Modified acidic nonsteroidal anti-inflammatory drugs as dual inhibitors of mPGES-1 and 5-LOX

Journal of Medicinal Chemistry

Volumn 55, Issue 20, 2012, Pages 8958-8962

  Elkady, Mahmoud ^a   Nieß, Raimund ^a   Schaible, Anja M ^b   Bauer, Julia ^a   Luderer, Susann ^a   Ambrosi, Giulia ^a   Werz, Oliver ^b   Laufer, Stefan A ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; 5 LOX INHIBITOR; BWA 4C; CARBOXYLIC ACID; CYCLOOXYGENASE 1; ENZYME INHIBITOR; INDOMETACIN DERIVATIVE; LONAZOLAC DERIVATIVE; MICROSOMAL PROSTAGLANDIN E SYNTHASE 1 INHIBITOR; N [3 (3 PHENOXYPHENYL)ALLYL]ACETOHYDROXAMIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARACHIDONATE 5-LIPOXYGENASE; CELL LINE; HUMANS; INDOMETHACIN; INTRAMOLECULAR OXIDOREDUCTASES; LIPOXYGENASE INHIBITORS; MICROSOMES; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 84867775593     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm3010543     Document Type: Article

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