Type I interferon is a therapeutic target for virus-induced lethal vascular damage

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 24, 2014, Pages 8925-8930

  Baccala, Roberto ^a   Welch, Megan J ^a   Gonzalez Quintial, Rosana ^a   Walsh, Kevin B ^a,b   Teijaro, John R ^a   Nguyen, Anthony ^a   Ng, Cherie T ^a   Sullivan, Brian M ^a   Zarpellon, Alessandro ^a   Ruggeri, Zaverio M ^a   De La Torre, Juan Carlos ^a   Theofilopoulos, Argyrios N ^a   Oldstone, Michael B A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b GENENTECH INC   (United States)

Author keywords

IFN alpha; Immunopathology; LCMV; Lung; Platelet loss

Indexed keywords

INTERFERON; INTERFERON RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARENAVIRUS; ARTICLE; BLOOD VESSEL INJURY; CELL LOSS; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HEMORRHAGIC FEVER; HOST SUSCEPTIBILITY; IMMUNE RESPONSE; IMMUNOREGULATION; LASSA VIRUS; LETHALITY; LUNG ENDOTHELIUM; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MOUSE; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; THROMBOCYTOPENIA; VIREMIA; VIRUS INFECTION; VIRUS TITRATION; VIRUS VIRULENCE;

IFN-ALPHA; IMMUNOPATHOLOGY; LCMV; LUNG; PLATELET LOSS;

ANIMALS; BRONCHOALVEOLAR LAVAGE; CELL LINE; CRICETINAE; CYTOKINES; FEMALE; INTERFERON TYPE I; LASSA FEVER; LASSA VIRUS; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED NZB; MICE, TRANSGENIC; SIGNAL TRANSDUCTION; STEM CELLS; T-LYMPHOCYTES, CYTOTOXIC; VASCULAR DISEASES; VIRUS ACTIVATION;

EID: 84902578750     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1408148111     Document Type: Article

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