Generation of TALE nickase-mediated gene-targeted cows expressing human serum albumin in mammary glands

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Luo, Yan ^a   Wang, Yongsheng ^a   Liu, Jun ^a   Cui, Chenchen ^a   Wu, Yongyan ^a   Lan, Hui ^a   Chen, Qi ^a   Liu, Xu ^a   Quan, Fusheng ^a   Guo, Zekun ^a   Zhang, Yong ^a  

^a NORTHWEST A F UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

LACTOGLOBULIN; RECOMBINANT PROTEIN; SERUM ALBUMIN; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE;

ANIMAL; BIOSYNTHESIS; BOVINE; CHEMISTRY; CIRCULAR DICHROISM; EXON; FEMALE; GENE LOCUS; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; MILK; NUCLEOTIDE SEQUENCE; UDDER;

ANIMALS; BASE SEQUENCE; CATTLE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; EXONS; FEMALE; GENETIC LOCI; HUMANS; LACTOGLOBULINS; MAMMARY GLANDS, ANIMAL; MILK; RECOMBINANT PROTEINS; SERUM ALBUMIN; TRANSCRIPTION ACTIVATOR-LIKE EFFECTOR NUCLEASES;

EID: 84957837142     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep20657     Document Type: Article

References (37)

1. Wall, R., Kerr, D. & Bondioli, K. Transgenic dairy cattle: genetic engineering on a large scale. J Dairy Sci 80, 2213-2224 (1997).
2. Yang, P. H. et al. Cattle Mammary Bioreactor Generated by a Novel Procedure of Transgenic Cloning for Large-Scale Production of Functional Human Lactoferrin. Plos One 3, 3453 (2008).
3. Li, T. et al. TAL nucleases (TALNs): hybrid proteins composed of TAL effectors and FokI DNA-cleavage domain. Nucleic Acids Res 39, 359-372 (2011).
4. Chen, K. & Gao, C. TALENs: customizable molecular DNA scissors for genome engineering of plants. J Genet Genomics 40, 271-279 (2013).
5. Bloom, K., Ely, A., Mussolino, C., Cathomen, T. & Arbuthnot, P. Inactivation of hepatitis B virus replication in cultured cells and in vivo with engineered transcription activator-like effector nucleases. Mol Ther 21, 1889-1897 (2013).
6. Zu, Y. et al. TALEN-mediated precise genome modification by homologous recombination in zebrafish. Nat methods 10, 329-331 (2013).
7. Katsuyama, T. et al. An efficient strategy for TALEN-mediated genome engineering in Drosophila. Nucleic Acids Res 41, e163-e163 (2013).
8. Wefers, B. et al. Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides. Proc Natl Acad Sci USA 110, 3782-3787 (2013).
9. Kim, E. et al. Precision genome engineering with programmable DNA-nicking enzymes. Genome Res 22, 1327-1333 (2012).
10. Hockemeyer, D. et al. Genetic engineering of human pluripotent cells using TALE nucleases. Nat Biotechnol 29, 731-734 (2011).
11. Wang, J. et al. Targeted gene addition to a predetermined site in the human genome using a ZFN-based nicking enzyme. Genome Res 22, 1316-1326 (2012).
12. Liu, X. et al. Zinc-finger nickase-mediated insertion of the lysostaphin gene into the beta-casein locus in cloned cows. Nat Commun 4, 2565 (2013).
13. Fanali, G. et al. Human serum albumin: from bench to bedside. Mol Aspects Med 33, 209-290 (2012).
14. Chamberland, M. E., Alter, H. J., Busch, M. P., Nemo, G. & Ricketts, M. Emerging infectious disease issues in blood safety. Emerg Infect Dis 7, 552 (2001).
15. Kontopidis, G., Holt, C. & Sawyer, L. Invited review: β-lactoglobulin: binding properties, structure, and function. J Dairy Sci 87, 785-796 (2004).
16. Cui, C. et al. Gene targeting by TALEN-induced homologous recombination in goats directs production of β-lactoglobulin-free, high-human lactoferrin milk. Sci Rep 5, 10482 (2015).
17. Ball, S., Polson, K., Emeny, J., Eyestone, W. & Akers, R. Induced lactation in prepubertal Holstein heifers. J Dairy Sci 83, 2459-2463 (2000).
18. Gaj, T., Gersbach, C. A. & Barbas, C. F. ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering. Trends Biotechnol 31, 397-405 (2013).
19. Xu, K. et al. Efficient genome engineering in eukaryotes using Cas9 from Streptococcus thermophilus. Cell Mol Life Sci 72, 383-399 (2015).
20. Kim, H. & Kim, J.-S. A guide to genome engineering with programmable nucleases. Nat Rev Genet 15, 321-334 (2014).
21. Zhou, X. et al. Generation of CRISPR/Cas9-mediated gene-targeted pigs via somatic cell nuclear transfer. Cell Mol Life Sci 72, 1175-1184 (2015).
22. Yao, J. et al. Efficient bi-allelic gene knockout and site-specific knock-in mediated by TALENs in pigs. Sci. Rep 4, 6926 (2014).
23. Gupta, A., Meng, X., Zhu, L. J., Lawson, N. D. & Wolfe, S. A. Zinc finger protein-dependent and-independent contributions to the in vivo off-target activity of zinc finger nucleases. Nucleic Acids Res 39, 381-392 (2010).
24. Fu, Y. et al. High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. Nat Biotechnol 31, 822-826 (2013).
25. Wu, Y. et al. TALE nickase mediates high efficient targeted transgene integration at the human multi-copy ribosomal DNA locus. Biochem Bioph Res Co 446, 261-266 (2014).
26. Wu, H. et al. TALE nickase-mediated SP110 knockin endows cattle with increased resistance to tuberculosis. Proc Natl Acad Sci USA 112, E1530-E1539 (2015).
27. Carlson, D. F. et al. Efficient TALEN-mediated gene knockout in livestock. Proc Natl Acad Sci USA 109, 17382-17387 (2012).
28. Voit, R. A., Hendel, A., Pruett-Miller, S. M. & Porteus, M. H. Nuclease-mediated gene editing by homologous recombination of the human globin locus. Nucleic Acids Res 42, 1365-1378 (2013).
29. Shani, M. et al. Expression of human serum albumin in the milk of transgenic mice. Transgenic Res 1, 195-208 (1992).
30. Wu, X. et al. The extremely high level expression of human serum albumin in the milk of transgenic mice. Transgenic Res 21, 1359-1366 (2012).
31. Barash, I. et al. In vivo and in vitro expression of human serum albumin genomic sequences in mammary epithelial cells with β-lactoglobulin and whey acidic protein promoters. Mol Reprod Dev 52, 241-252 (1999).
32. Echelard, Y. et al. Production of recombinant albumin by a herd of cloned transgenic cattle. Transgenic Res 18, 361-376 (2009).
33. Moghaddassi, S., Eyestone, W. & Bishop, C. E. TALEN-mediated modification of the bovine genome for large-scale production of human serum albumin. Plos One 9, e89631(2014).
34. Cermak, T. et al. Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting. Nucleic Acids Res 39, 1-11 (2011).
35. Huang, P. et al. Heritable gene targeting in zebrafish using customized TALENs. Nat Biotechnol 29, 699-700 (2011).
36. Szczepek, M. et al. Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases. Nat Biotechnol 25, 786-793 (2007).
37. Wang, Y. et al. Production of cloned calves by combination treatment of both donor cells and early cloned embryos with 5-aza-2/-deoxycytidine and trichostatin A. Theriogenology 75, 819-825 (2011).