Structural features of interfacial tyrosine residue in ROBO1 fibronectin domain-antibody complex: Crystallographic, thermodynamic, and molecular dynamic analyses

Protein Science

Volumn 24, Issue 3, 2015, Pages 328-340

  Nakayama, Taisuke ^a   Mizohata, Eiichi ^a   Yamashita, Takefumi ^b   Nagatoishi, Satoru ^c   Nakakido, Makoto ^c   Iwanari, Hiroko ^b   Mochizuki, Yasuhiro ^b   Kado, Yuji ^a   Yokota, Yuki ^a   Satoh, Reiko ^a   Tsumoto, Kouhei ^c   Fujitani, Hideaki ^b   Kodama, Tatsuhiko ^b   Hamakubo, Takao ^b   Inoue, Tsuyoshi ^a  

^a OSAKA UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

antibody engineering; antigen antibody interaction; crystallography; molecular dynamics; thermodynamics

Indexed keywords

IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY B2212A; ROUNDABOUT GUIDANCE RECEPTOR 1; ROUNDABOUT RECEPTOR; TYROSINE; UNCLASSIFIED DRUG; FIBRONECTIN; IMMUNOGLOBULIN RECEPTOR; NERVE PROTEIN; RECOMBINANT PROTEIN;

ANTIGEN ANTIBODY REACTION; ANTIGEN BINDING; ARTICLE; COMPARATIVE STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; HEAVY CHAIN; HUMAN; HYDROGEN BOND; ISOTHERMAL TITRATION CALORIMETRY; LIGHT CHAIN; LIVER CELL CARCINOMA; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY; CHEMISTRY; METABOLISM; PROTEIN TERTIARY STRUCTURE;

FIBRONECTINS; HUMANS; MOLECULAR DYNAMICS SIMULATION; NERVE TISSUE PROTEINS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, IMMUNOLOGIC; RECOMBINANT PROTEINS; THERMODYNAMICS; TYROSINE;

EID: 84957108848     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.2619     Document Type: Article

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