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Volumn 64, Issue 10, 2015, Pages 3464-3474

Alterations of a cellular cholesterol metabolism network are a molecular feature of obesity-related type 2 diabetes and cardiovascular disease

(29)  Ding, Jingzhong a   Reynolds, Lindsay M a   Zeller, Tanja b   Müller, Christian b   Lohman, Kurt a   Nicklas, Barbara J a   Kritchevsky, Stephen B a   Huang, Zhiqing c   De La Fuente, Alberto d   Soranzo, Nicola e   Settlage, Robert E f   Chuang, Chia Chi a   Howard, Timothy a   Xu, Ning g   Goodarzi, Mark O g   Chen, Y D Ida h   Rotter, Jerome I h   Siscovick, David S i   Parks, John S a   Murphy, Susan c   more..


Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER A1; ABC TRANSPORTER G1; ACYL COENZYME A DESATURASE; ACYL COENZYME A DESATURASE 1; CHOLESTEROL; FARNESYL DIPHOSPHATE FARNESYLTRANSFERASE 1; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE 1; LOW DENSITY LIPOPROTEIN RECEPTOR; METHYLSTEROL MONOOXYGENASE 1; MYOSIN REGULATORY LIGHT CHAIN INTERACTING PROTEIN; PROTEIN; SQUALENE MONOOXYGENASE; SQUALENE SYNTHASE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE; TRANSCRIPTOME;

EID: 84956912733     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db14-1314     Document Type: Article
Times cited : (81)

References (53)
  • 1
    • 69249205739 scopus 로고    scopus 로고
    • Obesity, inflammation, and atherosclerosis
    • Rocha VZ, Libby P. Obesity, inflammation, and atherosclerosis. Nat Rev Cardiol 2009;6:399-409
    • (2009) Nat Rev Cardiol , vol.6 , pp. 399-409
    • Rocha, V.Z.1    Libby, P.2
  • 3
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • Xu H, Barnes GT, Yang Q, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003;112:1821-1830
    • (2003) J Clin Invest , vol.112 , pp. 1821-1830
    • Xu, H.1    Barnes, G.T.2    Yang, Q.3
  • 4
    • 20044387026 scopus 로고    scopus 로고
    • IKK-beta links inflammation to obesity-induced insulin resistance
    • Arkan MC, Hevener AL, Greten FR, et al. IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 2005;11:191-198
    • (2005) Nat Med , vol.11 , pp. 191-198
    • Arkan, M.C.1    Hevener, A.L.2    Greten, F.R.3
  • 5
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006;444:860-867
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 6
    • 79955535643 scopus 로고    scopus 로고
    • Macrophages in the pathogenesis of atherosclerosis
    • Moore KJ, Tabas I. Macrophages in the pathogenesis of atherosclerosis. Cell 2011;145:341-355
    • (2011) Cell , vol.145 , pp. 341-355
    • Moore, K.J.1    Tabas, I.2
  • 7
    • 77953469917 scopus 로고    scopus 로고
    • Epigenetics as a unifying principle in the aetiology of complex traits and diseases
    • Petronis A. Epigenetics as a unifying principle in the aetiology of complex traits and diseases. Nature 2010;465:721-727
    • (2010) Nature , vol.465 , pp. 721-727
    • Petronis, A.1
  • 8
    • 0036840537 scopus 로고    scopus 로고
    • Multi-ethnic study of atherosclerosis: Objectives and design
    • Bild DE, Bluemke DA, Burke GL, et al. Multi-ethnic study of atherosclerosis: objectives and design. Am J Epidemiol 2002;156:871-881
    • (2002) Am J Epidemiol , vol.156 , pp. 871-881
    • Bild, D.E.1    Bluemke, D.A.2    Burke, G.L.3
  • 9
    • 0042424602 scopus 로고    scopus 로고
    • Statistical significance for genomewide studies
    • Storey JD, Tibshirani R. Statistical significance for genomewide studies. Proc Natl Acad Sci U S A 2003;100:9440-9445
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 9440-9445
    • Storey, J.D.1    Tibshirani, R.2
  • 10
    • 60549111634 scopus 로고    scopus 로고
    • WGCNA: An R package for weighted correlation network analysis
    • Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics 2008;9:559
    • (2008) BMC Bioinformatics , vol.9 , pp. 559
    • Langfelder, P.1    Horvath, S.2
  • 11
    • 0038005018 scopus 로고    scopus 로고
    • DAVID: Database for Annotation, Visualization, and Integrated Discovery
    • Dennis G Jr, Sherman BT, Hosack DA, et al. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 2003;4:3
    • (2003) Genome Biol , vol.4 , pp. 3
    • Dennis, G.1    Sherman, B.T.2    Hosack, D.A.3
  • 12
    • 84865790047 scopus 로고    scopus 로고
    • An integrated encyclopedia of DNA elements in the human genome
    • Dunham I, Kundaje A, Aldred SF, et al.; ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature 2012;489:57-74
    • (2012) Nature , vol.489 , pp. 57-74
    • ENCODE Project Consortium1    Dunham, I.2    Kundaje, A.3    Aldred, S.F.4
  • 13
    • 84875945705 scopus 로고    scopus 로고
    • ENCODE data in the UCSC Genome Browser: Year 5 update
    • Rosenbloom KR, Sloan CA, Malladi VS, et al. ENCODE data in the UCSC Genome Browser: year 5 update. Nucleic Acids Res 2013;41:D56-D63
    • (2013) Nucleic Acids Res , vol.41 , pp. D56-D63
    • Rosenbloom, K.R.1    Sloan, C.A.2    Malladi, V.S.3
  • 14
    • 84863986133 scopus 로고    scopus 로고
    • Functions of DNA methylation: Islands, start sites, gene bodies and beyond
    • Jones PA. Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat Rev Genet 2012;13:484-492
    • (2012) Nat Rev Genet , vol.13 , pp. 484-492
    • Jones, P.A.1
  • 15
    • 84863306901 scopus 로고    scopus 로고
    • Lavaan: An R package for structural equation modeling
    • Rosseel Y. lavaan: an R package for structural equation modeling. J Stat Softw 2012;48:1-36
    • (2012) J Stat Softw , vol.48 , pp. 1-36
    • Rosseel, Y.1
  • 16
    • 84856230364 scopus 로고    scopus 로고
    • Intervening on spontaneous physical activity to prevent weight regain in older adults: Design of a randomized, clinical trial
    • Nicklas BJ, Gaukstern JE, Legault C, Leng I, Rejeski WJ. Intervening on spontaneous physical activity to prevent weight regain in older adults: design of a randomized, clinical trial. Contemp Clin Trials 2012;33:450-455
    • (2012) Contemp Clin Trials , vol.33 , pp. 450-455
    • Nicklas, B.J.1    Gaukstern, J.E.2    Legault, C.3    Leng, I.4    Rejeski, W.J.5
  • 17
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-419
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 18
    • 3242823479 scopus 로고
    • Receptor-mediated endocytosis: Insights from the lipoprotein receptor system
    • Brown MS, Goldstein JL. Receptor-mediated endocytosis: insights from the lipoprotein receptor system. Proc Natl Acad Sci U S A 1979;76:3330-3337
    • (1979) Proc Natl Acad Sci U S A , vol.76 , pp. 3330-3337
    • Brown, M.S.1    Goldstein, J.L.2
  • 19
    • 67650092919 scopus 로고    scopus 로고
    • LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor
    • Zelcer N, Hong C, Boyadjian R, Tontonoz P. LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Science 2009;325:100-104
    • (2009) Science , vol.325 , pp. 100-104
    • Zelcer, N.1    Hong, C.2    Boyadjian, R.3    Tontonoz, P.4
  • 20
    • 43249127067 scopus 로고    scopus 로고
    • Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism
    • Flowers MT, Ntambi JM. Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism. Curr Opin Lipidol 2008;19:248-256
    • (2008) Curr Opin Lipidol , vol.19 , pp. 248-256
    • Flowers, M.T.1    Ntambi, J.M.2
  • 21
    • 77952849777 scopus 로고    scopus 로고
    • Role of FADS1 and FADS2 polymorphisms in polyunsaturated fatty acid metabolism
    • Glaser C, Heinrich J, Koletzko B. Role of FADS1 and FADS2 polymorphisms in polyunsaturated fatty acid metabolism. Metabolism 2010;59:993-999
    • (2010) Metabolism , vol.59 , pp. 993-999
    • Glaser, C.1    Heinrich, J.2    Koletzko, B.3
  • 22
    • 29844458402 scopus 로고    scopus 로고
    • 17Beta-hydroxysteroid dehydrogenase type 7 (Hsd17b7) reverts cholesterol auxotrophy in NS0 cells
    • Seth G, McIvor RS, Hu WS. 17Beta-hydroxysteroid dehydrogenase type 7 (Hsd17b7) reverts cholesterol auxotrophy in NS0 cells. J Biotechnol 2006;121:241-252
    • (2006) J Biotechnol , vol.121 , pp. 241-252
    • Seth, G.1    McIvor, R.S.2    Hu, W.S.3
  • 23
    • 34547700634 scopus 로고    scopus 로고
    • Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo
    • Wang X, Collins HL, Ranalletta M, et al. Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo. J Clin Invest 2007;117:2216-2224
    • (2007) J Clin Invest , vol.117 , pp. 2216-2224
    • Wang, X.1    Collins, H.L.2    Ranalletta, M.3
  • 24
    • 77956637896 scopus 로고    scopus 로고
    • Genetics and beyond-The transcriptome of human monocytes and disease susceptibility
    • Zeller T, Wild P, Szymczak S, et al. Genetics and beyond-the transcriptome of human monocytes and disease susceptibility. PLoS One 2010;5:e10693
    • (2010) PLoS One , vol.5 , pp. e10693
    • Zeller, T.1    Wild, P.2    Szymczak, S.3
  • 25
    • 84888155393 scopus 로고    scopus 로고
    • Methylomics of gene expression in human monocytes
    • Liu Y, Ding J, Reynolds LM, et al. Methylomics of gene expression in human monocytes. Hum Mol Genet 2013;22:5065-5074
    • (2013) Hum Mol Genet , vol.22 , pp. 5065-5074
    • Liu, Y.1    Ding, J.2    Reynolds, L.M.3
  • 26
    • 79954452300 scopus 로고    scopus 로고
    • Inflammatory stress exacerbates hepatic cholesterol accumulation via increasing cholesterol uptake and de novo synthesis
    • Zhao L, Chen Y, Tang R, et al. Inflammatory stress exacerbates hepatic cholesterol accumulation via increasing cholesterol uptake and de novo synthesis. J Gastroenterol Hepatol 2011;26:875-883
    • (2011) J Gastroenterol Hepatol , vol.26 , pp. 875-883
    • Zhao, L.1    Chen, Y.2    Tang, R.3
  • 27
    • 27444439757 scopus 로고    scopus 로고
    • Downregulation of liver X receptor-alpha in mouse kidney and HK-2 proximal tubular cells by LPS and cytokines
    • Wang Y, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR. Downregulation of liver X receptor-alpha in mouse kidney and HK-2 proximal tubular cells by LPS and cytokines. J Lipid Res 2005;46:2377-2387
    • (2005) J Lipid Res , vol.46 , pp. 2377-2387
    • Wang, Y.1    Moser, A.H.2    Shigenaga, J.K.3    Grunfeld, C.4    Feingold, K.R.5
  • 28
    • 3042606551 scopus 로고    scopus 로고
    • Effects of infection and inflammation on lipid and lipoprotein metabolism: Mechanisms and consequences to the host
    • Khovidhunkit W, Kim MS, Memon RA, et al. Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host. J Lipid Res 2004;45:1169-1196
    • (2004) J Lipid Res , vol.45 , pp. 1169-1196
    • Khovidhunkit, W.1    Kim, M.S.2    Memon, R.A.3
  • 29
    • 1442284350 scopus 로고    scopus 로고
    • Regulation of lipoprotein trafficking in the kidney: Role of inflammatory mediators and transcription factors
    • Ruan XZ, Moorhead JF, Fernando R, Wheeler DC, Powis SH, Varghese Z. Regulation of lipoprotein trafficking in the kidney: role of inflammatory mediators and transcription factors. Biochem Soc Trans 2004;32:88-91
    • (2004) Biochem Soc Trans , vol.32 , pp. 88-91
    • Ruan, X.Z.1    Moorhead, J.F.2    Fernando, R.3    Wheeler, D.C.4    Powis, S.H.5    Varghese, Z.6
  • 30
    • 84895059003 scopus 로고    scopus 로고
    • Inflammatory stress induces statin resistance by disrupting 3-hydroxy-3-methylglutaryl-CoA reductase feedback regulation
    • Chen Y, Ku H, Zhao L, et al. Inflammatory stress induces statin resistance by disrupting 3-hydroxy-3-methylglutaryl-CoA reductase feedback regulation. Arterioscler Thromb Vasc Biol 2014;34:365-376
    • (2014) Arterioscler Thromb Vasc Biol , vol.34 , pp. 365-376
    • Chen, Y.1    Ku, H.2    Zhao, L.3
  • 31
    • 82355163517 scopus 로고    scopus 로고
    • A distinct adipose tissue gene expression response to caloric restriction predicts 6-mo weight maintenance in obese subjects
    • Mutch DM, Pers TH, Temanni MR, et al.; DiOGenes Project. A distinct adipose tissue gene expression response to caloric restriction predicts 6-mo weight maintenance in obese subjects. Am J Clin Nutr 2011;94:1399-1409
    • (2011) Am J Clin Nutr , vol.94 , pp. 1399-1409
    • DiOGenes Project1    Mutch, D.M.2    Pers, T.H.3    Temanni, M.R.4
  • 32
    • 21944438331 scopus 로고    scopus 로고
    • Changes in adipose tissue gene expression with energy-restricted diets in obese women
    • Dahlman I, Linder K, Arvidsson Nordström E, et al. Changes in adipose tissue gene expression with energy-restricted diets in obese women. Am J Clin Nutr 2005;81:1275-1285
    • (2005) Am J Clin Nutr , vol.81 , pp. 1275-1285
    • Dahlman, I.1    Linder, K.2    Arvidsson Nordström, E.3
  • 33
    • 84863562798 scopus 로고    scopus 로고
    • Differential gene expression in adipose tissue from obese human subjects during weight loss and weight maintenance
    • Johansson LE, Danielsson AP, Parikh H, et al. Differential gene expression in adipose tissue from obese human subjects during weight loss and weight maintenance. Am J Clin Nutr 2012;96:196-207
    • (2012) Am J Clin Nutr , vol.96 , pp. 196-207
    • Johansson, L.E.1    Danielsson, A.P.2    Parikh, H.3
  • 34
    • 58149373769 scopus 로고    scopus 로고
    • Changes in the transcriptome of abdominal subcutaneous adipose tissue in response to short-term overfeeding in lean and obese men
    • Shea J, French CR, Bishop J, et al. Changes in the transcriptome of abdominal subcutaneous adipose tissue in response to short-term overfeeding in lean and obese men. Am J Clin Nutr 2009;89:407-415
    • (2009) Am J Clin Nutr , vol.89 , pp. 407-415
    • Shea, J.1    French, C.R.2    Bishop, J.3
  • 35
    • 0036790413 scopus 로고    scopus 로고
    • Consequences of cellular cholesterol accumulation: Basic concepts and physiological implications
    • Tabas I. Consequences of cellular cholesterol accumulation: basic concepts and physiological implications. J Clin Invest 2002;110:905-911
    • (2002) J Clin Invest , vol.110 , pp. 905-911
    • Tabas, I.1
  • 36
    • 77951603544 scopus 로고    scopus 로고
    • Improved insulin sensitivity in high fat- and high cholesterol-fed Ldlr-/-mice with macrophage-specific transgenic expression of cholesteryl ester hydrolase: Role of macrophage inflammation and infiltration into adipose tissue
    • Bie J, Zhao B, Song J, Ghosh S. Improved insulin sensitivity in high fat- and high cholesterol-fed Ldlr-/-mice with macrophage-specific transgenic expression of cholesteryl ester hydrolase: role of macrophage inflammation and infiltration into adipose tissue. J Biol Chem 2010;285:13630-13637
    • (2010) J Biol Chem , vol.285 , pp. 13630-13637
    • Bie, J.1    Zhao, B.2    Song, J.3    Ghosh, S.4
  • 37
    • 84861116568 scopus 로고    scopus 로고
    • Macrophagespecific transgenic expression of cholesteryl ester hydrolase attenuates hepatic lipid accumulation and also improves glucose tolerance in ob/ob mice
    • Bie J, Zhao B, Marqueen KE, Wang J, Szomju B, Ghosh S. Macrophagespecific transgenic expression of cholesteryl ester hydrolase attenuates hepatic lipid accumulation and also improves glucose tolerance in ob/ob mice. Am J Physiol Endocrinol Metab 2012;302:E1283-E1291
    • (2012) Am J Physiol Endocrinol Metab , vol.302 , pp. E1283-E1291
    • Bie, J.1    Zhao, B.2    Marqueen, K.E.3    Wang, J.4    Szomju, B.5    Ghosh, S.6
  • 38
  • 39
    • 77954725211 scopus 로고    scopus 로고
    • Cholesterol imbalance in adipocytes: A possible mechanism of adipocytes dysfunction in obesity
    • Yu BL, Zhao SP, Hu JR. Cholesterol imbalance in adipocytes: a possible mechanism of adipocytes dysfunction in obesity. Obes Rev 2010;11:560-567
    • (2010) Obes Rev , vol.11 , pp. 560-567
    • Yu, B.L.1    Zhao, S.P.2    Hu, J.R.3
  • 40
    • 84894822714 scopus 로고    scopus 로고
    • ABCA1 in adipocytes regulates adipose tissue lipid content, glucose tolerance, and insulin sensitivity
    • de Haan W, Bhattacharjee A, Ruddle P, Kang MH, Hayden MR; de. ABCA1 in adipocytes regulates adipose tissue lipid content, glucose tolerance, and insulin sensitivity. J Lipid Res 2014;55:516-523
    • (2014) J Lipid Res , vol.55 , pp. 516-523
    • De Haan, W.1    Bhattacharjee, A.2    Ruddle, P.3    Kang, M.H.4    De Hayden, M.R.5
  • 41
    • 67049155954 scopus 로고    scopus 로고
    • Cholesterol metabolism and pancreatic betacell function
    • Fryirs M, Barter PJ, Rye KA. Cholesterol metabolism and pancreatic betacell function. Curr Opin Lipidol 2009;20:159-164
    • (2009) Curr Opin Lipidol , vol.20 , pp. 159-164
    • Fryirs, M.1    Barter, P.J.2    Rye, K.A.3
  • 42
    • 28444479505 scopus 로고    scopus 로고
    • Role of cholesterol and lipid organization in disease
    • Maxfield FR, Tabas I. Role of cholesterol and lipid organization in disease. Nature 2005;438:612-621
    • (2005) Nature , vol.438 , pp. 612-621
    • Maxfield, F.R.1    Tabas, I.2
  • 43
    • 33847722655 scopus 로고    scopus 로고
    • Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment
    • Brunham LR, Kruit JK, Pape TD, et al. Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment. Nat Med 2007;13:340-347
    • (2007) Nat Med , vol.13 , pp. 340-347
    • Brunham, L.R.1    Kruit, J.K.2    Pape, T.D.3
  • 44
    • 20144381320 scopus 로고    scopus 로고
    • ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation
    • Kennedy MA, Barrera GC, Nakamura K, et al. ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation. Cell Metab 2005;1:121-131
    • (2005) Cell Metab , vol.1 , pp. 121-131
    • Kennedy, M.A.1    Barrera, G.C.2    Nakamura, K.3
  • 46
    • 33845886915 scopus 로고    scopus 로고
    • Abdominal obesity and metabolic syndrome
    • Després JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature 2006;444:881-887
    • (2006) Nature , vol.444 , pp. 881-887
    • Després, J.P.1    Lemieux, I.2
  • 47
    • 41349095280 scopus 로고    scopus 로고
    • Genetics of gene expression and its effect on disease
    • Emilsson V, Thorleifsson G, Zhang B, et al. Genetics of gene expression and its effect on disease. Nature 2008;452:423-428
    • (2008) Nature , vol.452 , pp. 423-428
    • Emilsson, V.1    Thorleifsson, G.2    Zhang, B.3
  • 48
    • 84855853767 scopus 로고    scopus 로고
    • Interleukin-1 receptor-associated kinase-3 is a key inhibitor of inflammation in obesity and metabolic syndrome
    • Hulsmans M, Geeraert B, De Keyzer D, et al. Interleukin-1 receptor-associated kinase-3 is a key inhibitor of inflammation in obesity and metabolic syndrome. PLoS One 2012;7:e30414
    • (2012) PLoS One , vol.7 , pp. e30414
    • Hulsmans, M.1    Geeraert, B.2    De Keyzer, D.3
  • 49
    • 77956913463 scopus 로고    scopus 로고
    • Personalized epigenomic signatures that are stable over time and covary with body mass index
    • Feinberg AP, Irizarry RA, Fradin D, et al. Personalized epigenomic signatures that are stable over time and covary with body mass index. Sci Transl Med 2010;2:49ra67
    • (2010) Sci Transl Med , vol.2 , pp. 49ra67
    • Feinberg, A.P.1    Irizarry, R.A.2    Fradin, D.3
  • 50
    • 77950339092 scopus 로고    scopus 로고
    • Integrating pathway analysis and genetics of gene expression for genome-wide association studies
    • Zhong H, Yang X, Kaplan LM, Molony C, Schadt EE. Integrating pathway analysis and genetics of gene expression for genome-wide association studies. Am J Hum Genet 2010;86:581-591
    • (2010) Am J Hum Genet , vol.86 , pp. 581-591
    • Zhong, H.1    Yang, X.2    Kaplan, L.M.3    Molony, C.4    Schadt, E.E.5
  • 51
    • 69949176863 scopus 로고    scopus 로고
    • Common regulatory variation impacts gene expression in a cell type-dependent manner
    • Dimas AS, Deutsch S, Stranger BE, et al. Common regulatory variation impacts gene expression in a cell type-dependent manner. Science 2009;325:1246-1250
    • (2009) Science , vol.325 , pp. 1246-1250
    • Dimas, A.S.1    Deutsch, S.2    Stranger, B.E.3
  • 52
    • 80355146868 scopus 로고    scopus 로고
    • Monocyte recruitment during infection and inflammation
    • Shi C, Pamer EG. Monocyte recruitment during infection and inflammation. Nat Rev Immunol 2011;11:762-774
    • (2011) Nat Rev Immunol , vol.11 , pp. 762-774
    • Shi, C.1    Pamer, E.G.2
  • 53
    • 79955388920 scopus 로고    scopus 로고
    • A high-fat meal promotes lipid-load and apolipoprotein B-48 receptor transcriptional activity in circulating monocytes
    • Varela LM, Ortega A, Bermudez B, et al. A high-fat meal promotes lipid-load and apolipoprotein B-48 receptor transcriptional activity in circulating monocytes. Am J Clin Nutr 2011;93:918-925
    • (2011) Am J Clin Nutr , vol.93 , pp. 918-925
    • Varela, L.M.1    Ortega, A.2    Bermudez, B.3


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