Ligand-induced repression of the glucocorticoid receptor gene is mediated by an NCoR1 repression complex formed by long-range chromatin interactions with intragenic glucocorticoid response elements

Molecular and Cellular Biology

Volumn 33, Issue 9, 2013, Pages 1711-1722

  Ramamoorthy, Sivapriya ^a   Cidlowski, John A ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID RECEPTOR; HISTONE DEACETYLASE 3;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHROMATIN; CONTROLLED STUDY; EXON; GENE INTERACTION; GENE REPRESSION; GENETIC TRANSCRIPTION; GLUCOCORTICOID RESPONSE ELEMENT; HORMONE RESPONSIVE ELEMENT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION INITIATION;

ANIMALS; CELL LINE; CHROMATIN; DOWN-REGULATION; DRUG RESISTANCE; EXONS; GLUCOCORTICOIDS; HISTONE DEACETYLASES; HUMANS; LIGANDS; MALE; MICE; MICE, INBRED C57BL; NUCLEAR RECEPTOR CO-REPRESSOR 1; RATS; RECEPTORS, GLUCOCORTICOID; RESPONSE ELEMENTS; TRANSCRIPTIONAL ACTIVATION;

EID: 84876422349     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.01151-12     Document Type: Article

References (42)

1. Barnes PJ. 1998. Anti-inflammatory actions of glucocorticoids: molecular mechanisms. Clin. Sci. (Lond.) 94:557-572.
2. Sapolsky RM, Romero LM, Munck AU. 2000. How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr. Rev. 21:55-89.
3. Rhen T, Cidlowski JA. 2005. Antiinflammatory action of glucocorticoids-new mechanisms for old drugs. N. Engl. J. Med. 353:1711-1723.
4. Schacke H, Docke WD, Asadullah K. 2002. Mechanisms involved in the side effects of glucocorticoids. Pharmacol. Ther. 96:23-43.
5. Schmidt S, Rainer J, Ploner C, Presul E, Riml S, Kofler R. 2004. Glucocorticoid-induced apoptosis and glucocorticoid resistance: molecular mechanisms and clinical relevance. Cell Death Differ. 11(Suppl 1):S45-S55.
6. Stanbury RM, Graham EM. 1998. Systemic corticosteroid therapy-side effects and their management. Br. J. Ophthalmol. 82:704-708.
7. Evans RM. 1988. The steroid and thyroid hormone receptor superfamily. Science 240:889-895.
8. Beato M. 1989. Gene regulation by steroid hormones. Cell 56:335-344.
9. Freedman LP. 1992. Anatomy of the steroid receptor zinc finger region. Endocr. Rev. 13:129-145.
10. Necela BM, Cidlowski JA. 2004. Mechanisms of glucocorticoid receptor action in noninflammatory and inflammatory cells. Proc. Am. Thorac. Soc. 1:239-246.
11. Yamamoto KR. 1985. Steroid receptor regulated transcription of specific genes and gene networks. Annu. Rev. Genet. 19:209-252.
12. Surjit M, Ganti KP, Mukherji A, Ye T, Hua G, Metzger D, Li M, Chambon P. 2011. Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor. Cell 145:224-241.
13. Bourgeois S, Newby RF. 1979. Correlation between glucocorticoid receptor and cytolytic response of murine lymphoid cell lines. Cancer Res. 39:4749-4751.
14. Vanderbilt JN, Miesfeld R, Maler BA, Yamamoto KR. 1987. Intracellular receptor concentration limits glucocorticoid-dependent enhancer activity. Mol. Endocrinol. 1:68-74.
15. Bloomfield CD, Smith KA, Peterson BA, Munck A. 1981. Glucocorticoid receptors in adult acute lymphoblastic leukemia. Cancer Res. 41: 4857-4860.
16. Silva CM, Powell-Oliver FE, Jewell CM, Sar M, Allgood VE, Cidlowski JA. 1994. Regulation of the human glucocorticoid receptor by long-term and chronic treatment with glucocorticoid. Steroids 59:436-442.
17. Alarid ET. 2006. Lives and times of nuclear receptors. Mol. Endocrinol. 20:1972-1981.
18. Hoeck W, Rusconi S, Groner B. 1989. Down-regulation and phosphorylation of glucocorticoid receptors in cultured cells. Investigations with a monospecific antiserum against a bacterially expressed receptor fragment. J. Biol. Chem. 264:14396-14402.
19. Cidlowski JA, Cidlowski NB. 1981. Regulation of glucocorticoid receptors by glucocorticoids in cultured HeLa S3 cells. Endocrinology 109: 1975-1982.
20. Danielsen M, Stallcup MR. 1984. Down-regulation of glucocorticoid receptors in mouse lymphoma cell variants. Mol. Cell. Biol. 4:449-453.
21. Lacroix A, Bonnard GD, Lippman ME. 1984. Modulation of glucocorticoid receptors by mitogenic stimuli, glucocorticoids and retinoids in normal human cultured T cells. J. Steroid Biochem. 21:73-80.
22. Schlechte JA, Ginsberg BH, Sherman BM. 1982. Regulation of the glucocorticoid receptor in human lymphocytes. J. Steroid Biochem. 16:69-74.
23. Svec F, Rudis M. 1981. Glucocorticoids regulate the glucocorticoid receptor in the AtT-20 cell. J. Biol. Chem. 256:5984-5987.
24. Tornello S, Orti E, De Nicola AF, Rainbow TC, McEwen BS. 1982. Regulation of glucocorticoid receptors in brain by corticosterone treatment of adrenalectomized rats. Neuroendocrinology 35:411-417.
25. Dong Y, Poellinger L, Gustafsson JA, Okret S. 1988. Regulation of glucocorticoid receptor expression: evidence for transcriptional and posttranslational mechanisms. Mol. Endocrinol. 2:1256-1264.
26. Rosewicz S, McDonald AR, Maddux BA, Goldfine ID, Miesfeld RL, Logsdon CD. 1988. Mechanism of glucocorticoid receptor downregulation by glucocorticoids. J. Biol. Chem. 263:2581-2584.
27. Vedeckis WV, Ali M, Allen HR. 1989. Regulation of glucocorticoid receptor protein and mRNA levels. Cancer Res. 49:2295s-2302s.
28. Govindan MV, Pothier F, Leclerc S, Palaniswami R, Xie B. 1991. Human glucocorticoid receptor gene promoter-homologous down regulation. J. Steroid Biochem. Mol. Biol. 40:317-323.
29. Burnstein KL, Jewell CM, Cidlowski JA. 1990. Human glucocorticoid receptor cDNA contains sequences sufficient for receptor downregulation. J. Biol. Chem. 265:7284-7291.
30. Burnstein KL, Jewell CM, Sar M, Cidlowski JA. 1994. Intragenic sequences of the human glucocorticoid receptor complementary DNA mediate hormone-inducible receptor messenger RNA down-regulation through multiple mechanisms. Mol. Endocrinol. 8:1764-1773.
31. Okret S, Poellinger L, Dong Y, Gustafsson JA. 1986. Down-regulation of glucocorticoid receptor mRNA by glucocorticoid hormones and recognition by the receptor of a specific binding sequence within a receptor cDNA clone. Proc. Natl. Acad. Sci. U. S. A. 83:5899-5903.
32. Wallace AD, Cidlowski JA. 2001. Proteasome-mediated glucocorticoid receptor degradation restricts transcriptional signaling by glucocorticoids. J. Biol. Chem. 276:42714-42721.
33. Lu NZ, Cidlowski JA. 2005. Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes. Mol. Cell 18:331-342.
34. Nissen RM, Yamamoto KR. 2000. The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain. Genes Dev. 14:2314-2329.
35. Hagege H, Klous P, Braem C, Splinter E, Dekker J, Cathala G, de Laat W, Forne T. 2007. Quantitative analysis of chromosome conformation capture assays (3C-qPCR). Nat. Protoc. 2:1722-1733.
36. Bamberger CM, Chrousos GP. 1995. The glucocorticoid receptor and RU 486 in man. Ann. N. Y. Acad. Sci. 761:296-310.
37. Burnstein KL, Bellingham DL, Jewell CM, Powell-Oliver FE, Cidlowski JA. 1991. Autoregulation of glucocorticoid receptor gene expression. Steroids 56:52-58.
38. Glass CK, Saijo K. 2010. Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells. Nat. Rev. Immunol.10:365-376.
39. Perissi V, Jepsen K, Glass CK, Rosenfeld MG. 2010. Deconstructing repression: evolving models of co-repressor action. Nat. Rev. Genet. 11: 109-123.
40. Carroll JS, Meyer CA, Song J, Li W, Geistlinger TR, Eeckhoute J, Brodsky AS, Keeton EK, Fertuck KC, Hall GF, Wang Q, Bekiranov S, Sementchenko V, Fox EA, Silver PA, Gingeras TR, Liu XS, Brown M. 2006. Genome-wide analysis of estrogen receptor binding sites. Nat.Genet. 38:1289-1297.
41. Hakim O, John S, Ling JQ, Biddie SC, Hoffman AR, Hager GL. 2009. Glucocorticoid receptor activation of the Ciz1-Lcn2 locus by long range interactions. J. Biol. Chem. 284:6048-6052.
42. Birnbaum RY, Clowney EJ, Agamy O, Kim MJ, Zhao J, Yamanaka T, Pappalardo Z, Clarke SL, Wenger AM, Nguyen L, Gurrieri F, Everman DB, Schwartz CE, Birk OS, Bejerano G, Lomvardas S, Ahituv N. 2012. Coding exons function as tissue-specific enhancers of nearby genes. Genome Res. 22:1059-1068.