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Volumn 7, Issue , 2016, Pages

PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; LUMINESPIB; 5-(2,4-DIHYDROXY-5-ISOPROPYLPHENYL)-4-(4-MORPHOLIN-4-YLMETHYLPHENYL)ISOXAZOLE-3-CARBOXYLIC ACID ETHYLAMIDE; ANTINEOPLASTIC AGENT; CARRIER PROTEIN; ISOXAZOLE DERIVATIVE; KIAA0101 PROTEIN, HUMAN; PAF PROTEIN, MOUSE; RESORCINOL DERIVATIVE;

EID: 84957575532     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms10633     Document Type: Article
Times cited : (76)

References (69)
  • 1
    • 0035182533 scopus 로고    scopus 로고
    • Stem and progenitor cells: Origins, phenotypes, lineage commitments, and transdifferentiations
    • Weissman, I. L., Anderson, D. J. & Gage, F. Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. Annu. Rev. Cell Dev. Biol. 17, 387-403 (2001).
    • (2001) Annu. Rev. Cell Dev. Biol. , vol.17 , pp. 387-403
    • Weissman, I.L.1    Anderson, D.J.2    Gage, F.3
  • 2
    • 22044450950 scopus 로고    scopus 로고
    • Bone marrow stromal cells generate muscle cells and repair muscle degeneration
    • Dezawa, M. et al. Bone marrow stromal cells generate muscle cells and repair muscle degeneration. Science 309, 314-317 (2005).
    • (2005) Science , vol.309 , pp. 314-317
    • Dezawa, M.1
  • 3
    • 0033406436 scopus 로고    scopus 로고
    • Hematopoietic potential of stem cells isolated from murine skeletal muscle
    • Jackson, K. A., Mi, T. & Goodell, M. A. Hematopoietic potential of stem cells isolated from murine skeletal muscle. Proc. Natl Acad. Sci. USA 96, 14482-14486 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 14482-14486
    • Jackson, K.A.1    Mi, T.2    Goodell, M.A.3
  • 4
    • 34848853915 scopus 로고    scopus 로고
    • Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors
    • Cobaleda, C., Jochum, W. & Busslinger, M. Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors. Nature 449, 473-477 (2007).
    • (2007) Nature , vol.449 , pp. 473-477
    • Cobaleda, C.1    Jochum, W.2    Busslinger, M.3
  • 5
    • 0037099497 scopus 로고    scopus 로고
    • Transcription factor-mediated lineage switching reveals plasticity in primary committed progenitor cells
    • Heyworth, C., Pearson, S., May, G. & Enver, T. Transcription factor-mediated lineage switching reveals plasticity in primary committed progenitor cells. EMBO J. 21, 3770-3781 (2002).
    • (2002) EMBO J , vol.21 , pp. 3770-3781
    • Heyworth, C.1    Pearson, S.2    May, G.3    Enver, T.4
  • 6
    • 80051674431 scopus 로고    scopus 로고
    • Direct generation of functional dopaminergic neurons from mouse and human fibroblasts
    • Caiazzo, M. et al. Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature 476, 224-227 (2011).
    • (2011) Nature , vol.476 , pp. 224-227
    • Caiazzo, M.1
  • 7
    • 79960854285 scopus 로고    scopus 로고
    • Induction of human neuronal cells by defined transcription factors
    • Pang, Z. P. et al. Induction of human neuronal cells by defined transcription factors. Nature 476, 220-223 (2011).
    • (2011) Nature , vol.476 , pp. 220-223
    • Pang, Z.P.1
  • 8
    • 79960649307 scopus 로고    scopus 로고
    • Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors
    • Sekiya, S. & Suzuki, A. Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors. Nature 475, 390-393 (2011).
    • (2011) Nature , vol.475 , pp. 390-393
    • Sekiya, S.1    Suzuki, A.2
  • 9
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
    • Dor, Y., Brown, J., Martinez, O. I. & Melton, D. A. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429, 41-46 (2004).
    • (2004) Nature , vol.429 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.A.4
  • 10
    • 77951611220 scopus 로고    scopus 로고
    • Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss
    • Thorel, F. et al. Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature 464, 1149-1154 (2010).
    • (2010) Nature , vol.464 , pp. 1149-1154
    • Thorel, F.1
  • 11
    • 53349178722 scopus 로고    scopus 로고
    • In vivo reprogramming of adult pancreatic exocrine cells to beta-cells
    • Zhou, Q., Brown, J., Kanarek, A., Rajagopal, J. & Melton, D. A. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 455, 627-632 (2008).
    • (2008) Nature , vol.455 , pp. 627-632
    • Zhou, Q.1    Brown, J.2    Kanarek, A.3    Rajagopal, J.4    Melton, D.A.5
  • 12
    • 16844368698 scopus 로고    scopus 로고
    • Tumour stem cells and drug resistance
    • Dean, M., Fojo, T. & Bates, S. Tumour stem cells and drug resistance. Nat. Rev. Cancer 5, 275-284 (2005).
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 275-284
    • Dean, M.1    Fojo, T.2    Bates, S.3
  • 13
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions
    • Visvader, J. E. & Lindeman, G. J. Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat. Rev. Cancer 8, 755-768 (2008).
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 755-768
    • Visvader, J.E.1    Lindeman, G.J.2
  • 14
    • 84858608410 scopus 로고    scopus 로고
    • Cancer stem cells: Impact, heterogeneity, and uncertainty
    • Magee, J. A., Piskounova, E. & Morrison, S. J. Cancer stem cells: impact, heterogeneity, and uncertainty. Cancer Cell 21, 283-296 (2012).
    • (2012) Cancer Cell , vol.21 , pp. 283-296
    • Magee, J.A.1    Piskounova, E.2    Morrison, S.J.3
  • 15
    • 0035945643 scopus 로고    scopus 로고
    • P15(PAF), a novel PCNA associated factor with increased expression in tumor tissues
    • Yu, P. et al. p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues. Oncogene 20, 484-489 (2001).
    • (2001) Oncogene , vol.20 , pp. 484-489
    • Yu, P.1
  • 16
    • 84867101049 scopus 로고    scopus 로고
    • Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass
    • Povlsen, L. K. et al. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Nat. Cell Biol. 14, 1089-1098 (2012).
    • (2012) Nat. Cell Biol. , vol.14 , pp. 1089-1098
    • Povlsen, L.K.1
  • 17
    • 84886310917 scopus 로고    scopus 로고
    • PAF and EZH2 induce Wnt/beta-catenin signaling hyperactivation
    • Jung, H. Y. et al. PAF and EZH2 induce Wnt/beta-catenin signaling hyperactivation. Mol. Cell 52, 193-205 (2013).
    • (2013) Mol. Cell , vol.52 , pp. 193-205
    • Jung, H.Y.1
  • 18
    • 0032816001 scopus 로고    scopus 로고
    • Multiple functions of human papillomavirus type 16 E6 contribute to the immortalization of mammary epithelial cells
    • Liu, Y. et al. Multiple functions of human papillomavirus type 16 E6 contribute to the immortalization of mammary epithelial cells. J. Virol. 73, 7297-7307 (1999).
    • (1999) J. Virol. , vol.73 , pp. 7297-7307
    • Liu, Y.1
  • 19
    • 84887024828 scopus 로고    scopus 로고
    • PAF-mediated MAPK signaling hyperactivation via LAMTOR3 induces pancreatic tumorigenesis
    • Jun, S. et al. PAF-mediated MAPK signaling hyperactivation via LAMTOR3 induces pancreatic tumorigenesis. Cell Rep. 5, 314-322 (2013).
    • (2013) Cell Rep. , vol.5 , pp. 314-322
    • Jun, S.1
  • 20
    • 0032912720 scopus 로고    scopus 로고
    • Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway
    • Wielenga, V. J. et al. Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway. Am. J. Pathol. 154, 515-523 (1999).
    • (1999) Am. J. Pathol. , vol.154 , pp. 515-523
    • Wielenga, V.J.1
  • 21
    • 0035177216 scopus 로고    scopus 로고
    • Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells
    • Elenbaas, B. et al. Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. Genes Dev. 15, 50-65 (2001).
    • (2001) Genes Dev. , vol.15 , pp. 50-65
    • Elenbaas, B.1
  • 23
    • 0025023538 scopus 로고
    • Human papilloma virus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirements
    • Band, V., Zajchowski, D., Kulesa, V. & Sager, R. Human papilloma virus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirements. Proc. Natl Acad. Sci. USA 87, 463-467 (1990).
    • (1990) Proc. Natl Acad. Sci. USA , vol.87 , pp. 463-467
    • Band, V.1    Zajchowski, D.2    Kulesa, V.3    Sager, R.4
  • 24
    • 35848955428 scopus 로고    scopus 로고
    • ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
    • Ginestier, C. et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 1, 555-567 (2007).
    • (2007) Cell Stem Cell , vol.1 , pp. 555-567
    • Ginestier, C.1
  • 25
    • 80051967505 scopus 로고    scopus 로고
    • Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
    • Gupta, P. B. et al. Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell 146, 633-644 (2011).
    • (2011) Cell , vol.146 , pp. 633-644
    • Gupta, P.B.1
  • 26
    • 0036149985 scopus 로고    scopus 로고
    • Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors
    • Lustig, B. et al. Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol. Cell. Biol. 22, 1184-1193 (2002).
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 1184-1193
    • Lustig, B.1
  • 27
    • 79955046668 scopus 로고    scopus 로고
    • An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway
    • Gonsalves, F. C. et al. An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. Proc. Natl Acad. Sci. USA 108, 5954-5963 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 5954-5963
    • Gonsalves, F.C.1
  • 28
    • 0032801892 scopus 로고    scopus 로고
    • Neoplastic transformation of RK3E by mutant beta-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression
    • Kolligs, F. T., Hu, G., Dang, C. V. & Fearon, E. R. Neoplastic transformation of RK3E by mutant beta-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression. Mol. Cell. Biol. 19, 5696-5706 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 5696-5706
    • Kolligs, F.T.1    Hu, G.2    Dang, C.V.3    Fearon, E.R.4
  • 29
    • 0032483439 scopus 로고    scopus 로고
    • Identification of c-MYC as a target of the APC pathway
    • He, T. C. et al. Identification of c-MYC as a target of the APC pathway. Science 281, 1509-1512 (1998).
    • (1998) Science , vol.281 , pp. 1509-1512
    • He, T.C.1
  • 30
    • 41449118521 scopus 로고    scopus 로고
    • Module map of stem cell genes guides creation of epithelial cancer stem cells
    • Wong, D. J. et al. Module map of stem cell genes guides creation of epithelial cancer stem cells. Cell Stem Cell 2, 333-344 (2008).
    • (2008) Cell Stem Cell , vol.2 , pp. 333-344
    • Wong, D.J.1
  • 31
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani, S. A. et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133, 704-715 (2008).
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1
  • 32
    • 39149130361 scopus 로고    scopus 로고
    • Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming
    • Jaenisch, R. & Young, R. Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell 132, 567-582 (2008).
    • (2008) Cell , vol.132 , pp. 567-582
    • Jaenisch, R.1    Young, R.2
  • 33
    • 33645381936 scopus 로고    scopus 로고
    • The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells
    • Loh, Y. H. et al. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat. Genet. 38, 431-440 (2006).
    • (2006) Nat. Genet. , vol.38 , pp. 431-440
    • Loh, Y.H.1
  • 34
    • 34249880066 scopus 로고    scopus 로고
    • Generation of germline-competent induced pluripotent stem cells
    • Okita, K., Ichisaka, T. & Yamanaka, S. Generation of germline-competent induced pluripotent stem cells. Nature 448, 313-317 (2007).
    • (2007) Nature , vol.448 , pp. 313-317
    • Okita, K.1    Ichisaka, T.2    Yamanaka, S.3
  • 35
    • 84858341630 scopus 로고    scopus 로고
    • Sox2 expression in breast tumours and activation in breast cancer stem cells
    • Leis, O. et al. Sox2 expression in breast tumours and activation in breast cancer stem cells. Oncogene 31, 1354-1365 (2012).
    • (2012) Oncogene , vol.31 , pp. 1354-1365
    • Leis, O.1
  • 36
    • 21344454219 scopus 로고    scopus 로고
    • Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties
    • Ponti, D. et al. Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res. 65, 5506-5511 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 5506-5511
    • Ponti, D.1
  • 37
    • 84870800355 scopus 로고    scopus 로고
    • Delineation of breast cancer cell hierarchy identifies the subset responsible for dormancy
    • Patel, S. A. et al. Delineation of breast cancer cell hierarchy identifies the subset responsible for dormancy. Sci. Rep. 2, 906 (2012).
    • (2012) Sci. Rep. , vol.2 , pp. 906
    • Patel, S.A.1
  • 38
    • 48949119473 scopus 로고    scopus 로고
    • Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy
    • Fillmore, C. M. & Kuperwasser, C. Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy. Breast Cancer Res. 10, R25 (2008).
    • (2008) Breast Cancer Res. , vol.10 , pp. R25
    • Fillmore, C.M.1    Kuperwasser, C.2
  • 39
    • 34247188473 scopus 로고    scopus 로고
    • Telomere and telomerase in stem cells
    • Hiyama, E. & Hiyama, K. Telomere and telomerase in stem cells. Br. J. Cancer 96, 1020-1024 (2007).
    • (2007) Br. J. Cancer , vol.96 , pp. 1020-1024
    • Hiyama, E.1    Hiyama, K.2
  • 40
    • 84874730918 scopus 로고    scopus 로고
    • Intestinal label-retaining cells are secretory precursors expressing Lgr5
    • Buczacki, S. J. et al. Intestinal label-retaining cells are secretory precursors expressing Lgr5. Nature 495, 65-69 (2013).
    • (2013) Nature , vol.495 , pp. 65-69
    • Buczacki, S.J.1
  • 41
    • 84887024828 scopus 로고    scopus 로고
    • PAF-mediated MAPK signaling hyperactivation via LAMTOR3 induces pancreatic tumorigenesis
    • Jun, S. et al. PAF-mediated MAPK signaling hyperactivation via LAMTOR3 induces pancreatic tumorigenesis. Cell Rep. 5, 314-322 (2013).
    • (2013) Cell Rep. , vol.5 , pp. 314-322
    • Jun, S.1
  • 42
    • 0033895709 scopus 로고    scopus 로고
    • Wnt signaling and cancer
    • Polakis, P. Wnt signaling and cancer. Genes Dev. 14, 1837-1851 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 1837-1851
    • Polakis, P.1
  • 43
    • 84861986053 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling and disease
    • Clevers, H. & Nusse, R. Wnt/beta-catenin signaling and disease. Cell 149, 1192-1205 (2012).
    • (2012) Cell , vol.149 , pp. 1192-1205
    • Clevers, H.1    Nusse, R.2
  • 44
    • 0024162530 scopus 로고
    • Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice
    • Tsukamoto, A. S., Grosschedl, R., Guzman, R. C., Parslow, T. & Varmus, H. E. Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice. Cell 55, 619-625 (1988).
    • (1988) Cell , vol.55 , pp. 619-625
    • Tsukamoto, A.S.1    Grosschedl, R.2    Guzman, R.C.3    Parslow, T.4    Varmus, H.E.5
  • 45
    • 33744938180 scopus 로고    scopus 로고
    • Quantitative in situ analysis of beta-catenin expression in breast cancer shows decreased expression is associated with poor outcome
    • Dolled-Filhart, M. et al. Quantitative in situ analysis of beta-catenin expression in breast cancer shows decreased expression is associated with poor outcome. Cancer Res. 66, 5487-5494 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 5487-5494
    • Dolled-Filhart, M.1
  • 46
    • 0034636153 scopus 로고    scopus 로고
    • Beta-catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression
    • Lin, S. Y. et al. Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. Proc. Natl Acad. Sci. USA 97, 4262-4266 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 4262-4266
    • Lin, S.Y.1
  • 47
    • 77953183234 scopus 로고    scopus 로고
    • Wnt/beta-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome
    • Khramtsov, A. I. et al. Wnt/beta-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome. Am. J. Pathol. 176, 2911-2920 (2010).
    • (2010) Am. J. Pathol. , vol.176 , pp. 2911-2920
    • Khramtsov, A.I.1
  • 48
    • 79551624262 scopus 로고    scopus 로고
    • Beta-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation
    • Geyer, F. C. et al. beta-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation. Mod. Pathol. 24, 209-231 (2011).
    • (2011) Mod. Pathol. , vol.24 , pp. 209-231
    • Geyer, F.C.1
  • 49
    • 48249155834 scopus 로고    scopus 로고
    • Genetic changes of Wnt pathway genes are common events in metaplastic carcinomas of the breast
    • Hayes, M. J., Thomas, D., Emmons, A., Giordano, T. J. & Kleer, C. G. Genetic changes of Wnt pathway genes are common events in metaplastic carcinomas of the breast. Clin. Cancer Res. 14, 4038-4044 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , pp. 4038-4044
    • Hayes, M.J.1    Thomas, D.2    Emmons, A.3    Giordano, T.J.4    Kleer, C.G.5
  • 50
    • 63649147784 scopus 로고    scopus 로고
    • Dysregulation of Hedgehog, Wnt and Notch signalling pathways in breast cancer
    • Zardawi, S. J., O'Toole, S. A., Sutherland, R. L. & Musgrove, E. A. Dysregulation of Hedgehog, Wnt and Notch signalling pathways in breast cancer. Histol. Histopathol. 24, 385-398 (2009).
    • (2009) Histol. Histopathol , vol.24 , pp. 385-398
    • Zardawi, S.J.1    O'Toole, S.A.2    Sutherland, R.L.3    Musgrove, E.A.4
  • 51
    • 0033545845 scopus 로고    scopus 로고
    • The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway
    • Shtutman, M. et al. The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc. Natl Acad. Sci. USA 96, 5522-5527 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 5522-5527
    • Shtutman, M.1
  • 52
    • 1642570244 scopus 로고    scopus 로고
    • The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells
    • Liu, B. Y., McDermott, S. P., Khwaja, S. S. & Alexander, C. M. The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells. Proc. Natl Acad. Sci. USA 101, 4158-4163 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 4158-4163
    • Liu, B.Y.1    McDermott, S.P.2    Khwaja, S.S.3    Alexander, C.M.4
  • 53
    • 84884137085 scopus 로고    scopus 로고
    • A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway
    • Kessenbrock, K. et al. A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway. Cell Stem Cell 13, 300-313 (2013).
    • (2013) Cell Stem Cell , vol.13 , pp. 300-313
    • Kessenbrock, K.1
  • 54
    • 77956628008 scopus 로고    scopus 로고
    • Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture
    • Zeng, Y. A. & Nusse, R. Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture. Cell Stem Cell 6, 568-577 (2010).
    • (2010) Cell Stem Cell , vol.6 , pp. 568-577
    • Zeng, Y.A.1    Nusse, R.2
  • 55
    • 77950287628 scopus 로고    scopus 로고
    • The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML
    • Wang, Y. et al. The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. Science 327, 1650-1653 (2010).
    • (2010) Science , vol.327 , pp. 1650-1653
    • Wang, Y.1
  • 56
    • 0036733656 scopus 로고    scopus 로고
    • Pathway pathology: Histological differences between ErbB/Ras and Wnt pathway transgenic mammary tumors
    • Rosner, A. et al. Pathway pathology: histological differences between ErbB/Ras and Wnt pathway transgenic mammary tumors. Am. J. Pathol. 161, 1087-1097 (2002).
    • (2002) Am. J. Pathol. , vol.161 , pp. 1087-1097
    • Rosner, A.1
  • 57
    • 84866114887 scopus 로고    scopus 로고
    • Developmental stage and time dictate the fate of Wnt/beta-catenin-responsive stem cells in the mammary gland
    • van Amerongen, R., Bowman, A. N. & Nusse, R. Developmental stage and time dictate the fate of Wnt/beta-catenin-responsive stem cells in the mammary gland. Cell Stem Cell 11, 387-400 (2012).
    • (2012) Cell Stem Cell , vol.11 , pp. 387-400
    • Van Amerongen, R.1    Bowman, A.N.2    Nusse, R.3
  • 58
    • 54249151684 scopus 로고    scopus 로고
    • Hypoxia enhances tumor stemness by increasing the invasive and tumorigenic side population fraction
    • Das, B. et al. Hypoxia enhances tumor stemness by increasing the invasive and tumorigenic side population fraction. Stem Cells 26, 1818-1830 (2008).
    • (2008) Stem Cells , vol.26 , pp. 1818-1830
    • Das, B.1
  • 59
    • 70350778443 scopus 로고    scopus 로고
    • An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation
    • Iliopoulos, D., Hirsch, H. A. & Struhl, K. An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell 139, 693-706 (2009).
    • (2009) Cell , vol.139 , pp. 693-706
    • Iliopoulos, D.1    Hirsch, H.A.2    Struhl, K.3
  • 60
    • 79956351015 scopus 로고    scopus 로고
    • Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state
    • Chaffer, C. L. et al. Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state. Proc. Natl Acad. Sci. USA 108, 7950-7955 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 7950-7955
    • Chaffer, C.L.1
  • 61
    • 34247603906 scopus 로고    scopus 로고
    • Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase
    • Mortlock, A. A. et al. Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase. J. Med. Chem. 50, 2213-2224 (2007).
    • (2007) J. Med. Chem. , vol.50 , pp. 2213-2224
    • Mortlock, A.A.1
  • 62
    • 44349168457 scopus 로고    scopus 로고
    • Enhancement of radiation response in p53-deficient cancer cells by the Aurora-B kinase inhibitor AZD1152
    • Tao, Y. et al. Enhancement of radiation response in p53-deficient cancer cells by the Aurora-B kinase inhibitor AZD1152. Oncogene 27, 3244-3255 (2008).
    • (2008) Oncogene , vol.27 , pp. 3244-3255
    • Tao, Y.1
  • 63
    • 79952282257 scopus 로고    scopus 로고
    • Aurora B kinase inhibitor AZD1152: Determinants of action and ability to enhance chemotherapeutics effectiveness in pancreatic and colon cancer
    • Azzariti, A. et al. Aurora B kinase inhibitor AZD1152: determinants of action and ability to enhance chemotherapeutics effectiveness in pancreatic and colon cancer. Br. J. Cancer 104, 769-780 (2011).
    • (2011) Br. J. Cancer , vol.104 , pp. 769-780
    • Azzariti, A.1
  • 64
    • 1842450527 scopus 로고    scopus 로고
    • Identification of compounds with nanomolar binding affinity for checkpoint kinase-1 using knowledge-based virtual screening
    • Lyne, P. D. et al. Identification of compounds with nanomolar binding affinity for checkpoint kinase-1 using knowledge-based virtual screening. J. Med. Chem. 47, 1962-1968 (2004).
    • (2004) J. Med. Chem. , vol.47 , pp. 1962-1968
    • Lyne, P.D.1
  • 65
    • 52949139387 scopus 로고    scopus 로고
    • AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies
    • Zabludoff, S. D. et al. AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies. Mol. Cancer Ther. 7, 2955-2966 (2008).
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 2955-2966
    • Zabludoff, S.D.1
  • 66
    • 77950650401 scopus 로고    scopus 로고
    • In vitro and in vivo radiation sensitization of human tumor cells by a novel checkpoint kinase inhibitor, AZD7762
    • Mitchell, J. B. et al. In vitro and in vivo radiation sensitization of human tumor cells by a novel checkpoint kinase inhibitor, AZD7762. Clin. Cancer Res. 16, 2076-2084 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , pp. 2076-2084
    • Mitchell, J.B.1
  • 67
    • 48949119477 scopus 로고    scopus 로고
    • NVP-AUY922: A small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models
    • Jensen, M. R. et al. NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models. Breast Cancer Res. 10, R33 (2008).
    • (2008) Breast Cancer Res. , vol.10 , pp. R33
    • Jensen, M.R.1
  • 68
    • 80054834594 scopus 로고    scopus 로고
    • The Paf oncogene is essential for hematopoietic stem cell function and development
    • Amrani, Y. M. et al. The Paf oncogene is essential for hematopoietic stem cell function and development. J. Exp. Med. 208, 1757-1765 (2011).
    • (2011) J. Exp. Med. , vol.208 , pp. 1757-1765
    • Amrani, Y.M.1
  • 69
    • 79151483638 scopus 로고    scopus 로고
    • An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients
    • Gyorffy, B. et al. An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients. Breast Cancer Res. Treat. 123, 725-731 (2010).
    • (2010) Breast Cancer Res. Treat , vol.123 , pp. 725-731
    • Gyorffy, B.1


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