메뉴 건너뛰기




Volumn 12, Issue 1, 2016, Pages

Residual Viremia in Treated HIV+Individuals

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ACTIVATION; DISEASES; DYNAMICS; LONG TERM EVOLUTION (LTE); STOCHASTIC MODELS; STOCHASTIC SYSTEMS;

EID: 84956780091     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1004677     Document Type: Article
Times cited : (56)

References (61)
  • 1
    • 0033613342 scopus 로고    scopus 로고
    • Re-emergence of HIV after stopping therapy
    • Chun TW, Davey RT, Engel D, Lane HC, Fauci AS, Re-emergence of HIV after stopping therapy. Nature. 1999;401:874–875. doi: 10.1038/44755 10553903
    • (1999) Nature , vol.401 , pp. 874-875
    • Chun, T.W.1    Davey, R.T.2    Engel, D.3    Lane, H.C.4    Fauci, A.S.5
  • 2
    • 34247584237 scopus 로고    scopus 로고
    • ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia
    • Maldarelli F, Palmer S, King MS, Wiegand A, Polis MA, Mican J, et al. ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia. PLoS Pathog. 2007;3(4):e46. doi: 10.1371/journal.ppat.0030046 17411338
    • (2007) PLoS Pathog , vol.3 , Issue.4 , pp. 46
    • Maldarelli, F.1    Palmer, S.2    King, M.S.3    Wiegand, A.4    Polis, M.A.5    Mican, J.6
  • 4
    • 0030913366 scopus 로고    scopus 로고
    • Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection
    • Chun TW, Carruth L, Finzi D, Shen X, DiGiuseppe JA, Taylor HY, et al. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature. 1997;387:183–188. doi: 10.1038/387183a0 9144289
    • (1997) Nature , vol.387 , pp. 183-188
    • Chun, T.W.1    Carruth, L.2    Finzi, D.3    Shen, X.4    DiGiuseppe, J.A.5    Taylor, H.Y.6
  • 5
    • 0032953920 scopus 로고    scopus 로고
    • Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
    • Finzi D, Blankson J, Siliciano JD, Margolick JB, Chadwick K, Pierson T, et al. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nat Med. 1999;5(5):512–517. doi: 10.1038/8394 10229227
    • (1999) Nat Med , vol.5 , Issue.5 , pp. 512-517
    • Finzi, D.1    Blankson, J.2    Siliciano, J.D.3    Margolick, J.B.4    Chadwick, K.5    Pierson, T.6
  • 7
    • 0032555117 scopus 로고    scopus 로고
    • Early establishment of a pool of latently infected, resting CD4+ T cells during primary HIV-1 infection
    • Chun TW, Engel D, Berrey MM, Shea T, Corey L, Fauci AS, Early establishment of a pool of latently infected, resting CD4+ T cells during primary HIV-1 infection. Proc Natl Acad Sci USA. 1998;95(15):8869–8873. doi: 10.1073/pnas.95.15.8869 9671771
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.15 , pp. 8869-8873
    • Chun, T.W.1    Engel, D.2    Berrey, M.M.3    Shea, T.4    Corey, L.5    Fauci, A.S.6
  • 8
    • 84905565097 scopus 로고    scopus 로고
    • Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys
    • Whitney JB, Hill AL, Sanisetty S, Penaloza-MacMaster P, Liu J, Shetty M, et al. Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys. Nature. 2014;512:74–77. doi: 10.1038/nature13594 25042999
    • (2014) Nature , vol.512 , pp. 74-77
    • Whitney, J.B.1    Hill, A.L.2    Sanisetty, S.3    Penaloza-MacMaster, P.4    Liu, J.5    Shetty, M.6
  • 9
    • 68349139711 scopus 로고    scopus 로고
    • HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
    • Chomont N, El-Far M, Ancuta P, Trautmann L, Procopio FA, Yassine-Diab B, et al. HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation. Nat Med. 2009;15(8):893–901. doi: 10.1038/nm.1972 19543283
    • (2009) Nat Med , vol.15 , Issue.8 , pp. 893-901
    • Chomont, N.1    El-Far, M.2    Ancuta, P.3    Trautmann, L.4    Procopio, F.A.5    Yassine-Diab, B.6
  • 10
    • 0038579210 scopus 로고    scopus 로고
    • Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells
    • Siliciano JD, Kajdas J, Finzi D, Quinn TC, Chadwick K, Margolick JB, et al. Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells. Nat Med. 2003;9(6):727–728. doi: 10.1038/nm880 12754504
    • (2003) Nat Med , vol.9 , Issue.6 , pp. 727-728
    • Siliciano, J.D.1    Kajdas, J.2    Finzi, D.3    Quinn, T.C.4    Chadwick, K.5    Margolick, J.B.6
  • 12
    • 0032490570 scopus 로고    scopus 로고
    • Induction of HIV-1 replication in latently infected CD4+ T cells using a combination of cytokines
    • Chun TW, Engel D, Mizell SB, Ehler LA, Fauci AS, Induction of HIV-1 replication in latently infected CD4+ T cells using a combination of cytokines. J Exp Med. 1998;188(1):83–91. doi: 10.1084/jem.188.1.83 9653086
    • (1998) J Exp Med , vol.188 , Issue.1 , pp. 83-91
    • Chun, T.W.1    Engel, D.2    Mizell, S.B.3    Ehler, L.A.4    Fauci, A.S.5
  • 13
    • 70350148394 scopus 로고    scopus 로고
    • Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs
    • Coiras M, López-Huertas MR, Pérez-Olmeda M, Alcamí J, Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs. Nat Rev Microbiol. 2009;7:798–812. doi: 10.1038/nrmicro2223 19834480
    • (2009) Nat Rev Microbiol , vol.7 , pp. 798-812
    • Coiras, M.1    López-Huertas, M.R.2    Pérez-Olmeda, M.3    Alcamí, J.4
  • 14
    • 0034040118 scopus 로고    scopus 로고
    • Reservoirs for HIV-1: Mechanisms for viral persistence in the presence of antiviral immune responses and antiretroviral therapy
    • Pierson T, McArthur J, Siliciano RF, Reservoirs for HIV-1: Mechanisms for viral persistence in the presence of antiviral immune responses and antiretroviral therapy. Annu Rev Immunol. 2000;18:665–708. doi: 10.1146/annurev.immunol.18.1.665 10837072
    • (2000) Annu Rev Immunol , vol.18 , pp. 665-708
    • Pierson, T.1    McArthur, J.2    Siliciano, R.F.3
  • 15
    • 79953000877 scopus 로고    scopus 로고
    • A randomized, controlled trial of raltegravir intensification in antiretroviral-treated, HIV-infected patients with a suboptimal CD4+ T cell response
    • Hatano H, L HT, Dahl V, Sinclair E, Lee TH, Hoh R, et al. A randomized, controlled trial of raltegravir intensification in antiretroviral-treated, HIV-infected patients with a suboptimal CD4+ T cell response. J Infect Dis. 2011;203:960–968. doi: 10.1093/infdis/jiq138 21402547
    • (2011) J Infect Dis , vol.203 , pp. 960-968
    • Hatano, H.1    L, H.T.2    Dahl, V.3    Sinclair, E.4    Lee, T.H.5    Hoh, R.6
  • 16
    • 67249121143 scopus 로고    scopus 로고
    • Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy
    • Dinoso JB, Kim SY, Wiegand AM, Palmer SE, Gange SJ, Cranmer L, et al. Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy. Proc Natl Acad Sci USA. 2009;106:9403–9408. doi: 10.1073/pnas.0903107106 19470482
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 9403-9408
    • Dinoso, J.B.1    Kim, S.Y.2    Wiegand, A.M.3    Palmer, S.E.4    Gange, S.J.5    Cranmer, L.6
  • 17
    • 2142829435 scopus 로고    scopus 로고
    • Genotypic analysis of HIV-1 drug resistance at the limit of detection: virus production without evolution in treated adults with undetectable HIV loads
    • Kieffer TL, Finucane MM, Nettles RE, Quinn TC, Broman KW, Ray SC, et al. Genotypic analysis of HIV-1 drug resistance at the limit of detection: virus production without evolution in treated adults with undetectable HIV loads. J Infect Dis. 2004;189:1452–1465. doi: 10.1086/382488 15073683
    • (2004) J Infect Dis , vol.189 , pp. 1452-1465
    • Kieffer, T.L.1    Finucane, M.M.2    Nettles, R.E.3    Quinn, T.C.4    Broman, K.W.5    Ray, S.C.6
  • 18
    • 0034946886 scopus 로고    scopus 로고
    • HIV-1 drug resistance profiles in children and adults with viral load of <50 copies/mL receiving combination therapy
    • Hermankova M, Ray SC, Ruff C, Powell-Davis M, Ingersoll R, D’Aquila RT, et al. HIV-1 drug resistance profiles in children and adults with viral load of <50 copies/mL receiving combination therapy. J Amer Med Assoc. 2001;286:196–207. doi: 10.1001/jama.286.2.196
    • (2001) J Amer Med Assoc , vol.286 , pp. 196-207
    • Hermankova, M.1    Ray, S.C.2    Ruff, C.3    Powell-Davis, M.4    Ingersoll, R.5    D’Aquila, R.T.6
  • 19
    • 79955402159 scopus 로고    scopus 로고
    • Clonal sequences recovered from plasma from patients with residual HIV-1 viremia and on intensified antiretroviral therapy are identical to replicating viral RNAs recovered from circulating resting CD4+ T cells
    • Anderson JA, Archin NM, Ince W, Parker D, Wiegand A, Coffin JM, et al. Clonal sequences recovered from plasma from patients with residual HIV-1 viremia and on intensified antiretroviral therapy are identical to replicating viral RNAs recovered from circulating resting CD4+ T cells. J Virol. 2011;85:5220–5223. doi: 10.1128/JVI.00284-11 21367910
    • (2011) J Virol , vol.85 , pp. 5220-5223
    • Anderson, J.A.1    Archin, N.M.2    Ince, W.3    Parker, D.4    Wiegand, A.5    Coffin, J.M.6
  • 20
    • 33745245733 scopus 로고    scopus 로고
    • Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy Is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells
    • Bailey JR, Sedaghat AR, Kieffer T, Brennan T, Lee PK, Wind-Rotolo M, et al. Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy Is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells. J Virol. 2006;80:6441–6457. doi: 10.1128/JVI.00591-06 16775332
    • (2006) J Virol , vol.80 , pp. 6441-6457
    • Bailey, J.R.1    Sedaghat, A.R.2    Kieffer, T.3    Brennan, T.4    Lee, P.K.5    Wind-Rotolo, M.6
  • 21
    • 84860908013 scopus 로고    scopus 로고
    • Absence of HIV-1 evolution in the gut-associated lymphoid tissue from patients on combination antiviral therapy initiated during primary infection
    • Evering TH, Mehandru S, Racz P, Tenner-Racz K, Poles MA, Figueroa A, et al. Absence of HIV-1 evolution in the gut-associated lymphoid tissue from patients on combination antiviral therapy initiated during primary infection. PLoS Pathog. 2012;8:e1002506. doi: 10.1371/journal.ppat.1002506 22319447
    • (2012) PLoS Pathog , vol.8 , pp. 1002506
    • Evering, T.H.1    Mehandru, S.2    Racz, P.3    Tenner-Racz, K.4    Poles, M.A.5    Figueroa, A.6
  • 22
    • 55949083820 scopus 로고    scopus 로고
    • HIV rebounds from latently infected cells, rather than from continuing low-level replication
    • Joos B, Fischer M, Kuster H, Pillai SK, Wong JK, Boeni J, et al. HIV rebounds from latently infected cells, rather than from continuing low-level replication. Proc Natl Acad Sci USA. 2008;105(43):16725–16730. doi: 10.1073/pnas.0804192105 18936487
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.43 , pp. 16725-16730
    • Joos, B.1    Fischer, M.2    Kuster, H.3    Pillai, S.K.4    Wong, J.K.5    Boeni, J.6
  • 23
    • 84860345691 scopus 로고    scopus 로고
    • Treatment intensification with raltegravir in subjects with sustained HIV-1 viraemia suppression: a randomized 48-week study
    • Llibre JM, Buzón MJ, Massanella M, Esteve A, Dahl V, Puertas MC, et al. Treatment intensification with raltegravir in subjects with sustained HIV-1 viraemia suppression: a randomized 48-week study. Antivir Ther. 2012;17:355–364. 22290239
    • (2012) Antivir Ther , vol.17 , pp. 355-364
    • Llibre, J.M.1    Buzón, M.J.2    Massanella, M.3    Esteve, A.4    Dahl, V.5    Puertas, M.C.6
  • 24
    • 79957966626 scopus 로고    scopus 로고
    • Relationship between residual plasma viremia and the size of HIV proviral DNA reservoirs in infected individuals receiving effective antiretroviral therapy
    • Chun TW, Murray D, Justement JS, Hallahan CW, Moir S, Kovacs C, et al. Relationship between residual plasma viremia and the size of HIV proviral DNA reservoirs in infected individuals receiving effective antiretroviral therapy. J Infect Dis. 2011;204:135–138. doi: 10.1093/infdis/jir208 21628667
    • (2011) J Infect Dis , vol.204 , pp. 135-138
    • Chun, T.W.1    Murray, D.2    Justement, J.S.3    Hallahan, C.W.4    Moir, S.5    Kovacs, C.6
  • 25
    • 84893830170 scopus 로고    scopus 로고
    • Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues
    • Fletcher CV, Staskus K, Wietgrefe SW, Rothenberger M, Reilly C, Chipman JG, et al. Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues. Proc Natl Acad Sci USA. 2014;111:2307–2312. doi: 10.1073/pnas.1318249111 24469825
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 2307-2312
    • Fletcher, C.V.1    Staskus, K.2    Wietgrefe, S.W.3    Rothenberger, M.4    Reilly, C.5    Chipman, J.G.6
  • 26
    • 57749177930 scopus 로고    scopus 로고
    • Asymmetric division of activated latently infected cells may explain the decay kinetics of the HIV-1 latent reservoir and intermittent viral blips
    • Rong L, Perelson AS, Asymmetric division of activated latently infected cells may explain the decay kinetics of the HIV-1 latent reservoir and intermittent viral blips. Math Biosci. 2009;217:77–87. doi: 10.1016/j.mbs.2008.10.006 18977369
    • (2009) Math Biosci , vol.217 , pp. 77-87
    • Rong, L.1    Perelson, A.S.2
  • 27
    • 84969424591 scopus 로고    scopus 로고
    • NIH. AIDSinfo: Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents; 2015.
  • 28
    • 0027457101 scopus 로고
    • Dynamics of HIV-infection of CD4+ T-cells
    • Perelson AS, Kirschner DE, De Boer RJ, Dynamics of HIV-infection of CD4+ T-cells. Math Biosci. 1993;114(1):81–125. doi: 10.1016/0025-5564(93)90043-A 8096155
    • (1993) Math Biosci , vol.114 , Issue.1 , pp. 81-125
    • Perelson, A.S.1    Kirschner, D.E.2    De Boer, R.J.3
  • 29
    • 0029967721 scopus 로고    scopus 로고
    • HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time
    • Perelson AS, Neumann AU, Markowitz M, Leonard JM, Ho DD, HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time. Science. 1996;271(5255):1582–1586. doi: 10.1126/science.271.5255.1582 8599114
    • (1996) Science , vol.271 , Issue.5255 , pp. 1582-1586
    • Perelson, A.S.1    Neumann, A.U.2    Markowitz, M.3    Leonard, J.M.4    Ho, D.D.5
  • 30
    • 0034615789 scopus 로고    scopus 로고
    • Modeling plasma virus concentration during primary HIV infection
    • Stafford MA, Corey L, Cao Y, Daar ES, Ho DD, Perelson AS, Modeling plasma virus concentration during primary HIV infection. J Theor Biol. 2000;203:285–301. doi: 10.1006/jtbi.2000.1076 10716909
    • (2000) J Theor Biol , vol.203 , pp. 285-301
    • Stafford, M.A.1    Corey, L.2    Cao, Y.3    Daar, E.S.4    Ho, D.D.5    Perelson, A.S.6
  • 31
    • 77950833850 scopus 로고    scopus 로고
    • Primary SIV infection: effect of time-dependent virus infectiousness
    • Vaidya NK, Ribeiro RM, Miller CJ, Perelson AS, Primary SIV infection: effect of time-dependent virus infectiousness. J Virol. 2010;84:4302–4310. doi: 10.1128/JVI.02284-09 20147390
    • (2010) J Virol , vol.84 , pp. 4302-4310
    • Vaidya, N.K.1    Ribeiro, R.M.2    Miller, C.J.3    Perelson, A.S.4
  • 32
    • 78649669772 scopus 로고    scopus 로고
    • Treatment-mediated alterations in HIV fitness preserve CD4+ T cell counts but have minimal effects on viral load
    • Vaidya NK, Rong L, Marconi VD, Kuritzkes DR, Deeks SG, Perelson AS, Treatment-mediated alterations in HIV fitness preserve CD4+ T cell counts but have minimal effects on viral load. PLoS Comput Biol. 2010;6(11):e1001012. doi: 10.1371/journal.pcbi.1001012 21124866
    • (2010) PLoS Comput Biol , vol.6 , Issue.11 , pp. 1001012
    • Vaidya, N.K.1    Rong, L.2    Marconi, V.D.3    Kuritzkes, D.R.4    Deeks, S.G.5    Perelson, A.S.6
  • 33
    • 77952686145 scopus 로고    scopus 로고
    • Estimation of the initial growth rate and basic reproduction number during acute HIV infection
    • Ribeiro RM, Qin L, Chavez LL, Li D, Self SG, Perelson AS, Estimation of the initial growth rate and basic reproduction number during acute HIV infection. J Virol. 2010;84:6096–6102. doi: 10.1128/JVI.00127-10 20357090
    • (2010) J Virol , vol.84 , pp. 6096-6102
    • Ribeiro, R.M.1    Qin, L.2    Chavez, L.L.3    Li, D.4    Self, S.G.5    Perelson, A.S.6
  • 34
    • 84862189831 scopus 로고    scopus 로고
    • Immediate antiviral therapy appears to restrict resting CD4+ cell HIV-1 infection without accelerating the decay of latent infection
    • Archin NM, Vaidya NK, Kuruc JD, Liberty AL, Wiegand A, Kearney MF, et al. Immediate antiviral therapy appears to restrict resting CD4+ cell HIV-1 infection without accelerating the decay of latent infection. Proc Natl Acad Sci USA. 2012;109(24):9523–9528. doi: 10.1073/pnas.1120248109 22645358
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.24 , pp. 9523-9528
    • Archin, N.M.1    Vaidya, N.K.2    Kuruc, J.D.3    Liberty, A.L.4    Wiegand, A.5    Kearney, M.F.6
  • 35
    • 0033589745 scopus 로고    scopus 로고
    • Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis
    • Ramratnam B, Bonhoeffer S, Binley J, Hurley A, Zhang LQ, Mittler JE, et al. Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis. Lancet. 1999;354(9192):1782–1785. doi: 10.1016/S0140-6736(99)02035-8 10577640
    • (1999) Lancet , vol.354 , Issue.9192 , pp. 1782-1785
    • Ramratnam, B.1    Bonhoeffer, S.2    Binley, J.3    Hurley, A.4    Zhang, L.Q.5    Mittler, J.E.6
  • 36
    • 78049444596 scopus 로고    scopus 로고
    • Current estimates for HIV-1 production imply rapid viral clearance in lymphoid tissues
    • de Boer RJ, Ribeiro RM, Perelson AS, Current estimates for HIV-1 production imply rapid viral clearance in lymphoid tissues. PLoS Comput Biol. 2010;6(9):e1000906. doi: 10.1371/journal.pcbi.1000906 20824126
    • (2010) PLoS Comput Biol , vol.6 , Issue.9 , pp. 1000906
    • de Boer, R.J.1    Ribeiro, R.M.2    Perelson, A.S.3
  • 37
    • 0037385686 scopus 로고    scopus 로고
    • A novel antiviral intervention results in more accurate assessment of human immunodeficiency virus type 1 replication dynamics and T-Cell decay in vivo
    • Markowitz M, Louie M, Hurley A, Sun E, Di Mascio M, A novel antiviral intervention results in more accurate assessment of human immunodeficiency virus type 1 replication dynamics and T-Cell decay in vivo. J Virol. 2003;77(8):5037–5038. doi: 10.1128/JVI.77.8.5037-5038.2003 12663814
    • (2003) J Virol , vol.77 , Issue.8 , pp. 5037-5038
    • Markowitz, M.1    Louie, M.2    Hurley, A.3    Sun, E.4    Di Mascio, M.5
  • 38
    • 0033577801 scopus 로고    scopus 로고
    • Constant mean viral copy number per infected cell in tissues regardless of high, low, or undetectable plasma HIV RNA
    • Hockett RD, Kilby JM, Derdeyn CA, Saag MS, Sillers M, Squires K, et al. Constant mean viral copy number per infected cell in tissues regardless of high, low, or undetectable plasma HIV RNA. J Exp Med. 1999;189(10):1545–1554. doi: 10.1084/jem.189.10.1545 10330433
    • (1999) J Exp Med , vol.189 , Issue.10 , pp. 1545-1554
    • Hockett, R.D.1    Kilby, J.M.2    Derdeyn, C.A.3    Saag, M.S.4    Sillers, M.5    Squires, K.6
  • 39
    • 37649007699 scopus 로고    scopus 로고
    • Determination of virus burst size in vivo using a single-cycle SIV in rhesus macaques
    • Chen HY, Di Mascio M, Perelson AS, Ho DD, Zhang L, Determination of virus burst size in vivo using a single-cycle SIV in rhesus macaques. Proc Natl Acad Sci USA. 2007;104(48):19079–19084. doi: 10.1073/pnas.0707449104 18025463
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.48 , pp. 19079-19084
    • Chen, H.Y.1    Di Mascio, M.2    Perelson, A.S.3    Ho, D.D.4    Zhang, L.5
  • 40
    • 84886769508 scopus 로고    scopus 로고
    • Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure
    • Ho YC, Shan L, Hosmane NN, Wang J, Laskey SB, Rosenbloom DIS, et al. Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure. Cell. 2013;155(3):540–551. doi: 10.1016/j.cell.2013.09.020 24243014
    • (2013) Cell , vol.155 , Issue.3 , pp. 540-551
    • Ho, Y.C.1    Shan, L.2    Hosmane, N.N.3    Wang, J.4    Laskey, S.B.5    Rosenbloom, D.I.S.6
  • 41
    • 84956842638 scopus 로고    scopus 로고
    • Early HIV RNA decay during raltegravir-containing regimes exhibits two distinct subphases (1a and 1b)
    • Andrade A, Guedj J, Rosenkranz SL, Lu D, Mellors J, Kuritzkes DR, et al. Early HIV RNA decay during raltegravir-containing regimes exhibits two distinct subphases (1a and 1b). AIDS. 2015;29:2419–2426. 26558541
    • (2015) AIDS , vol.29 , pp. 2419-2426
    • Andrade, A.1    Guedj, J.2    Rosenkranz, S.L.3    Lu, D.4    Mellors, J.5    Kuritzkes, D.R.6
  • 42
    • 70350558421 scopus 로고    scopus 로고
    • Sustained antiretroviral effect of raltegravir after 96 weeks of combination therapy in treatment-naive patients with HIV-1 infection
    • Markowitz M, Nguyen Y B, Gotuzzo E, Mendo F, Ratanasuwan W, Kovacs C, et al. Sustained antiretroviral effect of raltegravir after 96 weeks of combination therapy in treatment-naive patients with HIV-1 infection. JAIDS. 2009;52:350–356. 19648823
    • (2009) JAIDS , vol.52 , pp. 350-356
    • Markowitz, M.1    Nguyen, Y.B.2    Gotuzzo, E.3    Mendo, F.4    Ratanasuwan, W.5    Kovacs, C.6
  • 43
    • 77749277080 scopus 로고    scopus 로고
    • Short-course raltegravir intensification does not reduce persistent low-level viremia in patients with HIV-1 suppression during receipt of combination antiretroviral therapy
    • McMahon D, Jones H, Wiegand A, Gange SJ, Kearney M, Palmer S, et al. Short-course raltegravir intensification does not reduce persistent low-level viremia in patients with HIV-1 suppression during receipt of combination antiretroviral therapy. Clin Infect Dis. 2010;50:912–919. doi: 10.1086/650749 20156060
    • (2010) Clin Infect Dis , vol.50 , pp. 912-919
    • McMahon, D.1    Jones, H.2    Wiegand, A.3    Gange, S.J.4    Kearney, M.5    Palmer, S.6
  • 44
    • 84887335296 scopus 로고    scopus 로고
    • Closing the gap between T-cell life span estimates from stable isotope-labeling studies in mice and humans
    • Westera L, Drylewicz J, den Braber I, Mugwagwa T, van der Maas I, Kwast L, et al. Closing the gap between T-cell life span estimates from stable isotope-labeling studies in mice and humans. Blood. 2013;122:2205–2212. doi: 10.1182/blood-2013-03-488411 23945154
    • (2013) Blood , vol.122 , pp. 2205-2212
    • Westera, L.1    Drylewicz, J.2    den Braber, I.3    Mugwagwa, T.4    van der Maas, I.5    Kwast, L.6
  • 46
    • 0033520673 scopus 로고    scopus 로고
    • Residual HIV-1 RNA in blood plasma of patients taking suppressive highly active antiretroviral therapy
    • Dornadula G, Zhang H, VanUitert B, Stern J, Livornese L, JrIngerman MJ, et al. Residual HIV-1 RNA in blood plasma of patients taking suppressive highly active antiretroviral therapy. J Amer Med Assoc. 1999;282:1627–32. doi: 10.1001/jama.282.17.1627
    • (1999) J Amer Med Assoc , vol.282 , pp. 1627-1632
    • Dornadula, G.1    Zhang, H.2    VanUitert, B.3    Stern, J.4    Livornese, L.5    Ingerman, M.J.6
  • 47
    • 33645429016 scopus 로고
    • Exact stochastic simulation of coupled chemical reactions
    • Gillespie DT, Exact stochastic simulation of coupled chemical reactions. J Phys Chem. 1977;81:2340–2361. doi: 10.1021/j100540a008
    • (1977) J Phys Chem , vol.81 , pp. 2340-2361
    • Gillespie, D.T.1
  • 48
    • 0033236715 scopus 로고    scopus 로고
    • The distribution of time to extinction in subcritical branching processes: applications to outbreaks of infectious disease
    • Farrington CP, Grant AD, The distribution of time to extinction in subcritical branching processes: applications to outbreaks of infectious disease. J Appl Probab. 1999;36:771–779. doi: 10.1239/jap/1032374633
    • (1999) J Appl Probab , vol.36 , pp. 771-779
    • Farrington, C.P.1    Grant, A.D.2
  • 49
    • 84938774688 scopus 로고    scopus 로고
    • HIV rebound from latency occurs on average every 5–8 days—implications for HIV remission
    • Pinkevych M, Cromer D, Tolstrup M, Grimm DA, Cooper DA, Lewin SR, et al. HIV rebound from latency occurs on average every 5–8 days—implications for HIV remission. PLoS Pathog. 2015;11:e1005000. doi: 10.1371/journal.ppat.1005000 26133551
    • (2015) PLoS Pathog , vol.11 , pp. 1005000
    • Pinkevych, M.1    Cromer, D.2    Tolstrup, M.3    Grimm, D.A.4    Cooper, D.A.5    Lewin, S.R.6
  • 50
    • 0141958258 scopus 로고    scopus 로고
    • Different dynamics of CD4+ and CD8+ T cell responses during and after acute lymphocytic choriomeningitis virus infection
    • de Boer RJ, Homann D, Perelson AS, Different dynamics of CD4+ and CD8+ T cell responses during and after acute lymphocytic choriomeningitis virus infection. J Immunol. 2003;171:3928–3935. doi: 10.4049/jimmunol.171.8.3928 14530309
    • (2003) J Immunol , vol.171 , pp. 3928-3935
    • de Boer, R.J.1    Homann, D.2    Perelson, A.S.3
  • 51
    • 73449117263 scopus 로고    scopus 로고
    • Modeling latently infected cell activation: viral and latent reservoir persistence, and viral blips in HIV-infected patients on potent therapy
    • Rong L, Perelson AS, Modeling latently infected cell activation: viral and latent reservoir persistence, and viral blips in HIV-infected patients on potent therapy. PLoS Comput Biol. 2009;5:e1000533. doi: 10.1371/journal.pcbi.1000533 19834532
    • (2009) PLoS Comput Biol , vol.5 , pp. 1000533
    • Rong, L.1    Perelson, A.S.2
  • 52
    • 0029075130 scopus 로고
    • Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from fidelity of purified reverse transcriptase
    • Mansky LM, Temin HM, Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from fidelity of purified reverse transcriptase. J Virol. 1995;69:5087–5094. 7541846
    • (1995) J Virol , vol.69 , pp. 5087-5094
    • Mansky, L.M.1    Temin, H.M.2
  • 53
    • 84868664375 scopus 로고    scopus 로고
    • Antiretroviral dynamics determines HIV evolution and predicts therapy outcome
    • Rosenbloom DIS, Hill AL, Rabi SA, Siliciano RF, Nowak MA, Antiretroviral dynamics determines HIV evolution and predicts therapy outcome. Nat Med. 2012;18:1378–1385. doi: 10.1038/nm.2892 22941277
    • (2012) Nat Med , vol.18 , pp. 1378-1385
    • Rosenbloom, D.I.S.1    Hill, A.L.2    Rabi, S.A.3    Siliciano, R.F.4    Nowak, M.A.5
  • 54
    • 84907240033 scopus 로고    scopus 로고
    • Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1
    • Hill AL, Rosenbloom DIS, Fu F, Nowak MA, Siliciano RF, Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1. Proc Natl Acad Sci USA. 2014;111:13475—13480. doi: 10.1073/pnas.1406663111 25097264
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 13475-13480
    • Hill, A.L.1    Rosenbloom, D.I.S.2    Fu, F.3    Nowak, M.A.4    Siliciano, R.F.5
  • 55
    • 0034608864 scopus 로고    scopus 로고
    • Production of resistant HIV mutants during antiretroviral therapy
    • Ribeiro RM, Bonhoeffer S, Production of resistant HIV mutants during antiretroviral therapy. Proc Natl Acad Sci USA. 2000;97:7681–7686. doi: 10.1073/pnas.97.14.7681 10884399
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 7681-7686
    • Ribeiro, R.M.1    Bonhoeffer, S.2
  • 56
    • 84892374299 scopus 로고    scopus 로고
    • Incomplete adherence to antiretroviral therapy is associated with higher levels of residual HIV-1 viremia
    • Li JZ, Gallien S, Ribaudoc H, Heiseya A, Bangsberg DR, Kuritzkes DR, Incomplete adherence to antiretroviral therapy is associated with higher levels of residual HIV-1 viremia. AIDS. 2014;28:181–186. 24361679
    • (2014) AIDS , vol.28 , pp. 181-186
    • Li, J.Z.1    Gallien, S.2    Ribaudoc, H.3    Heiseya, A.4    Bangsberg, D.R.5    Kuritzkes, D.R.6
  • 57
    • 84873044224 scopus 로고    scopus 로고
    • An increasing proportion of monotypic HIV-1 DNA sequences during antiretroviral treatment suggests proliferation of HIV-infected cells
    • Wagner TA, McKernan JL, Tobin NH, Tapia KA, Mullins JI, Frenkel LM, An increasing proportion of monotypic HIV-1 DNA sequences during antiretroviral treatment suggests proliferation of HIV-infected cells. J Virol. 2013;87:1770–1778. doi: 10.1128/JVI.01985-12 23175380
    • (2013) J Virol , vol.87 , pp. 1770-1778
    • Wagner, T.A.1    McKernan, J.L.2    Tobin, N.H.3    Tapia, K.A.4    Mullins, J.I.5    Frenkel, L.M.6
  • 58
    • 84905917318 scopus 로고    scopus 로고
    • Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection
    • Wagner TA, McLaughlin S, Garg K, Cheung CY, Larsen BB, Styrchak S, et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science. 2014;345:570–573. doi: 10.1126/science.1256304 25011556
    • (2014) Science , vol.345 , pp. 570-573
    • Wagner, T.A.1    McLaughlin, S.2    Garg, K.3    Cheung, C.Y.4    Larsen, B.B.5    Styrchak, S.6
  • 59
    • 84904110055 scopus 로고    scopus 로고
    • Persistence by proliferation?
    • Margolis D, Bushman F, Persistence by proliferation? Science. 2014;345:143–144. doi: 10.1126/science.1257426 25013050
    • (2014) Science , vol.345 , pp. 143-144
    • Margolis, D.1    Bushman, F.2
  • 60
    • 84904115855 scopus 로고    scopus 로고
    • Specific HIV integration sites are linked to clonal expansion and persistence of infected cells
    • Maldarelli F, Wu X, Su L, Simonetti FR, Shao W, Hill S, et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science. 2014;345:179–183. doi: 10.1126/science.1254194 24968937
    • (2014) Science , vol.345 , pp. 179-183
    • Maldarelli, F.1    Wu, X.2    Su, L.3    Simonetti, F.R.4    Shao, W.5    Hill, S.6
  • 61
    • 84922249841 scopus 로고    scopus 로고
    • HIV-1 Integration landscape during latent and active infection
    • Cohn LB, Silva IT, Oliveira TY, Rosales RA, Parrish EH, Learn GH, et al. HIV-1 Integration landscape during latent and active infection. Cell. 2015;160:420–432. doi: 10.1016/j.cell.2015.01.020 25635456
    • (2015) Cell , vol.160 , pp. 420-432
    • Cohn, L.B.1    Silva, I.T.2    Oliveira, T.Y.3    Rosales, R.A.4    Parrish, E.H.5    Learn, G.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.