINE; HUMANS; NASAL POLYPS; RHINITIS; SINUSITIS; TREATMENT OUTCOME;

EID: 84872285110     PISSN: 20426976     EISSN: 20426984     Source Type: Journal    
DOI: 10.1002/alr.21064     Document Type: Article

References (79)

1. Scheid DC, Hamm RM. Acute bacterial rhinosinusitis in adults: part I. Evaluation. Am Fam Physician. 2004;70:1685-1692.
2. Kern RC, Conley DB, Walsh W, et al. Perspectives on the etiology of chronic rhinosinusitis: an immune barrier hypothesis. Am J Rhinol. 2008;22:549-559.
3. Luong A, Marple B. The role of fungi in chronic rhinosinusitis. Otolaryngol Clin North Am. 2005;38:1203-1213.
4. Shin SH, Ponikau JU, Sherris DA, et al. Chronic rhinosinusitis: an enhanced immune response to ubiquitous airborne fungi. J Allergy Clin Immunol. 2004;114:1369-1375.
5. Dubin MG, Liu C, Lin SY, Senior BA. American Rhinologic Society member survey on "maximal medical therapy" for chronic rhinosinusitis. Am J Rhinol. 2007;21:483-488.
6. Rosenfeld RM, Andes D, Bhattacharyya N, et al. Clinical practice guideline: adult sinusitis. Otolaryngol Head Neck Surg. 2007;137:S1-S31.
7. Rudmik L, Smith TL. Development of an evidence-based review with recommendations using an online iterative process. Int Forum Allergy Rhinol. 2011;1:431-437.
8. Rosenfeld RM, Shiffman RN. Clinical practice guidelines: a manual for developing evidence-based guidelines to facilitate performance measurement and quality improvement. Otolaryngol Head Neck Surg. 2006;135:S1-S28.
9. Shiffman RN, Shekelle P, Overhage JM, et al. Standardized reporting of clinical practice guidelines: a proposal from the Conference on Guideline Standardization. Ann Intern Med. 2003;139:493-498.
10. Development and validation of an international appraisal instrument for assessing the quality of clinical practice guidelines: the AGREE project. Qual Saf Health Care. 2003;12:18-23.
11. Fokkens W, Lund V, Mullol J. European position paper on rhinosinusitis and nasal polyps. Rhinol Suppl. 2007;20:1-136.
12. Oxford Centre for Evidence-based Medicine (CEBM). Levels of evidence. 2009 edition. http://www.cebm.net/index.aspx?o = 1025. Accessed May 29, 2012.
13. American Academy of Pediatrics Steering Committee on Quality Improvement and Management (AAP SCQIM): classifying recommendations for clinical practice guidelines. Pediatrics. 2004;114:874-877.
14. Van Zele T, Gevaert P, Holtappels G, et al. Oral steroids and doxycycline: two different approaches to treat nasal polyps. J Allergy Clin Immunol. 2010;125:1069-1076.
15. Galioto GB, Passali D, Catalano GB, et al. Oral therapy with flurithromycin in ear, nose and throat infections. Int J Clin Pharmacol Ther. 1995;33:204-207.
16. Dellanomica P, Choutet P, Lejeune JM, et al. Efficacy and tolerance of cefotiam hexetil in the super-infected chronic sinusitis. A randomized double-blind study in comparison with cefixime. Ann Otolaryngol Chir Cervicofac. 1994;111:217-222.
17. Legent F, Bordure P, Beauvillain C, Berche P. A double-blind comparison of ciprofloxacin and amoxicillin/clavulanic acid in the treatment of chronic sinusitis. Chemotherapy. 1994;40(Suppl 1):8-15.
18. Gehanno P, Cohen B. Effectiveness and safety of ofloxacin in chronic otitis media and chronic sinusitis in adult outpatients. Eur Arch Otorhinolaryngol. 1993;250(Suppl 1):S13-S14
19. Huck W, Reed BD, Nielsen RW, et al. Cefaclor vs amoxicillin in the treatment of acute, recurrent, and chronic sinusitis. Arch Fam Med. 1993;2:497-503.
20. Dubin MG, Kuhn FA, Melroy CT. Radiographic resolution of chronic rhinosinusitis without polyposis after 6 weeks vs 3 weeks of oral antibiotics. Ann Allergy Asthma Immunol. 2007;98:32-35.
21. Videler WJ, Badia L, Harvey RJ, et al. Lack of efficacy of long-term, low-dose azithromycin in chronic rhinosinusitis: a randomized controlled trial. Allergy. 2011;66:1457-1468.
22. Cervin A, Wallwork B, Mackay-Sim A, et al. Effects of long-term clarithromycin treatment on lavage-fluid markers of inflammation in chronic rhinosinusitis. Clin Physiol Funct Imaging. 2009;29:136-142.
23. Haruna S, Shimada C, Ozawa M, et al. A study of poor responders for long-term, low-dose macrolide administration for chronic sinusitis. Rhinology. 2009;47:66-71.
24. Song Y, Bai W, Ji W. [An empirical study of treating chronic sinusitis with low dose roxithromycin]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009;23:357-358, 363. [Chinese]
25. Wallwork B, Coman W, Mackay-Sim A, et al. A double-blind, randomized, placebo-controlled trial of macrolide in the treatment of chronic rhinosinusitis. Laryngoscope. 2006;116:189-193.
26. Cervin A, Kalm O, Sandkull P, Lindberg S. One-year low-dose erythromycin treatment of persistent chronic sinusitis after sinus surgery: clinical outcome and effects of mucociliary parameters and nasal nitric oxide. Otolaryngol Head and Neck Surg. 2002;126:481-489.
27. Katsuta S, Osafune H, Takita R, Sugamata M. Therapeutic effect of roxithromycin on chronic sinusitis with nasal-polyps clinical, computed tomography, and electron microscopy analysis. Nihon Jabiinkoka Gakkai Kaiho. 2002;105:1189-1197.
28. MacLeod CM, Hamid QA, Cameron L, et al. Anti-inflammatory activity of clarithromycin in adults with chronically inflamed sinus mucosa. Adv Ther. 2001;18:75-82.
29. Rhee CS, Majima Y, Arima S, et al. Effects of clarithromycin on rheological properties of nasal mucus in patients with chronic sinusitis. Ann Otol Rhinol Laryngol. 2000;109:484-487.
30. Yamada T, Fujieda S, Mori S, et al. Macrolide treatment decreased the size of nasal polyps and IL-8 levels in nasal lavage. Am J Rhinol. 2000;14:143-148.
31. Kimura N, Nishioka K, Nishizaki K, et al. Clinical effect of low-dose, long-term roxithromycin chemotherapy in patients with chronic sinusitis. Acta Med Okayama. 1997;51:33-37.
32. Suzuki H, Shimomura A, Ikeda K, et al. Effects of long-term low-dose macrolide administration on neutrophil recruitment and IL-8 in the nasal discharge of chronic sinusitis patients. Tohoku J Exp Med. 1997;182:115-124.
33. Hashiba M, Baba S. Efficacy of long-term administration of clarithromycin in the treatment of intractable chronic sinusitis. Acta Otolaryngol Suppl. 1996;525:73-78.
34. Kita H, Takezawa H, Isobe M, Kataura A. Long-term low dose erythromycin and roxithromycin therapy for chronic sinusitis. Practica Otologica Kyoto. 1995;84(Suppl):62-69.
35. Minami T, Kubo N, Kumazawa H, et al. Long-term low dose roxythromycin therapy for chronic sinusitis. Practica Otologica Kyoto. 1995;88:1229-1236.
36. Moriyama H, Yanagi K, Ohtori N, Fukami M. Evaluation of endoscopic sinus surgery for chronic sinusitis: post-operative erythromycin therapy. Rhinology. 1995;33:166-170.
37. Kikuchi S, Suzaki H, Aoki A, et al. Clinical effect of long-term low-dose erythromycin therapy for chronic sinusitis. Practica Otologica Kyoto. 1991;84:41-47.
38. Anand V, Levine H, Friedman M, et al. Intravenous antibiotics for refractory rhinosinusitis in nonsurgical patients: preliminary findings of a prospective study. Am J Rhinol. 2003;17:363-368.
39. Fowler KC, Duncavage JA, Murray JJ, Tanner S. Chronic sinusitis and intravenous antibiotic therapy: resolution, recurrence, and adverse events. J Allergy Clin Immunol. 2003;111:S85.
40. Lin JW, Kacker A, Anand VK, Leviene H. Catheter- and antibiotic-related complications of ambulatory intravenous antibiotic therapy for chronic refractory rhinosinusitis. Am J Rhinol. 2005;19:365-369.
41. Uren B, Psaltis A, Wormald PJ. Nasal lavage with mupirocin for the treatment of surgically recalcitrant chronic rhinosinusitis. Laryngoscope. 2008;118:1677-1680.
42. Videler WJ, van Drunen CM, Reitsma JB, Fokkens WJ. Nebulized bacitracin/colimycin: a treatment option in recalcitrant chronic rhinosinusitis with Staphylococcus aureus? A double-blind, randomized, placebo-controlled, cross-over pilot study. Rhinology. 2008;46:92-98.
43. Neher A, Fischer H, Appenroth E, et al. Tolerability of N-chlorotaurine in chronic rhinosinusitis applied via yamik catheter. Auris Nasus Larynx. 2005;32:359-364.
44. Scheinberg PA, Otsuji A. Nebulized antibiotics for the treatment of acute exacerbations of chronic rhinosinusitis. Ear Nose Throat J. 2002;81:648-652.
45. Vaughan WC, Carvalho G. Use of nebulized antibiotics for acute infections in chronic sinusitis. Otolaryngol Head Neck Surg. 2002;127:558-568.
46. Desrosiers MY, Salas-Prato M. Treatment of chronic rhinosinusitis refractory to other treatments with topical antibiotic therapy delivered by means of a large-particle nebulizer: results of a controlled trial. Otolaryngol Head Neck Surg. 2001;125:265-269.
47. Kamijyo A, Matsuzaki Z, Kikushima K, et al. Fosfomycin nebulizer therapy to chronic sinusitis. Auris Nasus Larynx. 2001;28:227-232.
48. Kobayashi T, Baba S. Topical use of antibiotics for paranasal sinusitis. Rhinol Suppl. 1992;14:77-81.
49. Sykes DA, Wilson R, Chan KL, et al. Relative importance of antibiotic and improved clearance in topical treatment of chronic mucopurulent rhinosinusitis. A controlled study. Lancet. 1986;2:359-360.
50. Whatley WS, Chandra RK, MacDonald CB. Systemic absorption of gentamicin nasal irrigations. Am J Rhinol. 2006;20:251-254.
51. Wong KK, Marglani O, Westerberg BD, Javer AR. Systemic absorption of topical gentamicin sinus irrigation. J Otolaryngol Head Neck Surg. 2008;37:395-398.
52. Conway SP. Nebulized antibiotic therapy: the evidence. Chron Respir Dis. 2005;2:35-41.
53. Alothman GA, Ho B, Alsaadi MM, et al. Bronchial constriction and inhaled colistin in cystic fibrosis. Chest. 2005;127:522-529.
54. Sieberling K, Wormald PJ. The role of itraconazole in recalcitrant fungal sinusitis. Am J Rhinol Allergy. 2009;23:303-306.
55. Chan KO, Genoway KA, Javer AR. Effectiveness of itraconazole in the management of refractory allergic fungal rhinosinusitis. J Otolaryngol Head Heck Surg. 2008;37:870-874.
56. Kennedy DW, Kuhn FA, Hamilos DL, et al. Treatment of chronic rhinosinusitis with high-dose oral terbinafine: a double blind, placebo-controlled study. Laryngoscope. 2005;115:1793-1799.
57. Ebbens FA, Georgalas C, Luiten S, et al. The effect of topical amphotericin B on inflammatory markers in patients with chronic rhinosinusitis: a multicenter randomized controlled study. Laryngoscope. 2009;119:401-408.
58. Gerlinger I, Fittler A, Fónai F, et al. Postoperative application of amphotericin B nasal spray in chronic rhinosinusitis with nasal polyposis, with a review of the antifungal therapy. Eur Arch Otorhinolaryngol. 2009;266:847-855.
59. Liang KL, Su MC, Shiao JY, et al. Amphotericin B irrigation for the treatment of chronic rhinosinusitis without nasal polyps: a randomized, placebo-controlled, double-blind study. Am J Rhinol. 2008;22:52-58.
60. Corradini C, Del Ninno M, Buonomo A, et al. Amphotericin B and lysine acetylsalicylate in the combined treatment of nasal polyposis associated with mycotic infection. J Investig Allergol Clin Immunol. 2006;16:188-193.
61. Ebbens FA, Scadding GK, Badia L, et al. Amphotericin B nasal lavages: not a solution for patients with chronic rhinosinusitis. J Allergy Clin Immunol. 2006;118:1149-1156.
62. Helbling A, Baumann A, Hänni C, Caversaccio M. Amphotericin B nasal spray has no effect on nasal polyps. J Laryngol Otol. 2006;120:1023-1025.
63. Weschta M, Rimek D, Formanek M, et al. Effect of nasal antifungal therapy on nasal cell activation markers in chronic rhinosinusitis. Arch Otolaryngol Head Neck Surg. 2006;132:743-747.
64. Ponikau JU, Sherris DA, Weaver A, Kita H. Treatment of chronic rhinosinusitis with intranasal amphotericin B: a randomized, placebo controlled, double-blind pilot trial. J Allergy Clin Immunol. 2005;115:125-131.
65. Jen A, Kacker A, Huang C, Anand V. Fluconazole nasal spray in the treatment of allergic fungal sinusitis: a pilot study. Ear Nose Throat J. 2004;83:692, 694-695.
66. Shin SH, Ye MK. Effects of topical amphotericin B on expression of cytokines in nasal polyps. Acta Otolaryngol. 2004;124:1174-1177.
67. Weschta M, Rimek D, Formanek M, et al. Topical antifungal treatment of chronic rhinosinusitis with nasal polyps: a randomized, double-blind clinical trial. J Allergy Clin Immunol. 2004;113:1122-1128.
68. Ponikau JU, Sherris DA, Kita H, Kern EB. Intranasal antifungal treatment in 51 patients with chronic rhinosinusitis. J Allergy Clin Immunol. 2002;110:862-866.
69. Richetti A, Landis BN, Maffioli A, et al. Effect of anti-fungal nasal lavage with amphotericin B on nasal polyposis. J Laryngol Otol. 2002;116:261-263.
70. Foreman A, Holtappels G, Psaltis AJ, et al. Adaptive immune responses in Staphylococcus aureus biofilm-associated chronic rhinosinusitis. Allergy. 2011;66:1449-1456.
71. Sachse F, Becker K, von Eiff C, et al. Staphylococcus aureus invades the epithelium in nasal polyposis and induces IL-6 in nasal epithelial cells in vitro. Allergy. 2010;65:1430-1437.
72. Bachert C, Zhang N, van Zele T, et al. Staphylococcus aureus enterotoxins as immune stimulants in chronic rhinosinusitis. Clin Allergy Immunol. 2007;20:163-175.
73. Videler WJ, Georgalas C, Menger DJ, et al. Osteitic bone in recalcitrant chronic rhinosinusitis. Rhinology. 2011;49:139-147.
74. Foreman A, Boase S, Psaltis A, Wormald PJ. Role of bacterial and fungal biofilms in chronic rhinosinusitis. Curr Allergy Asthma Rep. 2012;12:127-135.
75. Benninger M, Brook I, Bernstein JM, et al. Bacterial interference in upper respiratory tract infections: a systematic review. Am J Rhinol Allergy. 2011;25:82-88.
76. Littman DR, Pamer EG. Role of commensal microbiota in normal and pathogenic host immune responses. Cell Host Microbe. 2011;10:311-323.
77. Kountakis SE, Arango P, Bradley D, et al. Molecular and cellular staging for the severity of chronic rhinosinusitis. Laryngoscope. 2004;114:1895-1905.
78. Nakayama T, Yoshikawa M, Asaka D, et al. Mucosal eosinophilia and recurrence of nasal polyps-new classification of chronic rhinosinusitis. Rhinology. 2011;49:392-396.
79. Soler ZM, Sauer D, Mace J, Smith TL. Impact of mucosal eosinophilia and nasal polyposis on quality-of-life outcomes after sinus surgery. Otolaryngol Head Neck Surg. 2010;142:64-71.