The novel adipokine progranulin counteracts IL-1 and TLR4-driven inflammatory response in human and murine chondrocytes via TNFR1

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Abella, Vanessa ^a,b   Scotece, Morena ^a   Conde, Javier ^a   López, Verónica ^a   Pirozzi, Claudio ^a   Pino, Jesús ^a   Gómez, Rodolfo ^a   Lago, Francisca ^a   González Gay, Miguel Ángel ^a,c   Gualillo, Oreste ^a  

^a Instituto de Salud Carlos III   (Spain)

^b UNIVERSITY OF A CORUÑA   (Spain)

^c HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE 3; CYCLOOXYGENASE 2; GRN PROTEIN, HUMAN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; RECOMBINANT PROTEIN; SIGNAL PEPTIDE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR 1; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL; ANTAGONISTS AND INHIBITORS; ARTICULAR CARTILAGE; BIOSYNTHESIS; CELL DIFFERENTIATION; CELL LINE; CELL SURVIVAL; CHONDROCYTE; CYTOLOGY; DOWN REGULATION; DRUG EFFECTS; GENETICS; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; MOUSE; OSTEOARTHRITIS; PATHOLOGY; SYNOVIUM; UPREGULATION;

ANIMALS; CARTILAGE, ARTICULAR; CELL DIFFERENTIATION; CELL LINE; CELL SURVIVAL; CHONDROCYTES; CYCLOOXYGENASE 2; DOWN-REGULATION; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MATRIX METALLOPROTEINASE 13; MICE; OSTEOARTHRITIS; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RECOMBINANT PROTEINS; SYNOVIAL MEMBRANE; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84957559845     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep20356     Document Type: Article

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