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Volumn 3, Issue 1-3, 2012, Pages 16-24

Absorption of Casein Antihypertensive Peptides through an in Vitro Model of Intestinal Epithelium

Author keywords

Antihypertensive peptides; Bioavailability; Caco 2 cells; HPLC MS; HT29 MTX cells; Intestinal absorption

Indexed keywords


EID: 84871745882     PISSN: 18691978     EISSN: 18691986     Source Type: Journal    
DOI: 10.1007/s13228-012-0020-2     Document Type: Article
Times cited : (35)

References (40)
  • 1
    • 77949267657 scopus 로고    scopus 로고
    • Leakiness and size exclusion of paracellular channels in cultured epithelial cell monolayers - Interlaboratory comparison
    • 10.1007/s11095-009-0036-7 1:CAS:528:DC%2BC3cXksVequg%3D%3D
    • Avdeef A (2010) Leakiness and size exclusion of paracellular channels in cultured epithelial cell monolayers - interlaboratory comparison. Pharm Res 27:480-489
    • (2010) Pharm Res , vol.27 , pp. 480-489
    • Avdeef, A.1
  • 2
    • 0034807847 scopus 로고    scopus 로고
    • Transport of lipophilic drug molecules in a new mucus-secreting cell culture model based on HT29-MTX cells
    • 10.1023/A:1010974909998 1:CAS:528:DC%2BD3MXnt1ekt70%3D
    • Behrens I, Stenberg P, Artursson P, Kissel T (2001) Transport of lipophilic drug molecules in a new mucus-secreting cell culture model based on HT29-MTX cells. Pharm Res 18:1138-1145
    • (2001) Pharm Res , vol.18 , pp. 1138-1145
    • Behrens, I.1    Stenberg, P.2    Artursson, P.3    Kissel, T.4
  • 3
    • 4444383745 scopus 로고    scopus 로고
    • Transport of angiotensin peptides across the Caco-2 monolayer
    • 10.1016/j.peptides.2004.06.009 1:CAS:528:DC%2BD2cXntlelsrw%3D
    • Chua H-L, Seetharama J, Sim M-K, Go M-L (2004) Transport of angiotensin peptides across the Caco-2 monolayer. Peptides 25:1327-1338
    • (2004) Peptides , vol.25 , pp. 1327-1338
    • Chua, H.-L.1    Seetharama, J.2    Sim, M.-K.3    Go, M.-L.4
  • 5
    • 67650214679 scopus 로고    scopus 로고
    • Novel casein-derived peptides with antihypertensive activity
    • 10.1016/j.idairyj.2009.05.004 1:CAS:528:DC%2BD1MXoslaktrc%3D
    • Contreras MM, Carrón R, Montero MJ, Ramos M, Recio I (2009) Novel casein-derived peptides with antihypertensive activity. Int Dairy J 19:566-573
    • (2009) Int Dairy J , vol.19 , pp. 566-573
    • Contreras, M.M.1    Carrón, R.2    Montero, M.J.3    Ramos, M.4    Recio, I.5
  • 6
    • 77955981558 scopus 로고    scopus 로고
    • Monitoring the large-scale production of the antihypertensive peptides RYLGY and AYFYPEL by HPLC-MS
    • 10.1007/s00216-010-3647-2
    • Contreras MM, Gómez-Sala B, Martín-Álvarez PJ, Amigo L, Ramos M, Recio I (2010) Monitoring the large-scale production of the antihypertensive peptides RYLGY and AYFYPEL by HPLC-MS. Anal Bioanal Chem 397:2825-2832
    • (2010) Anal Bioanal Chem , vol.397 , pp. 2825-2832
    • Contreras, M.M.1    Gómez-Sala, B.2    Martín-Álvarez, P.J.3    Amigo, L.4    Ramos, M.5    Recio, I.6
  • 7
    • 79955549808 scopus 로고    scopus 로고
    • Food-grade production of an antihypertensive casein hydrolysate and resistance of active peptides to drying and storage
    • 10.1016/j.idairyj.2011.02.004 1:CAS:528:DC%2BC3MXlslKnt74%3D
    • Contreras MM, Sevilla MA, Monroy-Ruiz J, Amigo L, Gómez-Sala B, Molina E, Ramos M, Recio I (2011) Food-grade production of an antihypertensive casein hydrolysate and resistance of active peptides to drying and storage. Int Dairy J 21:470-476
    • (2011) Int Dairy J , vol.21 , pp. 470-476
    • Contreras, M.M.1    Sevilla, M.A.2    Monroy-Ruiz, J.3    Amigo, L.4    Gómez-Sala, B.5    Molina, E.6    Ramos, M.7    Recio, I.8
  • 9
    • 84955063932 scopus 로고    scopus 로고
    • Biological transport phenomena in the gastrointestinal tract: Cellular mechanisms
    • G.L. Amidon I. Lee E.M. Topp (eds) Marcel Dekker Inc New York
    • Fleisher D (2000) Biological transport phenomena in the gastrointestinal tract: cellular mechanisms. In: Amidon GL, Lee PI, Topp EM (eds) Transport processes in pharmaceutical systems. Marcel Dekker Inc, New York, pp 147-184
    • (2000) Transport Processes in Pharmaceutical Systems , pp. 147-184
    • Fleisher, D.1
  • 10
    • 47649099423 scopus 로고    scopus 로고
    • The angiotensin converting enzyme inhibitory tripeptides Ile-Pro-Pro and Val-Pro-Pro show increasing permeabilities with increasing physiological relevance of absorption models
    • 10.1016/j.peptides.2008.03.021 1:CAS:528:DC%2BD1cXptVGluro%3D
    • Foltz M, Cerstiaens A, van Meensel A, Mols R, van der Pijl PC, Duchateau GSMJE, Augustijns P (2008) The angiotensin converting enzyme inhibitory tripeptides Ile-Pro-Pro and Val-Pro-Pro show increasing permeabilities with increasing physiological relevance of absorption models. Peptides 29:1312-1320
    • (2008) Peptides , vol.29 , pp. 1312-1320
    • Foltz, M.1    Cerstiaens, A.2    Van Meensel, A.3    Mols, R.4    Van Der Pijl, P.C.5    Duchateau, G.6    Augustijns, P.7
  • 11
    • 34247153806 scopus 로고    scopus 로고
    • Angiotensin converting enzyme inhibitory peptides from a lactotripeptide-enriched milk beverage are absorbed intact into the circulation
    • 1:CAS:528:DC%2BD2sXktVSltbo%3D
    • Foltz M, Meynen EE, Bianco V, van Platerink C, Koning TMMG, Kloek J (2007) Angiotensin converting enzyme inhibitory peptides from a lactotripeptide-enriched milk beverage are absorbed intact into the circulation. J Nutr 137:953-958
    • (2007) J Nutr , vol.137 , pp. 953-958
    • Foltz, M.1    Meynen, E.E.2    Bianco, V.3    Van Platerink, C.4    Koning, T.5    Kloek, J.6
  • 14
    • 79955469107 scopus 로고    scopus 로고
    • Antihypertensive peptides: Production, bioavailability and incorporation into foods
    • 10.1016/j.cis.2010.11.001
    • Hernández-Ledesma B, Contreras MM, Recio I (2011) Antihypertensive peptides: production, bioavailability and incorporation into foods. Adv Colloid Interf Sci 165:23-35
    • (2011) Adv Colloid Interf Sci , vol.165 , pp. 23-35
    • Hernández-Ledesma, B.1    Contreras, M.M.2    Recio, I.3
  • 15
    • 0033973754 scopus 로고    scopus 로고
    • Caco-2 versus Caco-2/HT29-MTX co-cultured cell lines: Permeability via diffusion, inside- and outside-directed carrier-mediated transport
    • 10.1002/(SICI)1520-6017(200001)89:1<63: AID-JPS7>3.0.CO;2-6 1:CAS:528:DC%2BD3cXit1eisL0%3D
    • Hilgendorf C, Spahn-Langguth H, Regardh CG, Lipka E, Amidon GL, Langguth P (2000) Caco-2 versus Caco-2/HT29-MTX co-cultured cell lines: permeability via diffusion, inside- and outside-directed carrier-mediated transport. J Pharm Sci 89:63-75
    • (2000) J Pharm Sci , vol.89 , pp. 63-75
    • Hilgendorf, C.1    Spahn-Langguth, H.2    Regardh, C.G.3    Lipka, E.4    Amidon, G.L.5    Langguth, P.6
  • 16
    • 0026630977 scopus 로고
    • A survey of membrane peptidases in two human colonic cell lines, Caco-2 and HT-29
    • 1:CAS:528:DyaK38XksVGgur8%3D
    • Howell S, Kenny AJ, Turner AJ (1992) A survey of membrane peptidases in two human colonic cell lines, Caco-2 and HT-29. Biochem J 284:595-601
    • (1992) Biochem J , vol.284 , pp. 595-601
    • Howell, S.1    Kenny, A.J.2    Turner, A.J.3
  • 17
    • 43049162813 scopus 로고    scopus 로고
    • Transport of μ-opioid receptor agonists and antagonist peptides across Caco-2 monolayer
    • 10.1016/j.peptides.2008.01.018 1:CAS:528:DC%2BD1cXlvVCls7k%3D
    • Iwan M, Jarmołowska B, Bielikowicz K, Kostyra E, Kostyra H, Kaczmarski M (2008) Transport of μ-opioid receptor agonists and antagonist peptides across Caco-2 monolayer. Peptides 29:1042-1047
    • (2008) Peptides , vol.29 , pp. 1042-1047
    • Iwan, M.1    Jarmołowska, B.2    Bielikowicz, K.3    Kostyra, E.4    Kostyra, H.5    Kaczmarski, M.6
  • 18
    • 60149111908 scopus 로고    scopus 로고
    • Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues
    • 10.1016/j.addr.2008.11.002 1:CAS:528:DC%2BD1MXit1Ohtrw%3D
    • Lai SK, Wang Y-Y, Hanes J (2009) Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues. Adv Drug Deliv Rev 61:158-171
    • (2009) Adv Drug Deliv Rev , vol.61 , pp. 158-171
    • Lai, S.K.1    Wang, Y.-Y.2    Hanes, J.3
  • 19
    • 45549102579 scopus 로고    scopus 로고
    • Transport of val-leu-pro-val-pro in human intestinal epithelial (Caco-2) cell monolayers
    • 10.1021/jf703640p 1:CAS:528:DC%2BD1cXlt1Sltbk%3D
    • Lei L, Sun H, Liu D, Liu L, Shimin L (2008) Transport of val-leu-pro-val-pro in human intestinal epithelial (Caco-2) cell monolayers. J Agric Food Chem 56:3582-3586
    • (2008) J Agric Food Chem , vol.56 , pp. 3582-3586
    • Lei, L.1    Sun, H.2    Liu, D.3    Liu, L.4    Shimin, L.5
  • 20
    • 0025144305 scopus 로고
    • Growth adaptation to methotrexate of HT-29 human colon carcinoma cells is associated with their ability to differentiate into columnar absorptive and mucus-secreting cells
    • 1:CAS:528:DyaK3cXmtVCmsbY%3D
    • Lesuffleur T, Barbat A, Dussaulx E, Zweibaum A (1990) Growth adaptation to methotrexate of HT-29 human colon carcinoma cells is associated with their ability to differentiate into columnar absorptive and mucus-secreting cells. Cancer Res 50:6334-6343
    • (1990) Cancer Res , vol.50 , pp. 6334-6343
    • Lesuffleur, T.1    Barbat, A.2    Dussaulx, E.3    Zweibaum, A.4
  • 21
    • 67651015406 scopus 로고    scopus 로고
    • Characterization of Caco-2 and HT29-MTX cocultures in an in vitro digestion/cell culture model used to predict iron bioavailability
    • 10.1016/j.jnutbio.2008.05.006 1:CAS:528:DC%2BD1MXnt1Glsrw%3D
    • Mahler GJ, Shuler ML, Glahn RP (2009) Characterization of Caco-2 and HT29-MTX cocultures in an in vitro digestion/cell culture model used to predict iron bioavailability. J Nutr Biochem 20:494-502
    • (2009) J Nutr Biochem , vol.20 , pp. 494-502
    • Mahler, G.J.1    Shuler, M.L.2    Glahn, R.P.3
  • 22
    • 0030469762 scopus 로고    scopus 로고
    • Antihypertensive peptides are present in aorta after oral administration of sour milk containing these peptides in spontaneously hypertensive rats
    • 1:CAS:528:DyaK2sXjsFOlug%3D%3D
    • Masuda O, Nakamura Y, Takano T (1996) Antihypertensive peptides are present in aorta after oral administration of sour milk containing these peptides in spontaneously hypertensive rats. J Nutr 126:3063-3068
    • (1996) J Nutr , vol.126 , pp. 3063-3068
    • Masuda, O.1    Nakamura, Y.2    Takano, T.3
  • 23
    • 57549088511 scopus 로고    scopus 로고
    • Transepithelial transport across Caco-2 cell monolayers of antihypertensive egg-derived peptides. PepT1-mediated flux of Tyr-Pro-lle
    • 10.1002/mnfr.200700503 1:CAS:528:DC%2BD1MXlsFertQ%3D%3D
    • Miguel M, Davalos A, Manso MA, de la Pena G, Lasuncion MA, López-Fandiño R (2008) Transepithelial transport across Caco-2 cell monolayers of antihypertensive egg-derived peptides. PepT1-mediated flux of Tyr-Pro-lle. Mol Nutr Food Res 52:1507-1513
    • (2008) Mol Nutr Food Res , vol.52 , pp. 1507-1513
    • Miguel, M.1    Davalos, A.2    Manso, M.A.3    De La Pena, G.4    Lasuncion, M.A.5    López-Fandiño, R.6
  • 24
    • 33750967379 scopus 로고    scopus 로고
    • Uptake of 2S albumin allergens, Ber e 1 and Ses i 1, across human intestinal epithelial Caco-2 cell monolayers
    • 10.1021/jf061760h 1:CAS:528:DC%2BD28XhtVKitLfK
    • Moreno FJ, Rubio LA, Olano A, Clemente A (2006) Uptake of 2S albumin allergens, Ber e 1 and Ses i 1, across human intestinal epithelial Caco-2 cell monolayers. J Agric Food Chem 54:8631-8639
    • (2006) J Agric Food Chem , vol.54 , pp. 8631-8639
    • Moreno, F.J.1    Rubio, L.A.2    Olano, A.3    Clemente, A.4
  • 26
    • 80051848862 scopus 로고    scopus 로고
    • Producibility and digestibility of antihypertensive β-casein tripeptides, Val-Pro-Pro and Ile-Pro-Pro, in the gastrointestinal tract: Analyses using an in vitro model of mammalian gastrointestinal digestion
    • 10.1021/jf072671n 1:CAS:528:DC%2BD1cXmtF2hsA%3D%3D
    • Ohsawa K, Satsu H, Ohki K, Enjoh M, Takano T, Shimizu M (2008) Producibility and digestibility of antihypertensive β-casein tripeptides, Val-Pro-Pro and Ile-Pro-Pro, in the gastrointestinal tract: analyses using an in vitro model of mammalian gastrointestinal digestion. J Agric Food Chem 56:854-858
    • (2008) J Agric Food Chem , vol.56 , pp. 854-858
    • Ohsawa, K.1    Satsu, H.2    Ohki, K.3    Enjoh, M.4    Takano, T.5    Shimizu, M.6
  • 28
    • 0034763048 scopus 로고    scopus 로고
    • HT29-MTX and Caco-2/TC7 monolayers as predictive models for human intestinal absorption: Role of the mucus layer
    • 10.1002/jps.1111 1:CAS:528:DC%2BD3MXotVSru7k%3D
    • Pontier C, Pachot J, Botham R, Lenfant B, Arnaud P (2001) HT29-MTX and Caco-2/TC7 monolayers as predictive models for human intestinal absorption: role of the mucus layer. J Pharm Sci 90:1608-1619
    • (2001) J Pharm Sci , vol.90 , pp. 1608-1619
    • Pontier, C.1    Pachot, J.2    Botham, R.3    Lenfant, B.4    Arnaud, P.5
  • 29
    • 37549062630 scopus 로고    scopus 로고
    • Transport and metabolism of ferulic acid through the colonic epithelium
    • 10.1124/dmd.107.017558 1:CAS:528:DC%2BD1cXmtFGrtg%3D%3D
    • Poquet L, Clifford MN, Williamson G (2008) Transport and metabolism of ferulic acid through the colonic epithelium. Drug Metab Dispos 36:190-197
    • (2008) Drug Metab Dispos , vol.36 , pp. 190-197
    • Poquet, L.1    Clifford, M.N.2    Williamson, G.3
  • 30
    • 36549037733 scopus 로고    scopus 로고
    • Bioavailability of the antihypertensive peptide LHLPLP: Transepithelial flux of HLPLP
    • 10.1016/j.idairyj.2007.09.006
    • Quirós A, Davalos A, Lasunción MA, Ramos M, Recio I (2008) Bioavailability of the antihypertensive peptide LHLPLP: transepithelial flux of HLPLP. Int Dairy J 18:279-286
    • (2008) Int Dairy J , vol.18 , pp. 279-286
    • Quirós, A.1    Davalos, A.2    Lasunción, M.A.3    Ramos, M.4    Recio, I.5
  • 31
    • 79955466428 scopus 로고    scopus 로고
    • Long-term intake of a milk casein hydrolysate attenuates the development of hypertension and involves cardiovascular benefits
    • 10.1016/j.phrs.2011.01.015
    • Sánchez D, Kassan M, Contreras MM, Carrón R, Recio I, Montero M-J, Sevilla M-A (2011) Long-term intake of a milk casein hydrolysate attenuates the development of hypertension and involves cardiovascular benefits. Pharm Res 63:398-404
    • (2011) Pharm Res , vol.63 , pp. 398-404
    • Sánchez, D.1    Kassan, M.2    Contreras, M.M.3    Carrón, R.4    Recio, I.5    Montero, M.-J.6    Sevilla, M.-A.7
  • 32
    • 0036479384 scopus 로고    scopus 로고
    • Transepithelial transport of the bioactive tripeptide, Val-Pro-Pro, in human intestinal Caco-2 cell monolayers
    • 10.1271/bbb.66.378 1:CAS:528:DC%2BD38XitVWls7s%3D
    • Satake M, Enjoh M, Nakamura Y, Takano T, Kawamura Y, Arai S, Shimizu M (2002) Transepithelial transport of the bioactive tripeptide, Val-Pro-Pro, in human intestinal Caco-2 cell monolayers. Biosci Biotechnol Biochem 66:378-384
    • (2002) Biosci Biotechnol Biochem , vol.66 , pp. 378-384
    • Satake, M.1    Enjoh, M.2    Nakamura, Y.3    Takano, T.4    Kawamura, Y.5    Arai, S.6    Shimizu, M.7
  • 33
    • 0030759649 scopus 로고    scopus 로고
    • Transepithelial transport of oligopeptides in the human intestinal cell, Caco-2
    • 10.1016/S0196-9781(97)00002-8 1:CAS:528:DyaK2sXktFyjtb0%3D
    • Shimizu M, Tsunogai M, Arai S (1997) Transepithelial transport of oligopeptides in the human intestinal cell, Caco-2. Peptides 18:681-687
    • (1997) Peptides , vol.18 , pp. 681-687
    • Shimizu, M.1    Tsunogai, M.2    Arai, S.3
  • 35
    • 65249103391 scopus 로고    scopus 로고
    • Transepithelial transport characteristics of the antihypertensive peptide, Lys-Val-Leu-Pro-Val-Pro, in human intestinal Caco-2 cell monolayers
    • 10.1271/bbb.80473 1:CAS:528:DC%2BD1MXivFeltL4%3D
    • Sun H, Liu D, Li S, Qin Z (2009) Transepithelial transport characteristics of the antihypertensive peptide, Lys-Val-Leu-Pro-Val-Pro, in human intestinal Caco-2 cell monolayers. Biosci Biotechnol Biochem 73:293-298
    • (2009) Biosci Biotechnol Biochem , vol.73 , pp. 293-298
    • Sun, H.1    Liu, D.2    Li, S.3    Qin, Z.4
  • 37
    • 29244477860 scopus 로고    scopus 로고
    • Quantification of ACE inhibiting peptides in human plasma using high performance liquid chromatography-mass spectrometry
    • 10.1016/j.jchromb.2005.10.036
    • Van Platerink CJ, Janssen H-GM, Horsten R, Haverkamp J (2006) Quantification of ACE inhibiting peptides in human plasma using high performance liquid chromatography-mass spectrometry. J Chromatogr B 830:151-157
    • (2006) J Chromatogr B , vol.830 , pp. 151-157
    • Van Platerink, C.J.1    Janssen, H.-G.2    Horsten, R.3    Haverkamp, J.4
  • 38
    • 6944221879 scopus 로고    scopus 로고
    • Bioavailability of angiotensin i converting enzyme inhibitory peptides
    • 10.1079/BJN20041189 1:CAS:528:DC%2BD2cXosV2gtLo%3D
    • Vermeirssen V, van Camp J, Verstraete W (2004) Bioavailability of angiotensin I converting enzyme inhibitory peptides. Br J Nutr 92:357-366
    • (2004) Br J Nutr , vol.92 , pp. 357-366
    • Vermeirssen, V.1    Van Camp, J.2    Verstraete, W.3
  • 39
    • 0029836840 scopus 로고    scopus 로고
    • HT29-MTX/Caco-2 cocultures as an in vitro model for the intestinal epithelium: In vitro-in vivo correlation with permeability data from rats and humans
    • 10.1021/js960110x 1:CAS:528:DyaK28XlsVyhurY%3D
    • Walter E, Janich S, Roessler BJ, Hilfinger JM, Amidon GL (1996) HT29-MTX/Caco-2 cocultures as an in vitro model for the intestinal epithelium: in vitro-in vivo correlation with permeability data from rats and humans. J Pharm Sci 85:1070-1076
    • (1996) J Pharm Sci , vol.85 , pp. 1070-1076
    • Walter, E.1    Janich, S.2    Roessler, B.J.3    Hilfinger, J.M.4    Amidon, G.L.5
  • 40
    • 39649089143 scopus 로고    scopus 로고
    • Identification of ACE-inhibitory peptides in salt-free soy sauce that are transportable across caco-2 cell monolayers
    • 10.1016/j.peptides.2007.11.006 1:CAS:528:DC%2BD1cXislKksro%3D
    • Zhu X-L, Watanabe K, Shiraishi K, Ueki T, Noda Y, Matsui T, Matsumoto K (2008) Identification of ACE-inhibitory peptides in salt-free soy sauce that are transportable across caco-2 cell monolayers. Peptides 29:338-344
    • (2008) Peptides , vol.29 , pp. 338-344
    • Zhu, X.-L.1    Watanabe, K.2    Shiraishi, K.3    Ueki, T.4    Noda, Y.5    Matsui, T.6    Matsumoto, K.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.