Hydrophobic ion pairing of a minocycline/Ca2+/AOT complex for preparation of drug-loaded PLGA nanoparticles with improved sustained release

International Journal of Pharmaceutics

Volumn 499, Issue 1-2, 2016, Pages 351-357

  Holmkvist, Alexander Dontsios ^a,b   Friberg, Annika ^a   Nilsson, Ulf J ^b   Schouenborg, Jens ^a  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

Drug release; Emulsification solvent diffusion method; Hydrophobic ion paring; Minocycline; Nanoparticles; Poly(d,l lactic co glycolic acid) (PLGA)

Indexed keywords

ANIONIC SURFACTANT; CALCIUM; DOCUSATE SODIUM; MINOCYCLINE; NANOPARTICLE; POLYGLACTIN; 1,4-BIS(2-ETHYLHEXYL) SODIUM SULFOSUCCINATE; ANTIINFECTIVE AGENT; DELAYED RELEASE FORMULATION; DRUG CARRIER; LACTIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; SUCCINIC ACID DERIVATIVE; SURFACTANT;

ARTICLE; CENTRAL NERVOUS SYSTEM; COMPLEX FORMATION; DIFFUSION; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG STABILITY; EMULSION; HYDROPHOBICITY; LIGHT EXPOSURE; NANOENCAPSULATION; PARTICLE SIZE; PH; PRIORITY JOURNAL; SUSTAINED DRUG RELEASE; SUSTAINED RELEASE FORMULATION; THERMOSTABILITY; CHEMICAL PHENOMENA; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG RELEASE; MEDICINAL CHEMISTRY; PROCEDURES; SOLUBILITY;

ANTI-BACTERIAL AGENTS; CALCIUM; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG LIBERATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LACTIC ACID; MINOCYCLINE; NANOPARTICLES; PARTICLE SIZE; POLYGLYCOLIC ACID; SOLUBILITY; SUCCINATES; SURFACE-ACTIVE AGENTS;

EID: 84957824518     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2016.01.011     Document Type: Article

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