Transepithelial transport of dry-cured ham peptides with ACE inhibitory activity through a Caco-cell monolayer

Journal of Functional Foods

Volumn 21, Issue , 2016, Pages 388-395

  Gallego, Marta ^a,b   Grootaert, Charlotte ^b   Mora, Leticia ^a   Aristoy, M Concepción ^a   Van Camp, John ^b   Toldrá, Fidel ^a  

^a INSTITUTO DE AGROQUÍMICA Y TECNOLOGÍA DE ALIMENTOS CSIC   (Spain)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

ACE inhibitory peptides; Caco cell monolayer; Dry cured ham; Intestinal transport; Mass spectrometry

Indexed keywords

EID: 84957873635     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2015.11.046     Document Type: Article

References (34)

1. Artursson P., Palm K., Luthman K. Caco-monolayers in experimental and theoretical predictions of drug transport. Advanced Drug Delivery Reviews 2001, 64:280-289.
2. Basiricò L., Catalani E., Morera P., Cattaneo S., Stuknyte M., Bernabucci U., De Noni I., Nardone A. Release of angiotensin converting enzyme-inhibitor peptides during in vitro gastrointestinal digestion of Parmigiano Reggiano PDO cheese and their absorption through an in vitro model of intestinal epithelium. Journal of Dairy Science 2015, 98(11):7595-7601.
3. Bejjani S., Wu J. Transport of IRW, an ovotransferrin-derived antihypertensive peptide, in human intestinal epithelial Caco-cells. Journal of Agricultural and Food Chemistry 2013, 61(7):1487-1492.
4. Boisset M., Botham R.P., Haegele K.D., Lenfant B., Pachot J.I. Absorption of angiotensin II antagonists in Ussing chambers, Caco-2, perfused jejunum loop and in vivo: Importance of drug ionisation in the in vitro prediction of in vivo absorption. European Journal of Pharmaceutical Sciences 2000, 10(3):215-224.
5. Chua H.L., Jois S., Sim M.K., Go M.L. Transport of angiotensin peptides across the Caco-monolayer. Peptides 2004, 25(8):1327-1338.
6. Contreras M.M., Sancho A.I., Recio I., Mills C. Absorption of casein antihypertensive peptides through an in vitro model of intestinal epithelium. Food Digestion 2012, 3(1-3):16-24.
7. Escudero E., Aristoy M.C., Nishimura H., Arihara K., Toldrá F. Antihypertensive effect and antioxidant activity of peptide fractions extracted from Spanish dry-cured ham. Meat Science 2012, 91(3):306-311.
8. Escudero E., Mora L., Fraser P.D., Aristoy M.C., Arihara K., Toldrá F. Purification and identification of antihypertensive peptides in Spanish dry-cured ham. Journal of Proteomics 2013, 78:499-507.
9. Escudero E., Mora L., Toldrá F. Stability of ACE inhibitory ham peptides against heat treatment and in vitro digestion. Food Chemistry 2014, 161:305-311.
10. Fernández-Musoles R., Salom J.B., Castelló-Ruiz M., Contreras M.M., Recio I., Manzanares P. Bioavailability of antihypertensive lactoferricin B-derived peptides: Transepithelial transport and resistance to intestinal and plasma peptidases. International Dairy Journal 2013, 32(2):69-174.
11. Hidalgo I.J., Raub T.J., Borchardt R.T. Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology 1989, 96(3):736-749.
12. Lennernäs H., Palm K., Fagerholm U., Artursson P. Comparison between active and passive drug transport in human intestinal epithelial (Caco-2) cells in vitro and human jejunum in vivo. International Journal of Pharmaceutics 1996, 127(1):103-107.
13. Lifton R.P., Gharavi A.G., Geller D.S. Molecular mechanisms of human hypertension. Cell 2001, 104(4):545-556.
14. Majumder K., Wu J. Angiotensin I converting enzyme inhibitory peptides from simulated in vitro gastrointestinal digestion of cooked eggs. Journal of Agricultural and Food Chemistry 2009, 57(2):471-477.
15. Miguel M., Aleixandre A. Antihypertensive peptides derived from egg proteins. Journal of Nutrition 2006, 136(6):1457-1460.
16. Miguel M., Dávalos A., Manso M.A., De la Peña G., Lasunción M.A., López-Fandiño R. Transepithelial transport across Caco-cell monolayers of antihypertensive egg-derived peptides. PepT1-mediated flux of Tyr-Pro-Ile. Molecular Nutrition and Food Research 2004, 52(12):1507-1513.
17. Miguel M., Recio I., Gómez-Ruiz J.A., Ramos M., López-Fandiño R. Angiotensin I-converting enzyme inhibitory activity of peptides derived from egg white proteins by enzymatic hydrolysis. Journal of Food Protection 2004, 67(9):1914-1920.
18. Ondetti M.A., Rubin B., Cushman D.W. Design of specific inhibitors of angiotensin-converting enzyme: New class of orally active antihypertensive agents. Science 1977, 196(4288):441-444.
19. Pauletti G.M., Okumu F.W., Borchardt R.T. Effect of size and charge on the, passive diffusion of peptides across caco-cell monolayers via the paracellular pathway. Pharmaceutical Research 1997, 14(2):164-168.
20. Pihlanto-Leppälä A. Bioactive peptides derived from bovine whey proteins: Opioid and ace-inhibitory peptides. Trends in Food Science and Technology 2000, 11(9-10):347-356.
21. Quirós A., Dávalos A., Lasunción M.A., Ramos M., Recio I. Bioavailability of the antihypertensive peptide LHLPLP: Transepithelial flux of HLPLP. International Dairy Journal 2008, 18:279-286.
22. Rohrbach M.S., Williams E.B., Rolstad R.A. Purification and substrate specificity of bovine angiotensin converting enzyme. Journal of Biological Chemistry 1981, 256(1):225-230.
23. Sentandreu M.A., Toldrá F. A rapid, simple and sensitive fluorescence method for the assay of angiotensin-converting enzyme. Food Chemistry 2006, 97(3):546-554.
24. Shimizu M., Tsunogai M., Arai S. Transepithelial transport of oligopeptides in the human intestinal cell, Caco-2. Peptides 1997, 18(5):681-687.
25. Sienkiewicz-Szłapka E., Jarmołowska B., Krawczuk S., Kostyra E., Kostyra H., Bielikowicz K. Transport of bovine milk-derived opioid peptides across a Caco-monolayer. International Dairy Journal 2009, 19(4):252-257.
26. Skeggs L.T., Kahn J.R., Shumway N.P. The preparation and function of the hypertension-converting enzyme. Journal of Experimental Medicine 1956, 103(3):295-299.
27. Strohalm M., Kavan D., Novák P., Volný M., Havlíček V. mMass 3: A cross-platform software environment for precise analysis of mass spectrometric data. Analytical Chemistry 2010, 82(11):4648-4651.
28. Teng Z., Yuan C., Zhang F., Huan M., Cao W., Li K., Yang J., Cao D., Zhou S., Mei Q. Intestinal absorption and first-pass metabolism of polyphenol compounds in rat and their transport dynamics in caco-cells. PLoS ONE 2012, 7(1):e29647.
29. Unger T. The role of the renin-angiotensin system in the development of cardiovascular disease. American Journal of Cardiology 2002, 89:3A-10A.
30. Vermeirssen V., Augustijns P., Morel N., Van Camp J., Opsomer A., Verstraete W. In vitro intestinal transport and antihypertensive activity of ACE inhibitory pea and whey digests. International Journal of Food Sciences and Nutrition 2005, 56(6):415-430.
31. Vermeirssen V., Van Camp J., Verstraete W. Bioavailability of angiotensin I converting enzyme inhibitory peptides. British Journal of Nutrition 2004, 92(3):357-366.
32. Yamada Y., Matoba N., Usui H., Onishi K., Yoshikawa M. Design of a highly potent anti-hypertensive peptide based on ovokinin(2-7). Bioscience, Biotechnology, and Biochemistry 2002, 66(6):1213-1217.
33. Yee S. In vitro permeability across Caco-cells (colonic) can predict in vivo (small intestinal) absorption in man-fact or myth. Pharmaceutical Research 1997, 14(6):763-766.
34. Yoshioka M., Erickson R.H., Woodley J.F., Gulli R., Guan D., Kim Y.S. Role of rat intestinal brush-border membrane angiotensin-converting enzyme in dietary protein digestion. American Journal of Physiology. Gastrointestinal and Liver Physiology 1987, 253(6):G781-G786.