Formulation of hydrophilic non-aqueous gel: Drug stability in different solvents and rheological behavior of gel matrices

Pharmaceutical Research

Volumn 25, Issue 1, 2008, Pages 207-217

  Chow, Keat Theng ^a,b   Chan, Lai Wah ^a   Heng, Paul W S ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Minocycline hydrochloride; Non aqueous gel; Rheology; Stability; Viscoelastic

Indexed keywords

COPOLYMER; GLYCERIN PROPYLENE GLYCOL; GLYCOL; MAGNESIUM ION; MINOCYCLINE; N VINYLACETAMIDE CO SODIUM ACRYLATE COPOLYMER; SOLVENT; UNCLASSIFIED DRUG;

ARTICLE; DISSOLUTION; DRUG FORMULATION; DRUG STABILITY; DRUG SYNTHESIS; FLOW KINETICS; FLOW MEASUREMENT; GEL; HYDROPHILICITY; OSCILLATION; PRIORITY JOURNAL;

ADMINISTRATION, TOPICAL; ANTI-BACTERIAL AGENTS; CATIONS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG DELIVERY SYSTEMS; DRUG STABILITY; GELS; MINOCYCLINE; RHEOLOGY; SOLVENTS; VISCOSITY; WATER;

EID: 38049141851     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-007-9457-3     Document Type: Article

References (48)

1. S. Yoshioka, Y. Aso, and T. Terao. Effect of water mobility on drug hydrolysis rates in gelatin gels. Pharm. Res. 9(5):607-612 (1992).
2. Y. L. Loukas, V. Vraka, and G. Gregoriadis. Drugs, in cyclodextrins, in liposomes: A novel approach to the chemical stability of drugs sensitive to hydrolysis. Int. J. Pharm. 162(1-2):137-142 (1998).
3. V. Goulden, D. Glass, and W. J. Cunliffe. Safety of long-term high-dose minocycline in the treatment of acne. Brit. J. Dermatol. 134:693-695 (1996).
4. Y. Wu, and R. Fassihi. Stability of metronidazole, tetracycline HCl and famotidine alone or in combination. Int. J. Pharm. 290:1-13 (2005).
5. J. M. Moreno-Cerezo, M. Córdoba-Díaz, D. Córdoba-Díaz, and M. Córdoba-Borrego. A stability study of tetracycline and tetracycline cyclodextrins in tablets using a new HPLC method. J. Pharmaceut. Biomed. 26:417-426 (2001).
6. L. A. Mitscher. Degradation and structure proofs. In The Chemistry of Tetracycline Antibiotics, Medicinal Research Series, Vol 9. Marcel Dekker, New York, 1978, pp. 122-164.
7. E. G. Remmers, G. M. Sieger, and A. P. Doerschuk. Some observations on the kinetics of the C•4 epimerization of tetracycline. J. Pharm. Sci. 52:752-756 (1963).
8. K. G. McEvoy (ed.). Tetracyclines. In AHFS Drug Information. American Society of Health-System Pharmacist, Maryland, 2006, pp. 440-467.
9. T. H. El-Faham. Transdermal delivery of bromhexidine hydrochloride from various formulations through excised hairless mouse skin. S.T.P. Pharma Sci. 4(3):240-244 (1994).
10. T. H. El-Faham, and A. A. Massoud. Assessment of bromhexidine hydrochloride formulations in human dry eye patients. J. Control. Release 32(3):279-283 (1994).
11. J. S. Hao, L. W. Chan, Z. X. Shen, and P. W. S. Heng. Complexation between PVP and Gantrez polymer and its effect on release and bioadhesive properties of the composite PVP/Gantrez films. Pharm. Dev. Technol. 9(4):379-386 (2004).
12. L. W. Chan, K. T. Ong, and P. W. S. Heng. Novel film modifiers to alter the physical properties of composite ethylcellulose films. Pharm. Res. 22(3):476-489 (2005).
13. B. W. Barry. Dermatological formulations. Percutaneous absorption. Marcel Dekker, New York, 1983.
14. D. S. Jones, A. D. Woolfson, and A. F. Brown. Textural, viscoelastic and mucoadhesive properties of pharmaceutical gels composed of cellulose polymers. Int. J. Pharm. 151:223-233 (1997).
15. M. T. Islam, N. Rodríguez-Hornedo, S. Ciotti, and C. Ackermann. Rheological characterization of topical carbomer gels neutralized to different pH. Pharm. Res. 21(7):1192-1199 (2004).
16. E. Lizaso, M. E. Muñoz, and A. Santamaría. Formation of gels in ethylcellulose solutions. An interpretation from dynamic viscoelastic results. Macromolecules 32:1883-1889 (1999).
17. P. W. S. Heng, L. W. Chan, and K. T. Chow. Development of novel non-aqueous ethylcellulose gel matrices: rheological and mechanical characterization. Pharm. Res. 22(4):676-684 (2005).
18. B. W. Barry, and M. C. Meyer. The rheological properties of carbopol gels II. Oscillatory properties of carbopol gels. Int. J. Pharm. 2:27-40 (1979).
19. J. T. Carstensen. Solution kinetics. In Drug Stability: Principles and Practices. Marcel Dekker, New York, 2000, pp. 25-30.
20. D. A. Hussar, P. J. Niebergall, E. T. Sugita, and J. T. Doluisio. Aspects of epimerization of certain tetracycline derivatives. J. Pharm. Pharmac. 20:539-546 (1968).
21. H. J. C. F. Nelis, and A. P. De Leenheer. Metabolism of minocycline in humans. Drug Metab. Dispos. 10(2):142-146 (1982).
22. M. J. Nilges, W. S. Enochs, and H. M. Swartz. Identification and characterization of a tetracycline semiquinone formed during the oxidation of minocycline. J. Org. Chem. 56:5623-5630 (1991).
23. F. L. Bamba, and J. Wepiere. Role of appendageal pathway in percutaneous absorption of pyridostigmine bromide in various vehicles. Eur. J. Drug Metab. Pharmacokinet. 18:339-348 (1993).
24. R. Wolf, D. Wolf, B. Tüzün, and Y. Tüzün. Contact dermatitis to cosmetics. Clin. Dermatol. 19:502-515 (2001).
25. W. Johnson Jr. Final report on the safety assessment of PEG-25 propylene glycol stearate, PEG-75 propylene glycol stearate, PEG-120 propylene glycol stearate, PEG-10 propylene glycol, PEG-8 propylene glycol cocoate, and PEG-55 propylene glycol oleate. Int. J. Toxicol. 20(Suppl. 4):13-26 (2001).
26. M. J. Catanzaro, and J. G. Smith Jr. Propylene glycol dermatitis. J. Am. Acad. Dermatol. 24:90-95 (1991).
27. M. Lodén, A.-C. Andersson, C. Anderson, I.-M. Bergbrant, T. Frödin, H. Öhman, M.-H. Sandström, T. Särnhult, E. Voog, B. Stenberg, E. Pawlik, A. Preisler-Häggqvist,[InlineEquation not available: see fulltext.] Svensson, and M. Lindberg. A double-blind study comparing the effect of glycerin and urea on dry, eczematous skin in atopic patients. Acta Derm. Venereol. 82:45-47 (2002).
28. J. Q. Del Rosso. The role of the vehicle in combination acne therapy. CUTIS. 76(2):15-18 (2005).
29. Wikipedia, the free encyclopedia. http://en.wikipedia.org/wiki/Glycerin (accessed 3/22/07).
30. 2+: A Spectroscopic Study. J. Phys. Chem. B. 102:9323-9331 (1998).
31. L. Lambs, and G. Berthon. Metal ion-tetracycline interactions in biological fluids. Part 7. Quantitative investigation of methacycline complexes with Ca(II), Mg(II), Cu(II) and Zn(II) ions and assessment of their biological significance. Inorg. Chim. Acta. 151:33-43 (1988).
32. M. Novák-Pékli, M. E. Mesbah, G. Petho. Equilibrium studies on tetracyline-metal ion systems. J. Pharm. Biomed. Anal. 14:1025-1029 (1996).
33. W. B. De Almeida, H. F. Dos Santos, and M. C. Zerner. A theoretical studies of the interaction of anhydrotetracycline with Al(III). J. Pharm. Sci. 87(9):1101-1108 (1998).
34. K. Hasegawa, K. Nakashima, T. Eguchi, and M. Ota. US Patent, 1987, US 4701320.
35. 2+. Phys. Chem. Comm. 9:1-14 (2000).
36. Wikipedia, the free encyclopedia. http://en.wikipedia.org/wiki/ Ionic_radius (accessed 12/22/06).
37. WebElements. http://www.webelements.com/webelements/elements/text/Al/ radii.html (accessed 12/22/06).
38. T. Ohyama, and J. A. Cowan. Calorimetric studies of metal binding to tetracycline. Role of solvent structure in defining the selectivity of metal ion-drug interactions. Inorg. Chem. 34:3083-3086 (1995).
39. H. A. Duarte, S. Carvalho, E. B. Paniago, and A. M. Simas. Importance of tautomers in the chemical behaviour of tetracyclines. J. Pharm. Sci. 88(1):111-120 (1999).
40. S. S. Davis. Viscoelastic properties of pharmaceutical semisolids I: Ointment bases. J. Pharm. Sci. 58(4):412-418 (1969).
41. M. M. Talukdar, I. Vinckier, P. Moldenaers, and R. Kinget. Rheological characterization of xanthan gum and hydroxypropylmethylcellulose with respect to controlled-release drug delivery. J. Pharm. Sci. 85(5):537-540 (1996).
42. D. S. Jones, A. D. Woolfson, J. Djokic, and W. A. Coulter. Development and mechanical characterization of bioadhesive semi-solid, polymeric systems containing tetracycline for the treatment of periodontal diseases. Pharm. Res. 13(11):1734-1738 (1996).
43. S. Tamburic, and D. Q. M. Craig. A comparison of different in vitro methods for measuring mucoadhesive performance. Eur. J. Pharm. Biopharm. 44:159-167 (1997).
44. I. G. Needleman, G. P. Martin, and F. C. Smales. Characterisation of bioadhesives for periodontal and oral mucosal drug delivery. J. Clin. Periodontol. 25:74-82 (1998).
45. J. Y. Chang, Y. Oh, H. Choi, Y. B. Kim, and C. Kim. Rheological evaluation of thermosensitive and mucoadhesive vaginal gels in physiological conditions. Int. J. Pharm. 241:155-163 (2002).
46. S. Tamburic, and D. Q. M. Craig. An investigation into the rheological, dielectric and mucoadhesive properties of poly (acrylic acid) gel systems. J. Control. Release 37:59-68 (1995).
47. R. K. Gupta. Dynamic mechanical properties. In Polymer and Composite Rheology. Marcel Dekker, New York, 2000, p. 133.
48. B. W. Barry, and M. C. Meyer. The rheological properties of Carbopol gels I. Continuous shear and creep properties of Carbopol gels. Int. J. Pharm. 2:1-25 (1979).