Extended cytoprotective effect of autophagy in the late stages of sepsis and fluctuations in signal transduction pathways in a rat experimental model of kidney injury

Shock

Volumn 45, Issue 2, 2016, Pages 139-147

  Karagiannidis, Ioannis ^a   Kataki, Agapi ^a   Glustianou, Georgia ^b   Memos, Nikolaos ^a   Papalois, Apostolos ^c   Alexakis, Nikolaos ^d   Zografos, George C ^d   Konstadoulakis, Manoussos M ^d  

^a HIPPOKRATION HOSPITAL   (Greece)

^b Histopathological Diagnosis   (Greece)

^c Experimental Research Center ELPEN   (Greece)

^d UNIVERSITY OF ATHENS   (Greece)

Author keywords

14 3 3b; Autophagy; CLP model; MAPK kinases; pAkt; PC; S100

Indexed keywords

7 AMINODACTINOMYCIN; ENZYME PRECURSOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN C; PROTEIN KINASE B; PROTEIN S 100; 7-AMINOACTINOMYCIN D; DACTINOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CELL DEATH; CELL PROTECTION; CELL STRESS; CELL VIABILITY; CONTROLLED STUDY; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; IMMUNOLOCALIZATION; INFLAMMATION; KIDNEY INJURY; KINETICS; MALE; NEPHRITIS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SEPSIS; SIGNAL TRANSDUCTION; STAINING; STIMULATION; ACUTE KIDNEY FAILURE; ANALOGS AND DERIVATIVES; ANIMAL; APOPTOSIS; CECUM; CELL CULTURE; LIGATION; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; THEORETICAL MODEL; WISTAR RAT;

ACUTE KIDNEY INJURY; ANIMALS; APOPTOSIS; AUTOPHAGY; CECUM; CELLS, CULTURED; DACTINOMYCIN; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LIGATION; MALE; MODELS, THEORETICAL; RATS; RATS, WISTAR; SEPSIS; SIGNAL TRANSDUCTION;

EID: 84957810910     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0000000000000505     Document Type: Article

References (35)

1. Brunn GJ, Platt JL: The etiology of sepsis: turned inside out. Trends Mol Med 12(1):10-16, 2006.
2. Ulloa L, Tracey KJ: The 'cytokine profile': a code for sepsis. Trends Mol Med 11(2):56-63, 2005.
3. Abraham E, Singer M: Mechanisms of sepsis-induced organ dysfunction. Crit Care Med 35(10):2408-2416, 2007.
4. Pinto CF,Watanabe M, da Fonseca CD, Ogata CI, VattimoMde F: The sepsis as cause of acute kidney injury: an experimental model. Rev Esc Enferm USP 46(Esp):86-90, 2012.
5. Takahashi W, Watanabe E, Fujimura L, Watanabe-Takano H, Yoshidome H, Swanson PE, Tokuhisa T, Oda S, Hatano M: Kinetics and protective role of autophagy in a mouse cecal ligation and puncture-induced sepsis. Crit Care 17(4):R160, 2013.
6. Hsiao HW, Tsai KL, Wang LF, Chen YH, Chiang PC, Chuang SM, Hsu C: The decline of autophagy contributes to proximal tubular dysfunction during sepsis. Shock 37(3):289-296, 2012.
7. Sridharan S, Jain K, Basu A: Regulation of autophagy by kinases. Cancers 3(2):2630-2654, 2011.
8. Cagnol S, Chambard JC: ERK and cell death: mechanisms of ERK-induced cell death: apoptosis, autophagy and senescence. FEBS J 277(1):2-21, 2010.
9. Sui X, Kong N, Ye L, Han W, Zhou J, Zhang Q, He C: Pan H. p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents. Cancer Lett 344(2):174-179, 2014.
10. Pozuelo-Rubio M: 14-3-3 Proteins are regulators of autophagy. Cells 1(4):754-773, 2012.
11. Kroemer G, Mariño G, Levine B: Autophagy and the integrated stress response. Mol Cell 40(2):280-293, 2010.
12. Shen S, Kepp O, Kroemer G: The end of autophagic cell death? Autophagy 8(1):1-3, 2012.
13. Huang R, Xu Y, Wan W, Shou X, Qian J, You Z, Liu B, Chang C, Zhou T, Lippincott-Schwartz J, et al.: Deacetylation of nuclear LC3 drives autophagy initiation under starvation. Mol Cell 57(3):456-466, 2015.
14. Lo S, Yuan SS, Hsu C, Cheng YJ, Chang YF, Hsueh HW, Lee PH, Hsieh YC: Lc3 over-expression improves survival and attenuates lung injury through increasing autophagosomal clearance in septic mice. Ann Surg 57(2):352-363, 2013.
15. Zang QS, Wolf SE, Minei JP: Sepsis-induced cardiac mitochondrial damage and potential therapeutic interventions in the elderly. Aging Dis 5(2):137-149, 2014.
16. Yang S, Cioffi WG, Bland KI, Chaudry IH, Wang P: Differential alterations in systemic and regional oxygen delivery and consumption during the early and late stages of sepsis. J Trauma 47(4):706-712, 1999.
17. Foell D, Roth J: Proinflammatory S100 proteins in arthritis and autoimmune disease. Arthritis Rheum 50(12):3762-3771, 2004.
18. Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, et al.: Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 344(10):699-709, 2001.
19. Ranieri VM, Thompson BT, Barie PS, Dhainaut JF, Douglas IS, Finfer S, Gardlund B, Marshall JC, Rhodes A, Artigas A, et al.: Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med 366(22):2055-2064, 2012.
20. Messaris E, Betrosian AP, Memos N, Chatzigianni E, Boutsikou M, Economou V, Dontas I, Theodossiades G, Konstadoulakis MM, Douzinas EE: Administration of human protein C improves survival in an experimental model of sepsis. Crit Care Med 38(1):209-216, 2010.
21. Mosnier LO, Zlokovic BV, Griffin JH: The cytoprotective protein C pathway. Blood 109(8):3161-3172, 2007.
22. Schmid I, Uittenbogaart CH, Keld B, Giorgi JV: A rapid method for measuring apoptosis and dual-color immunofluorescence by single laser flow cytometry. J Immunol Methods 170(2):145-157, 1994.
23. Wu J, Dang Y, SuW, Liu C, Ma H, Shan Y, Pei Y,Wan B, Guo J, Yu L: Molecular cloning and characterization of rat LC3A and LC3B: two novel markers of autophagosome. Biochem Biophys Res Commun 339(1):437-442, 2006.
24. Hsieh YC, Athar M, Chaudry IH: When apoptosis meets autophagy: deciding cell fate after trauma and sepsis. Trends Mol Med 15(3):129-138, 2009.
25. Scherz-Shouval R, Shvets E, Fass E, Shorer H, Gil L, Elazar Z: Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J 26(7):1749-1760, 2007.
26. Pathak E, Mayeux PR: In vitro model of sepsis-induced renal epithelial reactive nitrogen species generation. Toxicol Sci 115(2):475-481, 2010.
27. Quoilin C, Mouithys-Mickalad A, Lécart S, Fontaine-Aupart MP, Hoebeke M: Evidence of oxidative stress and mitochondrial respiratory chain dysfunction in an in vitro model of sepsis-induced kidney injury. Biochim Biophys Acta 1837(10):1790-1800, 2014.
28. Martinez-Lopez N, Athonvarangkul D, Mishall P, Sahu S, Singh R: Autophagy proteins regulate ERK phosphorylation. Nat Commun 4:2799, 2013.
29. Lu Z, Xu S: ERK1/2 MAP kinases in cell survival and apoptosis. IUBMB Life 58(11):621-631, 2006.
30. Los FC, Randis TM, Aroian RV, Ratner AJ: Role of pore-forming toxins in bacterial infectious diseases. Microbiol Mol Biol Rev 77(2):173-207, 2013.
31. Webber JL, Tooze SA: Coordinated regulation of autophagy by p38alpha MAPK through mAtg9 and p38IP. EMBO J 29(1):27-40, 2010.
32. Li ZY, Yang Y, Ming M, Liu B: Mitochondrial ROS generation for regulation of autophagic pathways in cancer. Biochem Biophys Res Commun 414(1):5-8, 2011.
33. Mizushima N, Komatsu M: Autophagy: renovation of cells and tissues. Cell 147(4):728-741, 2011.
34. Walls KC, Ghosh AP, Franklin AV, Klocke BJ, Ballestas M, Shacka JJ, Zhang J, Roth KA: Lysosome dysfunction triggers Atg7 dependent neural apoptosis. J Biol Chem 285(14):10497-10507, 2010.
35. Cinel I, Serinol H, Ark M, Karabacak T, Kubat H, Yýldýrým H, Ayvaz L, Tamer L, Cinel L, Oral U: Possible protective effect of Akt phosphorylation by rhAPC in the LPS-induced lung injury. Shock 25(6):69, 2006.