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Volumn 37, Issue 5, 2013, Pages 273-279

Current advances in immunotherapy for pancreatic cancer

(2)  Uram, Jennifer N a   Le, Dung T a  

a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALGENPANTUCEL L; ANZ 100; BMS 936559; CA 19-9 ANTIGEN; CANCER VACCINE; CAPECITABINE; CRS 207; CYCLOPHOSPHAMIDE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR VACCINE; IPILIMUMAB; IRINOTECAN; MESOTHELIN; MONOCLONAL ANTIBODY; OXALIPLATIN; PD L1 ANTIBODY; TERTOMOTIDE; UNCLASSIFIED DRUG;

EID: 84890180205     PISSN: 01470272     EISSN: 15356345     Source Type: Journal    
DOI: 10.1016/j.currproblcancer.2013.10.004     Document Type: Article
Times cited : (13)

References (37)
  • 1
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • [Epub 2010/06/08]
    • Hodi F.S., O'Day S.J., McDermott D.F., et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010, 363(8):711-723. [Epub 2010/06/08].
    • (2010) N Engl J Med , vol.363 , Issue.8 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 2
    • 77954899030 scopus 로고    scopus 로고
    • Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates
    • [Epub 2010/06/03]
    • Brahmer J.R., Drake C.G., Wollner I., et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol 2010, 28(19):3167-3175. [Epub 2010/06/03].
    • (2010) J Clin Oncol , vol.28 , Issue.19 , pp. 3167-3175
    • Brahmer, J.R.1    Drake, C.G.2    Wollner, I.3
  • 3
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • [Epub 2012/06/05]
    • Brahmer J.R., Tykodi S.S., Chow L.Q., et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 2012, 366(26):2455-2465. [Epub 2012/06/05].
    • (2012) N Engl J Med , vol.366 , Issue.26 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3
  • 4
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • [Epub 2012/06/05]
    • Topalian S.L., Hodi F.S., Brahmer J.R., et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012, 366(26):2443-2454. [Epub 2012/06/05].
    • (2012) N Engl J Med , vol.366 , Issue.26 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 5
    • 84880709088 scopus 로고    scopus 로고
    • Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic CRC, gastric cancer (GC), SCCHN, or other tumors. ASCO Meeting Abstracts
    • Tabernero J, Powderly JD, Hamid O, et al. Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic CRC, gastric cancer (GC), SCCHN, or other tumors. ASCO Meeting Abstracts 2013;31(15_suppl):3622.
    • (2013) , vol.31 , Issue.15 SUPPL , pp. 3622
    • Tabernero, J.1    Powderly, J.D.2    Hamid, O.3
  • 6
    • 77955066199 scopus 로고    scopus 로고
    • Sipuleucel-T immunotherapy for castration-resistant prostate cancer
    • [Epub 2010/09/08]
    • Kantoff P.W., Higano C.S., Shore N.D., et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med 2010, 363(5):411-422. [Epub 2010/09/08].
    • (2010) N Engl J Med , vol.363 , Issue.5 , pp. 411-422
    • Kantoff, P.W.1    Higano, C.S.2    Shore, N.D.3
  • 7
    • 33845247353 scopus 로고    scopus 로고
    • Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: a dose escalating phase I/II study
    • [Epub 2006/10/25]
    • Bernhardt S.L., Gjertsen M.K., Trachsel S., et al. Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: a dose escalating phase I/II study. Br J Cancer 2006, 95(11):1474-1482. [Epub 2006/10/25].
    • (2006) Br J Cancer , vol.95 , Issue.11 , pp. 1474-1482
    • Bernhardt, S.L.1    Gjertsen, M.K.2    Trachsel, S.3
  • 8
    • 68649104725 scopus 로고    scopus 로고
    • Randomized phase III study of gemcitabine (G) versus GV1001 in sequential combination with G in patients with unresectable and metastatic pancreatic cancer (PC)
    • ASCO Meeting Abstracts
    • Buanes T, Maurel J, Liauw W, et al. Randomized phase III study of gemcitabine (G) versus GV1001 in sequential combination with G in patients with unresectable and metastatic pancreatic cancer (PC). ASCO Meeting Abstracts 2009;27(15S):4601.
    • (2009) , vol.27 , Issue.15 SUPPL , pp. 4601
    • Buanes, T.1    Maurel, J.2    Liauw, W.3
  • 9
    • 84880052883 scopus 로고    scopus 로고
    • A phase III randomized trial of chemoimmunotherapy comprising gemcitabine and capecitabine with or without telomerase vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer
    • ASCO Meeting Abstracts, LBA4004
    • Middleton GW, Valle JW, Wadsley J, et al. A phase III randomized trial of chemoimmunotherapy comprising gemcitabine and capecitabine with or without telomerase vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer. ASCO Meeting Abstracts 2013;31(18_suppl):LBA4004.
    • (2013) , vol.31 , Issue.18 SUPPL
    • Middleton, G.W.1    Valle, J.W.2    Wadsley, J.3
  • 10
    • 34250180939 scopus 로고    scopus 로고
    • Gemcitabine plus capecitabine compared with gemcitabine alone in advanced pancreatic cancer: a randomized, multicenter, phase III trial of the Swiss Group for Clinical Cancer Research and the Central European Cooperative Oncology Group
    • [Epub 2007/06/01]
    • Herrmann R., Bodoky G., Ruhstaller T., et al. Gemcitabine plus capecitabine compared with gemcitabine alone in advanced pancreatic cancer: a randomized, multicenter, phase III trial of the Swiss Group for Clinical Cancer Research and the Central European Cooperative Oncology Group. J Clin Oncol 2007, 25(16):2212-2217. [Epub 2007/06/01].
    • (2007) J Clin Oncol , vol.25 , Issue.16 , pp. 2212-2217
    • Herrmann, R.1    Bodoky, G.2    Ruhstaller, T.3
  • 11
    • 84890137437 scopus 로고    scopus 로고
    • Press release. Available from:
    • Press release. Available from:. http://www.businesswire.com/news/home/20130603005934/en/Final-Results-Phase-III-TeloVac-Trial-Pancreatic.
  • 12
    • 84871991189 scopus 로고    scopus 로고
    • Addition of algenpantucel-L immunotherapy to standard adjuvant therapy for pancreatic cancer: a phase 2 study
    • [discussion p-1. Epub 2012/12/12]
    • Hardacre J.M., Mulcahy M., Small W., et al. Addition of algenpantucel-L immunotherapy to standard adjuvant therapy for pancreatic cancer: a phase 2 study. J Gastrointest Surg 2013, 17(1):94-100. [discussion p-1. Epub 2012/12/12].
    • (2013) J Gastrointest Surg , vol.17 , Issue.1 , pp. 94-100
    • Hardacre, J.M.1    Mulcahy, M.2    Small, W.3
  • 13
    • 84883221480 scopus 로고    scopus 로고
    • Anti-Gal: an abundant human natural antibody of multiple pathogeneses and clinical benefits
    • [Epub 2013/04/13]
    • Galili U. Anti-Gal: an abundant human natural antibody of multiple pathogeneses and clinical benefits. Immunology 2013, [Epub 2013/04/13].
    • (2013) Immunology
    • Galili, U.1
  • 14
    • 84864505600 scopus 로고    scopus 로고
    • Addition of algenpantucel-L immunotherapy to standard of care (SOC) adjuvant therapy for pancreatic cancer
    • ASCO Meeting Abstracts
    • Hardacre JM, Mulcahy MF, Small W, et al. Addition of algenpantucel-L immunotherapy to standard of care (SOC) adjuvant therapy for pancreatic cancer. ASCO Meeting Abstracts 2012;30(15_suppl):4049.
    • (2012) , vol.30 , Issue.15 SUPPL , pp. 4049
    • Hardacre, J.M.1    Mulcahy, M.F.2    Small, W.3
  • 15
    • 84890238900 scopus 로고    scopus 로고
    • Effect of algenpantucel-L immunotherapy for pancreatic cancer on anti-mesothelin antibody (Ab) titers and correlation with improved overall survival
    • ASCO Meeting Abstracts
    • Rossi GR, Hardacre JM, Mulcahy MF, et al. Effect of algenpantucel-L immunotherapy for pancreatic cancer on anti-mesothelin antibody (Ab) titers and correlation with improved overall survival. ASCO Meeting Abstracts 2013;31(15_suppl):3007.
    • (2013) , vol.31 , Issue.15 SUPPL , pp. 3007
    • Rossi, G.R.1    Hardacre, J.M.2    Mulcahy, M.F.3
  • 16
    • 0035152718 scopus 로고    scopus 로고
    • Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: a phase I trial of safety and immune activation
    • [Epub 2001/01/03]
    • Jaffee E.M., Hruban R.H., Biedrzycki B., et al. Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: a phase I trial of safety and immune activation. J Clin Oncol 2001, 19(1):145-156. [Epub 2001/01/03].
    • (2001) J Clin Oncol , vol.19 , Issue.1 , pp. 145-156
    • Jaffee, E.M.1    Hruban, R.H.2    Biedrzycki, B.3
  • 17
    • 40949157885 scopus 로고    scopus 로고
    • Allogeneic granulocyte macrophage colony-stimulating factor-secreting tumor immunotherapy alone or in sequence with cyclophosphamide for metastatic pancreatic cancer: a pilot study of safety, feasibility, and immune activation
    • [Epub 2008/03/05]
    • Laheru D., Lutz E., Burke J., et al. Allogeneic granulocyte macrophage colony-stimulating factor-secreting tumor immunotherapy alone or in sequence with cyclophosphamide for metastatic pancreatic cancer: a pilot study of safety, feasibility, and immune activation. Clin Cancer Res 2008, 14(5):1455-1463. [Epub 2008/03/05].
    • (2008) Clin Cancer Res , vol.14 , Issue.5 , pp. 1455-1463
    • Laheru, D.1    Lutz, E.2    Burke, J.3
  • 18
    • 79151486551 scopus 로고    scopus 로고
    • A lethally irradiated allogeneic granulocyte-macrophage colony stimulating factor-secreting tumor vaccine for pancreatic adenocarcinoma. A phase II trial of safety, efficacy, and immune activation
    • [Epub 2011/01/11]
    • Lutz E., Yeo C.J., Lillemoe K.D., et al. A lethally irradiated allogeneic granulocyte-macrophage colony stimulating factor-secreting tumor vaccine for pancreatic adenocarcinoma. A phase II trial of safety, efficacy, and immune activation. Ann Surg 2011, 253(2):328-335. [Epub 2011/01/11].
    • (2011) Ann Surg , vol.253 , Issue.2 , pp. 328-335
    • Lutz, E.1    Yeo, C.J.2    Lillemoe, K.D.3
  • 19
    • 0035674996 scopus 로고    scopus 로고
    • Mesothelin is overexpressed in the vast majority of ductal adenocarcinomas of the pancreas: identification of a new pancreatic cancer marker by serial analysis of gene expression (SAGE)
    • [Epub 2001/12/26]
    • Argani P., Iacobuzio-Donahue C., Ryu B., et al. Mesothelin is overexpressed in the vast majority of ductal adenocarcinomas of the pancreas: identification of a new pancreatic cancer marker by serial analysis of gene expression (SAGE). Clin Cancer Res 2001, 7(12):3862-3868. [Epub 2001/12/26].
    • (2001) Clin Cancer Res , vol.7 , Issue.12 , pp. 3862-3868
    • Argani, P.1    Iacobuzio-Donahue, C.2    Ryu, B.3
  • 20
    • 3543060047 scopus 로고    scopus 로고
    • Mesothelin-specific CD8(+) T cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic cancer patients
    • [Epub 2004/08/04]
    • Thomas A.M., Santarsiero L.M., Lutz E.R., et al. Mesothelin-specific CD8(+) T cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic cancer patients. J Exp Med 2004, 200(3):297-306. [Epub 2004/08/04].
    • (2004) J Exp Med , vol.200 , Issue.3 , pp. 297-306
    • Thomas, A.M.1    Santarsiero, L.M.2    Lutz, E.R.3
  • 21
    • 84890169078 scopus 로고    scopus 로고
    • Novel tertiary lymphoid aggregates induced in pancreatic adenocarcinoma by an allogeneic GM-CSF secreting pancreatic tumor vaccine as a neoadjuvant treatment
    • ASCO Gastrointestinal Cancers Abstracts
    • Zheng L, Edil B, Nguyen T, et al. Novel tertiary lymphoid aggregates induced in pancreatic adenocarcinoma by an allogeneic GM-CSF secreting pancreatic tumor vaccine as a neoadjuvant treatment. ASCO Gastrointestinal Cancers Abstracts 157. 2010.
    • (2010) , vol.157
    • Zheng, L.1    Edil, B.2    Nguyen, T.3
  • 22
    • 84856519280 scopus 로고    scopus 로고
    • A live-attenuated Listeria vaccine (ANZ-100) and a live-attenuated Listeria vaccine expressing mesothelin (CRS-207) for advanced cancers: phase I studies of safety and immune induction
    • [Epub 2011/12/08]
    • Le D.T., Brockstedt D.G., Nir-Paz R., et al. A live-attenuated Listeria vaccine (ANZ-100) and a live-attenuated Listeria vaccine expressing mesothelin (CRS-207) for advanced cancers: phase I studies of safety and immune induction. Clin Cancer Res 2012, 18(3):858-868. [Epub 2011/12/08].
    • (2012) Clin Cancer Res , vol.18 , Issue.3 , pp. 858-868
    • Le, D.T.1    Brockstedt, D.G.2    Nir-Paz, R.3
  • 23
    • 84875228204 scopus 로고    scopus 로고
    • Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer
    • [Epub 2013/02/07]
    • Ino Y., Yamazaki-Itoh R., Shimada K., et al. Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer. Br J Cancer 2013, 108(4):914-923. [Epub 2013/02/07].
    • (2013) Br J Cancer , vol.108 , Issue.4 , pp. 914-923
    • Ino, Y.1    Yamazaki-Itoh, R.2    Shimada, K.3
  • 24
    • 0036721629 scopus 로고    scopus 로고
    • Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma
    • [Epub 2002/08/24]
    • Liyanage U.K., Moore T.T., Joo H.G., et al. Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma. J Immunol 2002, 169(5):2756-2761. [Epub 2002/08/24].
    • (2002) J Immunol , vol.169 , Issue.5 , pp. 2756-2761
    • Liyanage, U.K.1    Moore, T.T.2    Joo, H.G.3
  • 25
    • 33749317518 scopus 로고    scopus 로고
    • Prevalence of FOXP3+ regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions
    • [Epub 2006/09/27]
    • Hiraoka N., Onozato K., Kosuge T., et al. Prevalence of FOXP3+ regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions. Clin Cancer Res 2006, 12(18):5423-5434. [Epub 2006/09/27].
    • (2006) Clin Cancer Res , vol.12 , Issue.18 , pp. 5423-5434
    • Hiraoka, N.1    Onozato, K.2    Kosuge, T.3
  • 26
    • 84875463042 scopus 로고    scopus 로고
    • Molecular mechanisms of T cell co-stimulation and co-inhibition
    • [Epub 2013/03/09]
    • Chen L., Flies D.B. Molecular mechanisms of T cell co-stimulation and co-inhibition. Nat Rev Immunol 2013, 13(4):227-242. [Epub 2013/03/09].
    • (2013) Nat Rev Immunol , vol.13 , Issue.4 , pp. 227-242
    • Chen, L.1    Flies, D.B.2
  • 27
    • 84873129546 scopus 로고    scopus 로고
    • CTLA-4 blockade in tumor models: an overview of preclinical and translational research
    • [Epub 2013/02/08]
    • Grosso J.F., Jure-Kunkel M.N. CTLA-4 blockade in tumor models: an overview of preclinical and translational research. Cancer Immunol 2013, 13:5. [Epub 2013/02/08].
    • (2013) Cancer Immunol , vol.13 , pp. 5
    • Grosso, J.F.1    Jure-Kunkel, M.N.2
  • 28
    • 84878936788 scopus 로고    scopus 로고
    • Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells
    • [Epub 2013/04/07]
    • Selby M.J., Engelhardt J.J., Quigley M., et al. Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells. Cancer Immunol Res 2013, [Epub 2013/04/07].
    • (2013) Cancer Immunol Res
    • Selby, M.J.1    Engelhardt, J.J.2    Quigley, M.3
  • 29
    • 77958050577 scopus 로고    scopus 로고
    • Phase 2 trial of single agent ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma
    • [Epub 2010/09/16]
    • Royal R.E., Levy C., Turner K., et al. Phase 2 trial of single agent ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma. J Immunother 2010, 33(8):828-833. [Epub 2010/09/16].
    • (2010) J Immunother , vol.33 , Issue.8 , pp. 828-833
    • Royal, R.E.1    Levy, C.2    Turner, K.3
  • 30
    • 0034596948 scopus 로고    scopus 로고
    • Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    • [Epub 2000/10/04]
    • Freeman G.J., Long A.J., Iwai Y., et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med 2000, 192(7):1027. [Epub 2000/10/04].
    • (2000) J Exp Med , vol.192 , Issue.7 , pp. 1027
    • Freeman, G.J.1    Long, A.J.2    Iwai, Y.3
  • 31
    • 5844264920 scopus 로고    scopus 로고
    • PD-L2 is a second ligand for PD-1 and inhibits T cell activation
    • [Epub 2001/02/27]
    • Latchman Y., Wood C.R., Chernova T., et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol 2001, 2(3):261-268. [Epub 2001/02/27].
    • (2001) Nat Immunol , vol.2 , Issue.3 , pp. 261-268
    • Latchman, Y.1    Wood, C.R.2    Chernova, T.3
  • 32
    • 84875767509 scopus 로고    scopus 로고
    • Immunohistochemical staining of B7-H1 (PD-L1) on paraffin-embedded slides of pancreatic adenocarcinoma tissue
    • [Epub 2013/01/19]
    • Bigelow E., Bever K.M., Xu H., et al. Immunohistochemical staining of B7-H1 (PD-L1) on paraffin-embedded slides of pancreatic adenocarcinoma tissue. J Vis Exp 2013, (71). [Epub 2013/01/19].
    • (2013) J Vis Exp , Issue.71
    • Bigelow, E.1    Bever, K.M.2    Xu, H.3
  • 33
    • 67449110979 scopus 로고    scopus 로고
    • Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1
    • [Epub 2009/05/20]
    • Kuang D.M., Zhao Q., Peng C., et al. Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1. J Exp Med 2009, 206(6):1327-1337. [Epub 2009/05/20].
    • (2009) J Exp Med , vol.206 , Issue.6 , pp. 1327-1337
    • Kuang, D.M.1    Zhao, Q.2    Peng, C.3
  • 34
    • 76249090050 scopus 로고    scopus 로고
    • Dual control of antitumor CD8 T cells through the programmed death-1/programmed death-ligand 1 pathway and immunosuppressive CD4 T cells: regulation and counterregulation
    • [Epub 2009/12/17]
    • Currie A.J., Prosser A., McDonnell A., et al. Dual control of antitumor CD8 T cells through the programmed death-1/programmed death-ligand 1 pathway and immunosuppressive CD4 T cells: regulation and counterregulation. J Immunol 2009, 183(12):7898-7908. [Epub 2009/12/17].
    • (2009) J Immunol , vol.183 , Issue.12 , pp. 7898-7908
    • Currie, A.J.1    Prosser, A.2    McDonnell, A.3
  • 35
    • 0037126021 scopus 로고    scopus 로고
    • Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
    • [Epub 2002/09/10]
    • Iwai Y., Ishida M., Tanaka Y., et al. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci U S A 2002, 99(19):12293-12297. [Epub 2002/09/10].
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.19 , pp. 12293-12297
    • Iwai, Y.1    Ishida, M.2    Tanaka, Y.3
  • 36
    • 84872514622 scopus 로고    scopus 로고
    • Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody
    • [Epub 2012/11/22]
    • Lipson E.J., Sharfman W.H., Drake C.G., et al. Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody. Clin Cancer Res 2013, 19(2):462-468. [Epub 2012/11/22].
    • (2013) Clin Cancer Res , vol.19 , Issue.2 , pp. 462-468
    • Lipson, E.J.1    Sharfman, W.H.2    Drake, C.G.3
  • 37
    • 84883207410 scopus 로고    scopus 로고
    • Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer
    • doi:.
    • Le DT, Lutz E, Uram JN, et al. Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer. J Immunother 2013;36(7):382-9. doi:. http://10.1097/CJI.0b013e31829fb7a2.
    • (2013) J Immunother , vol.36 , Issue.7 , pp. 382-9
    • Le, D.T.1    Lutz, E.2    Uram, J.N.3


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