Synthesis and biological evaluation of novel 5-hydroxylaminoisoxazole derivatives as lipoxygenase inhibitors and metabolism enhancing agents

Bioorganic and Medicinal Chemistry

Volumn 24, Issue 4, 2016, Pages 712-720

  Averina, Elena B ^a,b   Vasilenko, Dmitry A ^a   Gracheva, Yulia A ^a   Grishin, Yuri K ^a   Radchenko, Eugene V ^a,b   Burmistrov, Vladimir V ^c   Butov, Gennady M ^c   Neganova, Margarita E ^b   Serkova, Tatyana P ^b   Redkozubova, Olga M ^b   Shevtsova, Elena F ^a,b   Milaeva, Elena R ^a,b   Kuznetsova, Tamara S ^a   Zefirov, Nikolay S ^a,b  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b INSTITUTE OF PHYSIOLOGICALLY ACTIVE COMPOUNDS   (Russian Federation)

^c VOLGOGRAD STATE TECHNICAL UNIVERSITY   (Russian Federation)

Author keywords

Heterocyclization; Isoxazole; Lipoxygenase; Mitochondria; Reduction

Indexed keywords

1 ADAMANTYL 5 NITROISOXAZOLE 3 CARBOXYLATE; 1 ADAMANTYL 5 [HYDROXY(TETRAHYDROFURAN 2 YL)AMINO]ISOXAZOLE 3 CARBOXYLATE; 1,1 DIPHENYL 2 PICRYLHYDRAZYL; 2 (1 ADAMANTYL)ETHYL 5 NITROISOXAZOLE 3 CARBOXYLATE; 2 (1 ADAMANTYL)ETHYL 5 [HYDROXY(TETRAHYDROFURAN 2 YL)AMINO]ISOXAZOLE 3 CARBOXYLATE; 2 (1 ADAMANTYL)ETHYL ACRYLATE; 2 (1 ADAMANTYLOXY)ETHYL 5 NITROISOXAZOLE 3 CARBOXYLATE; 2 (1 ADAMANTYLOXY)ETHYL 5 [HYDROXY(TETRAHYDROFURAN 2 YL)AMINO]ISOXAZOLE 3 CARBOXYLATE; 2 (1 ADAMANTYLOXY)ETHYL ACRYLATE; 2 ADAMANTYL 5 NITROISOXAZOLE 3 CARBOXYLATE; 2 ADAMANTYL 5 [HYDROXY(TETRAHYDROFURAN 2 YL)AMINO]ISOXAZOLE 3 CARBOXYLATE; 2 ADAMANTYL ACRYLATE; 3 (ACRYLOYLOXY)ADAMANTANE 1 CARBOXYLATE; 3 (PROPOXYCARBONYL) 1 ADAMANTYL 5 NITROISOXAZOLE 3 CARBOXYLATE; 3 (PROPOXYCARBONYL) 1 ADAMANTYL 5 [HYDROXY(TETRAHYDROFURAN 2 YL)AMINO]ISOXAZOLE 3 CARBOXYLATE; 3,5 DIMETHYL 1 ADAMANTYL 5 NITROISOXAZOLE 3 CARBOXYLATE; 3,5 DIMETHYL 1 ADAMANTYL 5 [HYDROXY(TETRAHYDROFURAN 2 YL)AMINO]ISOXAZOLE 3 CARBOXYLATE; 3,5 DIMETHYL 1 ADAMANTYL ACRYLATE; 4 (1 ADAMANTYL)BENZYL 5 NITROISOXAZOLE 3 CARBOXYLATE; 4 (1 ADAMANTYL)BENZYL 5 [HYDROXY(TETRAHYDROFURAN 2 YL)AMINO]ISOXAZOLE 3 CARBOXYLATE; 4 (1 ADAMANTYL)BENZYL ACRYLATE; 5 HYDROXYLAMINOISOXAZOLE DERIVATIVE; ADAMANTANE; ANTIOXIDANT; ISOXAZOLE DERIVATIVE; LIPOXYGENASE; LIPOXYGENASE INHIBITOR; TETRANITROMETHANE; TRIETHYLAMINE; UNCLASSIFIED DRUG; 1,1-DIPHENYL-2-PICRYLHYDRAZYL; ANTIMYCIN A1; BIPHENYL DERIVATIVE; OLIGOMYCIN; PICRIC ACID; SCAVENGER;

ADULT; ANIMAL CELL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN CORTEX; CELL VIABILITY; CONTROLLED STUDY; DRUG SYNTHESIS; EC50; ENZYME INHIBITION; IC50; LIPID PEROXIDATION; LIVER MITOCHONDRION; MALE; NONHUMAN; RAT; RESPIRATORY FUNCTION; STRUCTURE ACTIVITY RELATION; TOXICITY TESTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; ENZYMOLOGY; HUMAN; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NERVE CELL; PRIMARY CELL CULTURE; SOYBEAN; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; ANTIMYCIN A; BIPHENYL COMPOUNDS; BRAIN; CELL LINE, TUMOR; FREE RADICAL SCAVENGERS; HUMANS; ISOXAZOLES; LIPID PEROXIDATION; LIPOXYGENASE; LIPOXYGENASE INHIBITORS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NEURONS; OLIGOMYCINS; PICRATES; PRIMARY CELL CULTURE; RATS; SOYBEANS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84956808373     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.12.040     Document Type: Article

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