Asparagine deprivation mediated by Salmonella asparaginase causes suppression of activation-induced T cell metabolic reprogramming

Journal of Leukocyte Biology

Volumn 99, Issue 2, 2016, Pages 387-398

  Torres, Annmarie ^a,c   Luke, Joanna D ^a   Kullas, Amy L ^a,d   Kapilashrami, Kanishk ^a,e   Botbol, Yair ^b   Koller, Antonius ^a,f   Tonge, Peter J ^a   Chen, Emily I ^a,f   Macian, Fernando ^b   van der Velden, Adrianus W M ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^e MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^f NewYork Presbyterian Hospital   (United States)

Author keywords

Bacteria; Host; Inhibition; Pathogen; T lymphocyte

Indexed keywords

ASPARAGINASE; ASPARAGINE; HYDROLASE; LACTIC ACID; MAMMALIAN TARGET OF RAPAMYCIN; MYC PROTEIN; BACTERIAL PROTEIN; INTERLEUKIN 2; LYMPHOCYTE ANTIGEN RECEPTOR; MTOR PROTEIN, MOUSE; MYC PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ARTICLE; AUTOPHAGY; CELL METABOLISM; CONTROLLED STUDY; ENZYME ACTIVITY; IMMUNE RESPONSE; METABOLIC REPROGRAMMING; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; AMINO ACID SEQUENCE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; DEFICIENCY; DRUG EFFECTS; ENZYMOLOGY; FEMALE; GENETICS; IMMUNE EVASION; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MOLECULAR GENETICS; ONCOGENE MYC; PATHOGENICITY; PHYSIOLOGY; T LYMPHOCYTE SUBPOPULATION; VIRULENCE;

AMINO ACID SEQUENCE; ANIMALS; ASPARAGINASE; ASPARAGINE; AUTOPHAGY; BACTERIAL PROTEINS; CELLS, CULTURED; FEMALE; GENES, MYC; IMMUNE EVASION; INTERLEUKIN-2; LACTIC ACID; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; PROTO-ONCOGENE PROTEINS C-MYC; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SALMONELLA TYPHIMURIUM; T-LYMPHOCYTE SUBSETS; TOR SERINE-THREONINE KINASES; VIRULENCE;

EID: 84957666384     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.4A0615-252R     Document Type: Article

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