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Volumn 38, Issue 1, 2016, Pages 50-60

Prospects for adoptive immunotherapy of pancreatic cancer using chimeric antigen receptor-engineered T-cells

Author keywords

Chimeric antigen receptor; engineered T cell; pancreatic ductal adenocarcinoma; tumor infiltrating lymphocyte

Indexed keywords

CANCER VACCINE; CHIMERIC ANTIGEN RECEPTOR; CYCLOPHOSPHAMIDE; FLUDARABINE; GEMCITABINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR VACCINE; IPILIMUMAB; MESOTHELIN; METHYLPREDNISOLONE; MONOCLONAL ANTIBODY; PA 2024; PROSTATE STEM CELL ANTIGEN; SIPULEUCEL T; T LYMPHOCYTE RECEPTOR; TOCILIZUMAB; UNCLASSIFIED DRUG; LYMPHOCYTE ANTIGEN RECEPTOR;

EID: 84957441694     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.3109/08923973.2015.1100204     Document Type: Review
Times cited : (9)

References (134)
  • 1
    • 84893122015 scopus 로고    scopus 로고
    • Current developments, problems and solutions in the non-surgical treatment of pancreatic cancer
    • Guo XZ, Cui ZM, Liu X. Current developments, problems and solutions in the non-surgical treatment of pancreatic cancer. World J Gastrointest Oncol 2013; 5: 20-28
    • (2013) World J Gastrointest Oncol , vol.5 , pp. 20-28
    • Guo, X.Z.1    Cui, Z.M.2    Liu, X.3
  • 2
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
    • Burris HA III, Moore MJ, Andersen J, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 1997; 15: 2403-2413
    • (1997) J Clin Oncol , vol.15 , pp. 2403-2413
    • Burris, H.A.1    Moore, M.J.2    Andersen, J.3
  • 3
    • 77950838815 scopus 로고    scopus 로고
    • Metastatic pancreatic cancer: Is gemcitabine still the best standard treatment? (Review)
    • Di Marco M, Di Cicilia R, Macchini M, et al. Metastatic pancreatic cancer: is gemcitabine still the best standard treatment? (Review). Oncol Rep 2010; 23: 1183-1192
    • (2010) Oncol Rep , vol.23 , pp. 1183-1192
    • Di Marco, M.1    Di Cicilia, R.2    MacChini, M.3
  • 4
    • 79955921754 scopus 로고    scopus 로고
    • FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer
    • Conroy T, Desseigne F, Ychou M, et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med 2011; 364: 1817-1825
    • (2011) N Engl J Med , vol.364 , pp. 1817-1825
    • Conroy, T.1    Desseigne, F.2    Ychou, M.3
  • 5
    • 84886741654 scopus 로고    scopus 로고
    • Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine
    • Von Hoff DD, Ervin T, Arena FP, et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med 2013; 369: 1691-1703
    • (2013) N Engl J Med , vol.369 , pp. 1691-1703
    • Von Hoff, D.D.1    Ervin, T.2    Arena, F.P.3
  • 6
    • 85003053965 scopus 로고    scopus 로고
    • The current state of surgery for pancreatic cancer
    • Poruk KE, Weiss MJ. The current state of surgery for pancreatic cancer. Minerva Gastroenterol Dietol 2015; 61: 101-115
    • (2015) Minerva Gastroenterol Dietol , vol.61 , pp. 101-115
    • Poruk, K.E.1    Weiss, M.J.2
  • 7
    • 84902147062 scopus 로고    scopus 로고
    • Projecting cancer incidence and deaths to 2030: The unexpected burden of thyroid, liver, and pancreas cancers in the United States
    • Rahib L, Smith BD, Aizenberg R, et al. Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res 2014; 74: 2913-2921
    • (2014) Cancer Res , vol.74 , pp. 2913-2921
    • Rahib, L.1    Smith, B.D.2    Aizenberg, R.3
  • 9
    • 84909595006 scopus 로고    scopus 로고
    • Tumor antigen-specific monoclonal antibodies and induction of T-cell immunity
    • Trivedi S, Jie HB, Ferris RL. Tumor antigen-specific monoclonal antibodies and induction of T-cell immunity. Semin Oncol 2014; 41: 678-684
    • (2014) Semin Oncol , vol.41 , pp. 678-684
    • Trivedi, S.1    Jie, H.B.2    Ferris, R.L.3
  • 10
    • 84899112560 scopus 로고    scopus 로고
    • Trial Watch: Immunostimulatory monoclonal antibodies in cancer therapy
    • Aranda F, Vacchelli E, Eggermont A, et al. Trial Watch: immunostimulatory monoclonal antibodies in cancer therapy. Oncoimmunology 2014; 3: e27297
    • (2014) Oncoimmunology , vol.3 , pp. e27297
    • Aranda, F.1    Vacchelli, E.2    Eggermont, A.3
  • 12
    • 84946691816 scopus 로고    scopus 로고
    • Sipuleucel-T in the treatment of prostate cancer: An evidence-based review of its place in therapy
    • Graff JN, Chamberlain ED. Sipuleucel-T in the treatment of prostate cancer: an evidence-based review of its place in therapy. Core Evid 2015; 10: 1-10
    • (2015) Core Evid , vol.10 , pp. 1-10
    • Graff, J.N.1    Chamberlain, E.D.2
  • 13
    • 77955066199 scopus 로고    scopus 로고
    • Sipuleucel-T immunotherapy for castration-resistant prostate cancer
    • Kantoff PW, Higano CS, Shore ND, et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med 2010; 363: 411-422
    • (2010) N Engl J Med , vol.363 , pp. 411-422
    • Kantoff, P.W.1    Higano, C.S.2    Shore, N.D.3
  • 14
    • 84890147150 scopus 로고    scopus 로고
    • Exploiting the curative potential of adoptive T-cell therapy for cancer
    • Hinrichs CS, Rosenberg SA. Exploiting the curative potential of adoptive T-cell therapy for cancer. Immunol Rev 2014; 257: 56-71
    • (2014) Immunol Rev , vol.257 , pp. 56-71
    • Hinrichs, C.S.1    Rosenberg, S.A.2
  • 15
    • 84897400607 scopus 로고    scopus 로고
    • Clinical immunotherapy of B-cell malignancy using CD19-targeted CAR T-cells
    • Maher J. Clinical immunotherapy of B-cell malignancy using CD19-targeted CAR T-cells. Curr Gene Ther 2014; 14: 35-43
    • (2014) Curr Gene Ther , vol.14 , pp. 35-43
    • Maher, J.1
  • 17
    • 1842505346 scopus 로고    scopus 로고
    • CD8+ tumor-infiltrating lymphocytes together with CD4+ tumor-infiltrating lymphocytes and dendritic cells improve the prognosis of patients with pancreatic adenocarcinoma
    • Fukunaga A, Miyamoto M, Cho Y, et al. CD8+ tumor-infiltrating lymphocytes together with CD4+ tumor-infiltrating lymphocytes and dendritic cells improve the prognosis of patients with pancreatic adenocarcinoma. Pancreas 2004; 28: e26-e31
    • (2004) Pancreas , vol.28 , pp. e26-e31
    • Fukunaga, A.1    Miyamoto, M.2    Cho, Y.3
  • 18
    • 84855174106 scopus 로고    scopus 로고
    • T cells and adoptive immunotherapy: Recent developments and future prospects in gastrointestinal oncology
    • Amedei A, Niccolai E, D'Elios MM. T cells and adoptive immunotherapy: recent developments and future prospects in gastrointestinal oncology. Clin Dev Immunol 2011; 2011: 320571
    • (2011) Clin Dev Immunol , vol.2011 , pp. 320571
    • Amedei, A.1    Niccolai, E.2    D'Elios, M.M.3
  • 19
    • 27544506907 scopus 로고    scopus 로고
    • High frequencies of functional tumor-reactive T cells in bone marrow and blood of pancreatic cancer patients
    • Schmitz-Winnenthal FH, Volk C, Z'Graggen K, et al. High frequencies of functional tumor-reactive T cells in bone marrow and blood of pancreatic cancer patients. Cancer Res 2005; 65: 10079-10087
    • (2005) Cancer Res , vol.65 , pp. 10079-10087
    • Schmitz-Winnenthal, F.H.1    Volk, C.2    Z'Graggen, K.3
  • 20
    • 84900315697 scopus 로고    scopus 로고
    • Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia
    • McAllister F, Bailey JM, Alsina J, et al. Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia. Cancer Cell 2014; 25: 621-637
    • (2014) Cancer Cell , vol.25 , pp. 621-637
    • McAllister, F.1    Bailey, J.M.2    Alsina, J.3
  • 21
    • 84924700441 scopus 로고    scopus 로고
    • Targeting IL-17B-IL-17RB signaling with an anti-IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines
    • Wu HH, Hwang-Verslues WW, Lee WH, et al. Targeting IL-17B-IL-17RB signaling with an anti-IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines. J Exp Med 2015; 212: 333-349
    • (2015) J Exp Med , vol.212 , pp. 333-349
    • Wu, H.H.1    Hwang-Verslues, W.W.2    Lee, W.H.3
  • 22
    • 84877052290 scopus 로고    scopus 로고
    • Inflammatory networks and immune surveillance of pancreatic carcinoma
    • Vonderheide RH, Bayne LJ. Inflammatory networks and immune surveillance of pancreatic carcinoma. Curr Opin Immunol 2013; 25: 200-205
    • (2013) Curr Opin Immunol , vol.25 , pp. 200-205
    • Vonderheide, R.H.1    Bayne, L.J.2
  • 23
    • 84886780808 scopus 로고    scopus 로고
    • Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma
    • Ene-Obong A, Clear AJ, Watt J, et al. Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma. Gastroenterology 2013; 145: 1121-1132
    • (2013) Gastroenterology , vol.145 , pp. 1121-1132
    • Ene-Obong, A.1    Clear, A.J.2    Watt, J.3
  • 24
    • 84909606805 scopus 로고    scopus 로고
    • Complex role for the immune system in initiation and progression of pancreatic cancer
    • Inman KS, Francis AA, Murray NR. Complex role for the immune system in initiation and progression of pancreatic cancer. World J Gastroenterol 2014; 20: 11160-11181
    • (2014) World J Gastroenterol , vol.20 , pp. 11160-11181
    • Inman, K.S.1    Francis, A.A.2    Murray, N.R.3
  • 25
    • 84905901473 scopus 로고    scopus 로고
    • The carcinoma-associated fibroblast expressing fibroblast activation protein and escape from immune surveillance
    • Fearon DT. The carcinoma-associated fibroblast expressing fibroblast activation protein and escape from immune surveillance. Cancer Immunol Res 2014; 2: 187-193
    • (2014) Cancer Immunol Res , vol.2 , pp. 187-193
    • Fearon, D.T.1
  • 26
    • 84955326632 scopus 로고    scopus 로고
    • Trials of vaccines for pancreatic ductal adenocarcinoma: Is there any hope of an improved prognosis?
    • [Epub ahead of print]
    • Mizuguchi T, Torigoe T, Satomi F, et al. Trialsof vaccines for pancreatic ductal adenocarcinoma: is there any hope of an improved prognosis? Surg Today 2015. [Epub ahead of print]. doi: 10.1007/s00595-015-1120-8
    • (2015) Surg Today
    • Mizuguchi, T.1    Torigoe, T.2    Satomi, F.3
  • 27
    • 84890180205 scopus 로고    scopus 로고
    • Current advances in immunotherapy for pancreatic cancer
    • Uram JN, Le DT. Current advances in immunotherapy for pancreatic cancer. Curr Probl Cancer 2013; 37: 273-279
    • (2013) Curr Probl Cancer , vol.37 , pp. 273-279
    • Uram, J.N.1    Le, D.T.2
  • 28
    • 84929431322 scopus 로고    scopus 로고
    • Safety and survival with GVAX pancreas prime and Listeria Monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer
    • Le DT, Wang-Gillam A, Picozzi V, et al. Safety and survival with GVAX pancreas prime and Listeria Monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer. J Clin Oncol 2015; 33: 1325-1333
    • (2015) J Clin Oncol , vol.33 , pp. 1325-1333
    • Le, D.T.1    Wang-Gillam, A.2    Picozzi, V.3
  • 29
    • 84903527674 scopus 로고    scopus 로고
    • Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): An open-label, randomised, phase 3 trial
    • Middleton G, Silcocks P, Cox T, et al. Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial. Lancet Oncol 2014; 15: 829-840
    • (2014) Lancet Oncol , vol.15 , pp. 829-840
    • Middleton, G.1    Silcocks, P.2    Cox, T.3
  • 30
    • 79953154967 scopus 로고    scopus 로고
    • CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans
    • Beatty GL, Chiorean EG, Fishman MP, et al. CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science 2011; 331: 1612-1616
    • (2011) Science , vol.331 , pp. 1612-1616
    • Beatty, G.L.1    Chiorean, E.G.2    Fishman, M.P.3
  • 31
    • 84878849679 scopus 로고    scopus 로고
    • Dendritic cell immunotherapy combined with gemcitabine chemotherapy enhances survival in a murine model of pancreatic carcinoma
    • Ghansah T, Vohra N, Kinney K, et al. Dendritic cell immunotherapy combined with gemcitabine chemotherapy enhances survival in a murine model of pancreatic carcinoma. Cancer Immunol Immunother 2013; 62: 1083-1091
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 1083-1091
    • Ghansah, T.1    Vohra, N.2    Kinney, K.3
  • 32
    • 77958050577 scopus 로고    scopus 로고
    • Phase 2 trial of single agent Ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma
    • Royal RE, Levy C, Turner K, et al. Phase 2 trial of single agent Ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma. J Immunother 2010; 33: 828-833
    • (2010) J Immunother , vol.33 , pp. 828-833
    • Royal, R.E.1    Levy, C.2    Turner, K.3
  • 33
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer JR, Tykodi SS, Chow LQ, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 2012; 366: 2455-2465
    • (2012) N Engl J Med , vol.366 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3
  • 34
    • 84883207410 scopus 로고    scopus 로고
    • Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer
    • Le DT, Lutz E, Uram JN, et al. Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer. J Immunother 2013; 36: 382-389
    • (2013) J Immunother , vol.36 , pp. 382-389
    • Le, D.T.1    Lutz, E.2    Uram, J.N.3
  • 35
    • 84983372582 scopus 로고    scopus 로고
    • Induction of T cell immunity overcomes complete resistance to PD-1 and CTLA-4 blockade and improves survival in pancreatic carcinoma
    • Winograd R, Byrne K, Evans RA, et al. Induction of T cell immunity overcomes complete resistance to PD-1 and CTLA-4 blockade and improves survival in pancreatic carcinoma. Cancer Immunol Res 2015; 3: 399-411
    • (2015) Cancer Immunol Res , vol.3 , pp. 399-411
    • Winograd, R.1    Byrne, K.2    Evans, R.A.3
  • 36
    • 49849084482 scopus 로고    scopus 로고
    • Adoptive immunotherapy for pancreatic cancer: Cytotoxic T lymphocytes stimulated by the MUC1-expressing human pancreatic cancer cell line YPK-1
    • Kawaoka T, Oka M, Takashima M, et al. Adoptive immunotherapy for pancreatic cancer: cytotoxic T lymphocytes stimulated by the MUC1-expressing human pancreatic cancer cell line YPK-1. Oncol Rep 2008; 20: 155-163
    • (2008) Oncol Rep , vol.20 , pp. 155-163
    • Kawaoka, T.1    Oka, M.2    Takashima, M.3
  • 37
    • 40549097760 scopus 로고    scopus 로고
    • Adoptive immunotherapy for pancreatic cancer using MUC1 peptide-pulsed dendritic cells and activated T lymphocytes
    • Kondo H, Hazama S, Kawaoka T, et al. Adoptive immunotherapy for pancreatic cancer using MUC1 peptide-pulsed dendritic cells and activated T lymphocytes. Anticancer Res 2008; 28: 379-387
    • (2008) Anticancer Res , vol.28 , pp. 379-387
    • Kondo, H.1    Hazama, S.2    Kawaoka, T.3
  • 38
    • 84879227428 scopus 로고    scopus 로고
    • Whole blood interferon-gamma levels predict the therapeutic effects of adoptive T-cell therapy in patients with advanced pancreatic cancer
    • Ishikawa T, Kokura S, Sakamoto N, et al. Whole blood interferon-gamma levels predict the therapeutic effects of adoptive T-cell therapy in patients with advanced pancreatic cancer. Int J Cancer 2013; 133: 1119-1125
    • (2013) Int J Cancer , vol.133 , pp. 1119-1125
    • Ishikawa, T.1    Kokura, S.2    Sakamoto, N.3
  • 39
    • 84906938534 scopus 로고    scopus 로고
    • Phase II clinical trial of ex vivo-expanded cytokine-induced killer cells therapy in advanced pancreatic cancer
    • Chung MJ, Park JY, Bang S, et al. Phase II clinical trial of ex vivo-expanded cytokine-induced killer cells therapy in advanced pancreatic cancer. Cancer Immunol Immunother 2014; 63: 939-946
    • (2014) Cancer Immunol Immunother , vol.63 , pp. 939-946
    • Chung, M.J.1    Park, J.Y.2    Bang, S.3
  • 40
    • 69949132845 scopus 로고    scopus 로고
    • Ex vivo expanded telomerase-specific T cells are effective in an orthotopic mouse model for pancreatic adenocarcinoma
    • Hassanin H, Serba S, Schmidt J, Marten A. Ex vivo expanded telomerase-specific T cells are effective in an orthotopic mouse model for pancreatic adenocarcinoma. Clin Exp Immunol 2009; 158: 125-132
    • (2009) Clin Exp Immunol , vol.158 , pp. 125-132
    • Hassanin, H.1    Serba, S.2    Schmidt, J.3    Marten, A.4
  • 41
    • 84957436396 scopus 로고    scopus 로고
    • Generation of tumor-infiltrating lymphocytes from pancreatic cancer lesions for cellular therapy
    • Presented at the Society for Immunotherapy of Cancer 29th Annual Meeting National Harbor, MD, USA. 6-9 November 2014)
    • Meng Q, Rangelova EB, Zhenjiang L, et al. Generation of tumor-infiltrating lymphocytes from pancreatic cancer lesions for cellular therapy. J ImmunoTher Cancer 2014; 2: P26. (Presented at the Society for Immunotherapy of Cancer 29th Annual Meeting National Harbor, MD, USA. 6-9 November 2014)
    • (2014) J ImmunoTher Cancer , vol.2 , pp. P26
    • Meng, Q.1    Rangelova, E.B.2    Zhenjiang, L.3
  • 42
    • 4644289585 scopus 로고    scopus 로고
    • Targeting cytotoxic T lymphocytes for cancer immunotherapy
    • Maher J, Davies ET. Targeting cytotoxic T lymphocytes for cancer immunotherapy. Br J Cancer 2004; 91: 817-821
    • (2004) Br J Cancer , vol.91 , pp. 817-821
    • Maher, J.1    Davies, E.T.2
  • 43
    • 71049153709 scopus 로고    scopus 로고
    • Cancer/testis (CT) antigens: Potential targets for immunotherapy
    • Caballero OL, Chen YT. Cancer/testis (CT) antigens: potential targets for immunotherapy. Cancer Sci 2009; 100: 2014-2021
    • (2009) Cancer Sci , vol.100 , pp. 2014-2021
    • Caballero, O.L.1    Chen, Y.T.2
  • 44
    • 12144285654 scopus 로고    scopus 로고
    • Expression of cancer testis antigens in pancreatic carcinoma cell lines, pancreatic adenocarcinoma and chronic pancreatitis
    • Kubuschok B, Xie X, Jesnowski R, et al. Expression of cancer testis antigens in pancreatic carcinoma cell lines, pancreatic adenocarcinoma and chronic pancreatitis. Int J Cancer 2004; 109: 568-575
    • (2004) Int J Cancer , vol.109 , pp. 568-575
    • Kubuschok, B.1    Xie, X.2    Jesnowski, R.3
  • 45
    • 79952304769 scopus 로고    scopus 로고
    • Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1
    • Robbins PF, Morgan RA, Feldman SA, et al. Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1. J Clin Oncol 2011; 29: 917-924
    • (2011) J Clin Oncol , vol.29 , pp. 917-924
    • Robbins, P.F.1    Morgan, R.A.2    Feldman, S.A.3
  • 46
    • 84862122547 scopus 로고    scopus 로고
    • The role of classical and non-classical HLA class i antigens in human tumors
    • Bukur J, Jasinski S, Seliger B. The role of classical and non-classical HLA class I antigens in human tumors. Semin Cancer Biol 2012; 22: 350-358
    • (2012) Semin Cancer Biol , vol.22 , pp. 350-358
    • Bukur, J.1    Jasinski, S.2    Seliger, B.3
  • 47
    • 77952236875 scopus 로고    scopus 로고
    • Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy
    • Bendle GM, Linnemann C, Hooijkaas AI, et al. Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy. Nat Med 2010; 16: 565-570
    • (2010) Nat Med , vol.16 , pp. 565-570
    • Bendle, G.M.1    Linnemann, C.2    Hooijkaas, A.I.3
  • 48
    • 84887452876 scopus 로고    scopus 로고
    • Immunotherapy with gene-modified T cells: Limiting side effects provides new challenges
    • Stauss HJ, Morris EC. Immunotherapy with gene-modified T cells: limiting side effects provides new challenges. Gene Ther 2013; 20: 1029-1032
    • (2013) Gene Ther , vol.20 , pp. 1029-1032
    • Stauss, H.J.1    Morris, E.C.2
  • 49
    • 84873991752 scopus 로고    scopus 로고
    • Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy
    • Morgan RA, Chinnasamy N, Abate-Daga D, et al. Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy. J Immunother 2013; 36: 133-151
    • (2013) J Immunother , vol.36 , pp. 133-151
    • Morgan, R.A.1    Chinnasamy, N.2    Abate-Daga, D.3
  • 50
    • 84880730689 scopus 로고    scopus 로고
    • Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma
    • Linette GP, Stadtmauer EA, Maus MV, et al. Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma. Blood 2013; 122: 863-871
    • (2013) Blood , vol.122 , pp. 863-871
    • Linette, G.P.1    Stadtmauer, E.A.2    Maus, M.V.3
  • 51
    • 79952187823 scopus 로고    scopus 로고
    • T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis
    • Parkhurst MR, Yang JC, Langan RC, et al. T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis. Mol Ther 2011; 19: 620-626
    • (2011) Mol Ther , vol.19 , pp. 620-626
    • Parkhurst, M.R.1    Yang, J.C.2    Langan, R.C.3
  • 52
    • 84885845993 scopus 로고    scopus 로고
    • Immunotherapy of malignant disease using chimeric antigen receptor engrafted T cells
    • Maher J. Immunotherapy of malignant disease using chimeric antigen receptor engrafted T cells. ISRN Oncol 2012; 2012: 278093
    • (2012) ISRN Oncol , vol.2012 , pp. 278093
    • Maher, J.1
  • 53
    • 44449162630 scopus 로고    scopus 로고
    • Retargeting of human T cells to tumor-associated MUC1: The evolution of a chimeric antigen receptor
    • Wilkie S, Picco G, Foster J, et al. Retargeting of human T cells to tumor-associated MUC1: the evolution of a chimeric antigen receptor. J Immunol 2008; 180: 4901-4909
    • (2008) J Immunol , vol.180 , pp. 4901-4909
    • Wilkie, S.1    Picco, G.2    Foster, J.3
  • 54
    • 55549145071 scopus 로고    scopus 로고
    • Virus-specific T cells engineered to coexpress tumor-specific receptors: Persistence and antitumor activity in individuals with neuroblastoma
    • Pule MA, Savoldo B, Myers GD, et al. Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma. Nat Med 2008; 14: 1264-1270
    • (2008) Nat Med , vol.14 , pp. 1264-1270
    • Pule, M.A.1    Savoldo, B.2    Myers, G.D.3
  • 55
    • 84873987094 scopus 로고    scopus 로고
    • Sleeping beauty system to redirect T-cell specificity for human applications
    • Maiti SN, Huls H, Singh H, et al. Sleeping beauty system to redirect T-cell specificity for human applications. J Immunother 2013; 36: 112-123
    • (2013) J Immunother , vol.36 , pp. 112-123
    • Maiti, S.N.1    Huls, H.2    Singh, H.3
  • 56
    • 84878647061 scopus 로고    scopus 로고
    • Large volume flow electroporation of mRNA: Clinical scale process
    • Li L, Allen C, Shivakumar R, Peshwa MV. Large volume flow electroporation of mRNA: clinical scale process. Methods Mol Biol 2013; 969: 127-138
    • (2013) Methods Mol Biol , vol.969 , pp. 127-138
    • Li, L.1    Allen, C.2    Shivakumar, R.3    Peshwa, M.V.4
  • 57
    • 84863337890 scopus 로고    scopus 로고
    • Bcell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells
    • Kochenderfer JN, Dudley ME, Feldman SA, et al. Bcell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells. Blood 2012; 119: 2709-2720
    • (2012) Blood , vol.119 , pp. 2709-2720
    • Kochenderfer, J.N.1    Dudley, M.E.2    Feldman, S.A.3
  • 58
    • 0024834988 scopus 로고
    • Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity
    • Gross G, Waks T, Eshhar Z. Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity. Proc Natl Acad Sci USA 1989; 86: 10024-10028
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 10024-10028
    • Gross, G.1    Waks, T.2    Eshhar, Z.3
  • 59
    • 33750699642 scopus 로고    scopus 로고
    • A phase i study on adoptive immunotherapy using gene-modified T cells for ovarian cancer
    • Kershaw MH, Westwood JA, Parker LL, et al. A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer. Clin Cancer Res 2006; 12: 6106-6115
    • (2006) Clin Cancer Res , vol.12 , pp. 6106-6115
    • Kershaw, M.H.1    Westwood, J.A.2    Parker, L.L.3
  • 60
    • 77954849703 scopus 로고    scopus 로고
    • Clinical studies of regional and systemic gene therapy with autologous CC49-z modified T cells in colorectal cancer metastatic to the liver
    • Warren RSFG, Bergsland EK, Pennathur-Das R, et al. Clinical studies of regional and systemic gene therapy with autologous CC49-z modified T cells in colorectal cancer metastatic to the liver. Cancer Gene Ther 1998; 5: S1-S2
    • (1998) Cancer Gene Ther , vol.5 , pp. S1-S2
    • Warren, R.1    Bergsland, E.K.2    Pennathur-Das, R.3
  • 62
    • 33947265424 scopus 로고    scopus 로고
    • Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma
    • Park JR, Digiusto DL, Slovak M, et al. Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma. Mol Ther 2007; 15: 825-833
    • (2007) Mol Ther , vol.15 , pp. 825-833
    • Park, J.R.1    Digiusto, D.L.2    Slovak, M.3
  • 63
    • 33646440024 scopus 로고    scopus 로고
    • Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: First clinical experience
    • Lamers CH, Sleijfer S, Vulto AG, et al. Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience. J Clin Oncol 2006; 24: e20-e22
    • (2006) J Clin Oncol , vol.24 , pp. e20-e22
    • Lamers, C.H.1    Sleijfer, S.2    Vulto, A.G.3
  • 64
    • 78650969008 scopus 로고    scopus 로고
    • Immune responses to transgene and retroviral vector in patients treated with ex vivo-engineered T cells
    • Lamers CH, Willemsen R, van Elzakker P, et al. Immune responses to transgene and retroviral vector in patients treated with ex vivo-engineered T cells. Blood 2011; 117: 72-82
    • (2011) Blood , vol.117 , pp. 72-82
    • Lamers, C.H.1    Willemsen, R.2    Van Elzakker, P.3
  • 65
    • 84878605813 scopus 로고    scopus 로고
    • Treatment of metastatic renal cell carcinoma with CAIX CAR-engineered T cells: Clinical evaluation and management of on-target toxicity
    • Lamers CH, Sleijfer S, van Steenbergen S, et al. Treatment of metastatic renal cell carcinoma with CAIX CAR-engineered T cells: clinical evaluation and management of on-target toxicity. Mol Ther 2013; 21: 904-912
    • (2013) Mol Ther , vol.21 , pp. 904-912
    • Lamers, C.H.1    Sleijfer, S.2    Van Steenbergen, S.3
  • 66
    • 82955207691 scopus 로고    scopus 로고
    • Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma
    • Louis CU, Savoldo B, Dotti G, et al. Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma. Blood 2011; 118: 6050-6056
    • (2011) Blood , vol.118 , pp. 6050-6056
    • Louis, C.U.1    Savoldo, B.2    Dotti, G.3
  • 67
    • 0032531091 scopus 로고    scopus 로고
    • Chimeric receptors providing both primary and costimulatory signaling in T cells from a single gene product
    • Finney HM, Lawson AD, Bebbington CR, Weir AN. Chimeric receptors providing both primary and costimulatory signaling in T cells from a single gene product. J Immunol 1998; 161: 2791-2797
    • (1998) J Immunol , vol.161 , pp. 2791-2797
    • Finney, H.M.1    Lawson, A.D.2    Bebbington, C.R.3    Weir, A.N.4
  • 68
    • 0036137615 scopus 로고    scopus 로고
    • Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRzeta/CD28 receptor
    • Maher J, Brentjens RJ, Gunset G, et al. Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRzeta/CD28 receptor. Nat Biotechnol 2002; 20: 70-75
    • (2002) Nat Biotechnol , vol.20 , pp. 70-75
    • Maher, J.1    Brentjens, R.J.2    Gunset, G.3
  • 69
    • 3042551216 scopus 로고    scopus 로고
    • Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia
    • Imai C, Mihara K, Andreansky M, et al. Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia. Leukemia 2004; 18: 676-684
    • (2004) Leukemia , vol.18 , pp. 676-684
    • Imai, C.1    Mihara, K.2    Andreansky, M.3
  • 70
    • 27744566329 scopus 로고    scopus 로고
    • A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells
    • Pule MA, Straathof KC, Dotti G, et al. A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells. Mol Ther 2005; 12: 933-941
    • (2005) Mol Ther , vol.12 , pp. 933-941
    • Pule, M.A.1    Straathof, K.C.2    Dotti, G.3
  • 71
    • 25844484607 scopus 로고    scopus 로고
    • Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells
    • Gattinoni L, Finkelstein SE, Klebanoff CA, et al. Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells. J Exp Med 2005; 202: 907-912
    • (2005) J Exp Med , vol.202 , pp. 907-912
    • Gattinoni, L.1    Finkelstein, S.E.2    Klebanoff, C.A.3
  • 72
    • 84890207337 scopus 로고    scopus 로고
    • T cells expressing chimeric antigen receptors can cause anaphylaxis in humans
    • Maus MV, Haas AR, Beatty GL, et al. T cells expressing chimeric antigen receptors can cause anaphylaxis in humans. Cancer Immunol Res 2013; 1: 26-31
    • (2013) Cancer Immunol Res , vol.1 , pp. 26-31
    • Maus, M.V.1    Haas, A.R.2    Beatty, G.L.3
  • 73
    • 84969372032 scopus 로고    scopus 로고
    • Use of immunoglobulin replacement therapy in the management of primary immunodeficiency disorders
    • van Schalkwyk MC, Grosse-Kreul D, Maher J. Use of immunoglobulin replacement therapy in the management of primary immunodeficiency disorders. Foundation Years J 2014; 8: 18-25
    • (2014) Foundation Years J , vol.8 , pp. 18-25
    • Van Schalkwyk, M.C.1    Grosse-Kreul, D.2    Maher, J.3
  • 74
    • 84876325876 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
    • Grupp SA, Kalos M, Barrett D, et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N Engl J Med 2013; 368: 1509-1518
    • (2013) N Engl J Med , vol.368 , pp. 1509-1518
    • Grupp, S.A.1    Kalos, M.2    Barrett, D.3
  • 75
    • 84908073316 scopus 로고    scopus 로고
    • Chimeric antigen receptor T cells for sustained remissions in leukemia
    • Maude S, Frey N, Shaw P, et al. Chimeric antigen receptor T cells for sustained remissions in leukemia. N Engl J Med 2014; 371: 1507-1517
    • (2014) N Engl J Med , vol.371 , pp. 1507-1517
    • Maude, S.1    Frey, N.2    Shaw, P.3
  • 76
    • 84876005284 scopus 로고    scopus 로고
    • CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia
    • Brentjens RJ, Davila ML, Riviere I, et al. CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia. Sci Transl Med 2013; 5: 177ra38
    • (2013) Sci Transl Med , vol.5 , pp. 177ra38
    • Brentjens, R.J.1    Davila, M.L.2    Riviere, I.3
  • 77
    • 84896335556 scopus 로고    scopus 로고
    • Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia
    • Davila ML, Riviere I, Wang X, et al. Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia. Sci Transl Med 2014; 6: 224ra25
    • (2014) Sci Transl Med , vol.6 , pp. 224ra25
    • Davila, M.L.1    Riviere, I.2    Wang, X.3
  • 78
    • 84923019006 scopus 로고    scopus 로고
    • T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: A phase 1 dose-escalation trial
    • Lee DW, Kochenderfer JN, Stetler-Stevenson M, et al. T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial. Lancet 2015; 385: 517-528
    • (2015) Lancet , vol.385 , pp. 517-528
    • Lee, D.W.1    Kochenderfer, J.N.2    Stetler-Stevenson, M.3
  • 79
    • 84908073316 scopus 로고    scopus 로고
    • Chimeric antigen receptor T cells for sustained remissions in leukemia
    • Maude SL, Frey N, Shaw PA, et al. Chimeric antigen receptor T cells for sustained remissions in leukemia. N Engl J Med 2014; 371: 1507-1517
    • (2014) N Engl J Med , vol.371 , pp. 1507-1517
    • Maude, S.L.1    Frey, N.2    Shaw, P.A.3
  • 80
    • 84923118622 scopus 로고    scopus 로고
    • Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor
    • Kochenderfer JN, Dudley ME, Kassim SH, et al. Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor. J Clin Oncol 2015; 33: 540-549
    • (2015) J Clin Oncol , vol.33 , pp. 540-549
    • Kochenderfer, J.N.1    Dudley, M.E.2    Kassim, S.H.3
  • 81
    • 80051775476 scopus 로고    scopus 로고
    • T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia
    • Kalos M, Levine BL, Porter DL, et al. T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Sci Transl Med 2011; 3: 95ra73
    • (2011) Sci Transl Med , vol.3 , pp. 95ra73
    • Kalos, M.1    Levine, B.L.2    Porter, D.L.3
  • 82
    • 80051720194 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
    • Porter DL, Levine BL, Kalos M, et al. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N Engl J Med 2011; 365: 725-733
    • (2011) N Engl J Med , vol.365 , pp. 725-733
    • Porter, D.L.1    Levine, B.L.2    Kalos, M.3
  • 83
    • 80455179612 scopus 로고    scopus 로고
    • Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias
    • Brentjens RJ, Riviere I, Park JH, et al. Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias. Blood 2011; 118: 4817-4828
    • (2011) Blood , vol.118 , pp. 4817-4828
    • Brentjens, R.J.1    Riviere, I.2    Park, J.H.3
  • 84
    • 84897568616 scopus 로고    scopus 로고
    • Managing cytokine release syndrome associated with novel T cell-engaging therapies
    • Maude SL, Barrett D, Teachey DT, Grupp SA. Managing cytokine release syndrome associated with novel T cell-engaging therapies. Cancer J 2014; 20: 119-122
    • (2014) Cancer J , vol.20 , pp. 119-122
    • Maude, S.L.1    Barrett, D.2    Teachey, D.T.3    Grupp, S.A.4
  • 85
    • 84866653054 scopus 로고    scopus 로고
    • T cells that target carcinoembryonic antigen eradicate orthotopic pancreatic carcinomas without inducing autoimmune colitis in mice
    • Chmielewski M, Hahn O, Rappl G, et al. T cells that target carcinoembryonic antigen eradicate orthotopic pancreatic carcinomas without inducing autoimmune colitis in mice. Gastroenterology 2012; 143: 1095e2-1107e2
    • (2012) Gastroenterology , vol.143 , pp. 1095e2-1107e2
    • Chmielewski, M.1    Hahn, O.2    Rappl, G.3
  • 86
    • 0034793404 scopus 로고    scopus 로고
    • Overexpression of the HER-2/neu oncogene in pancreatic adenocarcinoma
    • Safran H, Steinhoff M, Mangray S, et al. Overexpression of the HER-2/neu oncogene in pancreatic adenocarcinoma. Am J Clin Oncol 2001; 24: 496-499
    • (2001) Am J Clin Oncol , vol.24 , pp. 496-499
    • Safran, H.1    Steinhoff, M.2    Mangray, S.3
  • 87
    • 33847052127 scopus 로고    scopus 로고
    • Identification of pancreatic cancer stem cells
    • Li C, Heidt DG, Dalerba P, et al. Identification of pancreatic cancer stem cells. Cancer Res 2007; 67: 1030-1037
    • (2007) Cancer Res , vol.67 , pp. 1030-1037
    • Li, C.1    Heidt, D.G.2    Dalerba, P.3
  • 88
    • 84868033755 scopus 로고    scopus 로고
    • Redirected T cells that target pancreatic adenocarcinoma antigens eliminate tumors and metastases in mice
    • e1-5
    • Maliar A, Servais C, Waks T, et al. Redirected T cells that target pancreatic adenocarcinoma antigens eliminate tumors and metastases in mice. Gastroenterology 2012; 143: 1375-1384. e1-5
    • (2012) Gastroenterology , vol.143 , pp. 1375-1384
    • Maliar, A.1    Servais, C.2    Waks, T.3
  • 89
    • 28444437055 scopus 로고    scopus 로고
    • Mesothelin is overexpressed in pancreaticobiliary adenocarcinomas but not in normal pancreas and chronic pancreatitis
    • Hassan R, Laszik ZG, Lerner M, et al. Mesothelin is overexpressed in pancreaticobiliary adenocarcinomas but not in normal pancreas and chronic pancreatitis. Am J Clin Pathol 2005; 124: 838-845
    • (2005) Am J Clin Pathol , vol.124 , pp. 838-845
    • Hassan, R.1    Laszik, Z.G.2    Lerner, M.3
  • 90
    • 14644394912 scopus 로고    scopus 로고
    • Immunohistochemistry can help distinguish metastatic pancreatic adenocarcinomas from bile duct adenomas and hamartomas of the liver
    • Hornick JL, Lauwers GY, Odze RD. Immunohistochemistry can help distinguish metastatic pancreatic adenocarcinomas from bile duct adenomas and hamartomas of the liver. Am J Surg Pathol 2005; 29: 381-389
    • (2005) Am J Surg Pathol , vol.29 , pp. 381-389
    • Hornick, J.L.1    Lauwers, G.Y.2    Odze, R.D.3
  • 91
    • 81555207563 scopus 로고    scopus 로고
    • Mesothelin and GPR30 staining among a spectrum of pancreatic epithelial neoplasms
    • Glass JP, Parasher G, Arias-Pulido H, et al. Mesothelin and GPR30 staining among a spectrum of pancreatic epithelial neoplasms. Int J Surg Pathol 2011; 19: 588-596
    • (2011) Int J Surg Pathol , vol.19 , pp. 588-596
    • Glass, J.P.1    Parasher, G.2    Arias-Pulido, H.3
  • 92
    • 62549097817 scopus 로고    scopus 로고
    • Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains
    • Carpenito C, Milone MC, Hassan R, et al. Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains. Proc Natl Acad Sci USA 2009; 106: 3360-3365
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 3360-3365
    • Carpenito, C.1    Milone, M.C.2    Hassan, R.3
  • 93
    • 78549253550 scopus 로고    scopus 로고
    • Multiple injections of electroporated autologous T cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor
    • Zhao Y, Moon E, Carpenito C, et al. Multiple injections of electroporated autologous T cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor. Cancer Res 2010; 70: 9053-9061
    • (2010) Cancer Res , vol.70 , pp. 9053-9061
    • Zhao, Y.1    Moon, E.2    Carpenito, C.3
  • 94
    • 84908891854 scopus 로고    scopus 로고
    • Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity
    • Adusumilli PS, Cherkassky L, Villena-Vargas J, et al. Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity. Sci Transl Med 2014; 6: 261ra151
    • (2014) Sci Transl Med , vol.6 , pp. 261ra151
    • Adusumilli, P.S.1    Cherkassky, L.2    Villena-Vargas, J.3
  • 95
    • 84857794017 scopus 로고    scopus 로고
    • Redirected antitumor activity of primary human lymphocytes transduced with a fully human anti-mesothelin chimeric receptor
    • Lanitis E, Poussin M, Hagemann IS, et al. Redirected antitumor activity of primary human lymphocytes transduced with a fully human anti-mesothelin chimeric receptor. Mol Ther 2012; 20: 633-643
    • (2012) Mol Ther , vol.20 , pp. 633-643
    • Lanitis, E.1    Poussin, M.2    Hagemann, I.S.3
  • 96
    • 19944430969 scopus 로고    scopus 로고
    • MUC1 expression in primary and metastatic pancreatic cancer cells for in vitro treatment by (213)Bi-C595 radioimmunoconjugate
    • Qu CF, Li Y, Song YJ, et al. MUC1 expression in primary and metastatic pancreatic cancer cells for in vitro treatment by (213)Bi-C595 radioimmunoconjugate. Br J Cancer 2004; 91: 2086-2093
    • (2004) Br J Cancer , vol.91 , pp. 2086-2093
    • Qu, C.F.1    Li, Y.2    Song, Y.J.3
  • 97
    • 84877096549 scopus 로고    scopus 로고
    • Aberrant expression of mucin core proteins and o-linked glycans associated with progression of pancreatic cancer
    • Remmers N, Anderson JM, Linde EM, et al. Aberrant expression of mucin core proteins and o-linked glycans associated with progression of pancreatic cancer. Clin Cancer Res 2013; 19: 1981-1993
    • (2013) Clin Cancer Res , vol.19 , pp. 1981-1993
    • Remmers, N.1    Anderson, J.M.2    Linde, E.M.3
  • 98
    • 0030070154 scopus 로고    scopus 로고
    • The epithelial mucin MUC1 contains at least two discrete signals specifying membrane localization in cells
    • Pemberton LF, Rughetti A, Taylor-Papadimitriou J, Gendler SJ. The epithelial mucin MUC1 contains at least two discrete signals specifying membrane localization in cells. J Biol Chem 1996; 271: 2332-2340
    • (1996) J Biol Chem , vol.271 , pp. 2332-2340
    • Pemberton, L.F.1    Rughetti, A.2    Taylor-Papadimitriou, J.3    Gendler, S.J.4
  • 99
    • 66349117960 scopus 로고    scopus 로고
    • CAR mechanics: Driving T cells into the MUC of cancer
    • Maher J, Wilkie S. CAR mechanics: driving T cells into the MUC of cancer. Cancer Res 2009; 69: 4559-4562
    • (2009) Cancer Res , vol.69 , pp. 4559-4562
    • Maher, J.1    Wilkie, S.2
  • 100
    • 84895500137 scopus 로고    scopus 로고
    • Kinetics of tumor destruction by chimeric antigen receptor-modified T cells
    • Anurathapan U, Chan RC, Hindi HF, et al. Kinetics of tumor destruction by chimeric antigen receptor-modified T cells. Mol Ther 2014; 22: 623-633
    • (2014) Mol Ther , vol.22 , pp. 623-633
    • Anurathapan, U.1    Chan, R.C.2    Hindi, H.F.3
  • 101
    • 0035360275 scopus 로고    scopus 로고
    • Discovery of new markers of cancer through serial analysis of gene expression: Prostate stem cell antigen is overexpressed in pancreatic adenocarcinoma
    • Argani P, Rosty C, Reiter RE, et al. Discovery of new markers of cancer through serial analysis of gene expression: prostate stem cell antigen is overexpressed in pancreatic adenocarcinoma. Cancer Res 2001; 61: 4320-4324
    • (2001) Cancer Res , vol.61 , pp. 4320-4324
    • Argani, P.1    Rosty, C.2    Reiter, R.E.3
  • 102
    • 23044451727 scopus 로고    scopus 로고
    • Prostate stem cell antigen is a putative target for immunotherapy in pancreatic cancer
    • Wente MN, Jain A, Kono E, et al. Prostate stem cell antigen is a putative target for immunotherapy in pancreatic cancer. Pancreas 2005; 31: 119-125
    • (2005) Pancreas , vol.31 , pp. 119-125
    • Wente, M.N.1    Jain, A.2    Kono, E.3
  • 103
    • 80051875696 scopus 로고    scopus 로고
    • Engineered T cells for pancreatic cancer treatment
    • Katari UL, Keirnan JM, Worth AC, et al. Engineered T cells for pancreatic cancer treatment. HPB (Oxford) 2011; 13: 643-650
    • (2011) HPB (Oxford) , vol.13 , pp. 643-650
    • Katari, U.L.1    Keirnan, J.M.2    Worth, A.C.3
  • 104
    • 84906508776 scopus 로고    scopus 로고
    • A novel chimeric antigen receptor against prostate stem cell antigen mediates tumor destruction in a humanized mouse model of pancreatic cancer
    • Abate-Daga D, Lagisetty KH, Tran E, et al. A novel chimeric antigen receptor against prostate stem cell antigen mediates tumor destruction in a humanized mouse model of pancreatic cancer. Hum. Gene Ther 2014; 25: 1003-1012
    • (2014) Hum. Gene Ther , vol.25 , pp. 1003-1012
    • Abate-Daga, D.1    Lagisetty, K.H.2    Tran, E.3
  • 105
    • 84906517258 scopus 로고    scopus 로고
    • Pancreatic cancer: Hurdles in the engineering of CAR-based immunotherapies
    • Abate-Daga D, Rosenberg SA, Morgan RA. Pancreatic cancer: Hurdles in the engineering of CAR-based immunotherapies. Oncoimmunology 2014; 3: e29194
    • (2014) Oncoimmunology , vol.3 , pp. e29194
    • Abate-Daga, D.1    Rosenberg, S.A.2    Morgan, R.A.3
  • 106
    • 84862185933 scopus 로고    scopus 로고
    • Flexible targeting of ErbB dimers that drive tumorigenesis using genetically engineered T-cells
    • Davies DM, VdSS, Parente ACP, Chiapero-Stanke L, et al. Flexible targeting of ErbB dimers that drive tumorigenesis using genetically engineered T-cells. Mol Med 2012; 18: 565-576
    • (2012) Mol Med , vol.18 , pp. 565-576
    • Davies, D.M.1    Parente, A.C.P.2    Chiapero-Stanke, L.3
  • 107
    • 84940676094 scopus 로고    scopus 로고
    • IGF1R-and ROR1-specific CAR T cells as a potential therapy for high risk sarcomas
    • Huang X, Park H, Greene J, et al. IGF1R-and ROR1-specific CAR T cells as a potential therapy for high risk sarcomas. PLoS One 2015; 10: e0133152
    • (2015) PLoS One , vol.10 , pp. e0133152
    • Huang, X.1    Park, H.2    Greene, J.3
  • 108
    • 84916900260 scopus 로고    scopus 로고
    • An NCR1-based chimeric receptor endows T-cells with multiple anti-tumor specificities
    • Tal Y, Yaakobi S, Horovitz-Fried M, et al. An NCR1-based chimeric receptor endows T-cells with multiple anti-tumor specificities. Oncotarget 2014; 5: 10949-10958
    • (2014) Oncotarget , vol.5 , pp. 10949-10958
    • Tal, Y.1    Yaakobi, S.2    Horovitz-Fried, M.3
  • 109
    • 4043109842 scopus 로고    scopus 로고
    • Membrane-associated heparan sulfate proteoglycans are involved in the recognition of cellular targets by NKp30 and NKp46
    • Bloushtain N, Qimron U, Bar-Ilan A, et al. Membrane-associated heparan sulfate proteoglycans are involved in the recognition of cellular targets by NKp30 and NKp46. J Immunol 2004; 173: 2392-2401
    • (2004) J Immunol , vol.173 , pp. 2392-2401
    • Bloushtain, N.1    Qimron, U.2    Bar-Ilan, A.3
  • 110
    • 84871391438 scopus 로고    scopus 로고
    • Re-directed T cells for the treatment of fibroblast activation protein (FAP)-positive malignant pleural mesothelioma (FAPME-1)
    • Petrausch U, Schuberth PC, Hagedorn C, et al. Re-directed T cells for the treatment of fibroblast activation protein (FAP)-positive malignant pleural mesothelioma (FAPME-1). BMC Cancer 2012; 12: 615
    • (2012) BMC Cancer , vol.12 , pp. 615
    • Petrausch, U.1    Schuberth, P.C.2    Hagedorn, C.3
  • 111
    • 84881312673 scopus 로고    scopus 로고
    • Antitumor effects of chimeric receptor engineered human T cells directed to tumor stroma
    • Kakarla S, Chow KK, Mata M, et al. Antitumor effects of chimeric receptor engineered human T cells directed to tumor stroma. Mol Ther 2013; 21: 1611-1620
    • (2013) Mol Ther , vol.21 , pp. 1611-1620
    • Kakarla, S.1    Chow, K.K.2    Mata, M.3
  • 112
    • 84880656055 scopus 로고    scopus 로고
    • Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia
    • Tran E, Chinnasamy D, Yu Z, et al. Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia. J Exp Med 2013; 210: 1125-1135
    • (2013) J Exp Med , vol.210 , pp. 1125-1135
    • Tran, E.1    Chinnasamy, D.2    Yu, Z.3
  • 113
    • 84996565577 scopus 로고    scopus 로고
    • Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity
    • Wang LC, Lo A, Scholler J, et al. Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity. Cancer Immunol Res 2014; 2: 154-166
    • (2014) Cancer Immunol Res , vol.2 , pp. 154-166
    • Wang, L.C.1    Lo, A.2    Scholler, J.3
  • 114
    • 84942919712 scopus 로고    scopus 로고
    • Tumor-promoting desmoplasia is disrupted by depleting FAP-expressing stromal cells
    • Lo A, Wang LC, Scholler J, et al. Tumor-promoting desmoplasia is disrupted by depleting FAP-expressing stromal cells. Cancer Res 2015; 75: 2800-2810
    • (2015) Cancer Res , vol.75 , pp. 2800-2810
    • Lo, A.1    Wang, L.C.2    Scholler, J.3
  • 115
    • 84937758074 scopus 로고    scopus 로고
    • Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes
    • Caruana I, Savoldo B, Hoyos V, et al. Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes. Nat Med 2015; 21: 524-529
    • (2015) Nat Med , vol.21 , pp. 524-529
    • Caruana, I.1    Savoldo, B.2    Hoyos, V.3
  • 116
    • 84902124061 scopus 로고    scopus 로고
    • Discovery of mesothelin and exploiting it as a target for immunotherapy
    • Pastan I, Hassan R. Discovery of mesothelin and exploiting it as a target for immunotherapy. Cancer Res 2014; 74: 2907-2912
    • (2014) Cancer Res , vol.74 , pp. 2907-2912
    • Pastan, I.1    Hassan, R.2
  • 117
    • 84996572349 scopus 로고    scopus 로고
    • Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce anti-tumor activity in solid malignancies
    • Beatty GL, Haas AR, Maus MV, et al. Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce anti-tumor activity in solid malignancies. Cancer Immunol Res 2014; 2: 112-120
    • (2014) Cancer Immunol Res , vol.2 , pp. 112-120
    • Beatty, G.L.1    Haas, A.R.2    Maus, M.V.3
  • 118
    • 84957442491 scopus 로고    scopus 로고
    • Safety and antitumor activity of chimeric antigen receptor modified T cells in patients with chemotherapy refractory metastatic pancreatic cancer
    • Abstract307
    • Beatty GL, O'Hara MH, Nelson AM, et al. Safety and antitumor activity of chimeric antigen receptor modified T cells in patients with chemotherapy refractory metastatic pancreatic cancer. J Clin Oncol 2015; 33: Abstract 3007
    • (2015) J Clin Oncol , vol.33
    • Beatty, G.L.1    O'Hara, M.H.2    Nelson, A.M.3
  • 119
    • 84924693659 scopus 로고    scopus 로고
    • Challenges to chimeric antigen receptor (CAR)-T cell therapy for cancer
    • Magee MS, Snook AE. Challenges to chimeric antigen receptor (CAR)-T cell therapy for cancer. Discov Med 2014; 18: 265-271
    • (2014) Discov Med , vol.18 , pp. 265-271
    • Magee, M.S.1    Snook, A.E.2
  • 120
    • 84885991395 scopus 로고    scopus 로고
    • Preclinical in vivo modeling of cytokine release syndrome induced by ErbB-retargeted human T cells: Identifying a window of therapeutic opportunity?
    • van der Stegen SJ, Davies DM, Wilkie S, et al. Preclinical in vivo modeling of cytokine release syndrome induced by ErbB-retargeted human T cells: identifying a window of therapeutic opportunity? J Immunol 2013; 191: 4589-4598
    • (2013) J Immunol , vol.191 , pp. 4589-4598
    • Van Der Stegen, S.J.1    Davies, D.M.2    Wilkie, S.3
  • 121
    • 80455162464 scopus 로고    scopus 로고
    • Inducible apoptosis as a safety switch for adoptive cell therapy
    • Di Stasi A, Tey SK, Dotti G, et al. Inducible apoptosis as a safety switch for adoptive cell therapy. N Engl J Med 2011; 365: 1673-1683
    • (2011) N Engl J Med , vol.365 , pp. 1673-1683
    • Di Stasi, A.1    Tey, S.K.2    Dotti, G.3
  • 122
    • 0035526336 scopus 로고    scopus 로고
    • MUC1-specific CTLs are non-functional within a pancreatic tumor microenvironment
    • Mukherjee P, Ginardi AR, Madsen CS, et al. MUC1-specific CTLs are non-functional within a pancreatic tumor microenvironment. Glycoconj J 2001; 18: 931-942
    • (2001) Glycoconj J , vol.18 , pp. 931-942
    • Mukherjee, P.1    Ginardi, A.R.2    Madsen, C.S.3
  • 123
    • 84902469661 scopus 로고    scopus 로고
    • Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival
    • Ozdemir BC, Pentcheva-Hoang T, Carstens JL, et al. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell 2014; 25: 719-734
    • (2014) Cancer Cell , vol.25 , pp. 719-734
    • Ozdemir, B.C.1    Pentcheva-Hoang, T.2    Carstens, J.L.3
  • 124
    • 84866740895 scopus 로고    scopus 로고
    • Dual targeting of ErbB2 and MUC1 in breast cancer using chimeric antigen receptors engineered to provide complementary signaling
    • Wilkie S, van Schalkwyk MC, Hobbs S, et al. Dual targeting of ErbB2 and MUC1 in breast cancer using chimeric antigen receptors engineered to provide complementary signaling. J Clin Immunol 2012; 32: 1059-1070
    • (2012) J Clin Immunol , vol.32 , pp. 1059-1070
    • Wilkie, S.1    Van Schalkwyk, M.C.2    Hobbs, S.3
  • 125
    • 84872196489 scopus 로고    scopus 로고
    • Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells
    • Kloss CC, Condomines M, Cartellieri M, et al. Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells. Nat Biotechnol 2013; 31: 71-75
    • (2013) Nat Biotechnol , vol.31 , pp. 71-75
    • Kloss, C.C.1    Condomines, M.2    Cartellieri, M.3
  • 126
    • 84880259439 scopus 로고    scopus 로고
    • TanCAR: A novel bispecific chimeric antigen receptor for cancer immunotherapy
    • Grada Z, Hegde M, Byrd T, et al. TanCAR: a novel bispecific chimeric antigen receptor for cancer immunotherapy. Mol Ther Nucleic Acids 2013; 2: e105
    • (2013) Mol Ther Nucleic Acids , vol.2 , pp. e105
    • Grada, Z.1    Hegde, M.2    Byrd, T.3
  • 127
    • 84942983455 scopus 로고    scopus 로고
    • Evolution to plasmablastic lymphoma evades CD19-directed chimeric antigen receptor T cells
    • Evans AG, Rothberg PG, Burack WR, et al. Evolution to plasmablastic lymphoma evades CD19-directed chimeric antigen receptor T cells. Br J Haematol 2015; 171: 205-209
    • (2015) Br J Haematol , vol.171 , pp. 205-209
    • Evans, A.G.1    Rothberg, P.G.2    Burack, W.R.3
  • 128
    • 84969384243 scopus 로고    scopus 로고
    • Inducible MyD88/CD40 Allows AP1903-Dependent Costimulation to Control Proliferation and Survival of Chimeric Antigen Receptor-Modified T Cells
    • Foster A, Mahendravada A, Chang P, et al. Inducible MyD88/CD40 Allows AP1903-Dependent Costimulation to Control Proliferation and Survival of Chimeric Antigen Receptor-Modified T Cells. Blood 2014; 124: 21
    • (2014) Blood , vol.124 , pp. 21
    • Foster, A.1    Mahendravada, A.2    Chang, P.3
  • 129
    • 0036428790 scopus 로고    scopus 로고
    • Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2
    • Kershaw MH, Wang G, Westwood JA, et al. Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2. Hum Gene Ther 2002; 13: 1971-1980
    • (2002) Hum Gene Ther , vol.13 , pp. 1971-1980
    • Kershaw, M.H.1    Wang, G.2    Westwood, J.A.3
  • 130
    • 78349255049 scopus 로고    scopus 로고
    • Transduction of tumor-specific T cells with CXCR2 chemokine receptor improves migration to tumor and antitumor immune responses
    • Peng W, Ye Y, Rabinovich BA, et al. Transduction of tumor-specific T cells with CXCR2 chemokine receptor improves migration to tumor and antitumor immune responses. Clin Cancer Res 2010; 16: 5458-5468
    • (2010) Clin Cancer Res , vol.16 , pp. 5458-5468
    • Peng, W.1    Ye, Y.2    Rabinovich, B.A.3
  • 131
    • 77958063691 scopus 로고    scopus 로고
    • Enhanced tumor trafficking of GD2 chimeric antigen receptor T cells by expression of the chemokine receptor CCR2b
    • Craddock JA, Lu A, Bear A, et al. Enhanced tumor trafficking of GD2 chimeric antigen receptor T cells by expression of the chemokine receptor CCR2b. J Immunother 2010; 33: 780-788
    • (2010) J Immunother , vol.33 , pp. 780-788
    • Craddock, J.A.1    Lu, A.2    Bear, A.3
  • 132
    • 79960403269 scopus 로고    scopus 로고
    • Expression of a functional CCR2 receptor enhances tumor localization and tumor eradication by retargeted human T cells expressing a mesothelin-specific chimeric antibody receptor
    • Moon EK, Carpenito C, Sun J, et al. Expression of a functional CCR2 receptor enhances tumor localization and tumor eradication by retargeted human T cells expressing a mesothelin-specific chimeric antibody receptor. Clin Cancer Res 2011; 17: 4719-4730
    • (2011) Clin Cancer Res , vol.17 , pp. 4719-4730
    • Moon, E.K.1    Carpenito, C.2    Sun, J.3
  • 133
    • 67650638846 scopus 로고    scopus 로고
    • T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model
    • Di Stasi A, De Angelis B, Rooney CM, et al. T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model. Blood 2009; 113: 6392-6402
    • (2009) Blood , vol.113 , pp. 6392-6402
    • Di Stasi, A.1    De Angelis, B.2    Rooney, C.M.3
  • 134
    • 84903820011 scopus 로고    scopus 로고
    • Manufacturing models permitting roll out/scale out of clinically led autologous cell therapies: Regulatory and scientific challenges for comparability
    • Hourd P, Ginty P, Chandra A, Williams DJ. Manufacturing models permitting roll out/scale out of clinically led autologous cell therapies: regulatory and scientific challenges for comparability. Cytotherapy 2014; 16: 1033-1047
    • (2014) Cytotherapy , vol.16 , pp. 1033-1047
    • Hourd, P.1    Ginty, P.2    Chandra, A.3    Williams, D.J.4


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