-
1
-
-
0035182533
-
Stem and progenitor cells: Origins, phenotypes, lineage commitments, and transdifferentiations
-
Weissman, I. L., Anderson, D. J. & Gage, F. Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. Annu. Rev. Cell Dev. Biol. 17, 387-403 (2001).
-
(2001)
Annu. Rev. Cell Dev. Biol.
, vol.17
, pp. 387-403
-
-
Weissman, I.L.1
Anderson, D.J.2
Gage, F.3
-
2
-
-
22044450950
-
Bone marrow stromal cells generate muscle cells and repair muscle degeneration
-
Dezawa, M. et al. Bone marrow stromal cells generate muscle cells and repair muscle degeneration. Science 309, 314-317 (2005).
-
(2005)
Science
, vol.309
, pp. 314-317
-
-
Dezawa, M.1
-
3
-
-
0033406436
-
Hematopoietic potential of stem cells isolated from murine skeletal muscle
-
Jackson, K. A., Mi, T. & Goodell, M. A. Hematopoietic potential of stem cells isolated from murine skeletal muscle. Proc. Natl Acad. Sci. USA 96, 14482-14486 (1999).
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 14482-14486
-
-
Jackson, K.A.1
Mi, T.2
Goodell, M.A.3
-
4
-
-
34848853915
-
Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors
-
Cobaleda, C., Jochum, W. & Busslinger, M. Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors. Nature 449, 473-477 (2007).
-
(2007)
Nature
, vol.449
, pp. 473-477
-
-
Cobaleda, C.1
Jochum, W.2
Busslinger, M.3
-
5
-
-
0037099497
-
Transcription factor-mediated lineage switching reveals plasticity in primary committed progenitor cells
-
Heyworth, C., Pearson, S., May, G. & Enver, T. Transcription factor-mediated lineage switching reveals plasticity in primary committed progenitor cells. EMBO J. 21, 3770-3781 (2002).
-
(2002)
EMBO J
, vol.21
, pp. 3770-3781
-
-
Heyworth, C.1
Pearson, S.2
May, G.3
Enver, T.4
-
6
-
-
80051674431
-
Direct generation of functional dopaminergic neurons from mouse and human fibroblasts
-
Caiazzo, M. et al. Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature 476, 224-227 (2011).
-
(2011)
Nature
, vol.476
, pp. 224-227
-
-
Caiazzo, M.1
-
7
-
-
79960854285
-
Induction of human neuronal cells by defined transcription factors
-
Pang, Z. P. et al. Induction of human neuronal cells by defined transcription factors. Nature 476, 220-223 (2011).
-
(2011)
Nature
, vol.476
, pp. 220-223
-
-
Pang, Z.P.1
-
8
-
-
79960649307
-
Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors
-
Sekiya, S. & Suzuki, A. Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors. Nature 475, 390-393 (2011).
-
(2011)
Nature
, vol.475
, pp. 390-393
-
-
Sekiya, S.1
Suzuki, A.2
-
9
-
-
2342510386
-
Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
-
Dor, Y., Brown, J., Martinez, O. I. & Melton, D. A. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429, 41-46 (2004).
-
(2004)
Nature
, vol.429
, pp. 41-46
-
-
Dor, Y.1
Brown, J.2
Martinez, O.I.3
Melton, D.A.4
-
10
-
-
77951611220
-
Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss
-
Thorel, F. et al. Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature 464, 1149-1154 (2010).
-
(2010)
Nature
, vol.464
, pp. 1149-1154
-
-
Thorel, F.1
-
11
-
-
53349178722
-
In vivo reprogramming of adult pancreatic exocrine cells to beta-cells
-
Zhou, Q., Brown, J., Kanarek, A., Rajagopal, J. & Melton, D. A. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 455, 627-632 (2008).
-
(2008)
Nature
, vol.455
, pp. 627-632
-
-
Zhou, Q.1
Brown, J.2
Kanarek, A.3
Rajagopal, J.4
Melton, D.A.5
-
12
-
-
16844368698
-
Tumour stem cells and drug resistance
-
Dean, M., Fojo, T. & Bates, S. Tumour stem cells and drug resistance. Nat. Rev. Cancer 5, 275-284 (2005).
-
(2005)
Nat. Rev. Cancer
, vol.5
, pp. 275-284
-
-
Dean, M.1
Fojo, T.2
Bates, S.3
-
13
-
-
52549087785
-
Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions
-
Visvader, J. E. & Lindeman, G. J. Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat. Rev. Cancer 8, 755-768 (2008).
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 755-768
-
-
Visvader, J.E.1
Lindeman, G.J.2
-
14
-
-
84858608410
-
Cancer stem cells: Impact, heterogeneity, and uncertainty
-
Magee, J. A., Piskounova, E. & Morrison, S. J. Cancer stem cells: impact, heterogeneity, and uncertainty. Cancer Cell 21, 283-296 (2012).
-
(2012)
Cancer Cell
, vol.21
, pp. 283-296
-
-
Magee, J.A.1
Piskounova, E.2
Morrison, S.J.3
-
15
-
-
0035945643
-
P15(PAF), a novel PCNA associated factor with increased expression in tumor tissues
-
Yu, P. et al. p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues. Oncogene 20, 484-489 (2001).
-
(2001)
Oncogene
, vol.20
, pp. 484-489
-
-
Yu, P.1
-
16
-
-
84867101049
-
Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass
-
Povlsen, L. K. et al. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Nat. Cell Biol. 14, 1089-1098 (2012).
-
(2012)
Nat. Cell Biol.
, vol.14
, pp. 1089-1098
-
-
Povlsen, L.K.1
-
17
-
-
84886310917
-
PAF and EZH2 induce Wnt/beta-catenin signaling hyperactivation
-
Jung, H. Y. et al. PAF and EZH2 induce Wnt/beta-catenin signaling hyperactivation. Mol. Cell 52, 193-205 (2013).
-
(2013)
Mol. Cell
, vol.52
, pp. 193-205
-
-
Jung, H.Y.1
-
18
-
-
0032816001
-
Multiple functions of human papillomavirus type 16 E6 contribute to the immortalization of mammary epithelial cells
-
Liu, Y. et al. Multiple functions of human papillomavirus type 16 E6 contribute to the immortalization of mammary epithelial cells. J. Virol. 73, 7297-7307 (1999).
-
(1999)
J. Virol.
, vol.73
, pp. 7297-7307
-
-
Liu, Y.1
-
19
-
-
84887024828
-
PAF-mediated MAPK signaling hyperactivation via LAMTOR3 induces pancreatic tumorigenesis
-
Jun, S. et al. PAF-mediated MAPK signaling hyperactivation via LAMTOR3 induces pancreatic tumorigenesis. Cell Rep. 5, 314-322 (2013).
-
(2013)
Cell Rep.
, vol.5
, pp. 314-322
-
-
Jun, S.1
-
20
-
-
0032912720
-
Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway
-
Wielenga, V. J. et al. Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway. Am. J. Pathol. 154, 515-523 (1999).
-
(1999)
Am. J. Pathol.
, vol.154
, pp. 515-523
-
-
Wielenga, V.J.1
-
21
-
-
0035177216
-
Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells
-
Elenbaas, B. et al. Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. Genes Dev. 15, 50-65 (2001).
-
(2001)
Genes Dev.
, vol.15
, pp. 50-65
-
-
Elenbaas, B.1
-
22
-
-
0037388204
-
Prospective identification of tumorigenic breast cancer cells
-
Al-Hajj, M., Wicha, M. S., Benito-Hernandez, A., Morrison, S. J. & Clarke, M. F. Prospective identification of tumorigenic breast cancer cells. Proc. Natl Acad. Sci. USA 100, 3983-3988 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 3983-3988
-
-
Al-Hajj, M.1
Wicha, M.S.2
Benito-Hernandez, A.3
Morrison, S.J.4
Clarke, M.F.5
-
23
-
-
0025023538
-
Human papilloma virus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirements
-
Band, V., Zajchowski, D., Kulesa, V. & Sager, R. Human papilloma virus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirements. Proc. Natl Acad. Sci. USA 87, 463-467 (1990).
-
(1990)
Proc. Natl Acad. Sci. USA
, vol.87
, pp. 463-467
-
-
Band, V.1
Zajchowski, D.2
Kulesa, V.3
Sager, R.4
-
24
-
-
35848955428
-
ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
-
Ginestier, C. et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 1, 555-567 (2007).
-
(2007)
Cell Stem Cell
, vol.1
, pp. 555-567
-
-
Ginestier, C.1
-
25
-
-
80051967505
-
Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
-
Gupta, P. B. et al. Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell 146, 633-644 (2011).
-
(2011)
Cell
, vol.146
, pp. 633-644
-
-
Gupta, P.B.1
-
26
-
-
0036149985
-
Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors
-
Lustig, B. et al. Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol. Cell. Biol. 22, 1184-1193 (2002).
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 1184-1193
-
-
Lustig, B.1
-
27
-
-
79955046668
-
An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway
-
Gonsalves, F. C. et al. An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. Proc. Natl Acad. Sci. USA 108, 5954-5963 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 5954-5963
-
-
Gonsalves, F.C.1
-
28
-
-
0032801892
-
Neoplastic transformation of RK3E by mutant beta-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression
-
Kolligs, F. T., Hu, G., Dang, C. V. & Fearon, E. R. Neoplastic transformation of RK3E by mutant beta-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression. Mol. Cell. Biol. 19, 5696-5706 (1999).
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 5696-5706
-
-
Kolligs, F.T.1
Hu, G.2
Dang, C.V.3
Fearon, E.R.4
-
29
-
-
0032483439
-
Identification of c-MYC as a target of the APC pathway
-
He, T. C. et al. Identification of c-MYC as a target of the APC pathway. Science 281, 1509-1512 (1998).
-
(1998)
Science
, vol.281
, pp. 1509-1512
-
-
He, T.C.1
-
30
-
-
41449118521
-
Module map of stem cell genes guides creation of epithelial cancer stem cells
-
Wong, D. J. et al. Module map of stem cell genes guides creation of epithelial cancer stem cells. Cell Stem Cell 2, 333-344 (2008).
-
(2008)
Cell Stem Cell
, vol.2
, pp. 333-344
-
-
Wong, D.J.1
-
31
-
-
43049165453
-
The epithelial-mesenchymal transition generates cells with properties of stem cells
-
Mani, S. A. et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133, 704-715 (2008).
-
(2008)
Cell
, vol.133
, pp. 704-715
-
-
Mani, S.A.1
-
32
-
-
39149130361
-
Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming
-
Jaenisch, R. & Young, R. Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell 132, 567-582 (2008).
-
(2008)
Cell
, vol.132
, pp. 567-582
-
-
Jaenisch, R.1
Young, R.2
-
33
-
-
33645381936
-
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells
-
Loh, Y. H. et al. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat. Genet. 38, 431-440 (2006).
-
(2006)
Nat. Genet.
, vol.38
, pp. 431-440
-
-
Loh, Y.H.1
-
34
-
-
34249880066
-
Generation of germline-competent induced pluripotent stem cells
-
Okita, K., Ichisaka, T. & Yamanaka, S. Generation of germline-competent induced pluripotent stem cells. Nature 448, 313-317 (2007).
-
(2007)
Nature
, vol.448
, pp. 313-317
-
-
Okita, K.1
Ichisaka, T.2
Yamanaka, S.3
-
35
-
-
84858341630
-
Sox2 expression in breast tumours and activation in breast cancer stem cells
-
Leis, O. et al. Sox2 expression in breast tumours and activation in breast cancer stem cells. Oncogene 31, 1354-1365 (2012).
-
(2012)
Oncogene
, vol.31
, pp. 1354-1365
-
-
Leis, O.1
-
36
-
-
21344454219
-
Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties
-
Ponti, D. et al. Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res. 65, 5506-5511 (2005).
-
(2005)
Cancer Res.
, vol.65
, pp. 5506-5511
-
-
Ponti, D.1
-
37
-
-
84870800355
-
Delineation of breast cancer cell hierarchy identifies the subset responsible for dormancy
-
Patel, S. A. et al. Delineation of breast cancer cell hierarchy identifies the subset responsible for dormancy. Sci. Rep. 2, 906 (2012).
-
(2012)
Sci. Rep.
, vol.2
, pp. 906
-
-
Patel, S.A.1
-
38
-
-
48949119473
-
Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy
-
Fillmore, C. M. & Kuperwasser, C. Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy. Breast Cancer Res. 10, R25 (2008).
-
(2008)
Breast Cancer Res.
, vol.10
, pp. R25
-
-
Fillmore, C.M.1
Kuperwasser, C.2
-
39
-
-
34247188473
-
Telomere and telomerase in stem cells
-
Hiyama, E. & Hiyama, K. Telomere and telomerase in stem cells. Br. J. Cancer 96, 1020-1024 (2007).
-
(2007)
Br. J. Cancer
, vol.96
, pp. 1020-1024
-
-
Hiyama, E.1
Hiyama, K.2
-
40
-
-
84874730918
-
Intestinal label-retaining cells are secretory precursors expressing Lgr5
-
Buczacki, S. J. et al. Intestinal label-retaining cells are secretory precursors expressing Lgr5. Nature 495, 65-69 (2013).
-
(2013)
Nature
, vol.495
, pp. 65-69
-
-
Buczacki, S.J.1
-
41
-
-
84887024828
-
PAF-mediated MAPK signaling hyperactivation via LAMTOR3 induces pancreatic tumorigenesis
-
Jun, S. et al. PAF-mediated MAPK signaling hyperactivation via LAMTOR3 induces pancreatic tumorigenesis. Cell Rep. 5, 314-322 (2013).
-
(2013)
Cell Rep.
, vol.5
, pp. 314-322
-
-
Jun, S.1
-
42
-
-
0033895709
-
Wnt signaling and cancer
-
Polakis, P. Wnt signaling and cancer. Genes Dev. 14, 1837-1851 (2000).
-
(2000)
Genes Dev.
, vol.14
, pp. 1837-1851
-
-
Polakis, P.1
-
43
-
-
84861986053
-
Wnt/beta-catenin signaling and disease
-
Clevers, H. & Nusse, R. Wnt/beta-catenin signaling and disease. Cell 149, 1192-1205 (2012).
-
(2012)
Cell
, vol.149
, pp. 1192-1205
-
-
Clevers, H.1
Nusse, R.2
-
44
-
-
0024162530
-
Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice
-
Tsukamoto, A. S., Grosschedl, R., Guzman, R. C., Parslow, T. & Varmus, H. E. Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice. Cell 55, 619-625 (1988).
-
(1988)
Cell
, vol.55
, pp. 619-625
-
-
Tsukamoto, A.S.1
Grosschedl, R.2
Guzman, R.C.3
Parslow, T.4
Varmus, H.E.5
-
45
-
-
33744938180
-
Quantitative in situ analysis of beta-catenin expression in breast cancer shows decreased expression is associated with poor outcome
-
Dolled-Filhart, M. et al. Quantitative in situ analysis of beta-catenin expression in breast cancer shows decreased expression is associated with poor outcome. Cancer Res. 66, 5487-5494 (2006).
-
(2006)
Cancer Res.
, vol.66
, pp. 5487-5494
-
-
Dolled-Filhart, M.1
-
46
-
-
0034636153
-
Beta-catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression
-
Lin, S. Y. et al. Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. Proc. Natl Acad. Sci. USA 97, 4262-4266 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 4262-4266
-
-
Lin, S.Y.1
-
47
-
-
77953183234
-
Wnt/beta-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome
-
Khramtsov, A. I. et al. Wnt/beta-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome. Am. J. Pathol. 176, 2911-2920 (2010).
-
(2010)
Am. J. Pathol.
, vol.176
, pp. 2911-2920
-
-
Khramtsov, A.I.1
-
48
-
-
79551624262
-
Beta-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation
-
Geyer, F. C. et al. beta-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation. Mod. Pathol. 24, 209-231 (2011).
-
(2011)
Mod. Pathol.
, vol.24
, pp. 209-231
-
-
Geyer, F.C.1
-
49
-
-
48249155834
-
Genetic changes of Wnt pathway genes are common events in metaplastic carcinomas of the breast
-
Hayes, M. J., Thomas, D., Emmons, A., Giordano, T. J. & Kleer, C. G. Genetic changes of Wnt pathway genes are common events in metaplastic carcinomas of the breast. Clin. Cancer Res. 14, 4038-4044 (2008).
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 4038-4044
-
-
Hayes, M.J.1
Thomas, D.2
Emmons, A.3
Giordano, T.J.4
Kleer, C.G.5
-
50
-
-
63649147784
-
Dysregulation of Hedgehog, Wnt and Notch signalling pathways in breast cancer
-
Zardawi, S. J., O'Toole, S. A., Sutherland, R. L. & Musgrove, E. A. Dysregulation of Hedgehog, Wnt and Notch signalling pathways in breast cancer. Histol. Histopathol. 24, 385-398 (2009).
-
(2009)
Histol. Histopathol
, vol.24
, pp. 385-398
-
-
Zardawi, S.J.1
O'Toole, S.A.2
Sutherland, R.L.3
Musgrove, E.A.4
-
51
-
-
0033545845
-
The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway
-
Shtutman, M. et al. The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc. Natl Acad. Sci. USA 96, 5522-5527 (1999).
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 5522-5527
-
-
Shtutman, M.1
-
52
-
-
1642570244
-
The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells
-
Liu, B. Y., McDermott, S. P., Khwaja, S. S. & Alexander, C. M. The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells. Proc. Natl Acad. Sci. USA 101, 4158-4163 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 4158-4163
-
-
Liu, B.Y.1
McDermott, S.P.2
Khwaja, S.S.3
Alexander, C.M.4
-
53
-
-
84884137085
-
A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway
-
Kessenbrock, K. et al. A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway. Cell Stem Cell 13, 300-313 (2013).
-
(2013)
Cell Stem Cell
, vol.13
, pp. 300-313
-
-
Kessenbrock, K.1
-
54
-
-
77956628008
-
Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture
-
Zeng, Y. A. & Nusse, R. Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture. Cell Stem Cell 6, 568-577 (2010).
-
(2010)
Cell Stem Cell
, vol.6
, pp. 568-577
-
-
Zeng, Y.A.1
Nusse, R.2
-
55
-
-
77950287628
-
The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML
-
Wang, Y. et al. The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. Science 327, 1650-1653 (2010).
-
(2010)
Science
, vol.327
, pp. 1650-1653
-
-
Wang, Y.1
-
56
-
-
0036733656
-
Pathway pathology: Histological differences between ErbB/Ras and Wnt pathway transgenic mammary tumors
-
Rosner, A. et al. Pathway pathology: histological differences between ErbB/Ras and Wnt pathway transgenic mammary tumors. Am. J. Pathol. 161, 1087-1097 (2002).
-
(2002)
Am. J. Pathol.
, vol.161
, pp. 1087-1097
-
-
Rosner, A.1
-
57
-
-
84866114887
-
Developmental stage and time dictate the fate of Wnt/beta-catenin-responsive stem cells in the mammary gland
-
van Amerongen, R., Bowman, A. N. & Nusse, R. Developmental stage and time dictate the fate of Wnt/beta-catenin-responsive stem cells in the mammary gland. Cell Stem Cell 11, 387-400 (2012).
-
(2012)
Cell Stem Cell
, vol.11
, pp. 387-400
-
-
Van Amerongen, R.1
Bowman, A.N.2
Nusse, R.3
-
58
-
-
54249151684
-
Hypoxia enhances tumor stemness by increasing the invasive and tumorigenic side population fraction
-
Das, B. et al. Hypoxia enhances tumor stemness by increasing the invasive and tumorigenic side population fraction. Stem Cells 26, 1818-1830 (2008).
-
(2008)
Stem Cells
, vol.26
, pp. 1818-1830
-
-
Das, B.1
-
59
-
-
70350778443
-
An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation
-
Iliopoulos, D., Hirsch, H. A. & Struhl, K. An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell 139, 693-706 (2009).
-
(2009)
Cell
, vol.139
, pp. 693-706
-
-
Iliopoulos, D.1
Hirsch, H.A.2
Struhl, K.3
-
60
-
-
79956351015
-
Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state
-
Chaffer, C. L. et al. Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state. Proc. Natl Acad. Sci. USA 108, 7950-7955 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 7950-7955
-
-
Chaffer, C.L.1
-
61
-
-
34247603906
-
Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase
-
Mortlock, A. A. et al. Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase. J. Med. Chem. 50, 2213-2224 (2007).
-
(2007)
J. Med. Chem.
, vol.50
, pp. 2213-2224
-
-
Mortlock, A.A.1
-
62
-
-
44349168457
-
Enhancement of radiation response in p53-deficient cancer cells by the Aurora-B kinase inhibitor AZD1152
-
Tao, Y. et al. Enhancement of radiation response in p53-deficient cancer cells by the Aurora-B kinase inhibitor AZD1152. Oncogene 27, 3244-3255 (2008).
-
(2008)
Oncogene
, vol.27
, pp. 3244-3255
-
-
Tao, Y.1
-
63
-
-
79952282257
-
Aurora B kinase inhibitor AZD1152: Determinants of action and ability to enhance chemotherapeutics effectiveness in pancreatic and colon cancer
-
Azzariti, A. et al. Aurora B kinase inhibitor AZD1152: determinants of action and ability to enhance chemotherapeutics effectiveness in pancreatic and colon cancer. Br. J. Cancer 104, 769-780 (2011).
-
(2011)
Br. J. Cancer
, vol.104
, pp. 769-780
-
-
Azzariti, A.1
-
64
-
-
1842450527
-
Identification of compounds with nanomolar binding affinity for checkpoint kinase-1 using knowledge-based virtual screening
-
Lyne, P. D. et al. Identification of compounds with nanomolar binding affinity for checkpoint kinase-1 using knowledge-based virtual screening. J. Med. Chem. 47, 1962-1968 (2004).
-
(2004)
J. Med. Chem.
, vol.47
, pp. 1962-1968
-
-
Lyne, P.D.1
-
65
-
-
52949139387
-
AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies
-
Zabludoff, S. D. et al. AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies. Mol. Cancer Ther. 7, 2955-2966 (2008).
-
(2008)
Mol. Cancer Ther.
, vol.7
, pp. 2955-2966
-
-
Zabludoff, S.D.1
-
66
-
-
77950650401
-
In vitro and in vivo radiation sensitization of human tumor cells by a novel checkpoint kinase inhibitor, AZD7762
-
Mitchell, J. B. et al. In vitro and in vivo radiation sensitization of human tumor cells by a novel checkpoint kinase inhibitor, AZD7762. Clin. Cancer Res. 16, 2076-2084 (2010).
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 2076-2084
-
-
Mitchell, J.B.1
-
67
-
-
48949119477
-
NVP-AUY922: A small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models
-
Jensen, M. R. et al. NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models. Breast Cancer Res. 10, R33 (2008).
-
(2008)
Breast Cancer Res.
, vol.10
, pp. R33
-
-
Jensen, M.R.1
-
68
-
-
80054834594
-
The Paf oncogene is essential for hematopoietic stem cell function and development
-
Amrani, Y. M. et al. The Paf oncogene is essential for hematopoietic stem cell function and development. J. Exp. Med. 208, 1757-1765 (2011).
-
(2011)
J. Exp. Med.
, vol.208
, pp. 1757-1765
-
-
Amrani, Y.M.1
-
69
-
-
79151483638
-
An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients
-
Gyorffy, B. et al. An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients. Breast Cancer Res. Treat. 123, 725-731 (2010).
-
(2010)
Breast Cancer Res. Treat
, vol.123
, pp. 725-731
-
-
Gyorffy, B.1
|