Physical Origins of Codon Positions That Strongly Influence Cotranslational Folding: A Framework for Controlling Nascent-Protein Folding

Journal of the American Chemical Society

Volumn 138, Issue 4, 2016, Pages 1180-1195

  Sharma, Ajeet K ^a   Bukau, Bernd ^b   O'Brien, Edward P ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGY; CHAINS; MOLECULAR DYNAMICS; MONTE CARLO METHODS; POLYPEPTIDES; PROTEIN FOLDING; THERMODYNAMIC PROPERTIES;

COARSE-GRAINED MOLECULAR DYNAMICS SIMULATIONS; CODON SUBSTITUTIONS; FOLDING PROCESS; MASTER EQUATION METHOD; NON-EQUILIBRIUM PHENOMENA; RATIONAL DESIGN; TRANSLATION ELONGATION; TRANSLATION RATES;

PROTEINS;

MESSENGER RNA; NASCENT PROTEIN; PROTEIN; UNCLASSIFIED DRUG; CODON; ESCHERICHIA COLI PROTEIN;

ALGORITHM; AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CODON; CODON USAGE; COMPUTER MODEL; CONTROLLED STUDY; ESCHERICHIA COLI; GENETIC CODE; GENETIC TRANSCRIPTION; HYPOTHESIS; MATHEMATICAL MODEL; MOLECULAR BIOLOGY; MOLECULAR DYNAMICS; MOLECULAR MODEL; MONTE CARLO METHOD; NONHUMAN; POINT MUTATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STABILITY; RIBOSOME; RNA SEQUENCE; RNA SYNTHESIS; STEADY STATE; CHEMISTRY; GENETICS; PROTEIN SYNTHESIS;

CODON; ESCHERICHIA COLI PROTEINS; PROTEIN BIOSYNTHESIS; PROTEIN FOLDING; RNA, MESSENGER;

EID: 84957050566     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.5b08145     Document Type: Article

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