Tyrosine plays a dominant functional role in the paratope of a synthetic antibody derived from a four amino acid code

Journal of Molecular Biology

Volumn 357, Issue 1, 2006, Pages 100-114

  Fellouse, Frederic A ^a   Barthelemy, Pierre A ^a   Kelley, Robert F ^a   Sidhu, Sachdev S ^a  

^a GENENTECH INC   (United States)

Author keywords

Antibody library; Combinatorial mutagenesis; Phage display; Protein engineering; Vascular endothelial growth factor

Indexed keywords

ALANINE; AMINO ACID; ASPARTIC ACID; IMMUNOGLOBULIN F(AB) FRAGMENT; PHENYLALANINE; SERINE; TYROSINE; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN ANTIBODY; VASCULOTROPIN RECEPTOR 1; YADS1; YADS2;

ANTIBODY COMBINING SITE; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CELL ASSAY; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYDROPHILICITY; HYDROPHOBICITY; ISOTHERMAL TITRATION CALORIMETRY; LIGHT CHAIN; MOLECULAR RECOGNITION; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN STRUCTURE; SCANNING ELECTRON MICROSCOPY; THERMODYNAMICS;

EID: 33644783935     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2005.11.092     Document Type: Article

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