Glucocorticoid-induced tethered transrepression requires SUMOylation of GR and formation of a SUMO-SMRT/NCoR1-HDAC3 repressing complex

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 5, 2016, Pages E635-E643

  Hua, Guoqiang ^a   Ganti, Krishna Priya ^a   Chambon, Pierre ^a,b,c  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c Paris Sciences et Lettres   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; HISTONE DEACETYLASE 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; RECEPTOR INTERACTING PROTEIN 140; SILENCING MEDIATOR OF RETINOID AND THYROID HORMONE RECEPTOR; SUMO PROTEIN; DEXAMETHASONE; HISTONE DEACETYLASE; LIGAND; NCOR1 PROTEIN, MOUSE; NCOR2 PROTEIN, MOUSE; REPRESSOR PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DERMATITIS; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUMOYLATION; TRANSACTIVATION; ANIMAL; METABOLISM; MUTANT MOUSE STRAIN;

ANIMALS; DEXAMETHASONE; HISTONE DEACETYLASES; LIGANDS; MICE; MICE, MUTANT STRAINS; NUCLEAR RECEPTOR CO-REPRESSOR 1; NUCLEAR RECEPTOR CO-REPRESSOR 2; RECEPTORS, GLUCOCORTICOID; REPRESSOR PROTEINS; SMALL UBIQUITIN-RELATED MODIFIER PROTEINS; SUMOYLATION;

EID: 84956663291     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1522826113     Document Type: Article

References (29)

1. Clark AR, Belvisi MG (2012) Maps and legends: The quest for dissociated ligands of the glucocorticoid receptor. Pharmacol Ther 134(1):54-67.
2. Meijsing SH, et al. (2009) DNA binding site sequence directs glucocorticoid receptor structure and activity. Science 324(5925):407-410.
3. Surjit M, et al. (2011) Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor. Cell 145(2):224-241.
4. Ratman D, et al. (2013) How glucocorticoid receptors modulate the activity of other transcription factors: A scope beyond tethering. Mol Cell Endocrinol 380(1-2):41-54.
5. Langlais D, Couture C, Balsalobre A, Drouin J (2012) The Stat3/GR interaction code: Predictive value of direct/indirect DNA recruitment for transcription outcome. Mol Cell 47(1):38-49.
6. Rogatsky I, Luecke HF, Leitman DC, Yamamoto KR (2002) Alternate surfaces of transcriptional coregulator GRIP1 function in different glucocorticoid receptor activation and repression contexts. Proc Natl Acad Sci USA 99(26):16701-16706.
7. Cruz-Topete D, Cidlowski JA (2015) One hormone, two actions: Anti-And proinflammatory effects of glucocorticoids. Neuroimmunomodulation 22(1-2):20-32.
8. Glass CK, Saijo K (2010) Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells. Nat Rev Immunol 10(5):365-376.
9. Luecke HF, Yamamoto KR (2005) The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression. Genes Dev 19(9):1116-1127.
10. Nissen RM, Yamamoto KR (2000) The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-Terminal domain. Genes Dev 14(18):2314-2329.
11. Hua G, Paulen L, Chambon P (2016) GR SUMOylation and formation of an SUMOSMRT/NCoR1-HDAC3 repressing complex is mandatory for GC-induced IR nGREmediated transrepression. Proc Natl Acad Sci USA 113:E626-E634.
12. Gross KL, Oakley RH, Scoltock AB, Jewell CM, Cidlowski JA (2011) Glucocorticoid receptor alpha isoform-selective regulation of antiapoptotic genes in osteosarcoma cells: A new mechanism for glucocorticoid resistance. Mol Endocrinol 25(7):1087-1099.
13. Chinenov Y, et al. (2012) Role of transcriptional coregulator GRIP1 in the antiinflammatory actions of glucocorticoids. Proc Natl Acad Sci USA 109(29):11776-11781.
14. Reily MM, Pantoja C, Hu X, Chinenov Y, Rogatsky I (2006) The GRIP1:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression. EMBO J 25(1): 108-117.
15. Gehin M, et al. (2002) The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP. Mol Cell Biol 22(16):5923-5937.
16. Heck S, et al. (1994) A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1. EMBO J 13(17): 4087-4095.
17. Ramamoorthy S, Cidlowski JA (2013) Ligand-induced repression of the glucocorticoid receptor gene is mediated by an NCoR1 repression complex formed by long-range chromatin interactions with intragenic glucocorticoid response elements. Mol Cell Biol 33(9):1711-1722.
18. Baiula M, et al. (2014) Mapracorat, a selective glucocorticoid receptor agonist, causes apoptosis of eosinophils infiltrating the conjunctiva in late-phase experimental ocular allergy. Drug Des Devel Ther 8:745-757.
19. Schäcke H, et al. (2009) Characterization of ZK 245186, a novel, selective glucocorticoid receptor agonist for the topical treatment of inflammatory skin diseases. Br J Pharmacol 158(4):1088-1103.
20. Uhlenhaut NH, et al. (2013) Insights into negative regulation by the glucocorticoid receptor from genome-wide profiling of inflammatory cistromes. Mol Cell 49(1): 158-171.
21. Godowski PJ, Rusconi S, Miesfeld R, Yamamoto KR (1987) Glucocorticoid receptor mutants that are constitutive activators of transcriptional enhancement. Nature 325(6102):365-368.
22. Hudson WH, Youn C, Ortlund EA (2013) The structural basis of direct glucocorticoidmediated transrepression. Nat Struct Mol Biol 20(1):53-58.
23. Liden J, Delaunay F, Rafter I, Gustafsson J, Okret S (1997) A new function for the C-Terminal zinc finger of the glucocorticoid receptor. Repression of RelA transactivation. J Biol Chem 272(34):21467-21472.
24. Beck IM, et al. (2009) Crosstalk in inflammation: The interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases. Endocr Rev 30(7):830-882.
25. Beurel E, Grieco SF, Jope RS (2015) Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases. Pharmacol Ther 148:114-131.
26. Luisi BF, et al. (1991) Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA. Nature 352(6335):497-505.
27. Höbner S, Dejager L, Libert C, Tuckermann JP (2015) The glucocorticoid receptor in inflammatory processes: Transrepression is not enough. Biol Chem 396(11): 1223-1231.
28. Biddie SC, Conway-Campbell BL, Lightman SL (2012) Dynamic regulation of glucocorticoid signalling in health and disease. Rheumatology (Oxford) 51(3):403-412.
29. Buttgereit F, Smolen JS, Coogan AN, Cajochen C (2015) Clocking in: chronobiology in rheumatoid arthritis. Nat Rev Rheumatol 11(6):349-356.