Kinetics and protective role of autophagy in a mouse cecal ligation and puncture-induced sepsis

Critical Care

Volumn 17, Issue 4, 2013, Pages

  Takahashi, Waka ^a   Watanabe, Eizo ^a   Fujimura, Lisa ^a   Watanabe Takano, Haruko ^a   Yoshidome, Hiroyuki ^a   Swanson, Paul E ^b   Tokuhisa, Takeshi ^a   Oda, Shigeto ^a   Hatano, Masahiko ^a  

^a CHIBA UNIVERSITY   (Japan)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOTRANSFERASE; CHLOROQUINE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1;

AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOLYSOSOME; AUTOPHAGOSOME; AUTOPHAGY; C57BL 6 MOUSE; CONTROLLED STUDY; ELECTRON MICROSCOPY; IMMUNOFLUORESCENCE; IMMUNOFLUORESCENCE TEST; KINETICS; LIVER CELL; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEPSIS; TRANSGENIC MOUSE; WESTERN BLOTTING; ADVERSE EFFECTS; ANIMAL; C57BL MOUSE; CECUM; DISEASE MODEL; LIGATION; LIVER; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; PUNCTURE; ULTRASTRUCTURE;

ANIMALS; AUTOPHAGY; CECUM; DISEASE MODELS, ANIMAL; LIGATION; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PUNCTURES; SEPSIS;

EID: 84880387372     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc12839     Document Type: Article

References (47)

1. Russell JA. Management of sepsis. N Engl J Med 2006, 355:1699-1713. 10.1056/NEJMra043632, 17050894.
2. Kumar G, Kumar N, Taneja A, Kaleekal T, Tarima S, McGinley E, Jimenez E, Mohan A, Khan RA, Whittle J, Jacobs E, Nanchal R. Milwaukee Initiative in Critical Care Outcomes Research Group of I: Nationwide trends of severe sepsis in the 21st century (2000-2007). Chest 2011, 140:1223-1231. 10.1378/chest.11-0352, 21852297.
3. Hotchkiss RS, Monneret G, Payen D. Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach. Lancet Infect Dis 2013, 13:260-268. 10.1016/S1473-3099(13)70001-X, 23427891.
4. Hotchkiss RS, Strasser A, McDunn JE, Swanson PE. Cell death. N Engl J Med 2009, 361:1570-1583. 10.1056/NEJMra0901217, 19828534.
5. Levine B, Klionsky DJ. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 2004, 6:463-477. 10.1016/S1534-5807(04)00099-1, 15068787.
6. Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008, 132:27-42. 10.1016/j.cell.2007.12.018, 2696814, 18191218.
7. Mizushima N, Ohsumi Y, Yoshimori T. Autophagosome formation in mammalian cells. Cell Struct Funct 2002, 27:421-429. 10.1247/csf.27.421, 12576635.
8. Levine B, Mizushima N, Virgin HW. Autophagy in immunity and inflammation. Nature 2011, 469:323-335. 10.1038/nature09782, 3131688, 21248839.
9. Mizushima N, Levine B. Autophagy in mammalian development and differentiation. Nat Cell Biol 2010, 12:823-830. 10.1038/ncb0910-823, 3127249, 20811354.
10. Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T, Ohsumi Y, Tokuhisa T, Mizushima N. The role of autophagy during the early neonatal starvation period. Nature 2004, 432:1032-1036. 10.1038/nature03029, 15525940.
11. Miller BC, Zhao Z, Stephenson LM, Cadwell K, Pua HH, Lee HK, Mizushima NN, Iwasaki A, He YW, Swat W, Virgin HW. The autophagy gene ATG5 plays an essential role in B lymphocyte development. Autophagy 2008, 4:309-314.
12. Mortensen M, Ferguson DJ, Edelmann M, Kessler B, Morten KJ, Komatsu M, Simon AK. Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo. Proc Natl Acad Sci USA 2010, 107:832-837. 10.1073/pnas.0913170107, 2818953, 20080761.
13. Shibata M, Yoshimura K, Tamura H, Ueno T, Nishimura T, Inoue T, Sasaki M, Koike M, Arai H, Kominami E, Uchiyama. LC3, a microtubule-associated protein1A/B light chain3, is involved in cytoplasmic lipid droplet formation. Biochem Biophys Res Commun 2010, 393:274-279. 10.1016/j.bbrc.2010.01.121, 20132792.
14. Goldberg AL. Protein degradation and protection against misfolded or damaged proteins. Nature 2003, 426:895-899. 10.1038/nature02263, 14685250.
15. Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R, Yokoyama M, Mishima K, Saito I, Okano H, Mizushima N. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 2006, 441:885-889. 10.1038/nature04724, 16625204.
16. Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, Tanida I, Ueno T, Koike M, Uchiyama Y, Kominami E, Tanaka K. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 2006, 441:880-884. 10.1038/nature04723, 16625205.
17. Crotzer VL, Blum JS. Autophagy and adaptive immunity. Immunology 2010, 131:9-17. 2966753, 20586810.
18. Nakagawa I, Amano A, Mizushima N, Yamamoto A, Yamaguchi H, Kamimoto T, Nara A, Funao J, Nakata M, Tsuda K, Hamada S, Yoshimori T. Autophagy defends cells against invading group A Streptococcus. Science 2004, 306:1037-1040. 10.1126/science.1103966, 15528445.
19. Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature 2008, 451:1069-1075. 10.1038/nature06639, 2670399, 18305538.
20. Hsieh CH, Pai PY, Hsueh HW, Yuan SS, Hsieh YC. Complete induction of autophagy is essential for cardioprotection in sepsis. Ann Surg 2011, 253:1190-1200. 10.1097/SLA.0b013e318214b67e, 21412148.
21. Carchman EH, Rao J, Loughran PA, Rosengart MR, Zuckerbraun BS. Heme oxygenase-1-mediated autophagy protects against hepatocyte cell death and hepatic injury from infection/sepsis in mice. Hepatology 2011, 53:2053-2062. 10.1002/hep.24324, 21437926.
22. Chien WS, Chen YH, Chiang PC, Hsiao HW, Chuang SM, Lue SI, Hsu C. Suppression of autophagy in rat liver at late stage of polymicrobial sepsis. Shock 2011, 35:506-511. 10.1097/SHK.0b013e31820b2f05, 21263383.
23. Mofarrahi M, Sigala I, Guo Y, Godin R, Davis EC, Petrof B, Sandri M, Burelle Y, Hussain SN. Autophagy and skeletal muscles in sepsis. PLoS One 2012, 7:e47265. 10.1371/journal.pone.0047265, 3467208, 23056618.
24. Lo S, Yuan SS, Hsu C, Cheng YJ, Chang YF, Hsueh HW, Lee PH, Hsieh YC. Lc3 transgene improves survival and attenuates lung injury through increasing autophagosomal clearance in septic mice. Ann Surg 2013, 257:352-363. 10.1097/SLA.0b013e318269d0e2, 22968077.
25. Nakahira K, Haspel JA, Rathinam VA, Lee SJ, Dolinay T, Lam HC, Englert JA, Rabinovitch M, Cernadas M, Kim HP, Fitzgerald KA, Ryter SW, Choi A. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol 2011, 12:222-230. 3079381, 21151103.
26. Gunst J, Derese I, Aertgeerts A, Ververs EJ, Wauters A, Van den Berghe G, Vanhorebeek I. Insufficient autophagy contributes to mitochondrial dysfunction, organ failure, and adverse outcome in an animal model of critical illness. Crit Care Med 2013, 41:182-194. 10.1097/CCM.0b013e31828e928d, 23222264.
27. Crouser ED, Julian MW, Huff JE, Struck J, Cook CH. Carbamoyl phosphate synthase-1: A marker of mitochondrial damage and depletion in the liver during sepsis. Crit Care Med 2006, 39:2439-2446.
28. Watanabe E, Muenzer JT, Hawkins WG, Davis CG, Dixon DJ, McDunn JE, Brackett DJ, Lerner MR, Swanson PE, Hotchkiss RS. Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study. Lab Invest 2009, 89:549-561. 10.1038/labinvest.2009.8, 19188912.
29. Hubbard WJ, Choudhry M, Schwacha MG, Kerby JD, Rue LW, Bland KI, Chaudry IH. Cecal ligation and puncture. Shock 2005, 24:52-57. 10.1097/01.shk.0000191414.94461.7e, 16374373.
30. Rittirsch D, Huber-Lang MS, Flierl MA, Ward PA. Immunodesign of experimental sepsis by cecal ligation and puncture. Nat Protoc 2009, 4:31-36. 2754226, 19131954.
31. Ding WX, Li M, Chen X, Ni HM, Lin CW, Gao W, Lu B, Stolz DB, Clemens DL, Yin XM. Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice. Gastroenterology 2010, 139:1740-1752. 10.1053/j.gastro.2010.07.041, 20659474.
32. Morrison TB, Weis JJ, Wittwer CT. Quantification of low-copy transcripts by continuous SYBR Green I monitoring during amplification. Biotechniques 1998, 24:954-958. 960.
33. Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 2004, 15:1101-1111. 363084, 14699058.
34. Mizushima N, Yoshimoto T, Levine B. Methods in mammalian autophagy research. Cell 2010, 140:313-326. 10.1016/j.cell.2010.01.028, 2852113, 20144757.
35. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, et al. Guidlines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012, 8:445-544. 10.4161/auto.19496, 3404883, 22966490.
36. Iwai-Kanai E, Yuan H, Huang C, Sayen MR, Perry-Garza CN, Kim L, Gottlieb RA. A method to measure cardiac autophagic flux in vivo. Autophagy 2008, 4:322-329. 3709927, 18216495.
37. Ni H-M, Bockus A, Wozniak AL, Jones K, Weinman S, Yin X-M, Ding W-X. Dissecting the dynamic turnover of gfp-lc3 in the autolysosome. Autophagy 2011, 7:188-204. 10.4161/auto.7.2.14181, 3039769, 21107021.
38. Hsiao HW, Tsai KL, Wang LF, Chen YH, Chiang PC, Chuang SM, Hsu C. The decline of autophagy contributes to proximal tubular dysfunction during sepsis. Shock 2012, 37:289-296. 10.1097/SHK.0b013e318240b52a, 22089196.
39. Ni HM, Bockus A, Boggess N, Jaeschke H, Ding WX. Activation of autophagy protects against acetaminophen-induced hepatotoxicity. Hepatology 2012, 55:222-232. 10.1002/hep.24690, 3245329, 21932416.
40. Wang Y, Singh R, Xiang Y, Czaja MJ. Macroautophagy and chaperone-mediated autophagy are required for hepatocyte resistance to oxidant stress. Hepatology 2010, 52:266-277. 10.1002/hep.23645, 2924621, 20578144.
41. Komatsu M, Waguri S, Koike M, Sou YS, Ueno T, Hara T, Mizushima N, Iwata J, Ezaki J, Murata S, Hamazaki J, Nishito Y, Iemura S, Natsume T, Yanagawa T, Uwayama J, Warabi E, Yoshida H, Ishii T, Kobayashi A, Yamamoto M, Yue Z, Uchiyama Y, Kominami E, Tanaka K. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 2007, 131:1149-1163. 10.1016/j.cell.2007.10.035, 18083104.
42. Takamura A, Komatsu M, Hara T, Sakamoto A, Kishi C, Waguri S, Eishi Y, Hino O, Tanaka K, Mizushima N. Autophagy-deficient mice develop multiple liver tumors. Genes Dev 2011, 25:795-800. 10.1101/gad.2016211, 3078705, 21498569.
43. Yin XM, Ding WX, Gao W. Autophagy in the liver. Hepatology 2008, 47:1773-1785. 10.1002/hep.22146, 18393362.
44. Araki K, Ellebedy AH, Ahmed R. TOR in the immune system. Curr Opin Cell Biol 2011, 23:707-715. 10.1016/j.ceb.2011.08.006, 3241972, 21925855.
45. Waickman AT, Powell JD. mTOR, metabolism, and the regulation of T-cell differentiation and function. Immunol Rev 2012, 249:43-58. 10.1111/j.1600-065X.2012.01152.x, 22889214.
46. Steel HC, Theron AJ, Cockeran R, Anderson R, Feldman C. Pathogen- and host-directed anti-inflammatory activities of macrolide antibiotics. Mediators Inflamm 2012, 2012:584262. 3388425, 22778497.
47. Casaer MP, Mesotten D, Hermans G, Wouters PJ, Schetz M, Meyfroidt G, Van Cromphaut S, Ingels C, Meersseman P, Muller J, Vlasselaers D, Debaveye Y, Desmet L, Dubois J, Van Assche A, Vanderheyden S, Wilmer A, Van den Berghe G. Early versus late parenteral nutrition in critically ill adults. N Engl J Med 2011, 365:506-517. 10.1056/NEJMoa1102662, 21714640.