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Volumn 28, Issue 2, 2016, Pages 202-215

In Vitro and in Vivo Atheroprotective Effects of Gossypetin against Endothelial Cell Injury by Induction of Autophagy

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLADENINE; BECLIN 1; CHLOROQUINE; GOSSYPETIN; OXIDIZED LOW DENSITY LIPOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; FLAVONOID; HYPOCHOLESTEROLEMIC AGENT;

EID: 84956653529     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx5003518     Document Type: Article
Times cited : (29)

References (55)
  • 1
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis - an inflammatory disease
    • Ross, R. (1999) Atherosclerosis-an inflammatory disease N. Engl. J. Med. 340, 115-126
    • (1999) N. Engl. J. Med. , vol.340 , pp. 115-126
    • Ross, R.1
  • 2
    • 79953793361 scopus 로고    scopus 로고
    • Protective role of autophagy in AGE-induced early injury of human vascular endothelial cells
    • Xie, Y., You, S. J., Zhang, Y. L., Han, Q., Cao, Y. J., Xu, X. S., Yang, Y. P., Li, J., and Liu, C. F. (2011) Protective role of autophagy in AGE-induced early injury of human vascular endothelial cells Mol. Med. Rep. 4, 459-464
    • (2011) Mol. Med. Rep. , vol.4 , pp. 459-464
    • Xie, Y.1    You, S.J.2    Zhang, Y.L.3    Han, Q.4    Cao, Y.J.5    Xu, X.S.6    Yang, Y.P.7    Li, J.8    Liu, C.F.9
  • 3
    • 77950188875 scopus 로고    scopus 로고
    • The autophagy-lysosome pathway: a novel mechanism involved in the processing of oxidized LDL in human vascular endothelial cells
    • Zhang, Y. L., Cao, Y. J., Zhang, X., Liu, H. H., Tong, T., Xiao, G. D., Yang, Y. P., and Liu, C. F. (2010) The autophagy-lysosome pathway: a novel mechanism involved in the processing of oxidized LDL in human vascular endothelial cells Biochem. Biophys. Res. Commun. 394, 377-382
    • (2010) Biochem. Biophys. Res. Commun. , vol.394 , pp. 377-382
    • Zhang, Y.L.1    Cao, Y.J.2    Zhang, X.3    Liu, H.H.4    Tong, T.5    Xiao, G.D.6    Yang, Y.P.7    Liu, C.F.8
  • 4
    • 2642585697 scopus 로고    scopus 로고
    • In vivo induction of endothelial apoptosis leads to vessel thrombosis and endothelial denudation: a clue to the understanding of the mechanisms of thrombotic plaque erosion
    • Durand, E., Scoazec, A., Lafont, A., Boddaert, J., Al Hajzen, A., Addad, F., Mirshahi, M., Desnos, M., Tedgui, A., and Mallat, Z. (2004) In vivo induction of endothelial apoptosis leads to vessel thrombosis and endothelial denudation: a clue to the understanding of the mechanisms of thrombotic plaque erosion Circulation 109, 2503-2506
    • (2004) Circulation , vol.109 , pp. 2503-2506
    • Durand, E.1    Scoazec, A.2    Lafont, A.3    Boddaert, J.4    Al Hajzen, A.5    Addad, F.6    Mirshahi, M.7    Desnos, M.8    Tedgui, A.9    Mallat, Z.10
  • 5
    • 20344387475 scopus 로고    scopus 로고
    • Autophagy: dual roles in life and death
    • Baehrecke, E. H. (2005) Autophagy: dual roles in life and death Nat. Rev. Mol. Cell. Biol. 6, 505-510
    • (2005) Nat. Rev. Mol. Cell. Biol. , vol.6 , pp. 505-510
    • Baehrecke, E.H.1
  • 6
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • Mizushima, N., Levine, B., Cuervo, A. M., and Klionsky, D. J. (2008) Autophagy fights disease through cellular self-digestion Nature 451, 1069-1075
    • (2008) Nature , vol.451 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Cuervo, A.M.3    Klionsky, D.J.4
  • 7
    • 61949233502 scopus 로고    scopus 로고
    • Autophagy in atherosclerosis: a cell survival and death phenomenon with therapeutic potential
    • Martinet, W. and De Meyer, G. R. (2009) Autophagy in atherosclerosis: a cell survival and death phenomenon with therapeutic potential Circ. Res. 104, 304-317
    • (2009) Circ. Res. , vol.104 , pp. 304-317
    • Martinet, W.1    De Meyer, G.R.2
  • 8
    • 27644484061 scopus 로고    scopus 로고
    • Autophagy: molecular machinery for selfeating
    • Yorimitsu, T. and Klionsky, D. J. (2005) Autophagy: molecular machinery for selfeating Cell Death Differ. 12, 1542-1552
    • (2005) Cell Death Differ. , vol.12 , pp. 1542-1552
    • Yorimitsu, T.1    Klionsky, D.J.2
  • 9
    • 0024366081 scopus 로고
    • Modulating effect of plant flavonoids on the mutagenicity of N-methyl-N′-nitro-N-nitrosoguanidine
    • Francis, A. R., Shetty, T. K., and Bhattacharya, R. K. (1989) Modulating effect of plant flavonoids on the mutagenicity of N-methyl-N′-nitro-N-nitrosoguanidine Carcinogenesis 10, 1953-1955
    • (1989) Carcinogenesis , vol.10 , pp. 1953-1955
    • Francis, A.R.1    Shetty, T.K.2    Bhattacharya, R.K.3
  • 10
    • 0025287069 scopus 로고
    • Flavonoids inhibit the oxidative modification of low density lipoproteins by macrophages
    • de Whalley, C. V., Rankin, S. M., Hoult, J. R., Jessup, W., and Leake, D. S. (1990) Flavonoids inhibit the oxidative modification of low density lipoproteins by macrophages Biochem. Pharmacol. 39, 1743-1750
    • (1990) Biochem. Pharmacol. , vol.39 , pp. 1743-1750
    • De Whalley, C.V.1    Rankin, S.M.2    Hoult, J.R.3    Jessup, W.4    Leake, D.S.5
  • 11
    • 0028989698 scopus 로고
    • Dietary flavonoids in atherosclerosis prevention
    • Wedworth, S. M. and Lynch, S. (1995) Dietary flavonoids in atherosclerosis prevention Ann. Pharmacother. 29, 627-628
    • (1995) Ann. Pharmacother. , vol.29 , pp. 627-628
    • Wedworth, S.M.1    Lynch, S.2
  • 12
    • 70249116086 scopus 로고    scopus 로고
    • Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities
    • Jeong, H. J., Ryu, Y. B., Park, S. J., Kim, J. H., Kwon, H. J., Kim, J. H., Park, K. H., Rho, M. C., and Lee, W. S. (2009) Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities Bioorg. Med. Chem. 17, 6816-6823
    • (2009) Bioorg. Med. Chem. , vol.17 , pp. 6816-6823
    • Jeong, H.J.1    Ryu, Y.B.2    Park, S.J.3    Kim, J.H.4    Kwon, H.J.5    Kim, J.H.6    Park, K.H.7    Rho, M.C.8    Lee, W.S.9
  • 13
    • 79952801717 scopus 로고    scopus 로고
    • Chemopreventive properties and molecular mechanisms of the bioactive compounds in Hibiscus sabdariffa Linne
    • Lin, H. H., Chen, J. H., and Wang, C. J. (2011) Chemopreventive properties and molecular mechanisms of the bioactive compounds in Hibiscus sabdariffa Linne Curr. Med. Chem. 18, 1245-1254
    • (2011) Curr. Med. Chem. , vol.18 , pp. 1245-1254
    • Lin, H.H.1    Chen, J.H.2    Wang, C.J.3
  • 14
    • 84883784008 scopus 로고    scopus 로고
    • Anti-atherosclerotic potential of gossypetin via inhibiting LDL oxidation and foam cell formation
    • Chen, J. H., Tsai, C. W., Wang, C. P., and Lin, H. H. (2013) Anti-atherosclerotic potential of gossypetin via inhibiting LDL oxidation and foam cell formation Toxicol. Appl. Pharmacol. 272, 313-324
    • (2013) Toxicol. Appl. Pharmacol. , vol.272 , pp. 313-324
    • Chen, J.H.1    Tsai, C.W.2    Wang, C.P.3    Lin, H.H.4
  • 15
    • 33745026603 scopus 로고
    • The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum
    • Havel, R. J., Eder, H. A., and Bragdon, J. H. (1955) The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum J. Clin. Invest. 34, 1345-1353
    • (1955) J. Clin. Invest. , vol.34 , pp. 1345-1353
    • Havel, R.J.1    Eder, H.A.2    Bragdon, J.H.3
  • 17
    • 84866417611 scopus 로고    scopus 로고
    • Carnosic acid prevents 6-hydroxydopamine-induced cell death in SH-SY5Y cells via mediation of glutathione synthesis
    • Chen, J. H., Ou, H. P., Lin, C. Y., Lin, F. J., Wu, C. R., Chang, S. W., and Tsai, C. W. (2012) Carnosic acid prevents 6-hydroxydopamine-induced cell death in SH-SY5Y cells via mediation of glutathione synthesis Chem. Res. Toxicol. 25, 1893-1901
    • (2012) Chem. Res. Toxicol. , vol.25 , pp. 1893-1901
    • Chen, J.H.1    Ou, H.P.2    Lin, C.Y.3    Lin, F.J.4    Wu, C.R.5    Chang, S.W.6    Tsai, C.W.7
  • 19
    • 75749122303 scopus 로고    scopus 로고
    • Methods in mammalian autophagy research
    • Mizushima, N., Yoshimori, T., and Levine, B. (2010) Methods in mammalian autophagy research Cell 140, 313-326
    • (2010) Cell , vol.140 , pp. 313-326
    • Mizushima, N.1    Yoshimori, T.2    Levine, B.3
  • 21
    • 35348886043 scopus 로고    scopus 로고
    • Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein
    • Cao, Y. and Klionsky, D. J. (2007) Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein Cell Res. 17, 839-849
    • (2007) Cell Res. , vol.17 , pp. 839-849
    • Cao, Y.1    Klionsky, D.J.2
  • 22
    • 84871782298 scopus 로고    scopus 로고
    • Effect of advanced glycation end products on lectin-like oxidized low density lipoprotein receptor-1 expression in endothelial cells
    • Shiu, S. W., Wong, Y., and Tan, K. C. (2012) Effect of advanced glycation end products on lectin-like oxidized low density lipoprotein receptor-1 expression in endothelial cells J. Atheroscler. Thromb. 19, 1083-1092
    • (2012) J. Atheroscler. Thromb. , vol.19 , pp. 1083-1092
    • Shiu, S.W.1    Wong, Y.2    Tan, K.C.3
  • 23
    • 0023729899 scopus 로고
    • 3-Methyladenine, an inhibitor of autophagy, has multiple effects on metabolism
    • Caro, L. H., Plomp, P. J., Wolvetang, E. J., Kerkhof, C., and Meijer, A. J. (1988) 3-Methyladenine, an inhibitor of autophagy, has multiple effects on metabolism Eur. J. Biochem. 175, 325-329
    • (1988) Eur. J. Biochem. , vol.175 , pp. 325-329
    • Caro, L.H.1    Plomp, P.J.2    Wolvetang, E.J.3    Kerkhof, C.4    Meijer, A.J.5
  • 24
    • 79959235806 scopus 로고    scopus 로고
    • Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model
    • Li, Y., Prasad, A., Jia, Y., Roy, S. G., Loison, F., Mondal, S., Kocjan, P., Silberstein, L. E., Ding, S., and Luo, H. R. (2011) Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model Blood 117, 6702-6713
    • (2011) Blood , vol.117 , pp. 6702-6713
    • Li, Y.1    Prasad, A.2    Jia, Y.3    Roy, S.G.4    Loison, F.5    Mondal, S.6    Kocjan, P.7    Silberstein, L.E.8    Ding, S.9    Luo, H.R.10
  • 25
    • 70349675632 scopus 로고    scopus 로고
    • Molecular insights and therapeutic targets for diabetic endothelial dysfunction
    • Xu, J. and Zou, M. H. (2009) Molecular insights and therapeutic targets for diabetic endothelial dysfunction Circulation 120, 1266-1286
    • (2009) Circulation , vol.120 , pp. 1266-1286
    • Xu, J.1    Zou, M.H.2
  • 27
    • 45449120489 scopus 로고    scopus 로고
    • Relationship between biomarkers of oxidized low-density lipoprotein, statin therapy, quantitative coronary angiography, and atheroma: volume observations from the REVERSAL (Reversal of Atherosclerosis with Aggressive Lipid Lowering) study
    • Choi, S. H., Chae, A., Miller, E., Messig, M., Ntanios, F., DeMaria, A. N., Nissen, S. E., Witztum, J. L., and Tsimikas, S. (2008) Relationship between biomarkers of oxidized low-density lipoprotein, statin therapy, quantitative coronary angiography, and atheroma: volume observations from the REVERSAL (Reversal of Atherosclerosis with Aggressive Lipid Lowering) study J. Am. Coll. Cardiol. 52, 24-32
    • (2008) J. Am. Coll. Cardiol. , vol.52 , pp. 24-32
    • Choi, S.H.1    Chae, A.2    Miller, E.3    Messig, M.4    Ntanios, F.5    Demaria, A.N.6    Nissen, S.E.7    Witztum, J.L.8    Tsimikas, S.9
  • 28
    • 38749131263 scopus 로고    scopus 로고
    • Effects of dietary polyphenols on gene expression in human vascular endothelial cells
    • Nicholson, S. K., Tucker, G. A., and Brameld, J. M. (2008) Effects of dietary polyphenols on gene expression in human vascular endothelial cells Proc. Nutr. Soc. 67, 42-47
    • (2008) Proc. Nutr. Soc. , vol.67 , pp. 42-47
    • Nicholson, S.K.1    Tucker, G.A.2    Brameld, J.M.3
  • 29
    • 0022567358 scopus 로고
    • Flavonoids in the human diet
    • Pierpoint, W. S. (1986) Flavonoids in the human diet Prog. Clin. Biol. Res. 213, 125-140
    • (1986) Prog. Clin. Biol. Res. , vol.213 , pp. 125-140
    • Pierpoint, W.S.1
  • 30
    • 84892138934 scopus 로고
    • The impact of plant flavonoids on mammalian biology: implications for immunity, inflammation and cancer
    • (Harborne, J. B. Ed.) pp, Chapman & Hall, London
    • Middleton, E. J. and Kandaswami, C. (1993) The impact of plant flavonoids on mammalian biology: implications for immunity, inflammation and cancer, in The Flavonoids: Advances in Research since 1986 (Harborne, J. B., Ed.) pp 619-652, Chapman & Hall, London.
    • (1993) The Flavonoids: Advances in Research since 1986 , pp. 619-652
    • Middleton, E.J.1    Kandaswami, C.2
  • 31
    • 0031048299 scopus 로고    scopus 로고
    • Lewis A. Conner Memorial Lecture. Oxidative modification of LDL and atherogenesis
    • Steinberg, D. (1997) Lewis A. Conner Memorial Lecture. Oxidative modification of LDL and atherogenesis Circulation 95, 1062-1071
    • (1997) Circulation , vol.95 , pp. 1062-1071
    • Steinberg, D.1
  • 32
    • 1242297561 scopus 로고    scopus 로고
    • Role of caspases in ox-LDL-induced apoptotic cascade in human coronary artery endothelial cells
    • Chen, J., Mehta, J. L., Haider, N., Zhang, X., Narula, J., and Li, D. (2004) Role of caspases in ox-LDL-induced apoptotic cascade in human coronary artery endothelial cells Circ. Res. 94, 370-376
    • (2004) Circ. Res. , vol.94 , pp. 370-376
    • Chen, J.1    Mehta, J.L.2    Haider, N.3    Zhang, X.4    Narula, J.5    Li, D.6
  • 34
    • 24344459055 scopus 로고    scopus 로고
    • Differential inhibition of oxidized LDL-induced apoptosis in human endothelial cells treated with different flavonoids
    • Jeong, Y. J., Choi, Y. J., Kwon, H. M., Kang, S. W., Park, H. S., Lee, M., and Kang, Y. H. (2005) Differential inhibition of oxidized LDL-induced apoptosis in human endothelial cells treated with different flavonoids Br. J. Nutr. 93, 581-591
    • (2005) Br. J. Nutr. , vol.93 , pp. 581-591
    • Jeong, Y.J.1    Choi, Y.J.2    Kwon, H.M.3    Kang, S.W.4    Park, H.S.5    Lee, M.6    Kang, Y.H.7
  • 39
    • 78650774201 scopus 로고    scopus 로고
    • Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells
    • Chen, Q., Ganapathy, S., Singh, K. P., Shankar, S., and Srivastava, R. K. (2010) Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells PLoS One 5, e15288
    • (2010) PLoS One , vol.5
    • Chen, Q.1    Ganapathy, S.2    Singh, K.P.3    Shankar, S.4    Srivastava, R.K.5
  • 40
    • 0037027751 scopus 로고    scopus 로고
    • Purging effect of dibutyl phthalate on leukemia cells involves fas independent activation of caspase-3/CPP32 protease
    • Wang, L. S., Liu, H. J., Zhang, J. H., and Wu, C. T. (2002) Purging effect of dibutyl phthalate on leukemia cells involves fas independent activation of caspase-3/CPP32 protease Cancer Lett. 186, 177-182
    • (2002) Cancer Lett. , vol.186 , pp. 177-182
    • Wang, L.S.1    Liu, H.J.2    Zhang, J.H.3    Wu, C.T.4
  • 41
    • 0028176651 scopus 로고
    • Oxidative stress as a mediator of apoptosis
    • Buttke, T. M. and Sandstrom, P. A. (1994) Oxidative stress as a mediator of apoptosis Immunol. Today 15, 7-10
    • (1994) Immunol. Today , vol.15 , pp. 7-10
    • Buttke, T.M.1    Sandstrom, P.A.2
  • 42
    • 8344242220 scopus 로고    scopus 로고
    • Autophagy in health and disease: a double-edged sword
    • Shintani, T. and Klionsky, D. J. (2004) Autophagy in health and disease: a double-edged sword Science 306, 990-995
    • (2004) Science , vol.306 , pp. 990-995
    • Shintani, T.1    Klionsky, D.J.2
  • 43
    • 84887346480 scopus 로고    scopus 로고
    • Resveratrol protects HUVECs from oxidized-LDL induced oxidative damage by autophagy upregulation via the AMPK/SIRT1 pathway
    • Guo, H., Chen, Y., Liao, L., and Wu, W. (2013) Resveratrol protects HUVECs from oxidized-LDL induced oxidative damage by autophagy upregulation via the AMPK/SIRT1 pathway Cardiovasc. Drugs Ther. 27, 189-198
    • (2013) Cardiovasc. Drugs Ther. , vol.27 , pp. 189-198
    • Guo, H.1    Chen, Y.2    Liao, L.3    Wu, W.4
  • 45
    • 0035929650 scopus 로고    scopus 로고
    • The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway
    • Arico, S., Petiot, A., Bauvy, C., Dubbelhuis, P. F., Meijer, A. J., Codogno, P., and Ogier-Denis, E. (2001) The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway J. Biol. Chem. 276, 35243-35246
    • (2001) J. Biol. Chem. , vol.276 , pp. 35243-35246
    • Arico, S.1    Petiot, A.2    Bauvy, C.3    Dubbelhuis, P.F.4    Meijer, A.J.5    Codogno, P.6    Ogier-Denis, E.7
  • 46
    • 0033978633 scopus 로고    scopus 로고
    • Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells
    • Petiot, A., Ogier-Denis, E., Blommaart, E. F., Meijer, A. J., and Codogno, P. (2000) Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells J. Biol. Chem. 275, 992-998
    • (2000) J. Biol. Chem. , vol.275 , pp. 992-998
    • Petiot, A.1    Ogier-Denis, E.2    Blommaart, E.F.3    Meijer, A.J.4    Codogno, P.5
  • 47
    • 0032431032 scopus 로고
    • The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway
    • Wu, X., Senechal, K., Neshat, M. S., Whang, Y. E., and Sawyers, C. L. (1988) The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway Proc. Natl. Acad. Sci. U.S.A. 95, 15587-15591
    • (1988) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 15587-15591
    • Wu, X.1    Senechal, K.2    Neshat, M.S.3    Whang, Y.E.4    Sawyers, C.L.5
  • 50
    • 77950890848 scopus 로고    scopus 로고
    • Oxidized low-density lipoproteins upregulate proline oxidase to initiate ROS-dependent autophagy
    • Zabirnyk, O., Liu, W., Khalil, S., Sharma, A., and Phang, J. M. (2010) Oxidized low-density lipoproteins upregulate proline oxidase to initiate ROS-dependent autophagy Carcinogenesis 31, 446-454
    • (2010) Carcinogenesis , vol.31 , pp. 446-454
    • Zabirnyk, O.1    Liu, W.2    Khalil, S.3    Sharma, A.4    Phang, J.M.5
  • 51
    • 82255186823 scopus 로고    scopus 로고
    • Toll-like receptor 4 is up-regulated by mTOR activation during THP-1 macrophage foam cells formation
    • Yu, M., Kang, X., Xue, H., and Yin, H. (2011) Toll-like receptor 4 is up-regulated by mTOR activation during THP-1 macrophage foam cells formation Acta Biochim. Biophys. Sin. 940-947
    • (2011) Acta Biochim. Biophys. Sin. , pp. 940-947
    • Yu, M.1    Kang, X.2    Xue, H.3    Yin, H.4
  • 55
    • 77953703298 scopus 로고    scopus 로고
    • Simultaneous inhibition of mTORC1 and mTORC2 by mTOR kinase inhibitor AZD8055 induces autophagy and cell death in cancer cells
    • Sini, P., James, D., Chresta, C., and Guichard, S. (2010) Simultaneous inhibition of mTORC1 and mTORC2 by mTOR kinase inhibitor AZD8055 induces autophagy and cell death in cancer cells Autophagy 6, 553-554
    • (2010) Autophagy , vol.6 , pp. 553-554
    • Sini, P.1    James, D.2    Chresta, C.3    Guichard, S.4


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