Progranulin Knockout Accelerates Intervertebral Disc Degeneration in Aging Mice

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Zhao, Yun Peng ^a,b   Tian, Qing Yun ^a   Liu, Ben ^a   Cuellar, Jason ^a   Richbourgh, Brendon ^a   Jia, Tang Hong ^c   Liu, Chuan Ju ^a,d  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b SHANDONG UNIVERSITY   (China)

^c SHANDONG UNIVERSITY   (China)

^d NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; GRN PROTEIN, MOUSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SIGNAL PEPTIDE;

AGE; ANIMAL; BONE DEVELOPMENT; CARTILAGE; DEFICIENCY; DISEASE COURSE; DISEASE MODEL; GENE EXPRESSION; GENETIC ASSOCIATION STUDY; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISC DEGENERATION; INTERVERTEBRAL DISK; KNOCKOUT MOUSE; METABOLISM; MICRO-COMPUTED TOMOGRAPHY; MOUSE; OSTEOCLAST; OSTEOLYSIS; PATHOLOGY; SIGNAL TRANSDUCTION; SPINE;

AGE FACTORS; ANIMALS; BETA CATENIN; BONE RESORPTION; CARTILAGE; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; GENE EXPRESSION; GENETIC ASSOCIATION STUDIES; HUMANS; IMMUNOHISTOCHEMISTRY; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERVERTEBRAL DISC; INTERVERTEBRAL DISC DEGENERATION; MICE; MICE, KNOCKOUT; NF-KAPPA B; OSTEOCLASTS; OSTEOGENESIS; SIGNAL TRANSDUCTION; SPINE; X-RAY MICROTOMOGRAPHY;

EID: 84925237257     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep09102     Document Type: Article

References (46)

1. Cheung, K. M. The relationship between disc degeneration, low back pain, and human pain genetics. Spine J 10, 958-60 (2010).
2. Livshits, G. et al. Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the UK Twin Spine Study. Ann Rheum Dis 70, 1740-5 (2011).
3. Pye, S. R., Reid, D. M., Adams, J. E., Silman, A. J. & O'Neill, T. W. Radiographic features of lumbar disc degeneration and bone mineral density in men and women. Ann Rheum Dis 65, 234-8 (2006).
4. Liang, Q. Q. et al. Prolonged upright posture induces degenerative changes in intervertebral discs of rat cervical spine. Bone 48, 1362-9 (2011).
5. Yu, H. & Zhu, Y. Expression of ADAMTS-7 and ADAMTS-12 in the nucleus pulposus during degeneration of rat caudal intervetebral disc. J Vet Med Sci 74, 9-15 (2012).
6. Gruber, H. E. et al. Constitutive expression of cathepsin K in the human intervertebral disc: new insight into disc extracellular matrix remodeling via cathepsin K and receptor activator of nuclear factor-kappaB ligand. Arthritis research & therapy 13, R140 (2011).
7. He, Z., Ong, C. H., Halper, J. & Bateman, A. Progranulin is a mediator of the wound response. Nat Med 9, 225-9 (2003).
8. Roughley, P. J. Biology of intervertebral disc aging and degeneration: involvement of the extracellular matrix. Spine (Phila Pa 1976) 29, 2691-9 (2004).
9. Martens, L. H. et al. Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury. J Clin Invest 122, 3955-9 (2012).
10. Liu, C. J. Progranulin: a promising therapeutic target for rheumatoid arthritis. FEBS Lett 585, 3675-80.
11. Zhao, Y. P., Tian, Q. Y. & Liu, C. J. Progranulin deficiency exaggerates, whereas progranulin-derived Atsttrin attenuates, severity of dermatitis in mice. FEBS Lett 587, 1805-10 (2013).
12. Caroppo, P. et al. Extensive White Matter Involvement in Patients With Frontotemporal Lobar Degeneration: Think Progranulin. JAMA Neurol (2014) doi:10.1001/jamaneurol.2014.1316. [Epub ahead of print].
13. Wils, H. et al. Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice. J Pathol 228, 67-76 (2012).
14. Guo, F. et al. Granulin-epithelin precursor binds directly to ADAMTS-7 and ADAMTS-12 and inhibits their degradation of cartilage oligomeric matrix protein. Arthritis Rheum 62, 2023-36 (2010).
15. Xu, K. et al. Cartilage oligomeric matrix protein associates with granulin-epithelin precursor (GEP) and potentiates GEP-stimulated chondrocyte proliferation. J Biol Chem 282, 11347-55 (2007).
16. Bai, X. H. et al. ADAMTS-7, a direct target of PTHrP, adversely regulates endochondral bone growth by associating with and inactivating GEP growth factor. Mol Cell Biol 29, 4201-19 (2009).
17. Tang, W. et al. The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Science 332, 478-84 (2011).
18. Zhao, Y. P. et al. Progranulin protects against osteoarthritis through interacting with TNF-alpha and beta-Catenin signalling. Ann Rheum Dis (2014) doi:10.1136/annrheumdis-2014-205779. [Epub ahead of print].
19. Zhao, Y., Liu, B. & Liu, C. J. Establishment of a surgically-induced model in mice to investigate the protective role of progranulin in osteoarthritis. J Vis Exp, e50924 (2014).
20. Boos, N. et al. Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science. Spine (Phila Pa 1976) 27, 2631-44 (2002).
21. Tang, W. et al. The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice. Science 332, 478-484 (2011).
22. Wuertz, K. et al. The red wine polyphenol resveratrol shows promising potential for the treatment of nucleus pulposus-mediated pain in vitro and in vivo. Spine (Phila Pa 1976) 36, E1373-84 (2011).
23. Ellman, M. B. et al. Toll-like receptor adaptor signaling molecule MyD88 on intervertebral disk homeostasis: in vitro, ex vivo studies. Gene 505, 283-90 (2012).
24. Haynes, K. R. et al. Excessive bone formation in a mouse model of ankylosing spondylitis is associated with decreases in Wnt pathway inhibitors. Arthritis research & therapy 14, R253 (2012).
25. Alquezar, C. et al. PGRN haploinsufficiency increased Wnt5a signaling in peripheral cells from frontotemporal lobar degeneration-progranulin mutation carriers. Neurobiol Aging 35, 886-98 (2014).
26. Rosen, E. Y. et al. Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling. Neuron 71, 1030-42 (2011).
27. Romanello, M. et al. Osteoblastic cell secretome: A novel role for progranulin during risedronate treatment. Bone 58, 81-91 (2014).
28. Fukuta, S. et al. Abundance of calpain and aggrecan-cleavage products of calpain in degenerated human intervertebral discs. Osteoarthritis Cartilage 19, 1254-62 (2011).
29. Gu, S. X. et al. MicroRNA-146a reduces IL-1 dependent inflammatory responses in the intervertebral disc. Gene (2014) doi:10.1016/j.gene.2014.10.024. [Epub ahead of print].
30. McCann, M. R. et al. Acute vibration induces transient expression of anabolic genes in the murine intervertebral disc. Arthritis Rheum 65, 1853-64 (2013).
31. Illien-Junger, S. et al. Combined anti-inflammatory and anti-AGE drug treatments have a protective effect on intervertebral discs in mice with diabetes. PLoS One 8, e64302 (2013).
32. Liang, Q. Q. et al. The expression of osteoprotegerin is required for maintaining the intervertebral disc endplate of aged mice. Bone 48, 1362-9 (2011).
33. Lotz, M. & Loeser, R. F. Effects of aging on articular cartilage homeostasis. Bone 51, 241-8 (2012).
34. Urban, J. P., Smith, S. & Fairbank, J. C. Nutrition of the intervertebral disc. Spine (Phila Pa 1976) 29, 2700-9 (2004).
35. Holm, S., Holm, A. K., Ekstrom, L., Karladani, A. & Hansson, T. Experimental disc degeneration due to endplate injury. J Spinal Disord Tech 17, 64-71 (2004).
36. Keffer, J. et al. Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. Embo J 10, 4025-31 (1991).
37. Druce, K. L., Jones, G. T., Macfarlane, G. J. & Basu, N. Patients receiving anti-TNF therapies experience clinically important improvements in RA-related fatigue: results from the British Society of Rheumatology Biologics Register for Rheumatoid Arthritis. Rheumatology (Oxford) (2014) [Epub ahead of print].
38. Erwin, W. M. & Fehlings, M. G. Intervertebral disc degeneration: genes hold the key. World Neurosurg 80, e131-3 (2013).
39. Liu, H. et al. LIM mineralization protein-1 suppresses TNF-alpha induced intervertebral disc degeneration by maintaining nucleus pulposus extracellular matrix production and inhibiting matrix metalloproteinases expression. J Orthop Res (2014) doi:10.1002/jor.22732. [Epub ahead of print].
40. Sinclair, S. M. et al. Attenuation of inflammatory events in human intervertebral disc cells with a tumor necrosis factor antagonist. Spine (Phila Pa 1976) 36, 1190-6.
41. Tran, C. M. et al. CCN2 suppresses catabolic effects of interleukin-1beta through alpha5beta1 and alphaVbeta3 integrins in nucleus pulposus cells: implications in intervertebral disc degeneration. J Biol Chem 289, 7374-87 (2014).
42. Tian, Y. et al. Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-kappaB. Am J Pathol 182, 2310-21 (2013).
43. Wang, M. et al. Conditional activation of beta-catenin signaling in mice leads to severe defects in intervertebral disc tissue. Arthritis Rheum 64, 2611-23 (2012).
44. Jin, H. et al. TGF-beta signaling plays an essential role in the growth and maintenance of intervertebral disc tissue. FEBS letters 585, 1209-15 (2011).
45. Wang, M. et al. Conditional activation of beta-catenin signaling leads to severe defects in intervertebral disc tissue. Arthritis Rheum 64, 2611-23 (2012).
46. Zhang, Y. et al. Histological features of endplates of the mammalian spine: from mice to men. Spine 39, E312-7 (2014).