S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-α autoamplification

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 5, 2016, Pages 1351-1356

  Teijaro, John R ^a   Studer, Sean ^a   Leaf, Nora ^a   Kiosses, William B ^a   Nguyen, Nhan ^a   Matsuki, Kosuke ^b   Negishi, Hideo ^b   Taniguchi, Tadatsugu ^b   Oldstone, Michael B A ^a   Rosen, Hugh ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b INSTITUTE OF INDUSTRIAL SCIENCE   (Japan)

Author keywords

IFNAR1; Interferon ; Plasmacytoid dendritic cell; S1PR1; Sphingosine 1 phosphate

Indexed keywords

ALPHA INTERFERON; ALPHA INTERFERON RECEPTOR; ALPHA INTERFERON RECEPTOR 1; BETA ARRESTIN; FLT3 LIGAND; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 2; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 1; STAT1 PROTEIN; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; TRANSACTIVATOR PROTEIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; ALPHA BETA INTERFERON RECEPTOR; IFNAR1 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; ENDOSOME; FEEDBACK SYSTEM; FLOW CYTOMETRY; GENE AMPLIFICATION; HUMAN; HUMAN CELL; IC50; IMMUNE RESPONSE; IN VIVO STUDY; INTERFERON PRODUCTION; INTERNALIZATION; LUNG ALVEOLUS MACROPHAGE; MOUSE; NONHUMAN; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; DENDRITIC CELL; GENETICS; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY;

ANIMALS; DENDRITIC CELLS; INTERFERON-ALPHA; MICE; MICE, KNOCKOUT; PROTEOLYSIS; RECEPTOR, INTERFERON ALPHA-BETA; RECEPTORS, LYSOSPHINGOLIPID;

EID: 84956658839     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1525356113     Document Type: Article

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