CHCHD10 mutations promote loss of mitochondrial cristae junctions with impaired mitochondrial genome maintenance and inhibition of apoptosis

EMBO Molecular Medicine

Volumn 8, Issue 1, 2016, Pages 58-72

  Genin, Emmanuelle C ^a   Plutino, Morgane ^a   Bannwarth, Sylvie ^a,b   Villa, Elodie ^c   Cisneros Barroso, Eugenia ^d   Roy, Madhuparna ^e   Ortega Vila, Bernardo ^d   Fragaki, Konstantina ^a,b   Lespinasse, Françoise ^a   Pinero Martos, Estefania ^d   Augé, Gaëlle ^a,b   Moore, David ^f,g   Burté, Florence ^f,g   Lacas Gervais, Sandra ^h   Kageyama, Yusuke ^e   Itoh, Kie ^e   Yu Wai Man, Patrick ^f,g   Sesaki, Hiromi ^e   Ricci, Jean Ehrland ^c   Vives Bauza, Cristofol ^d   Paquis Flucklinger, Véronique ^a,b   more..

^a UNIVERSITY OF NICE SOPHIA ANTIPOLIS   (France)

^b UNIVERSITY HOSPITAL OF NICE   (France)

^c CENTRE MÉDITERRANÉEN DE MÉDECINE MOLÉCULAIRE C3M   (France)

^d HOSPITAL UNIVERSITARIO SON ESPASES   (Spain)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f NEWCASTLE UNIVERSITY   (United Kingdom)

^g ROYAL VICTORIA INFIRMARY   (United Kingdom)

^h UNIVERSITÉ CÔTE D'AZUR   (France)

Author keywords

CHCHD10; Mitochondria; Mitochondrial disease; Motor neuron disease; mtDNA instability

Indexed keywords

CYTOCHROME C; MITOCHONDRIAL CONTACT SITE AND CRISTAE ORGANIZING SYSTEM PROTEIN; MITOCHONDRIAL DNA; MITOCHONDRIAL PROTEIN; MITOFILIN; PROTEIN CHCHD10; PROTEIN CHCHD3; PROTEIN CHCHD6; UNCLASSIFIED DRUG; CHCHD10 PROTEIN, HUMAN; CHCHD3 PROTEIN, HUMAN; HYDROGEN PEROXIDE;

ALLELE; APOPTOSIS; ARTICLE; CHCHD10 GENE; CONTROLLED STUDY; DNA REPAIR; GENE DOSAGE; GENE EXPRESSION; GENE MUTATION; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; MITOCHONDRIAL DNA DEPLETION; MITOCHONDRIAL GENOME; MITOPHAGY; OXIDATIVE STRESS; PRIORITY JOURNAL; CELL LINE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG EFFECTS; GENETICS; HELA CELL LINE; LYSOSOME; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MUTATION; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION;

ALLELES; APOPTOSIS; CELL LINE; CYTOCHROMES C; DNA REPAIR; DNA, MITOCHONDRIAL; GENOME, MITOCHONDRIAL; HELA CELLS; HUMANS; HYDROGEN PEROXIDE; LYSOSOMES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MITOCHONDRIAL DISEASES; MITOCHONDRIAL PROTEINS; MUTATION; OXIDATIVE STRESS; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84956738385     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.15252/emmm.201505496     Document Type: Article

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