Intra- and inter-laboratory reproducibility and accuracy of the LuSens assay: A reporter gene-cell line to detect keratinocyte activation by skin sensitizers

Toxicology in Vitro

Volumn 32, Issue , 2016, Pages 278-286

  Ramirez, Tzutzuy ^a   Stein, Nadine ^a   Aumann, Alexandra ^a   Remus, Tina ^b   Edwards, Amber ^c   Norman, Kimberly G ^d   Ryan, Cindy ^e   Bader, Jackie E ^d   Fehr, Markus ^b   Burleson, Florence ^c   Foertsch, Leslie ^e   Wang, Xiaohong ^e   Gerberick, Frank ^e   Beilstein, Paul ^b   Hoffmann, Sebastian ^f   Mehling, Annette ^a   van Ravenzwaay, Bennard ^a   Landsiedel, Robert ^a  

^a BASF SE   (Germany)

^b DSM NUTRITIONAL PRODUCTS LTD   (Switzerland)

^c Burleson Research Technologies   (United States)

^d Institute for in Vitro Sciences   (United States)

^e PROCTER AND GAMBLE COMPANY   (United States)

^f services   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

LUCIFERASE; ALLERGEN; NFE2L2 PROTEIN, MOUSE; TRANSCRIPTION FACTOR NRF2;

ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; BIOASSAY; CELL ACTIVATION; CONTROLLED STUDY; GENE; GERMANY; HAZARD ASSESSMENT; HUMAN; HUMAN CELL; KERATINOCYTE; LUCIFERASE GENE; LUSENS ASSAY; MEASUREMENT ACCURACY; NADPH QUINONE OXIDOREDUCTASE 1 GENE; REPORTER GENE; REPRODUCIBILITY; SKIN SENSITIZATION; SWITZERLAND; UNITED STATES; VALIDATION STUDY; ANIMAL TESTING ALTERNATIVE; CELL LINE; CONTACT DERMATITIS; DRUG EFFECTS; GENETICS; LABORATORY; METABOLISM; SENSITIVITY AND SPECIFICITY;

ALLERGENS; ANIMAL TESTING ALTERNATIVES; ANTIOXIDANT RESPONSE ELEMENTS; BIOLOGICAL ASSAY; CELL LINE; DERMATITIS, CONTACT; GENES, REPORTER; HUMANS; KERATINOCYTES; LABORATORIES; LUCIFERASES; NF-E2-RELATED FACTOR 2; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 84957866468     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2016.01.004     Document Type: Article

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