Glucocorticoid receptor α isoform-selective regulation of antiapoptotic genes in osteosarcoma cells: A new mechanism for glucocorticoid resistance

Molecular Endocrinology

Volumn 25, Issue 7, 2011, Pages 1087-1099

  Gross, Katherine L ^a,b   Oakley, Robert H ^a   Scoltock, Alyson B ^a   Jewell, Christine M ^a   Cidlowski, John A ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b SOUTHERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR INHIBITOR OF APOPTOSIS PROTEIN 1; GLUCOCORTICOID RECEPTOR ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MEMBRANE PROTEIN; PROTEIN BCL XL; SURVIVIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL NUCLEUS; CONTROLLED STUDY; DISORDERS OF HORMONE METABOLISM; DOWN REGULATION; GENE DELETION; GENE EXPRESSION REGULATION; GENE REPRESSION; GENETIC TRANSCRIPTION; GLUCOCORTICOID RESISTANCE; IMMUNOCYTOCHEMISTRY; IMMUNOPRECIPITATION; IN VITRO STUDY; INHIBITION KINETICS; MOLECULAR INTERACTION; OSTEOSARCOMA CELL; PHENOTYPE; PRIORITY JOURNAL; REPORTER GENE; RESISTANCE TRAINING; WESTERN BLOTTING;

AMINO ACID MOTIFS; APOPTOSIS; BCL-X PROTEIN; CASPASES; CELL LINE, TUMOR; DEXAMETHASONE; DRUG RESISTANCE, NEOPLASM; GENES, REPORTER; GLUCOCORTICOIDS; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; LUCIFERASES, RENILLA; NF-KAPPA B; OSTEOSARCOMA; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN ISOFORMS; RECEPTORS, GLUCOCORTICOID; SIGNAL TRANSDUCTION;

EID: 79959832986     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2010-0051     Document Type: Article

References (65)

1. Francke U, Foellmer BE 1989 The glucocorticoid receptor gene is in 5q31-q32 [corrected]. Genomics 4:610-612
2. Theriault A, Boyd E, Harrap SB, Hollenberg SM, Connor JM 1989 Regional chromosomal assignment of the human glucocorticoid receptor gene to 5q31. Hum Genet 83:289-291
3. Lu NZ, Cidlowski JA 2004 The origin and functions of multiple human glucocorticoid receptor isoforms. Ann NY Acad Sci 1024:102-123
4. Chrousos GP, Kino T 2005 Intracellular glucocorticoid signaling: a formerly simple system turns stochastic. Sci STKE 2005: p e48
5. Oakley RH, Cidlowski JA 2011 Cellular processing of the glucocorticoid receptor gene and protein: new mechanisms for generating tissuespecific actions of glucocorticoids. J Biol Chem 286:3177-3184
6. Freedman ND, Yamamoto KR 2004 Importin 7 and importin α/importin β are nuclear import receptors for the glucocorticoid receptor. Mol Biol Cell 15:2276-2286
7. Wang Q, Blackford Jr JA, Song LN, Huang Y, Cho S, Simons Jr SS 2004 Equilibrium interactions of corepressors and coactivators with agonist and antagonist complexes of glucocorticoid receptors. Mol Endocrinol 18:1376-1395
8. Tronche F, Opherk C, Moriggl R, Kellendonk C, Reimann A, Schwake L, Reichardt HM, Stangl K, Gau D, Hoeflich A, Beug H, Schmid W, Schütz G 2004 Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth. Genes Dev 18:492-497
9. Carpentier R, Sacchetti P, Ségard P, Staels B, Lefebvre P 2008 The glucocorticoid receptor is a co-regulator of the orphan nuclear receptor Nurr1. J Neurochem 104:777-789
10. Reichardt HM, Tuckermann JP, Göttlicher M, Vujic M, Weih F, Angel P, Herrlich P, Schütz G 2001 Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor. EMBO J 20:7168-7173
11. Baeuerle PA, Baltimore D 1988 IκB: a specific inhibitor of the NF-κB transcription factor. Science 242:540-546
12. Graham JR, Tullai JW, Cooper GM 2010 GSK-3 represses growth factor-inducible genes by inhibiting NF-κB in quiescent cells. J Biol Chem 285:4472-4480
13. van Essen D, Zhu Y, Saccani S 2010 A feed-forward circuit controlling inducible NF-κB target gene activation by promoter histone demethylation. Mol Cell 39:750-760
14. Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M. 1997 The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation. Cell 91:243-252
15. Henkel T, Machleidt T, Alkalay I, Krönke M, Ben-Neriah Y, Baeuerle PA 1993 Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB. Nature 365:182-185
16. Baeuerle PA, Baltimore D. 1988 Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor. Cell 53:211-217
17. Caldenhoven E, Liden J, Wissink S, Van de Stolpe A, Raaijmakers J, Koenderman L, Okret S, Gustafsson JA, Van der Saag PT 1995 Negative cross-talk between RelA and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids. Mol Endocrinol 9:401-412
18. Scheinman RI, Gualberto A, Jewell CM, Cidlowski JA, Baldwin Jr AS 1995 Characterization of mechanisms involved in transrepression of NF-κB by activated glucocorticoid receptors. Mol Cell Biol 15:943-953
19. Giri DK, Aggarwal BB 1998 Constitutive activation of NF-κB causes resistance to apoptosis in human cutaneous T cell lymphoma HuT-78 cells. Autocrine role of tumor necrosis factor and reactive oxygen intermediates. J Biol Chem 273:14008-14014
20. Bharti AC, Donato N, Singh S, Aggarwal BB 2003 Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-κB and IκBα kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis. Blood 101:1053-1062
21. Shishodia S, Sethi G, Konopleva M, Andreeff M, Aggarwal BB. 2006 A synthetic triterpenoid, CDDO-Me, inhibits IκBα kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor κB-regulated gene products in human leukemic cells. Clin Cancer Res 12:1828-1838
22. Frankfurt O, Rosen ST 2004 Mechanisms of glucocorticoid-induced apoptosis in hematologic malignancies: updates. Curr Opin Oncol 16:553-563
23. Greenstein S, Ghias K, Krett NL, Rosen ST 2002 Mechanisms of glucocorticoid-mediated apoptosis in hematological malignancies. Clin Cancer Res 8:1681-1694
24. Wang W, Wykrzykowska J, Johnson T, Sen R, Sen J 1999 A NF-κB/c-myc-dependent survival pathway is targeted by corticosteroids in immature thymocytes. J Immunol 162:314-322
25. Hollenberg SM, Weinberger C, Ong ES, Cerelli G, Oro A, Lebo R, Thompson EB, Rosenfeld MG, Evans RM 1985 Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature 318:635-641
26. Oakley RH, Sar M, Cidlowski JA 1996 The human glucocorticoid receptor β isoform. Expression, biochemical properties, and putative function. J Biol Chem 271:9550-9559
27. Rivers C, Levy A, Hancock J, Lightman S, Norman M 1999 Inser-tion of an amino acid in the DNA-binding domain of the glucocorticoid receptor as a result of alternative splicing. J Clin Endocrinol Metab 84:4283-4286
28. Moalli PA, Pillay S, Krett NL, Rosen ST 1993 Alternatively spliced glucocorticoid receptor messenger RNAs in glucocorticoid-resistant human multiple myeloma cells. Cancer Res 53:3877-3879
29. de Lange P, Segeren CM, Koper JW, Wiemer E, Sonneveld P, Brinkmann AO, White A, Brogan IJ, de Jong FH, Lamberts SW 2001 Expression in hematological malignancies of a glucocorticoid receptor splice variant that augments glucocorticoid receptor-mediated effects in transfected cells. Cancer Res 61:3937-3941
30. Russcher H, Dalm VA, de Jong FH, Brinkmann AO, Hofland LJ, Lamberts SW, Koper JW 2007 Associations between promoter usage and alternative splicing of the glucocorticoid receptor gene. J Mol Endocrinol 38:91-98
31. Lu NZ, Cidlowski JA 2005 Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes. Mol Cell 18:331-342
32. Lu NZ, Collins JB, Grissom SF, Cidlowski JA 2007 Selective regulation of bone cell apoptosis by translational isoforms of the glucocorticoid receptor. Mol Cell Biol 27:7143-7160
33. Dahlman-Wright K, Baumann H, McEwan IJ, Almlöf T, Wright AP, Gustafsson JA, Härd T 1995 Structural characterization of a minimal functional transactivation domain from the human glucocorticoid receptor. Proc Natl Acad Sci USA 92:1699-1703
34. Dahlman-Wright K, Almlöf T, McEwan IJ, Gustafsson JA, Wright AP 1994 Delineation of a small region within the major transactivation domain of the human glucocorticoid receptor that mediates transactivation of gene expression. Proc Natl Acad Sci USA 91:1619-1623
35. Wang D, Simons Jr SS 2005 Corepressor binding to progesterone and glucocorticoid receptors involves the activation function-1 domain and is inhibited by molybdate. Mol Endocrinol 19:1483-1500
36. Wallberg AE, Neely KE, Hassan AH, Gustafsson JA, Workman JL, Wright AP 2000 Recruitment of the SWI-SNF chromatin remodeling complex as a mechanism of gene activation by the glucocorticoid receptor tau1 activation domain. Mol Cell Biol 20:2004-2013
37. Amsterdam A, Sasson R 2002 The anti-inflammatory action of glucocorticoids is mediated by cell type specific regulation of apoptosis. Mol Cell Endocrinol 189:1-9
38. Viegas LR, Hoijman E, Beato M, Pecci A 2008 Mechanisms involved in tissue-specific apopotosis regulated by glucocorticoids. J Steroid Biochem Mol Biol 109:273-278
39. Arlt A, Rosenstiel P, Kruse ML, Grohmann F, Minkenberg J, Perkins ND, Fölsch UR, Schreiber S, Schäfer H 2008 IEX-1 directly interferes with RelA/p65 dependent transactivation and regulation of apoptosis. Biochim Biophys Acta 1783:941-952
40. Campbell KJ, Rocha S, Perkins ND. 2004 Active repression of antiapoptotic gene expression by RelA(p65) NF-κB. Mol Cell 13:853-865
41. Ray A, Prefontaine KE 1994 Physical association and functional antagonism between the p65 subunit of transcription factor NF-κB and the glucocorticoid receptor. Proc Natl Acad Sci USA 91:752-756
42. Doucas V, Shi Y, Miyamoto S, West A, Verma I, Evans RM 2000 Cytoplasmic catalytic subunit of protein kinase A mediates crossrepression by NF-κB and the glucocorticoid receptor. Proc Natl Acad Sci USA 97:11893-11898
43. Widén C, Gustafsson JA, Wikström AC 2003 Cytosolic glucocorticoid receptor interaction with nuclear factor-κB proteins in rat liver cells. Biochem J 373:211-220
44. McKay LI, Cidlowski JA 1998 Cross-talk between nuclear factor-κB and the steroid hormone receptors: mechanisms of mutual antagonism. Mol Endocrinol 12:45-56
45. Black BE, Holaska JM, Rastinejad F, Paschal BM 2001 DNA binding domains in diverse nuclear receptors function as nuclear export signals. Curr Biol 11:1749-1758
46. Picard D, Yamamoto KR 1987 Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor. EMBO J 6:3333-3340
47. Savory JG, Hsu B, Laquian IR, Giffin W, Reich T, Haché RJ, Lefebvre YA 1999 Discrimination between NL1-and NL2-mediated nuclear localization of the glucocorticoid receptor. Mol Cell Biol 19:1025-1037
48. Carrigan A, Walther RF, Salem HA, Wu D, Atlas E, Lefebvre YA, Haché RJ 2007 An active nuclear retention signal in the glucocorticoid receptor functions as a strong inducer of transcriptional activation. J Biol Chem 282:10963-10971
49. Charmandari E, Kino T, Chrousos GP 2004 Familial/sporadic glucocorticoid resistance: clinical phenotype and molecular mechanisms. Ann NY Acad Sci 1024:168-181
50. Derijk RH, de Kloet ER 2008 Corticosteroid receptor polymorphisms: determinants of vulnerability and resilience. Eur J Pharmacol 583:303-311
51. Beesley AH, Weller RE, Senanayake S, Welch M, Kees UR 2009 Receptor mutation is not a common mechanism of naturally occurring glucocorticoid resistance in leukaemia cell lines. Leuk Res 33:321-325
52. Gross KL, Cidlowski JA 2008 Tissue-specific glucocorticoid action: a family affair. Trends Endocrinol Metab 19:331-339
53. Shahidi H, Vottero A, Stratakis CA, Taymans SE, Karl M, Longui CA, Chrousos GP, Daughaday WH, Gregory SA, Plate JM 1999 Imbalanced expression of the glucocorticoid receptor isoforms in cultured lymphocytes from a patient with systemic glucocorticoid resistance and chronic lymphocytic leukemia. Biochem Biophys Res Commun 254:559-565
54. Longui CA, Vottero A, Adamson PC, Cole DE, Kino T, Monte O, Chrousos GP 2000 Low glucocorticoid receptor α/β ratio in T-cell lymphoblastic leukemia. Horm Metab Res 32:401-406
55. Koga Y, Matsuzaki A, Suminoe A, Hattori H, Kanemitsu S, Hara T 2005 Differential mRNA expression of glucocorticoid receptor α and β is associated with glucocorticoid sensitivity of acute lymphoblastic leukemia in children. Pediatr Blood Cancer 45:121-127
56. Beger C, Gerdes K, Lauten M, Tissing WJ, Fernandez-Munoz I, Schrappe M, Welte K 2003 Expression and structural analysis of glucocorticoid receptor isoform γ in human leukaemia cells using an isoform-specific real-time polymerase chain reaction approach. Br J Haematol 122:245-252
57. Haarman EG, Kaspers GJ, Pieters R, Rottier MM, Veerman AJ 2004 Glucocorticoid receptor α,β and γ expression vs in vitro glucocorticod resistance in childhood leukemia. Leukemia 18:530-537
58. Krett NL, Pillay S, Moalli PA, Greipp PR, Rosen ST 1995 A variant glucocorticoid receptor messenger RNA is expressed in multiple myeloma patients. Cancer Res 55:2727-2729
59. Dördelmann M, Reiter A, Borkhardt A, Ludwig WD, Götz N, Viehmann S, Gadner H, Riehm H, Schrappe M 1999 Prednisone response is the strongest predictor of treatment outcome in infant acute lymphoblastic leukemia. Blood 94:1209-1217
60. Felice MS, Zubizarreta PA, Alfaro EM, Sackmann-Muriel F 2001 Childhood acute lymphoblastic leukemia: prognostic value of initial peripheral blast count in good responders to prednisone. J Pediatr Hematol Oncol 23:411-415
61. Sinclair D, Webster MJ, Wong J, Weickert CS 2010 Dynamic molecular and anatomical changes in the glucocorticoid receptor in human cortical development. Mol Psychiatry 1-12
62. Wang SC, Myers S, Dooms C, Capon R, Muscat GE 2010 An ERR β/γ agonist modulates GRα expression, and glucocorticoid responsive gene expression in skeletal muscle cells. Mol Cell Endocrinol 315:146-152
63. Cidlowski JA, Bellingham DL, Powell-Oliver FE, Lubahn DB, Sar M. 1990 Novel antipeptide antibodies to the human glucocorticoid receptor: recognition of multiple receptorforms in vitroanddistinct localization of cytoplasmic and nuclear receptors. Mol Endocrinol 4:1427-1437
64. Bryne JC, Valen E, Tang MH, Marstrand T, Winther O, da Piedade I, Krogh A, Lenhard B, Sandelin A 2008 JASPAR, the open access database of transcription factor-binding profiles: new content and tools in the 2008 update. Nucleic Acids Res 36:D102-D106
65. McKay LI, Cidlowski JA 2000 CBP (CREB binding protein) integrates NF-κB (nuclear factor-κB) and glucocorticoid receptor physical interactions and antagonism. Mol Endocrinol 14:1222-1234