Bisdemethoxycurcumin Inhibits Adipogenesis in 3T3-L1 Preadipocytes and Suppresses Obesity in High-Fat Diet-Fed C57BL/6 Mice

Journal of Agricultural and Food Chemistry

Volumn 64, Issue 4, 2016, Pages 821-830

  Lai, Ching Shu ^a,b   Chen, Ying Yi ^a   Lee, Pei Sheng ^a   Kalyanam, Nagabhushanam ^c   Ho, Chi Tang ^d   Liou, Wen Shiung ^e   Yu, Roch Chui ^a   Pan, Min Hsiung ^a,f,g,h  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL KAOHSIUNG UNIVERSITY OF APPLIED SCIENCES   (Taiwan)

^c SABINSA CORPORATION   (United States)

^d RUTGERS UNIVERSITY   (United States)

^e KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^f HUANGGANG NORMAL UNIVERSITY   (China)

^g CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^h ASIA UNIVERSITY   (Taiwan)

Author keywords

adipogenesis; bisdemethoxycurcumin (BDMC); high fat diet; mitotic clonal expansion (MCE); obesity

Indexed keywords

CELL SIGNALING; CYTOLOGY; DERIVATIVES; MAMMALS; MOLECULAR WEIGHT; PATHOLOGY; PROTEINS;

ADIPOGENESIS; BISDEMETHOXYCURCUMIN; CLONAL EXPANSION; HIGH-FAT DIET; OBESITY;

NUTRITION;

BIS(4-HYDROXYCINNAMOYL)METHANE; CCAAT ENHANCER BINDING PROTEIN ALPHA; CURCUMIN; MITOGEN ACTIVATED PROTEIN KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

3T3-L1 CELL LINE; ADIPOCYTE; ADIPOGENESIS; ADVERSE EFFECTS; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; CELL DIFFERENTIATION; CYTOLOGY; DOWN REGULATION; DRUG EFFECTS; GENETICS; HUMAN; LIPID DIET; MALE; METABOLISM; MOUSE; OBESITY;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ANIMALS; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CELL DIFFERENTIATION; CURCUMIN; DIET, HIGH-FAT; DOWN-REGULATION; HUMANS; MALE; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; OBESITY; PPAR GAMMA;

EID: 84956896207     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/acs.jafc.5b05577     Document Type: Article

References (28)

1. Ng, M.; Fleming, T.; Robinson, M.; Thomson, B. et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013 Lancet 2014, 384, 766-781 10.1016/S0140-6736(14)60460-8
2. Kelly, T.; Yang, W.; Chen, C. S.; Reynolds, K.; He, J. Global burden of obesity in 2005 and projections to 2030 Int. J. Obes. 2008, 32, 1431-1437 10.1038/ijo.2008.102
3. Spiegelman, B. M.; Flier, J. S. Obesity and the regulation of energy balance Cell 2001, 104, 531-543 10.1016/S0092-8674(01)00240-9
4. Jo, J.; Gavrilova, O.; Pack, S.; Jou, W.; Mullen, S.; Sumner, A. E.; Cushman, S. W.; Periwal, V. Hypertrophy and/or Hyperplasia: Dynamics of Adipose Tissue Growth PLoS Comput. Biol. 2009, 5, e1000324 10.1371/journal.pcbi.1000324
5. Lefterova, M. I.; Lazar, M. A. New developments in adipogenesis Trends Endocrinol. Metab. 2009, 20, 107-114 10.1016/j.tem.2008.11.005
6. Ali, A. T.; Hochfeld, W. E.; Myburgh, R.; Pepper, M. S. Adipocyte and adipogenesis Eur. J. Cell Biol. 2013, 92, 229-236 10.1016/j.ejcb.2013.06.001
7. Rosen, E. D.; Walkey, C. J.; Puigserver, P.; Spiegelman, B. M. Transcriptional regulation of adipogenesis Genes Dev. 2000, 14, 1293-1307
8. Tang, Q. Q.; Otto, T. C.; Lane, M. D. Mitotic clonal expansion: a synchronous process required for adipogenesis Proc. Natl. Acad. Sci. U. S. A. 2003, 100, 44-49 10.1073/pnas.0137044100
9. Farmer, S. R. Transcriptional control of adipocyte formation Cell Metab. 2006, 4, 263-273 10.1016/j.cmet.2006.07.001
10. Bost, F.; Aouadi, M.; Caron, L.; Binetruy, B. The role of MAPKs in adipocyte differentiation and obesity Biochimie 2005, 87, 51-56 10.1016/j.biochi.2004.10.018
11. Prusty, D.; Park, B. H.; Davis, K. E.; Farmer, S. R. Activation of MEK/ERK signaling promotes adipogenesis by enhancing peroxisome proliferator-activated receptor gamma (PPARgamma) and C/EBPalpha gene expression during the differentiation of 3T3-L1 preadipocytes J. Biol. Chem. 2002, 277, 46226-46232 10.1074/jbc.M207776200
12. Tang, Q. Q.; Gronborg, M.; Huang, H.; Kim, J. W.; Otto, T. C.; Pandey, A.; Lane, M. D. Sequential phosphorylation of CCAAT enhancer-binding protein beta by MAPK and glycogen synthase kinase 3beta is required for adipogenesis Proc. Natl. Acad. Sci. U. S. A. 2005, 102, 9766-9771 10.1073/pnas.0503891102
13. Min, S. Y.; Yang, H.; Seo, S. G.; Shin, S. H.; Chung, M. Y.; Kim, J.; Lee, S. J.; Lee, H. J.; Lee, K. W. Cocoa polyphenols suppress adipogenesis in vitro and obesity in vivo by targeting insulin receptor Int. J. Obes. 2013, 37, 584-592 10.1038/ijo.2012.85
14. Gordon, O. N.; Luis, P. B.; Ashley, R. E.; Osheroff, N.; Schneider, C. Oxidative Transformation of Demethoxy- and Bisdemethoxycurcumin: Products, Mechanism of Formation, and Poisoning of Human Topoisomerase IIalpha Chem. Res. Toxicol. 2015, 28, 989-996 10.1021/acs.chemrestox.5b00009
15. Anand, P.; Thomas, S. G.; Kunnumakkara, A. B.; Sundaram, C.; Harikumar, K. B.; Sung, B.; Tharakan, S. T.; Misra, K.; Priyadarsini, I. K.; Rajasekharan, K. N.; Aggarwal, B. B. Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature Biochem. Pharmacol. 2008, 76, 1590-1611 10.1016/j.bcp.2008.08.008
16. Aggarwal, B. B.; Harikumar, K. B. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases Int. J. Biochem. Cell Biol. 2009, 41, 40-59 10.1016/j.biocel.2008.06.010
17. Ejaz, A.; Wu, D.; Kwan, P.; Meydani, M. Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL mice J. Nutr. 2009, 139, 919-925 10.3945/jn.108.100966
18. Kim, C. Y.; Le, T. T.; Chen, C.; Cheng, J. X.; Kim, K. H. Curcumin inhibits adipocyte differentiation through modulation of mitotic clonal expansion J. Nutr. Biochem. 2011, 22, 910-920 10.1016/j.jnutbio.2010.08.003
19. Bettini, S.; Vergara, D.; Bonsegna, S.; Giotta, L.; Toto, C.; Chieppa, M.; Maffia, M.; Giovinazzo, G.; Valli, L. Santino. Efficient stabilization of natural curcuminoids mediated by oil body encapsulation RSC Adv. 2013, 3, 5422-5429 10.1039/c3ra40552d
20. Lai, C. S.; Ho, M. H.; Tsai, M. L.; Li, S.; Badmaev, V.; Ho, C. T.; Pan, M. H. Suppression of adipogenesis and obesity in high-fat induced mouse model by hydroxylated polymethoxyflavones J. Agric. Food Chem. 2013, 61, 10320-10328 10.1021/jf402257t
21. Lai, C. S.; Liao, S. N.; Tsai, M. L.; Kalyanam, N.; Majeed, M.; Majeed, A.; Ho, C. T.; Pan, M. H. Calebin-A inhibits adipogenesis and hepatic steatosis in high-fat diet-induced obesity via activation of AMPK signaling Mol. Nutr. Food Res. 2015, 59, 1883-1895 10.1002/mnfr.201400809
22. Gregoire, F. M.; Smas, C. M.; Sul, H. S. Understanding adipocyte differentiation Physiol Rev. 1998, 78, 783-809
23. Belmonte, N.; Phillips, B. W.; Massiera, F.; Villageois, P.; Wdziekonski, B.; Saint-Marc, P.; Nichols, J.; Aubert, J.; Saeki, K.; Yuo, A.; Narumiya, S.; Ailhaud, G.; Dani, C. Activation of extracellular signal-regulated kinases and CREB/ATF-1 mediate the expression of CCAAT/enhancer binding proteins beta and -delta in preadipocytes Mol. Endocrinol. 2001, 15, 2037-2049 10.1210/mend.15.11.0721
24. Bray, G. A.; Tartaglia, L. A. Medicinal strategies in the treatment of obesity Nature 2000, 404, 672-677
25. Colitti, M.; Grasso, S. Nutraceuticals and regulation of adipocyte life: premises or promises Biofactors 2014, 40, 398-418 10.1002/biof.1164
26. Xu, J.; Liao, K. Protein kinase B/AKT 1 plays a pivotal role in insulin-like growth factor-1 receptor signaling induced 3T3-L1 adipocyte differentiation J. Biol. Chem. 2004, 279, 35914-35922 10.1074/jbc.M402297200
27. Miki, H.; Yamauchi, T.; Suzuki, R.; Komeda, K.; Tsuchida, A.; Kubota, N.; Terauchi, Y.; Kamon, J.; Kaburagi, Y.; Matsui, J.; Akanuma, Y.; Nagai, R.; Kimura, S.; Tobe, K.; Kadowaki, T. Essential role of insulin receptor substrate 1 (IRS-1) and IRS-2 in adipocyte differentiation Mol. Cell. Biol. 2001, 21, 2521-2532 10.1128/MCB.21.7.2521-2532.2001
28. Hirosumi, J.; Tuncman, G.; Chang, L.; Gorgun, C. Z.; Uysal, K. T.; Maeda, K.; Karin, M.; Hotamisligil, G. S. A central role for JNK in obesity and insulin resistance Nature 2002, 420, 333-336 10.1038/nature01137