Inhibition of LOX by flavonoids: A structure-activity relationship study

European Journal of Medicinal Chemistry

Volumn 72, Issue , 2014, Pages 137-145

  Ribeiro, Daniela ^a   Freitas, Marisa ^a   Tomé, Sara M ^b   Silva, Artur M S ^b   Porto, Graça ^c   Cabrita, Eurico J ^d   Marques, M Manuel B ^d   Fernandes, Eduarda ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY OF AVEIRO   (Portugal)

^c HOSPITAL DE SANTO ANTÓNIO   (Portugal)

^d UNIVERSIDADE NOVA DE LISBOA   (Portugal)

Author keywords

5 LOX inhibition; Flavonoids; Neutrophils; Saturation transfer difference 1H NMR; Soybean LOX 1

Indexed keywords

ACACETIN; APIGENIN; ARACHIDONATE 5 LIPOXYGENASE; CHRYSIN; CHRYSOERIOL; DIOSMETIN; ERIODICTYOL; FLAVONE; FLAVONOID; LEUKOTRIENE B4; LIPOXYGENASE; LIPOXYGENASE I; LUTEOLIN; NARINGENIN; QUERCETIN; TAXIFOLIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG RESPONSE; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME INHIBITION ASSAY; HUMAN; HUMAN CELL; IC 50; MICHAELIS MENTEN KINETICS; NEUTROPHIL; PROTON NUCLEAR MAGNETIC RESONANCE; SOYBEAN; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; ENZYMOLOGY; METABOLISM;

DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONOIDS; HUMANS; LEUKOTRIENE B4; LIPOXYGENASE; MOLECULAR STRUCTURE; NEUTROPHILS; SOYBEANS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84890960018     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.11.030     Document Type: Article

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