Discovery of lesser known flavones as inhibitors of NF-κB signaling in MDA-MB-231 breast cancer cells - A SAR study

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 19, 2014, Pages 4735-4742

  Amrutha, K ^a   Nanjan, Pandurangan ^a   Shaji, Sanu K ^a   Sunilkumar, Damu ^a   Subhalakshmi, K ^a   Rajakrishna, Lakshmi ^b   Banerji, Asoke ^a  

^a AMRITA UNIVERSITY   (India)

^b Anthem Biosciences Pvt Ltd   (India)

Author keywords

Breast cancer; Chrysoeriol; COX 2; Metastasis; Methylated flavonoids; NF B

Indexed keywords

2,3 DIHYDROCHRYSOERIOL; 2,3 DIHYDROISORHAMNETIN; 5 DEOXYCHRYSOERIOL; 5,7 DIDEOXYCHRYSOERIOL; ACACETIN; APIGENIN; CHRYSOERIOL; DIOSMETIN; FLAVONE; FLAVONE DERIVATIVE; GALANGIN; GOSSYPETIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISORHAMNETIN; KAEMPFERIDE; KAEMPFEROL; LUTEOLIN; QUERCETAGETIN; QUERCETIN; TAMARIXETIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CANCER CELL LINE; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; G2 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; METASTASIS; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CELL MOTION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG DEVELOPMENT; DRUG EFFECTS; HUMAN; METABOLISM; SYNTHESIS; TUMOR CELL LINE;

APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL MOVEMENT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; FLAVONES; HUMANS; MOLECULAR STRUCTURE; NF-KAPPA B; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84907216718     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.07.093     Document Type: Article

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